Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5719
Gene name	Proteasome 26S subunit, non-ATPase 13
Gene symbol	PSMD13
Synonyms (NCBI Gene)	HSPC027Rpn9S11p40.5
Chromosome	11
Chromosome location	11p15.5
Summary	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits a

Show/Hide all (84)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047716	hsa-miR-10a-5p	CLASH	23622248
MIRT047503	hsa-miR-10b-5p	CLASH	23622248
MIRT047134	hsa-miR-183-5p	CLASH	23622248
MIRT045260	hsa-miR-186-5p	CLASH	23622248
MIRT040064	hsa-miR-615-3p	CLASH	23622248
MIRT038884	hsa-miR-93-3p	CLASH	23622248
MIRT1270458	hsa-miR-604	CLIP-seq
MIRT1270459	hsa-miR-647	CLIP-seq
MIRT2603050	hsa-miR-1184	CLIP-seq
MIRT2603051	hsa-miR-1205	CLIP-seq
MIRT2603052	hsa-miR-125a-5p	CLIP-seq
MIRT2603053	hsa-miR-125b	CLIP-seq
MIRT2603054	hsa-miR-1286	CLIP-seq
MIRT2603055	hsa-miR-1303	CLIP-seq
MIRT2603056	hsa-miR-132	CLIP-seq
MIRT2603057	hsa-miR-1324	CLIP-seq
MIRT2603058	hsa-miR-149	CLIP-seq
MIRT2603059	hsa-miR-185	CLIP-seq
MIRT2603060	hsa-miR-1910	CLIP-seq
MIRT2603061	hsa-miR-212	CLIP-seq
MIRT2603062	hsa-miR-2278	CLIP-seq
MIRT2603063	hsa-miR-3158-5p	CLIP-seq
MIRT2603064	hsa-miR-339-5p	CLIP-seq
MIRT2603065	hsa-miR-3667-5p	CLIP-seq
MIRT2603066	hsa-miR-4270	CLIP-seq
MIRT2603067	hsa-miR-4303	CLIP-seq
MIRT2603068	hsa-miR-4306	CLIP-seq
MIRT2603069	hsa-miR-4319	CLIP-seq
MIRT2603070	hsa-miR-4324	CLIP-seq
MIRT2603071	hsa-miR-4329	CLIP-seq
MIRT2603072	hsa-miR-4441	CLIP-seq
MIRT2603073	hsa-miR-4468	CLIP-seq
MIRT2603074	hsa-miR-451b	CLIP-seq
MIRT2603075	hsa-miR-4644	CLIP-seq
MIRT2603076	hsa-miR-4661-3p	CLIP-seq
MIRT2603077	hsa-miR-4722-5p	CLIP-seq
MIRT2603078	hsa-miR-4725-5p	CLIP-seq
MIRT2603079	hsa-miR-4733-5p	CLIP-seq
MIRT2603080	hsa-miR-4768-3p	CLIP-seq
MIRT2603081	hsa-miR-4768-5p	CLIP-seq
MIRT2603082	hsa-miR-4773	CLIP-seq
MIRT2603083	hsa-miR-4786-5p	CLIP-seq
MIRT2603084	hsa-miR-504	CLIP-seq
MIRT2603085	hsa-miR-564	CLIP-seq
MIRT2603086	hsa-miR-622	CLIP-seq
MIRT2603087	hsa-miR-663b	CLIP-seq
MIRT2603088	hsa-miR-769-5p	CLIP-seq
MIRT2603050	hsa-miR-1184	CLIP-seq
MIRT2603051	hsa-miR-1205	CLIP-seq
MIRT2603052	hsa-miR-125a-5p	CLIP-seq
MIRT2603053	hsa-miR-125b	CLIP-seq
MIRT2603054	hsa-miR-1286	CLIP-seq
MIRT2603055	hsa-miR-1303	CLIP-seq
MIRT2603056	hsa-miR-132	CLIP-seq
MIRT2603057	hsa-miR-1324	CLIP-seq
MIRT2603058	hsa-miR-149	CLIP-seq
MIRT2603059	hsa-miR-185	CLIP-seq
MIRT2603060	hsa-miR-1910	CLIP-seq
MIRT2603061	hsa-miR-212	CLIP-seq
MIRT2603062	hsa-miR-2278	CLIP-seq
MIRT2603063	hsa-miR-3158-5p	CLIP-seq
MIRT2603064	hsa-miR-339-5p	CLIP-seq
MIRT2603065	hsa-miR-3667-5p	CLIP-seq
MIRT2603066	hsa-miR-4270	CLIP-seq
MIRT2603068	hsa-miR-4306	CLIP-seq
MIRT2603069	hsa-miR-4319	CLIP-seq
MIRT2603070	hsa-miR-4324	CLIP-seq
MIRT2603071	hsa-miR-4329	CLIP-seq
MIRT2603072	hsa-miR-4441	CLIP-seq
MIRT2603074	hsa-miR-451b	CLIP-seq
MIRT2603075	hsa-miR-4644	CLIP-seq
MIRT2603076	hsa-miR-4661-3p	CLIP-seq
MIRT2603077	hsa-miR-4722-5p	CLIP-seq
MIRT2603078	hsa-miR-4725-5p	CLIP-seq
MIRT2603079	hsa-miR-4733-5p	CLIP-seq
MIRT2603080	hsa-miR-4768-3p	CLIP-seq
MIRT2603081	hsa-miR-4768-5p	CLIP-seq
MIRT2603082	hsa-miR-4773	CLIP-seq
MIRT2603083	hsa-miR-4786-5p	CLIP-seq
MIRT2603084	hsa-miR-504	CLIP-seq
MIRT2603085	hsa-miR-564	CLIP-seq
MIRT2603086	hsa-miR-622	CLIP-seq
MIRT2603087	hsa-miR-663b	CLIP-seq
MIRT2603088	hsa-miR-769-5p	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000502	Component	Proteasome complex	IDA	17323924
GO:0000502	Component	Proteasome complex	IEA
GO:0000502	Component	Proteasome complex	NAS	29636472
GO:0000502	Component	Proteasome complex	TAS	8811196
GO:0005198	Function	Structural molecule activity	IBA
GO:0005515	Function	Protein binding	IPI	16990800, 33961781, 35271311
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005838	Component	Proteasome regulatory particle	IEA
GO:0005838	Component	Proteasome regulatory particle	TAS	9714768
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA
GO:0007127	Process	Meiosis I	IEA
GO:0008541	Component	Proteasome regulatory particle, lid subcomplex	IBA
GO:0016020	Component	Membrane	HDA	19946888
GO:0022624	Component	Proteasome accessory complex	IEA
GO:0022624	Component	Proteasome accessory complex	ISS
GO:0034774	Component	Secretory granule lumen	TAS
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	NAS	19489727
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

