Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5723
Gene name	Phosphoserine phosphatase
Gene symbol	PSPH
Synonyms (NCBI Gene)	PSPPSPHD
Chromosome	7
Chromosome location	7p11.2
Summary	The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved i

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SNP ID	Visualize variation	Clinical significance	Consequence
rs73343752	A>G	Likely-benign, conflicting-interpretations-of-pathogenicity	Missense variant, non coding transcript variant, coding sequence variant
rs104894035	C>T	Pathogenic	Non coding transcript variant, missense variant, coding sequence variant
rs104894036	A>G	Pathogenic	Non coding transcript variant, intron variant, coding sequence variant, missense variant
rs786204793	C>T	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023338	hsa-miR-122-5p	Proteomics	21750653
MIRT032012	hsa-miR-16-5p	Proteomics	18668040
MIRT038375	hsa-miR-296-3p	CLASH	23622248
MIRT654660	hsa-miR-3163	HITS-CLIP	23824327
MIRT654659	hsa-miR-4729	HITS-CLIP	23824327
MIRT654658	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT654657	hsa-miR-496	HITS-CLIP	23824327
MIRT654656	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT654655	hsa-miR-5696	HITS-CLIP	23824327
MIRT654654	hsa-miR-4444	HITS-CLIP	23824327
MIRT654660	hsa-miR-3163	HITS-CLIP	23824327
MIRT654659	hsa-miR-4729	HITS-CLIP	23824327
MIRT654658	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT654657	hsa-miR-496	HITS-CLIP	23824327
MIRT654656	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT654655	hsa-miR-5696	HITS-CLIP	23824327
MIRT654654	hsa-miR-4444	HITS-CLIP	23824327
MIRT1271103	hsa-miR-1243	CLIP-seq
MIRT1271104	hsa-miR-139-5p	CLIP-seq
MIRT1271105	hsa-miR-144	CLIP-seq
MIRT1271106	hsa-miR-1827	CLIP-seq
MIRT1271107	hsa-miR-1908	CLIP-seq
MIRT1271108	hsa-miR-200b	CLIP-seq
MIRT1271109	hsa-miR-200c	CLIP-seq
MIRT1271110	hsa-miR-2114	CLIP-seq
MIRT1271111	hsa-miR-297	CLIP-seq
MIRT1271112	hsa-miR-3122	CLIP-seq
MIRT1271113	hsa-miR-3136-3p	CLIP-seq
MIRT1271114	hsa-miR-3149	CLIP-seq
MIRT1271115	hsa-miR-3178	CLIP-seq
MIRT1271116	hsa-miR-3192	CLIP-seq
MIRT1271117	hsa-miR-3612	CLIP-seq
MIRT1271118	hsa-miR-3654	CLIP-seq
MIRT1271119	hsa-miR-3656	CLIP-seq
MIRT1271120	hsa-miR-3689a-3p	CLIP-seq
MIRT1271121	hsa-miR-3689c	CLIP-seq
MIRT1271122	hsa-miR-369-3p	CLIP-seq
MIRT1271123	hsa-miR-374a	CLIP-seq
MIRT1271124	hsa-miR-374b	CLIP-seq
MIRT1271125	hsa-miR-3913-5p	CLIP-seq
MIRT1271126	hsa-miR-3929	CLIP-seq
