Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5733
Gene name Gene Name - the full gene name approved by the HGNC.	Prostaglandin E receptor 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PTGER3
Synonyms (NCBI Gene) Gene synonyms aliases	EP3, EP3-I, EP3-II, EP3-III, EP3-IV, EP3-VI, EP3e, PGE2-R, lnc003875
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p31.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system,

Show/Hide all(126)

miRTarBase ID	miRNA	Experiments	Reference
MIRT528588	hsa-miR-519d-5p	PAR-CLIP	22012620
MIRT528587	hsa-miR-5695	PAR-CLIP	22012620
MIRT528586	hsa-miR-515-5p	PAR-CLIP	22012620
MIRT528585	hsa-miR-519e-5p	PAR-CLIP	22012620
MIRT528584	hsa-miR-489-3p	PAR-CLIP	22012620
MIRT528583	hsa-miR-6818-3p	PAR-CLIP	22012620
MIRT528582	hsa-miR-514a-3p	PAR-CLIP	22012620
MIRT528581	hsa-miR-514b-3p	PAR-CLIP	22012620
MIRT445841	hsa-miR-5003-3p	PAR-CLIP	22100165
MIRT445840	hsa-miR-556-5p	PAR-CLIP	22100165
MIRT445839	hsa-miR-27b-5p	PAR-CLIP	22100165
MIRT732988	hsa-miR-106b-5p	Microarray	33435900
MIRT528588	hsa-miR-519d-5p	PAR-CLIP	22012620
MIRT528587	hsa-miR-5695	PAR-CLIP	22012620
MIRT528586	hsa-miR-515-5p	PAR-CLIP	22012620
MIRT528585	hsa-miR-519e-5p	PAR-CLIP	22012620
MIRT528584	hsa-miR-489-3p	PAR-CLIP	22012620
MIRT528583	hsa-miR-6818-3p	PAR-CLIP	22012620
MIRT528582	hsa-miR-514a-3p	PAR-CLIP	22012620
MIRT528581	hsa-miR-514b-3p	PAR-CLIP	22012620
MIRT445841	hsa-miR-5003-3p	PAR-CLIP	22100165
MIRT445840	hsa-miR-556-5p	PAR-CLIP	22100165
MIRT445839	hsa-miR-27b-5p	PAR-CLIP	22100165
MIRT1272629	hsa-miR-1200	CLIP-seq
MIRT1272630	hsa-miR-181a	CLIP-seq
MIRT1272631	hsa-miR-181b	CLIP-seq
MIRT1272632	hsa-miR-181c	CLIP-seq
MIRT1272633	hsa-miR-181d	CLIP-seq
MIRT1272634	hsa-miR-186	CLIP-seq
MIRT1272635	hsa-miR-208a	CLIP-seq
MIRT1272636	hsa-miR-208b	CLIP-seq
MIRT1272637	hsa-miR-3074-5p	CLIP-seq
MIRT737845	hsa-miR-3120-3p	CLIP-seq
MIRT1272638	hsa-miR-3129-3p	CLIP-seq
MIRT1272639	hsa-miR-3133	CLIP-seq
MIRT1272640	hsa-miR-3140-5p	CLIP-seq
MIRT1272641	hsa-miR-3145-3p	CLIP-seq
MIRT1272642	hsa-miR-3177-5p	CLIP-seq
MIRT1272643	hsa-miR-320a	CLIP-seq
MIRT1272644	hsa-miR-320b	CLIP-seq
MIRT1272645	hsa-miR-320c	CLIP-seq
MIRT1272646	hsa-miR-320d	CLIP-seq
MIRT1272647	hsa-miR-3617	CLIP-seq
MIRT1272648	hsa-miR-3658	CLIP-seq
MIRT737844	hsa-miR-3908	CLIP-seq
MIRT1272649	hsa-miR-3920	CLIP-seq
MIRT737842	hsa-miR-3925-5p	CLIP-seq
MIRT1272650	hsa-miR-4262	CLIP-seq
MIRT737843	hsa-miR-4311	CLIP-seq
MIRT1272651	hsa-miR-4312	CLIP-seq
MIRT1272652	hsa-miR-4429	CLIP-seq
MIRT1272653	hsa-miR-4668-3p	CLIP-seq
