PTGDR (prostaglandin D2 receptor)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 5729
Gene name Prostaglandin D2 receptor
Gene symbol PTGDR
Synonyms (NCBI Gene)
AS1ASRT1DPDP1PTGDR1
Chromosome 14
Chromosome location 14q22.1
Summary This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pat
miRNA miRNA information provided by mirtarbase database.
35
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (35)
miRTarBase ID miRNA Experiments Reference
MIRT534936 hsa-miR-541-5p PAR-CLIP 22012620
MIRT534935 hsa-miR-495-5p PAR-CLIP 22012620
MIRT534934 hsa-miR-382-5p PAR-CLIP 22012620
MIRT534933 hsa-miR-4477b PAR-CLIP 22012620
MIRT534932 hsa-miR-7856-5p PAR-CLIP 22012620
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
24
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (24)
GO ID Ontology Definition Evidence Reference
GO:0001785 Function Prostaglandin J receptor activity IEA
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004956 Function Prostaglandin D receptor activity IBA
GO:0004956 Function Prostaglandin D receptor activity IEA
GO:0004956 Function Prostaglandin D receptor activity NAS 7642548
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604687 9591 ENSG00000168229
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q13258
Protein name Prostaglandin D2 receptor (PGD receptor) (PGD2 receptor) (Prostanoid DP receptor)
Protein function Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without fo
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 50 → 323 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes. {ECO:0000269|PubMed:11082108, ECO:0000269|PubMed:6302737}.
Sequence
Sequence length 359
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Neuroactive ligand-receptor interaction   Prostanoid ligand receptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
9
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (9)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTHMA — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 1 — CTD, ClinVar, Disgenet
CTD, ClinVar, Disgenet
CTD, ClinVar, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney Likely benign ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIABETIC RETINOPATHY — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (203)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma Associate 19096147, 23333711, 26482433, 33024199
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Stimulate 27577754
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of Lung Associate 29247949, 33992085, 34061466, 35291911, 35603556, 37482612
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Inhibit 23049694
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Associate 32124921, 37354922
★★★★★
★☆☆☆☆
Found in Text Mining only
Amyotrophic lateral sclerosis 1 Inhibit 36736597
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm Abdominal Stimulate 35968497
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm Thoracic Stimulate 25550800
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Dissection Associate 25550800
★★★★★
★☆☆☆☆
Found in Text Mining only
Arrhythmogenic Right Ventricular Dysplasia Associate 16175511
★★★★★
★☆☆☆☆
Found in Text Mining only