MIRT1271127	hsa-miR-3937	CLIP-seq
MIRT1271128	hsa-miR-3974	CLIP-seq
MIRT1271129	hsa-miR-4252	CLIP-seq
MIRT1271130	hsa-miR-429	CLIP-seq
MIRT1271131	hsa-miR-4327	CLIP-seq
MIRT1271132	hsa-miR-4419b	CLIP-seq
MIRT1271133	hsa-miR-4422	CLIP-seq
MIRT1271134	hsa-miR-4433	CLIP-seq
MIRT1271135	hsa-miR-4457	CLIP-seq
MIRT1271136	hsa-miR-4459	CLIP-seq
MIRT1271137	hsa-miR-4478	CLIP-seq
MIRT1271138	hsa-miR-4486	CLIP-seq
MIRT1271139	hsa-miR-4537	CLIP-seq
MIRT1271140	hsa-miR-4649-3p	CLIP-seq
MIRT1271141	hsa-miR-4683	CLIP-seq
MIRT1271142	hsa-miR-4722-5p	CLIP-seq
MIRT1271143	hsa-miR-4728-5p	CLIP-seq
MIRT1271144	hsa-miR-4768-3p	CLIP-seq
MIRT1271145	hsa-miR-4793-3p	CLIP-seq
MIRT1271146	hsa-miR-4793-5p	CLIP-seq
MIRT1271147	hsa-miR-4794	CLIP-seq
MIRT1271148	hsa-miR-485-5p	CLIP-seq
MIRT1271149	hsa-miR-490-3p	CLIP-seq
MIRT1271150	hsa-miR-508-5p	CLIP-seq
MIRT1271151	hsa-miR-513b	CLIP-seq
MIRT1271152	hsa-miR-550a	CLIP-seq
MIRT1271153	hsa-miR-582-5p	CLIP-seq
MIRT1271154	hsa-miR-624	CLIP-seq
MIRT1271155	hsa-miR-650	CLIP-seq
MIRT1271156	hsa-miR-663	CLIP-seq
MIRT1271157	hsa-miR-663b	CLIP-seq
MIRT1271158	hsa-miR-766	CLIP-seq
MIRT1271159	hsa-miR-940	CLIP-seq
MIRT1552664	hsa-miR-382	CLIP-seq
MIRT2079737	hsa-miR-1197	CLIP-seq
MIRT2079738	hsa-miR-1251	CLIP-seq
MIRT2079739	hsa-miR-1285	CLIP-seq
MIRT2079740	hsa-miR-1323	CLIP-seq
MIRT1271106	hsa-miR-1827	CLIP-seq
MIRT1271107	hsa-miR-1908	CLIP-seq
MIRT1271110	hsa-miR-2114	CLIP-seq
MIRT1271112	hsa-miR-3122	CLIP-seq
MIRT2079741	hsa-miR-3187-5p	CLIP-seq
MIRT1271116	hsa-miR-3192	CLIP-seq
MIRT1271117	hsa-miR-3612	CLIP-seq
MIRT1271119	hsa-miR-3656	CLIP-seq
MIRT1271120	hsa-miR-3689a-3p	CLIP-seq
MIRT1271121	hsa-miR-3689c	CLIP-seq
MIRT1552664	hsa-miR-382	CLIP-seq
MIRT1271125	hsa-miR-3913-5p	CLIP-seq
MIRT1271126	hsa-miR-3929	CLIP-seq
MIRT1271127	hsa-miR-3937	CLIP-seq
MIRT2079742	hsa-miR-3942-3p	CLIP-seq
MIRT1271128	hsa-miR-3974	CLIP-seq
MIRT1271129	hsa-miR-4252	CLIP-seq
MIRT1271131	hsa-miR-4327	CLIP-seq
MIRT1271132	hsa-miR-4419b	CLIP-seq
MIRT1271134	hsa-miR-4433	CLIP-seq
MIRT1271135	hsa-miR-4457	CLIP-seq
MIRT1271136	hsa-miR-4459	CLIP-seq
MIRT1271137	hsa-miR-4478	CLIP-seq
MIRT2079743	hsa-miR-451b	CLIP-seq
MIRT1271139	hsa-miR-4537	CLIP-seq
MIRT1271140	hsa-miR-4649-3p	CLIP-seq
MIRT1271141	hsa-miR-4683	CLIP-seq
MIRT2079744	hsa-miR-4719	CLIP-seq
MIRT1271142	hsa-miR-4722-5p	CLIP-seq
MIRT1271143	hsa-miR-4728-5p	CLIP-seq
MIRT1271144	hsa-miR-4768-3p	CLIP-seq
MIRT2079745	hsa-miR-4778-5p	CLIP-seq