MIRT1272654	hsa-miR-4719	CLIP-seq
MIRT1272655	hsa-miR-4744	CLIP-seq
MIRT1272656	hsa-miR-487a	CLIP-seq
MIRT1272657	hsa-miR-488	CLIP-seq
MIRT1272658	hsa-miR-499-5p	CLIP-seq
MIRT1272659	hsa-miR-561	CLIP-seq
MIRT1272660	hsa-miR-579	CLIP-seq
MIRT1272661	hsa-miR-598	CLIP-seq
MIRT1272662	hsa-miR-641	CLIP-seq
MIRT1272663	hsa-miR-1238	CLIP-seq
MIRT1272664	hsa-miR-4272	CLIP-seq
MIRT1272653	hsa-miR-4668-3p	CLIP-seq
MIRT1272665	hsa-miR-4691-5p	CLIP-seq
MIRT1272666	hsa-miR-4698	CLIP-seq
MIRT1272667	hsa-miR-605	CLIP-seq
MIRT1552675	hsa-miR-3622b-5p	CLIP-seq
MIRT1552676	hsa-miR-4461	CLIP-seq
MIRT1921278	hsa-miR-203	CLIP-seq
MIRT1921279	hsa-miR-2681	CLIP-seq
MIRT2080159	hsa-miR-106a	CLIP-seq
MIRT2080160	hsa-miR-106b	CLIP-seq
MIRT2080161	hsa-miR-17	CLIP-seq
MIRT2080162	hsa-miR-20a	CLIP-seq
MIRT2080163	hsa-miR-20b	CLIP-seq
MIRT2080164	hsa-miR-302a	CLIP-seq
MIRT2080165	hsa-miR-302b	CLIP-seq
MIRT2080166	hsa-miR-302c	CLIP-seq
MIRT2080167	hsa-miR-302d	CLIP-seq
MIRT2080168	hsa-miR-302e	CLIP-seq
MIRT2080169	hsa-miR-3688-3p	CLIP-seq
MIRT2080170	hsa-miR-371b-5p	CLIP-seq
MIRT2080171	hsa-miR-372	CLIP-seq
MIRT2080172	hsa-miR-373	CLIP-seq
MIRT2080173	hsa-miR-3978	CLIP-seq
MIRT2080174	hsa-miR-4643	CLIP-seq
MIRT1272666	hsa-miR-4698	CLIP-seq
MIRT2080175	hsa-miR-4717-3p	CLIP-seq
MIRT2080176	hsa-miR-4802-3p	CLIP-seq
MIRT2080177	hsa-miR-519d	CLIP-seq
MIRT2080178	hsa-miR-520a-3p	CLIP-seq
MIRT2080179	hsa-miR-520b	CLIP-seq
MIRT2080180	hsa-miR-520c-3p	CLIP-seq
MIRT2080181	hsa-miR-520d-3p	CLIP-seq
MIRT2080182	hsa-miR-520e	CLIP-seq
MIRT2080183	hsa-miR-93	CLIP-seq
MIRT2306430	hsa-miR-128	CLIP-seq
MIRT1272630	hsa-miR-181a	CLIP-seq
MIRT1272631	hsa-miR-181b	CLIP-seq
MIRT1272632	hsa-miR-181c	CLIP-seq
MIRT1272633	hsa-miR-181d	CLIP-seq
MIRT1272634	hsa-miR-186	CLIP-seq
MIRT2306431	hsa-miR-27a	CLIP-seq
MIRT2306432	hsa-miR-27b	CLIP-seq
MIRT1272639	hsa-miR-3133	CLIP-seq
MIRT1272641	hsa-miR-3145-3p	CLIP-seq
MIRT2306433	hsa-miR-3149	CLIP-seq
MIRT2306434	hsa-miR-34b	CLIP-seq
MIRT1272650	hsa-miR-4262	CLIP-seq
MIRT2306435	hsa-miR-450b-5p	CLIP-seq
MIRT2306436	hsa-miR-4659a-3p	CLIP-seq
MIRT2306437	hsa-miR-4659b-3p	CLIP-seq
MIRT1272666	hsa-miR-4698	CLIP-seq
MIRT2306438	hsa-miR-4700-3p	CLIP-seq
MIRT2306439	hsa-miR-4708-5p	CLIP-seq
MIRT2306440	hsa-miR-4756-3p	CLIP-seq
MIRT2306441	hsa-miR-4760-3p	CLIP-seq
MIRT2306442	hsa-miR-507	CLIP-seq
MIRT2306443	hsa-miR-513a-5p	CLIP-seq
MIRT2306444	hsa-miR-520d-5p	CLIP-seq
MIRT2306445	hsa-miR-524-5p	CLIP-seq
MIRT2306446	hsa-miR-557	CLIP-seq
MIRT1272660	hsa-miR-579	CLIP-seq
MIRT2306447	hsa-miR-630	CLIP-seq
MIRT2306448	hsa-miR-664	CLIP-seq