MIM	HGNC	e!Ensembl
603481	9558	ENSG00000185627

Q9UNM6

Protein name

26S proteasome non-ATPase regulatory subunit 13 (26S proteasome regulatory subunit RPN9) (26S proteasome regulatory subunit S11) (26S proteasome regulatory subunit p40.5)

Protein function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which

PDB

5GJQ , 5GJR , 5L4K , 5LN3 , 5M32 , 5T0C , 5T0G , 5T0H , 5T0I , 5T0J , 5VFP , 5VFQ , 5VFR , 5VFS , 5VFT , 5VFU , 5VGZ , 5VHF , 5VHH , 5VHI , 5VHS , 6MSB , 6MSD , 6MSE , 6MSG , 6MSH , 6MSJ , 6MSK , 6WJD , 6WJN , 7QXN , 7QXP , 7QXU , 7QXW , 7QXX , 7QY7 , 7QYA , 7QYB , 7W37 , 7W38 , 7W39 , 7W3A , 7W3B , 7W3C , 7W3F , 7W3G , 7W3H , 7W3I , 7W3J , 7W3K , 7W3M

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01399	PCI	231 → 335	PCI domain	Domain

Sequence

MKDVPGFLQQSQNSGPGQPAVWHRLEELYTKKLWHQLTLQVLDFVQDPCFAQGDGLIKLY
ENFISEFEHRVNPLSLVEIILHVVRQMTDPNVALTFLEKTREKVKSSDEAVILCKTAIGA
LKLNIGDLQVTKETIEDVEEMLNNLPGVTSVHSRFYDLSSKYYQTIGNHASYYKDALRFL
GCVDIKDLPVSEQQERAFTLGLAGLLGEGVFNFGELLMHPVLESLRNTDRQWLIDTLYAF
NSGNVERFQTLKTAWGQQPDLAANEAQLLRKIQLLCLMEMTFTRPANHRQLTFEEIAKSA
KITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDV
KSMEMLVEHQAHDILT

Sequence length

376

Interactions

View interactions

	KEGG		Reactome
	Proteasome Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Epstein-Barr virus infection		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants that don't undergo autocatalytic processing are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BRAIN ANEURYSM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FEMALE REPRODUCTIVE SYSTEM DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSMD13-related disorder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Arthritis Rheumatoid	Associate	27534557	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Associate	39239747	★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive Disorder Major	Associate	26624926	★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive Disorder Treatment Resistant	Associate	26624926	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Associate	36731897	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leber Congenital Amaurosis	Associate	25752820	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Inhibit	37653079	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precancerous Conditions	Associate	36731897	★★★★★ ★☆☆☆☆ Found in Text Mining only
Skin Diseases	Associate	40443672	★★★★★ ★☆☆☆☆ Found in Text Mining only
Vitiligo	Associate	40443672	★★★★★ ★☆☆☆☆ Found in Text Mining only

PSMD13 (proteasome 26S subunit, non-ATPase 13)