MIRT1271145	hsa-miR-4793-3p	CLIP-seq
MIRT1271146	hsa-miR-4793-5p	CLIP-seq
MIRT1271148	hsa-miR-485-5p	CLIP-seq
MIRT1271149	hsa-miR-490-3p	CLIP-seq
MIRT1271150	hsa-miR-508-5p	CLIP-seq
MIRT1271151	hsa-miR-513b	CLIP-seq
MIRT2079746	hsa-miR-548o	CLIP-seq
MIRT1271152	hsa-miR-550a	CLIP-seq
MIRT2079747	hsa-miR-612	CLIP-seq
MIRT1271154	hsa-miR-624	CLIP-seq
MIRT1271155	hsa-miR-650	CLIP-seq
MIRT2079748	hsa-miR-661	CLIP-seq
MIRT1271156	hsa-miR-663	CLIP-seq
MIRT1271158	hsa-miR-766	CLIP-seq
MIRT1271159	hsa-miR-940	CLIP-seq
MIRT2306051	hsa-miR-1183	CLIP-seq
MIRT2079737	hsa-miR-1197	CLIP-seq
MIRT1271103	hsa-miR-1243	CLIP-seq
MIRT2079739	hsa-miR-1285	CLIP-seq
MIRT1271104	hsa-miR-139-5p	CLIP-seq
MIRT1271105	hsa-miR-144	CLIP-seq
MIRT1271106	hsa-miR-1827	CLIP-seq
MIRT1271108	hsa-miR-200b	CLIP-seq
MIRT1271109	hsa-miR-200c	CLIP-seq
MIRT2306052	hsa-miR-2054	CLIP-seq
MIRT1271111	hsa-miR-297	CLIP-seq
MIRT2306053	hsa-miR-3120-5p	CLIP-seq
MIRT1271112	hsa-miR-3122	CLIP-seq
MIRT1271114	hsa-miR-3149	CLIP-seq
MIRT2306054	hsa-miR-3159	CLIP-seq
MIRT2079741	hsa-miR-3187-5p	CLIP-seq
MIRT1271116	hsa-miR-3192	CLIP-seq
MIRT1271117	hsa-miR-3612	CLIP-seq
MIRT2306055	hsa-miR-3613-3p	CLIP-seq
MIRT1271118	hsa-miR-3654	CLIP-seq
MIRT1271120	hsa-miR-3689a-3p	CLIP-seq
MIRT1271121	hsa-miR-3689c	CLIP-seq
MIRT1271122	hsa-miR-369-3p	CLIP-seq
MIRT2306056	hsa-miR-371-5p	CLIP-seq
MIRT2306057	hsa-miR-371b-5p	CLIP-seq
MIRT1271123	hsa-miR-374a	CLIP-seq
MIRT1271124	hsa-miR-374b	CLIP-seq
MIRT1552664	hsa-miR-382	CLIP-seq
MIRT1271125	hsa-miR-3913-5p	CLIP-seq
MIRT1271126	hsa-miR-3929	CLIP-seq
MIRT1271127	hsa-miR-3937	CLIP-seq
MIRT1271128	hsa-miR-3974	CLIP-seq
MIRT1271129	hsa-miR-4252	CLIP-seq
MIRT1271130	hsa-miR-429	CLIP-seq
MIRT1271131	hsa-miR-4327	CLIP-seq
MIRT1271132	hsa-miR-4419b	CLIP-seq
MIRT2306058	hsa-miR-4420	CLIP-seq
MIRT1271133	hsa-miR-4422	CLIP-seq
MIRT1271134	hsa-miR-4433	CLIP-seq
MIRT1271135	hsa-miR-4457	CLIP-seq
MIRT1271136	hsa-miR-4459	CLIP-seq
MIRT1271137	hsa-miR-4478	CLIP-seq
MIRT2306059	hsa-miR-4493	CLIP-seq
MIRT2079743	hsa-miR-451b	CLIP-seq
MIRT2306060	hsa-miR-4522	CLIP-seq
MIRT1271139	hsa-miR-4537	CLIP-seq
MIRT1271140	hsa-miR-4649-3p	CLIP-seq
MIRT1271141	hsa-miR-4683	CLIP-seq
MIRT2306061	hsa-miR-4703-3p	CLIP-seq
MIRT1271142	hsa-miR-4722-5p	CLIP-seq
MIRT1271143	hsa-miR-4728-5p	CLIP-seq
MIRT1271144	hsa-miR-4768-3p	CLIP-seq
MIRT2079745	hsa-miR-4778-5p	CLIP-seq
MIRT1271145	hsa-miR-4793-3p	CLIP-seq
MIRT1271146	hsa-miR-4793-5p	CLIP-seq