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004955	Function	Prostaglandin receptor activity	IEA
GO:0004957	Function	Prostaglandin E receptor activity	IBA
GO:0004957	Function	Prostaglandin E receptor activity	IEA
GO:0004957	Function	Prostaglandin E receptor activity	NAS	9073510
GO:0004957	Function	Prostaglandin E receptor activity	TAS	10947062
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005635	Component	Nuclear envelope	TAS	10336471
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	31097585
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8307176, 10336471
GO:0006954	Process	Inflammatory response	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	8307176
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IBA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA
GO:0008219	Process	Cell death	TAS	10947062
GO:0014827	Process	Intestine smooth muscle contraction	IBA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	9073510
GO:0031622	Process	Positive regulation of fever generation	ISS
GO:0060455	Process	Negative regulation of gastric acid secretion	IBA

MIM	HGNC	e!Ensembl
176806	9595	ENSG00000050628

Protein

UniProt ID

P43115

Protein name

Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor)

Protein function

Receptor for prostaglandin E2 (PGE2) (PubMed:7883006, PubMed:7981210, PubMed:8117308, PubMed:8135729, PubMed:8307176). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elev

PDB

6AK3 , 6M9T , 7WU9 , 8GDC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	65 → 346	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in kidney (PubMed:8117308, PubMed:8135729). Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels. {ECO:0000269|PubMed:18023986, ECO:0000269|PubMed:8117308, ECO:0000269|PubM

Sequence

MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL
TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW
EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG
VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL
ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI
MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQI
RYHTNNYASSSTSLPCQCSSTLMWSDHLER

Sequence length

390

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Regulation of lipolysis in adipocytes Human cytomegalovirus infection Pathways in cancer		Prostanoid ligand receptors G alpha (i) signalling events

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (59)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	11997037, 28415726
Adrenocortical Carcinoma	Associate	34220331
Alzheimer Disease	Associate	34981809
Apnea	Associate	23155414
Arrhythmogenic Right Ventricular Dysplasia	Associate	30664203
Arthritis Rheumatoid	Associate	33273889
Asthma Aspirin Induced	Inhibit	20587336
Asthma Aspirin Induced	Associate	20587336
Blood Platelet Disorders	Associate	19012178
Breast Neoplasms	Associate	20503412, 33849622
Burns Chemical	Associate	21966456
Carcinoma Renal Cell	Associate	32144299, 32788609
Carcinoma Renal Cell	Inhibit	37455526
Coronary Artery Disease	Associate	32971215
Death	Associate	34220331
Diabetic Nephropathies	Associate	33435900
Endometrial Neoplasms	Inhibit	21589857
Endometrial Neoplasms	Stimulate	26240828
Endometriosis	Stimulate	26240828
Endometriosis	Associate	36524127
Fever	Associate	35022648
Hypertension	Associate	19562039
Inflammation	Inhibit	21966456
Inflammation	Associate	25333975
Inflammatory Breast Neoplasms	Associate	20503412
Leukemia	Associate	8910368
Liver Diseases	Associate	21966456
Mouth Diseases	Associate	20388794
Moyamoya Disease	Stimulate	39948449
Nasal Polyps	Associate	16689996
Neoplasm Metastasis	Associate	37455526
Neoplasms	Associate	30655206, 30987861, 31253108, 36436093, 37455526
Neoplasms	Inhibit	32144299
Neuroblastoma	Associate	22276108
Osteoarthritis	Associate	33273889
Ovarian Diseases	Associate	22355044
Ovarian Neoplasms	Associate	30655206
Pemphigoid Benign Mucous Membrane	Inhibit	21966456
Peritoneal Neoplasms	Associate	21966456
Plaque Atherosclerotic	Inhibit	25333975
Polyps	Associate	22551900
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	32251289
Prostatic Neoplasms	Inhibit	23364535
Prostatitis	Associate	27012192
Seizures Febrile	Associate	35022648
Sleep Apnea Obstructive	Associate	23155414
Squamous Cell Carcinoma of Head and Neck	Associate	20951077, 31969157
Status Asthmaticus	Associate	20587336
Stevens Johnson Syndrome	Inhibit	21966456, 35113749
Stomach Neoplasms	Associate	30510283, 35627105
Thrombosis	Associate	22870195
Thyroid Cancer Papillary	Associate	26511970
Ulcer	Associate	21966456
Urinary Bladder Neoplasms	Associate	40696737
Uterine Cervical Dysplasia	Associate	30402741
Uterine Cervical Neoplasms	Associate	28753926, 30402741, 31980713, 32488496
Uterine Cervicitis	Associate	32488496
Uterine Diseases	Associate	26240828
Wounds and Injuries	Associate	33273889

PTGER3 (prostaglandin E receptor 3)