Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	573
Gene name Gene Name - the full gene name approved by the HGNC.	BAG cochaperone 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	BAG1
Synonyms (NCBI Gene) Gene synonyms aliases	BAG-1, HAP, RAP46
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects

Show/Hide all(304)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047188	hsa-miR-182-5p	CLASH	23622248
MIRT053755	hsa-miR-494-3p	Flow, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24606447
MIRT054749	hsa-miR-28-5p	Luciferase reporter assay, QRTPCR, Western blot	24843176
MIRT550024	hsa-miR-888-5p	PAR-CLIP	21572407
MIRT550023	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT550022	hsa-miR-6852-5p	PAR-CLIP	21572407
MIRT550021	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT550020	hsa-miR-371a-5p	PAR-CLIP	21572407
MIRT550019	hsa-miR-1343-3p	PAR-CLIP	21572407
MIRT550018	hsa-miR-6783-3p	PAR-CLIP	21572407
MIRT733929	hsa-miR-146b-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blotting	33084403
MIRT736919	hsa-miR-342-3p	Western blotting, Microarray, RNA-seq, Immunofluorescence, qRT-PCR, Flow cytometry	32488063
MIRT550024	hsa-miR-888-5p	PAR-CLIP	21572407
MIRT550023	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT550022	hsa-miR-6852-5p	PAR-CLIP	21572407
MIRT550021	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT550020	hsa-miR-371a-5p	PAR-CLIP	21572407
MIRT550019	hsa-miR-1343-3p	PAR-CLIP	21572407
MIRT550018	hsa-miR-6783-3p	PAR-CLIP	21572407
MIRT814417	hsa-let-7a	CLIP-seq
MIRT814418	hsa-let-7b	CLIP-seq
MIRT814419	hsa-let-7c	CLIP-seq
MIRT814420	hsa-let-7d	CLIP-seq
MIRT814421	hsa-let-7e	CLIP-seq
MIRT814422	hsa-let-7f	CLIP-seq
MIRT814423	hsa-let-7g	CLIP-seq
MIRT814424	hsa-let-7i	CLIP-seq
MIRT814425	hsa-miR-1207-3p	CLIP-seq
MIRT814426	hsa-miR-1224-5p	CLIP-seq
MIRT814427	hsa-miR-1226	CLIP-seq
MIRT814428	hsa-miR-1229	CLIP-seq
MIRT814429	hsa-miR-1252	CLIP-seq
MIRT814430	hsa-miR-1307	CLIP-seq
MIRT814431	hsa-miR-148a	CLIP-seq
MIRT814432	hsa-miR-148b	CLIP-seq
MIRT814433	hsa-miR-152	CLIP-seq
MIRT814434	hsa-miR-1909	CLIP-seq
MIRT814435	hsa-miR-1912	CLIP-seq
MIRT814436	hsa-miR-193a-5p	CLIP-seq
MIRT814437	hsa-miR-196a	CLIP-seq
MIRT814438	hsa-miR-196b	CLIP-seq
MIRT814439	hsa-miR-216a	CLIP-seq
MIRT814440	hsa-miR-216b	CLIP-seq
MIRT814441	hsa-miR-2467-3p	CLIP-seq
MIRT814442	hsa-miR-296-3p	CLIP-seq
MIRT814443	hsa-miR-300	CLIP-seq
MIRT814444	hsa-miR-3120-3p	CLIP-seq
MIRT814445	hsa-miR-3139	CLIP-seq
MIRT814446	hsa-miR-3150b-3p	CLIP-seq
MIRT814447	hsa-miR-3153	CLIP-seq
MIRT814448	hsa-miR-3200-5p	CLIP-seq
MIRT814449	hsa-miR-361-3p	CLIP-seq
MIRT814450	hsa-miR-3647-3p	CLIP-seq
MIRT814451	hsa-miR-3667-5p	CLIP-seq
MIRT814452	hsa-miR-371-5p	CLIP-seq
MIRT814453	hsa-miR-381	CLIP-seq
MIRT814454	hsa-miR-4257	CLIP-seq
MIRT814455	hsa-miR-4282	CLIP-seq