MIRT1271148	hsa-miR-485-5p	CLIP-seq
MIRT1271149	hsa-miR-490-3p	CLIP-seq
MIRT1271150	hsa-miR-508-5p	CLIP-seq
MIRT1271151	hsa-miR-513b	CLIP-seq
MIRT2306062	hsa-miR-548a-5p	CLIP-seq
MIRT2306063	hsa-miR-548ab	CLIP-seq
MIRT2306064	hsa-miR-548ak	CLIP-seq
MIRT2306065	hsa-miR-548b-5p	CLIP-seq
MIRT2306066	hsa-miR-548c-5p	CLIP-seq
MIRT2306067	hsa-miR-548d-5p	CLIP-seq
MIRT2306068	hsa-miR-548h	CLIP-seq
MIRT2306069	hsa-miR-548i	CLIP-seq
MIRT2306070	hsa-miR-548j	CLIP-seq
MIRT2306071	hsa-miR-548k	CLIP-seq
MIRT2306072	hsa-miR-548l	CLIP-seq
MIRT2306073	hsa-miR-548w	CLIP-seq
MIRT2306074	hsa-miR-548y	CLIP-seq
MIRT2306075	hsa-miR-559	CLIP-seq
MIRT2306076	hsa-miR-579	CLIP-seq
MIRT2079747	hsa-miR-612	CLIP-seq
MIRT1271154	hsa-miR-624	CLIP-seq
MIRT2306077	hsa-miR-647	CLIP-seq
MIRT1271155	hsa-miR-650	CLIP-seq
MIRT2079748	hsa-miR-661	CLIP-seq
MIRT1271158	hsa-miR-766	CLIP-seq
MIRT1271159	hsa-miR-940	CLIP-seq
MIRT1271106	hsa-miR-1827	CLIP-seq
MIRT1271116	hsa-miR-3192	CLIP-seq
MIRT1271120	hsa-miR-3689a-3p	CLIP-seq
MIRT1271121	hsa-miR-3689c	CLIP-seq
MIRT1271126	hsa-miR-3929	CLIP-seq
MIRT1271132	hsa-miR-4419b	CLIP-seq
MIRT1271137	hsa-miR-4478	CLIP-seq
MIRT1271140	hsa-miR-4649-3p	CLIP-seq
MIRT1271142	hsa-miR-4722-5p	CLIP-seq
MIRT1271143	hsa-miR-4728-5p	CLIP-seq
MIRT1271144	hsa-miR-4768-3p	CLIP-seq
MIRT1271148	hsa-miR-485-5p	CLIP-seq
MIRT1271149	hsa-miR-490-3p	CLIP-seq
MIRT1271159	hsa-miR-940	CLIP-seq
MIRT1552664	hsa-miR-382	CLIP-seq
MIRT2439625	hsa-miR-4633-3p	CLIP-seq
MIRT2439626	hsa-miR-4670-3p	CLIP-seq
MIRT2439627	hsa-miR-4760-3p	CLIP-seq
MIRT1552664	hsa-miR-382	CLIP-seq
MIRT2439625	hsa-miR-4633-3p	CLIP-seq
MIRT2439626	hsa-miR-4670-3p	CLIP-seq
MIRT2439627	hsa-miR-4760-3p	CLIP-seq
MIRT1271106	hsa-miR-1827	CLIP-seq
MIRT1271107	hsa-miR-1908	CLIP-seq
MIRT1271112	hsa-miR-3122	CLIP-seq
MIRT2306055	hsa-miR-3613-3p	CLIP-seq
MIRT1271120	hsa-miR-3689a-3p	CLIP-seq
MIRT1271121	hsa-miR-3689c	CLIP-seq
MIRT1271125	hsa-miR-3913-5p	CLIP-seq
MIRT1271126	hsa-miR-3929	CLIP-seq
MIRT1271127	hsa-miR-3937	CLIP-seq
MIRT1271132	hsa-miR-4419b	CLIP-seq
MIRT1271135	hsa-miR-4457	CLIP-seq
MIRT1271137	hsa-miR-4478	CLIP-seq
MIRT1271140	hsa-miR-4649-3p	CLIP-seq
MIRT2457365	hsa-miR-4684-5p	CLIP-seq
MIRT1271143	hsa-miR-4728-5p	CLIP-seq
MIRT2457366	hsa-miR-4764-5p	CLIP-seq
MIRT1271144	hsa-miR-4768-3p	CLIP-seq
MIRT1271148	hsa-miR-485-5p	CLIP-seq
MIRT1271151	hsa-miR-513b	CLIP-seq
MIRT2457367	hsa-miR-548c-3p	CLIP-seq
MIRT1271156	hsa-miR-663	CLIP-seq
MIRT1271159	hsa-miR-940	CLIP-seq
MIRT1271106	hsa-miR-1827	CLIP-seq
MIRT1271110	hsa-miR-2114	CLIP-seq
MIRT1271112	hsa-miR-3122	CLIP-seq
MIRT1271116	hsa-miR-3192	CLIP-seq
MIRT1271117	hsa-miR-3612	CLIP-seq
MIRT1271120	hsa-miR-3689a-3p	CLIP-seq
MIRT1271121	hsa-miR-3689c	CLIP-seq
MIRT1271125	hsa-miR-3913-5p	CLIP-seq
MIRT1271126	hsa-miR-3929	CLIP-seq
MIRT1271127	hsa-miR-3937	CLIP-seq
MIRT1271132	hsa-miR-4419b	CLIP-seq
MIRT1271137	hsa-miR-4478	CLIP-seq
MIRT1271140	hsa-miR-4649-3p	CLIP-seq
MIRT1271142	hsa-miR-4722-5p	CLIP-seq
MIRT1271143	hsa-miR-4728-5p	CLIP-seq
MIRT1271144	hsa-miR-4768-3p	CLIP-seq
MIRT1271148	hsa-miR-485-5p	CLIP-seq
MIRT1271149	hsa-miR-490-3p	CLIP-seq
MIRT1271152	hsa-miR-550a	CLIP-seq
MIRT1271155	hsa-miR-650	CLIP-seq
MIRT1271159	hsa-miR-940	CLIP-seq
MIRT2079739	hsa-miR-1285	CLIP-seq
MIRT1271106	hsa-miR-1827	CLIP-seq
MIRT1271107	hsa-miR-1908	CLIP-seq
MIRT1271110	hsa-miR-2114	CLIP-seq
MIRT2306053	hsa-miR-3120-5p	CLIP-seq
MIRT1271112	hsa-miR-3122	CLIP-seq
MIRT2079741	hsa-miR-3187-5p	CLIP-seq
MIRT1271116	hsa-miR-3192	CLIP-seq
MIRT1271117	hsa-miR-3612	CLIP-seq
MIRT2306055	hsa-miR-3613-3p	CLIP-seq
MIRT1271119	hsa-miR-3656	CLIP-seq
MIRT1271120	hsa-miR-3689a-3p	CLIP-seq
MIRT1271121	hsa-miR-3689c	CLIP-seq
MIRT2306056	hsa-miR-371-5p	CLIP-seq
MIRT2306057	hsa-miR-371b-5p	CLIP-seq
MIRT1271125	hsa-miR-3913-5p	CLIP-seq
MIRT1271126	hsa-miR-3929	CLIP-seq
MIRT1271127	hsa-miR-3937	CLIP-seq
MIRT1271128	hsa-miR-3974	CLIP-seq
MIRT1271129	hsa-miR-4252	CLIP-seq
MIRT2603347	hsa-miR-4263	CLIP-seq
MIRT2603348	hsa-miR-4311	CLIP-seq
MIRT1271131	hsa-miR-4327	CLIP-seq
MIRT1271132	hsa-miR-4419b	CLIP-seq
MIRT2306058	hsa-miR-4420	CLIP-seq
MIRT1271133	hsa-miR-4422	CLIP-seq
MIRT1271134	hsa-miR-4433	CLIP-seq
MIRT1271135	hsa-miR-4457	CLIP-seq
MIRT1271136	hsa-miR-4459	CLIP-seq
MIRT1271137	hsa-miR-4478	CLIP-seq
MIRT2306059	hsa-miR-4493	CLIP-seq
MIRT2079743	hsa-miR-451b	CLIP-seq
MIRT2306060	hsa-miR-4522	CLIP-seq
MIRT1271139	hsa-miR-4537	CLIP-seq
MIRT1271140	hsa-miR-4649-3p	CLIP-seq
MIRT1271141	hsa-miR-4683	CLIP-seq
MIRT2457365	hsa-miR-4684-5p	CLIP-seq
MIRT1271142	hsa-miR-4722-5p	CLIP-seq
MIRT1271143	hsa-miR-4728-5p	CLIP-seq
MIRT2457366	hsa-miR-4764-5p	CLIP-seq
MIRT1271144	hsa-miR-4768-3p	CLIP-seq
MIRT2079745	hsa-miR-4778-5p	CLIP-seq
MIRT1271145	hsa-miR-4793-3p	CLIP-seq
MIRT1271148	hsa-miR-485-5p	CLIP-seq
MIRT2603349	hsa-miR-489	CLIP-seq
MIRT1271149	hsa-miR-490-3p	CLIP-seq
MIRT1271150	hsa-miR-508-5p	CLIP-seq