MIRT814456	hsa-miR-4284	CLIP-seq
MIRT814457	hsa-miR-431	CLIP-seq
MIRT814458	hsa-miR-4423-5p	CLIP-seq
MIRT814459	hsa-miR-4443	CLIP-seq
MIRT814460	hsa-miR-4458	CLIP-seq
MIRT814461	hsa-miR-4476	CLIP-seq
MIRT814462	hsa-miR-4500	CLIP-seq
MIRT814463	hsa-miR-4514	CLIP-seq
MIRT814464	hsa-miR-4533	CLIP-seq
MIRT814465	hsa-miR-4638-5p	CLIP-seq
MIRT814466	hsa-miR-4645-5p	CLIP-seq
MIRT814467	hsa-miR-4646-5p	CLIP-seq
MIRT814468	hsa-miR-4649-3p	CLIP-seq
MIRT814469	hsa-miR-4666-3p	CLIP-seq
MIRT814470	hsa-miR-4668-5p	CLIP-seq
MIRT814471	hsa-miR-4673	CLIP-seq
MIRT814472	hsa-miR-4689	CLIP-seq
MIRT814473	hsa-miR-4690-3p	CLIP-seq
MIRT814474	hsa-miR-4690-5p	CLIP-seq
MIRT814475	hsa-miR-4692	CLIP-seq
MIRT814476	hsa-miR-4710	CLIP-seq
MIRT814477	hsa-miR-4722-5p	CLIP-seq
MIRT814478	hsa-miR-4733-3p	CLIP-seq
MIRT814479	hsa-miR-4751	CLIP-seq
MIRT814480	hsa-miR-4768-3p	CLIP-seq
MIRT814481	hsa-miR-4781-3p	CLIP-seq
MIRT814482	hsa-miR-4784	CLIP-seq
MIRT814483	hsa-miR-498	CLIP-seq
MIRT814484	hsa-miR-585	CLIP-seq
MIRT814485	hsa-miR-624	CLIP-seq
MIRT814486	hsa-miR-708	CLIP-seq
MIRT814487	hsa-miR-765	CLIP-seq
MIRT814488	hsa-miR-888	CLIP-seq
MIRT814489	hsa-miR-940	CLIP-seq
MIRT814490	hsa-miR-98	CLIP-seq
MIRT814417	hsa-let-7a	CLIP-seq
MIRT814418	hsa-let-7b	CLIP-seq
MIRT814419	hsa-let-7c	CLIP-seq
MIRT814420	hsa-let-7d	CLIP-seq
MIRT814421	hsa-let-7e	CLIP-seq
MIRT814422	hsa-let-7f	CLIP-seq
MIRT814423	hsa-let-7g	CLIP-seq
MIRT814424	hsa-let-7i	CLIP-seq
MIRT814491	hsa-miR-122	CLIP-seq
MIRT814492	hsa-miR-1245	CLIP-seq
MIRT814429	hsa-miR-1252	CLIP-seq
MIRT814493	hsa-miR-1273f	CLIP-seq
MIRT814494	hsa-miR-1303	CLIP-seq
MIRT814495	hsa-miR-149	CLIP-seq
MIRT814496	hsa-miR-150	CLIP-seq
MIRT814497	hsa-miR-1587	CLIP-seq
MIRT814498	hsa-miR-182	CLIP-seq
MIRT814434	hsa-miR-1909	CLIP-seq
MIRT814436	hsa-miR-193a-5p	CLIP-seq
MIRT814437	hsa-miR-196a	CLIP-seq
MIRT814438	hsa-miR-196b	CLIP-seq
MIRT814441	hsa-miR-2467-3p	CLIP-seq
MIRT814442	hsa-miR-296-3p	CLIP-seq
MIRT814443	hsa-miR-300	CLIP-seq
MIRT814499	hsa-miR-31	CLIP-seq
MIRT814500	hsa-miR-3135b	CLIP-seq
MIRT814445	hsa-miR-3139	CLIP-seq
MIRT814446	hsa-miR-3150b-3p	CLIP-seq
MIRT814501	hsa-miR-3176	CLIP-seq
MIRT814502	hsa-miR-331-3p	CLIP-seq
MIRT814449	hsa-miR-361-3p	CLIP-seq
MIRT814450	hsa-miR-3647-3p	CLIP-seq
MIRT814503	hsa-miR-3652	CLIP-seq
MIRT814504	hsa-miR-3663-5p	CLIP-seq
MIRT814451	hsa-miR-3667-5p	CLIP-seq
MIRT814452	hsa-miR-371-5p	CLIP-seq
MIRT814505	hsa-miR-371b-5p	CLIP-seq
MIRT814506	hsa-miR-378g	CLIP-seq
MIRT814453	hsa-miR-381	CLIP-seq
MIRT814507	hsa-miR-3922-3p	CLIP-seq
MIRT814508	hsa-miR-3944-3p	CLIP-seq
MIRT814454	hsa-miR-4257	CLIP-seq
MIRT814457	hsa-miR-431	CLIP-seq
MIRT814509	hsa-miR-4313	CLIP-seq
MIRT814510	hsa-miR-4325	CLIP-seq
MIRT814511	hsa-miR-433	CLIP-seq
MIRT814458	hsa-miR-4423-5p	CLIP-seq
MIRT814512	hsa-miR-4430	CLIP-seq