MIRT1271151	hsa-miR-513b	CLIP-seq
MIRT2457367	hsa-miR-548c-3p	CLIP-seq
MIRT2603350	hsa-miR-548m	CLIP-seq
MIRT1271152	hsa-miR-550a	CLIP-seq
MIRT2603351	hsa-miR-576-5p	CLIP-seq
MIRT2079747	hsa-miR-612	CLIP-seq
MIRT1271154	hsa-miR-624	CLIP-seq
MIRT1271155	hsa-miR-650	CLIP-seq
MIRT2079748	hsa-miR-661	CLIP-seq
MIRT1271156	hsa-miR-663	CLIP-seq
MIRT1271158	hsa-miR-766	CLIP-seq
MIRT1271159	hsa-miR-940	CLIP-seq
MIRT2079739	hsa-miR-1285	CLIP-seq
MIRT1271106	hsa-miR-1827	CLIP-seq
MIRT1271107	hsa-miR-1908	CLIP-seq
MIRT1271110	hsa-miR-2114	CLIP-seq
MIRT2306053	hsa-miR-3120-5p	CLIP-seq
MIRT1271112	hsa-miR-3122	CLIP-seq
MIRT2079741	hsa-miR-3187-5p	CLIP-seq
MIRT1271116	hsa-miR-3192	CLIP-seq
MIRT1271117	hsa-miR-3612	CLIP-seq
MIRT2306055	hsa-miR-3613-3p	CLIP-seq
MIRT1271119	hsa-miR-3656	CLIP-seq
MIRT1271120	hsa-miR-3689a-3p	CLIP-seq
MIRT1271121	hsa-miR-3689c	CLIP-seq
MIRT2306056	hsa-miR-371-5p	CLIP-seq
MIRT2306057	hsa-miR-371b-5p	CLIP-seq
MIRT1271125	hsa-miR-3913-5p	CLIP-seq
MIRT1271126	hsa-miR-3929	CLIP-seq
MIRT1271127	hsa-miR-3937	CLIP-seq
MIRT1271128	hsa-miR-3974	CLIP-seq
MIRT1271129	hsa-miR-4252	CLIP-seq
MIRT2603347	hsa-miR-4263	CLIP-seq
MIRT2603348	hsa-miR-4311	CLIP-seq
MIRT1271131	hsa-miR-4327	CLIP-seq
MIRT1271132	hsa-miR-4419b	CLIP-seq
MIRT2306058	hsa-miR-4420	CLIP-seq
MIRT1271133	hsa-miR-4422	CLIP-seq
MIRT1271134	hsa-miR-4433	CLIP-seq
MIRT1271135	hsa-miR-4457	CLIP-seq
MIRT1271136	hsa-miR-4459	CLIP-seq
MIRT1271137	hsa-miR-4478	CLIP-seq
MIRT2306059	hsa-miR-4493	CLIP-seq
MIRT2079743	hsa-miR-451b	CLIP-seq
MIRT2306060	hsa-miR-4522	CLIP-seq
MIRT1271140	hsa-miR-4649-3p	CLIP-seq
MIRT1271141	hsa-miR-4683	CLIP-seq
MIRT2457365	hsa-miR-4684-5p	CLIP-seq
MIRT1271142	hsa-miR-4722-5p	CLIP-seq
MIRT1271143	hsa-miR-4728-5p	CLIP-seq
MIRT2457366	hsa-miR-4764-5p	CLIP-seq
MIRT1271144	hsa-miR-4768-3p	CLIP-seq
MIRT2079745	hsa-miR-4778-5p	CLIP-seq
MIRT1271145	hsa-miR-4793-3p	CLIP-seq
MIRT1271148	hsa-miR-485-5p	CLIP-seq
MIRT2603349	hsa-miR-489	CLIP-seq
MIRT1271149	hsa-miR-490-3p	CLIP-seq
MIRT1271150	hsa-miR-508-5p	CLIP-seq
MIRT1271151	hsa-miR-513b	CLIP-seq
MIRT2457367	hsa-miR-548c-3p	CLIP-seq
MIRT2603350	hsa-miR-548m	CLIP-seq
MIRT1271152	hsa-miR-550a	CLIP-seq
MIRT2603351	hsa-miR-576-5p	CLIP-seq
MIRT2079747	hsa-miR-612	CLIP-seq
MIRT1271154	hsa-miR-624	CLIP-seq
MIRT1271155	hsa-miR-650	CLIP-seq
MIRT2079748	hsa-miR-661	CLIP-seq
MIRT1271156	hsa-miR-663	CLIP-seq
MIRT1271158	hsa-miR-766	CLIP-seq
MIRT1271159	hsa-miR-940	CLIP-seq

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IBA
GO:0000287	Function	Magnesium ion binding	IDA	15291819
GO:0001701	Process	In utero embryonic development	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006563	Process	L-serine metabolic process	IDA	15291819
GO:0006563	Process	L-serine metabolic process	TAS	9188776
GO:0006564	Process	L-serine biosynthetic process	IBA
GO:0006564	Process	L-serine biosynthetic process	IEA
GO:0006564	Process	L-serine biosynthetic process	IMP	14673469
GO:0008652	Process	Amino acid biosynthetic process	IEA
GO:0009612	Process	Response to mechanical stimulus	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031667	Process	Response to nutrient levels	IEA
GO:0033574	Process	Response to testosterone	IEA
GO:0036424	Function	L-phosphoserine phosphatase activity	IBA
GO:0036424	Function	L-phosphoserine phosphatase activity	IDA	15291819
GO:0036424	Function	L-phosphoserine phosphatase activity	IEA
GO:0036424	Function	L-phosphoserine phosphatase activity	IMP	14673469
GO:0042802	Function	Identical protein binding	IPI	25416956, 25502805, 31515488
GO:0042803	Function	Protein homodimerization activity	IPI	12777757
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
172480	9577	ENSG00000146733

P78330

Protein name

Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (L-3-phosphoserine phosphatase) (O-phosphoserine phosphohydrolase)

Protein function

Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine (PubMed:12213811, PubMed:14673469, PubMed:15291819, PubMed:25080166, PubMed:9222972). L-serine can t

PDB

1L8L , 1L8O , 1NNL , 6HYJ , 6HYY , 6Q6J

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00702	Hydrolase	14 → 191		Domain

Sequence

MVSHSELRKLFYSADAVCFDVDSTVIREEGIDELAKICGVEDAVSEMTRRAMGGAVPFKA
ALTERLALIQPSREQVQRLIAEQPPHLTPGIRELVSRLQERNVQVFLISGGFRSIVEHVA
SKLNIPATNVFANRLKFYFNGEYAGFDETQPTAESGGKGKVIKLLKEKFHFKKIIMIGDG
ATDMEACPPADAFIGFGGNVIRQQVKDNAKWYITDFVELLGELEE

Sequence length

225

Interactions

View interactions

	KEGG		Reactome
	Glycine, serine and threonine metabolism Metabolic pathways Carbon metabolism Biosynthesis of amino acids		Serine biosynthesis

217

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Deficiency of phosphoserine phosphatase	Pathogenic; Likely pathogenic	rs786204793, rs104894036, rs1264747554, rs1788688718	RCV000169687 RCV000014594 RCV004799409 RCV001283838