MIRT814513	hsa-miR-4435	CLIP-seq
MIRT814459	hsa-miR-4443	CLIP-seq
MIRT814514	hsa-miR-4454	CLIP-seq
MIRT814460	hsa-miR-4458	CLIP-seq
MIRT814515	hsa-miR-4470	CLIP-seq
MIRT814516	hsa-miR-4474-3p	CLIP-seq
MIRT814461	hsa-miR-4476	CLIP-seq
MIRT814517	hsa-miR-4492	CLIP-seq
MIRT814518	hsa-miR-4496	CLIP-seq
MIRT814519	hsa-miR-4498	CLIP-seq
MIRT814462	hsa-miR-4500	CLIP-seq
MIRT814463	hsa-miR-4514	CLIP-seq
MIRT814464	hsa-miR-4533	CLIP-seq
MIRT814466	hsa-miR-4645-5p	CLIP-seq
MIRT814520	hsa-miR-4656	CLIP-seq
MIRT814469	hsa-miR-4666-3p	CLIP-seq
MIRT814470	hsa-miR-4668-5p	CLIP-seq
MIRT814471	hsa-miR-4673	CLIP-seq
MIRT814521	hsa-miR-4675	CLIP-seq
MIRT814472	hsa-miR-4689	CLIP-seq
MIRT814474	hsa-miR-4690-5p	CLIP-seq
MIRT814475	hsa-miR-4692	CLIP-seq
MIRT814522	hsa-miR-4693-3p	CLIP-seq
MIRT814523	hsa-miR-4707-3p	CLIP-seq
MIRT814476	hsa-miR-4710	CLIP-seq
MIRT814477	hsa-miR-4722-5p	CLIP-seq
MIRT814524	hsa-miR-4741	CLIP-seq
MIRT814525	hsa-miR-4757-5p	CLIP-seq
MIRT814526	hsa-miR-4766-5p	CLIP-seq
MIRT814480	hsa-miR-4768-3p	CLIP-seq
MIRT814527	hsa-miR-4774-5p	CLIP-seq
MIRT814481	hsa-miR-4781-3p	CLIP-seq
MIRT814482	hsa-miR-4784	CLIP-seq
MIRT814483	hsa-miR-498	CLIP-seq
MIRT814528	hsa-miR-507	CLIP-seq
MIRT814529	hsa-miR-557	CLIP-seq
MIRT814484	hsa-miR-585	CLIP-seq
MIRT814530	hsa-miR-590-3p	CLIP-seq
MIRT814531	hsa-miR-615-5p	CLIP-seq
MIRT814485	hsa-miR-624	CLIP-seq
MIRT814532	hsa-miR-661	CLIP-seq
MIRT814486	hsa-miR-708	CLIP-seq
MIRT814533	hsa-miR-760	CLIP-seq
MIRT814534	hsa-miR-762	CLIP-seq
MIRT814487	hsa-miR-765	CLIP-seq
MIRT814535	hsa-miR-892b	CLIP-seq
MIRT814489	hsa-miR-940	CLIP-seq
MIRT814490	hsa-miR-98	CLIP-seq
MIRT1921530	hsa-miR-4422	CLIP-seq
MIRT814441	hsa-miR-2467-3p	CLIP-seq
MIRT814426	hsa-miR-1224-5p	CLIP-seq
MIRT814429	hsa-miR-1252	CLIP-seq
MIRT814501	hsa-miR-3176	CLIP-seq
MIRT814450	hsa-miR-3647-3p	CLIP-seq
MIRT814507	hsa-miR-3922-3p	CLIP-seq
MIRT814455	hsa-miR-4282	CLIP-seq
MIRT1940790	hsa-miR-4461	CLIP-seq
MIRT814476	hsa-miR-4710	CLIP-seq
MIRT814417	hsa-let-7a	CLIP-seq
MIRT814418	hsa-let-7b	CLIP-seq
MIRT814419	hsa-let-7c	CLIP-seq
MIRT814420	hsa-let-7d	CLIP-seq
MIRT814421	hsa-let-7e	CLIP-seq
MIRT814422	hsa-let-7f	CLIP-seq
MIRT814423	hsa-let-7g	CLIP-seq
MIRT814424	hsa-let-7i	CLIP-seq
MIRT814491	hsa-miR-122	CLIP-seq
MIRT814492	hsa-miR-1245	CLIP-seq
MIRT814429	hsa-miR-1252	CLIP-seq
MIRT2179797	hsa-miR-1284	CLIP-seq
MIRT814430	hsa-miR-1307	CLIP-seq
MIRT2179798	hsa-miR-146a	CLIP-seq
MIRT814496	hsa-miR-150	CLIP-seq
MIRT814434	hsa-miR-1909	CLIP-seq
MIRT814437	hsa-miR-196a	CLIP-seq
MIRT814438	hsa-miR-196b	CLIP-seq
MIRT2179799	hsa-miR-199a-5p	CLIP-seq
MIRT2179800	hsa-miR-199b-5p	CLIP-seq
MIRT814439	hsa-miR-216a	CLIP-seq
MIRT814440	hsa-miR-216b	CLIP-seq
MIRT814441	hsa-miR-2467-3p	CLIP-seq
MIRT814442	hsa-miR-296-3p	CLIP-seq
MIRT814443	hsa-miR-300	CLIP-seq
MIRT2179801	hsa-miR-3117-5p	CLIP-seq
MIRT814444	hsa-miR-3120-3p	CLIP-seq
MIRT814500	hsa-miR-3135b	CLIP-seq
MIRT814445	hsa-miR-3139	CLIP-seq
MIRT814446	hsa-miR-3150b-3p	CLIP-seq
MIRT814501	hsa-miR-3176	CLIP-seq
MIRT2179802	hsa-miR-3184	CLIP-seq
MIRT2179803	hsa-miR-3199	CLIP-seq
MIRT814503	hsa-miR-3652	CLIP-seq
MIRT2179804	hsa-miR-3664-5p	CLIP-seq
MIRT814452	hsa-miR-371-5p	CLIP-seq
MIRT814505	hsa-miR-371b-5p	CLIP-seq
MIRT2179805	hsa-miR-376c	CLIP-seq
MIRT814453	hsa-miR-381	CLIP-seq
MIRT814507	hsa-miR-3922-3p	CLIP-seq
MIRT2179806	hsa-miR-423-5p	CLIP-seq
MIRT814454	hsa-miR-4257	CLIP-seq
MIRT2179807	hsa-miR-4261	CLIP-seq
MIRT814456	hsa-miR-4284	CLIP-seq
MIRT2179808	hsa-miR-4299	CLIP-seq
MIRT2179809	hsa-miR-4302	CLIP-seq
MIRT814458	hsa-miR-4423-5p	CLIP-seq
MIRT814512	hsa-miR-4430	CLIP-seq
MIRT814459	hsa-miR-4443	CLIP-seq
MIRT814514	hsa-miR-4454	CLIP-seq
MIRT814460	hsa-miR-4458	CLIP-seq
MIRT1940790	hsa-miR-4461	CLIP-seq
MIRT814461	hsa-miR-4476	CLIP-seq
MIRT814517	hsa-miR-4492	CLIP-seq
MIRT814519	hsa-miR-4498	CLIP-seq
MIRT814462	hsa-miR-4500	CLIP-seq
MIRT814464	hsa-miR-4533	CLIP-seq
MIRT814465	hsa-miR-4638-5p	CLIP-seq
MIRT814469	hsa-miR-4666-3p	CLIP-seq
MIRT2179810	hsa-miR-4677-3p	CLIP-seq
MIRT2179811	hsa-miR-4679	CLIP-seq
MIRT814472	hsa-miR-4689	CLIP-seq
MIRT814522	hsa-miR-4693-3p	CLIP-seq
MIRT2179812	hsa-miR-4696	CLIP-seq
MIRT2179813	hsa-miR-4698	CLIP-seq
MIRT814523	hsa-miR-4707-3p	CLIP-seq
MIRT814476	hsa-miR-4710	CLIP-seq
MIRT2179814	hsa-miR-4719	CLIP-seq
MIRT814525	hsa-miR-4757-5p	CLIP-seq
MIRT814481	hsa-miR-4781-3p	CLIP-seq
MIRT814482	hsa-miR-4784	CLIP-seq
MIRT2179815	hsa-miR-494	CLIP-seq
MIRT814483	hsa-miR-498	CLIP-seq
MIRT2179816	hsa-miR-580	CLIP-seq
MIRT814484	hsa-miR-585	CLIP-seq
MIRT2179817	hsa-miR-589	CLIP-seq
MIRT814485	hsa-miR-624	CLIP-seq
MIRT814486	hsa-miR-708	CLIP-seq
MIRT814534	hsa-miR-762	CLIP-seq
MIRT814487	hsa-miR-765	CLIP-seq
MIRT814488	hsa-miR-888	CLIP-seq
MIRT814490	hsa-miR-98	CLIP-seq
MIRT2675851	hsa-miR-1827	CLIP-seq
MIRT2675852	hsa-miR-186	CLIP-seq
MIRT2675853	hsa-miR-2278	CLIP-seq
MIRT814499	hsa-miR-31	CLIP-seq
MIRT2675854	hsa-miR-3125	CLIP-seq
MIRT2675855	hsa-miR-3133	CLIP-seq
MIRT2675856	hsa-miR-3646	CLIP-seq
MIRT2675857	hsa-miR-3662	CLIP-seq
MIRT2675858	hsa-miR-3916	CLIP-seq
MIRT814508	hsa-miR-3944-3p	CLIP-seq
MIRT2675859	hsa-miR-4300	CLIP-seq
MIRT814510	hsa-miR-4325	CLIP-seq
MIRT814511	hsa-miR-433	CLIP-seq
MIRT2675860	hsa-miR-4419a	CLIP-seq
MIRT2675861	hsa-miR-4468	CLIP-seq
MIRT2675862	hsa-miR-4509	CLIP-seq
MIRT2675863	hsa-miR-4510	CLIP-seq
MIRT2675864	hsa-miR-4633-3p	CLIP-seq
MIRT2675865	hsa-miR-4744	CLIP-seq
MIRT2675866	hsa-miR-4795-5p	CLIP-seq
MIRT814528	hsa-miR-507	CLIP-seq
MIRT814529	hsa-miR-557	CLIP-seq
MIRT2675867	hsa-miR-920	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
CTCFL	Activation	18413740
DNMT1	Unknown	18413740