Show/Hide Unknown Diseases (29)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs145544909, rs200942360	RCV005899226 RCV005913982
Adrenocortical carcinoma, hereditary	Benign; Likely benign	rs78599516	RCV005899241
Amelogenesis imperfecta	Uncertain significance	rs148469975	RCV001089669
Cervical cancer	Benign	rs145544909, rs74874687, rs200942360	RCV005899228 RCV005899233 RCV005913986
Cholangiocarcinoma	Benign; Likely benign	rs145544909, rs74874687, rs78599516, rs200942360	RCV005899231 RCV005899238 RCV005899248 RCV005913991
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign; Likely benign	rs78599516	RCV005899249
Clear cell carcinoma of kidney	Conflicting classifications of pathogenicity	rs139106189	RCV005869458
Colorectal cancer	Benign; Likely benign	rs78599516	RCV005899245
Familial cancer of breast	Benign; Conflicting classifications of pathogenicity	rs145544909, rs74874687, rs139106189, rs200942360	RCV005899225 RCV005899232 RCV005869453 RCV005913981
Familial pancreatic carcinoma	Benign; Likely benign	rs78599516	RCV005899244
Gastric cancer	Conflicting classifications of pathogenicity	rs139106189	RCV005869459
Glioma susceptibility 1	Conflicting classifications of pathogenicity	rs139106189	RCV005869454
Hepatocellular carcinoma	Benign	rs200942360	RCV005913984
Lymphoma	Benign; Likely benign	rs78599516	RCV005899246
Malignant lymphoma, large B-cell, diffuse	Benign	rs200942360	RCV005913987
Malignant tumor of esophagus	Benign; Conflicting classifications of pathogenicity	rs145544909, rs139106189, rs200942360	RCV005899227 RCV005869457 RCV005913985
Malignant tumor of urinary bladder	Conflicting classifications of pathogenicity; Benign	rs139106189, rs200942360	RCV005869456 RCV005913983
Melanoma	Benign; Conflicting classifications of pathogenicity	rs74874687, rs139106189	RCV005899237 RCV005869460
Neurometabolic disorder due to serine deficiency	Conflicting classifications of pathogenicity	rs139106189	RCV005355791
Nonpapillary renal cell carcinoma	Benign; Likely benign	rs78599516	RCV005899240
Ovarian cancer	Benign; Likely benign	rs78599516	RCV005899242
Ovarian serous cystadenocarcinoma	Benign	rs145544909, rs74874687, rs200942360	RCV005899230 RCV005899235 RCV005913989
Papillary renal cell carcinoma type 1	Conflicting classifications of pathogenicity	rs139106189	RCV005869455
PSPH-related disorder	Benign; Conflicting classifications of pathogenicity; Likely benign	rs202027697, rs147304638, rs767359030	RCV003972518 RCV003912543 RCV003933856
Sarcoma	Benign	rs145544909, rs74874687, rs200942360	RCV005899229 RCV005899234 RCV005913988
Thymoma	Benign	rs200942360	RCV005913990
Uterine carcinosarcoma	Benign; Likely benign	rs74874687, rs78599516	RCV005899236 RCV005899247
Uterine corpus endometrial carcinoma	Benign	rs74874687, rs200942360	RCV005899239 RCV005913992
Uveal melanoma	Benign; Likely benign	rs78599516	RCV005899243

Show/Hide Text Mining Associations (29)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	39735553
Breast Neoplasms	Associate	24979213, 25496516, 26109344, 29228969
Carcinoma Ductal	Associate	25053597
Carcinoma Hepatocellular	Associate	30176945
Carcinoma Lobular	Associate	25053597
Carcinoma Medullary	Inhibit	27277113
Carcinoma Non Small Cell Lung	Associate	30662358
Carcinoma Non Small Cell Lung	Stimulate	30977310
Colorectal Neoplasms	Associate	22276153, 24146633, 34201061
Fatty Liver Alcoholic	Associate	24419221
Genetic Diseases Inborn	Associate	37812589
Glioblastoma	Associate	38098117
Growth Disorders	Associate	37812589
Hepatitis C	Associate	29228969
Hypoxia	Inhibit	37823569
Intellectual Disability	Associate	37812589
Lymphoma Mantle Cell	Stimulate	27277113
Melanoma	Associate	28500236
Neoplasm Metastasis	Associate	30662358, 30977310
Neoplasms	Associate	24979213, 26109344, 30662358, 30977310, 34979926, 36615660, 37299011
Neu Laxova syndrome	Associate	32077105, 37812589
Ovarian Diseases	Associate	37533289
Peritonitis	Associate	15154633
Primary hyperoxaluria type 1	Associate	24419221, 25152457, 32077105, 37812589
Sleep Apnea Obstructive	Associate	20093640
Stomach Neoplasms	Associate	15154633, 34979926
Thyroid Cancer Papillary	Associate	27277113
Thyroid Neoplasms	Associate	27277113
Triple Negative Breast Neoplasms	Associate	24390667

PSPH (phosphoserine phosphatase)