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000774	Function	Adenyl-nucleotide exchange factor activity	IBA
GO:0000774	Function	Adenyl-nucleotide exchange factor activity	IDA	24318877
GO:0005515	Function	Protein binding	IPI	9305631, 19060904, 19800331, 24318877, 25036637, 25416956, 26871637, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	9679980
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	8947043
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006457	Process	Protein folding	IDA	12853476
GO:0006915	Process	Apoptotic process	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	8947043
GO:0016020	Component	Membrane	IBA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	16207813
GO:0034393	Process	Positive regulation of smooth muscle cell apoptotic process	ISS
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	TAS	8947043
GO:0050821	Process	Protein stabilization	IBA
GO:0051087	Function	Protein-folding chaperone binding	IBA
GO:0051087	Function	Protein-folding chaperone binding	IEA

MIM	HGNC	e!Ensembl
601497	937	ENSG00000107262

Protein

UniProt ID

Q99933

Protein name

BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1)

Protein function

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated vi

PDB

1HX1 , 1WXV , 3FZF , 3FZH , 3FZK , 3FZL , 3FZM , 3LDQ , 3M3Z , 5AQF , 5AQG , 5AQH , 5AQI , 5AQJ , 5AQK , 5AQL , 5AQM , 5AQN , 5AQO , 5AQP , 5AQQ , 5AQR , 5AQS , 5AQT , 5AQU , 5AQV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00240	ubiquitin	144 → 222	Ubiquitin family	Domain
PF02179	BAG	227 → 325	BAG domain	Family

Tissue specificity

TISSUE SPECIFICITY: Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in

Sequence

MAQRGGARRPRGDRERLGSRLRALRPGREPRQSEPPAQRGPPPSGRPPARSTASGHDRPT
RGAAAGARRPRMKKKTRRRSTRSEELTRSEELTLSEEATWSEEATQSEEATQGEEMNRSQ
EVTRDEESTRSEEVTREEMAAAGLTVTVTHSNEKHDLHVTSQQGSSEPVVQDLAQVVEEV
IGVPQSFQKLIFKGKSLKEMETPLSALGIQDGCRVMLIGKKNSPQEEVELKKLKHLEKSV
EKIADQLEELNKELTGIQQGFLPKDLQAEALCKLDRRVKATIEQFMKILEEIDTLILPEN
FKDSRLKRKGLVKKVQAFLAECDTVEQNICQETERLQSTNFALAE

Sequence length

345

Interactions

View interactions

	KEGG		Reactome
	Protein processing in endoplasmic reticulum		Regulation of HSF1-mediated heat shock response

BAG1 (BAG cochaperone 1)