CAMK1G (calcium/calmodulin dependent protein kinase IG)

Gene

• Entrez ID: 57172
• Gene name: Calcium/calmodulin dependent protein kinase IG
• Gene symbol: CAMK1G
• Synonyms (NCBI Gene): CLICK3, CLICKIII, VWS1
• Chromosome: 1
• Chromosome location: 1q32.2
• Summary: This gene encodes a protein similar to calcium/calmodulin dependent protein kinase, however, its exact function is not known. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT860090	hsa-miR-1976	CLIP-seq
MIRT860091	hsa-miR-3173-5p	CLIP-seq
MIRT860092	hsa-miR-370	CLIP-seq
MIRT860093	hsa-miR-4268	CLIP-seq
MIRT860094	hsa-miR-4448	CLIP-seq
MIRT860095	hsa-miR-4639-5p	CLIP-seq
MIRT860096	hsa-miR-4738-3p	CLIP-seq
MIRT1955233	hsa-miR-138	CLIP-seq
MIRT860090	hsa-miR-1976	CLIP-seq
MIRT860091	hsa-miR-3173-5p	CLIP-seq
MIRT860092	hsa-miR-370	CLIP-seq
MIRT860093	hsa-miR-4268	CLIP-seq
MIRT860094	hsa-miR-4448	CLIP-seq
MIRT860095	hsa-miR-4639-5p	CLIP-seq
MIRT860096	hsa-miR-4738-3p	CLIP-seq
MIRT2496003	hsa-miR-4742-5p	CLIP-seq
MIRT2496003	hsa-miR-4742-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004683	Function	Calcium/calmodulin-dependent protein kinase activity	IBA
GO:0004683	Function	Calcium/calmodulin-dependent protein kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005516	Function	Calmodulin binding	IBA
GO:0005516	Function	Calmodulin binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005954	Component	Calcium- and calmodulin-dependent protein kinase complex	IEA
GO:0007165	Process	Signal transduction	IBA
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

Other IDs

• MIM: 614994
• HGNC: 14585
• e!Ensembl: ENSG00000008118

Protein

• UniProt ID: Q96NX5
• Protein name: Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase I gamma) (CaM kinase IG) (CaM-KI gamma) (CaMKI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III)
• Protein function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity).
• PDB: 2JAM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	23 → 277	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Mainly expressed in brain with small amounts in skeletal muscles, kidney, spleen and liver. Strongly expressed in forebrain neocortex, striatum and limbic system. {ECO:0000269|PubMed:12637513}.
• Sequence:

  MGRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAF
  RDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDA
  SLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTAC
  GTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFES
  PFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFA
  KSKWRQAFNAAAVVHHMRKLHMNLHSPGVRPEVENRPPETQASETSRPSSPEITITEAPV
  LDHSVALPALTQLPCQHGRRPTAPGGRSLNCLVNGSLHISSSLVPMHQGSLAAGPCGCCS
  SCLNIGSKGKSSYCSEPTLLKKANKKQNFKSEVMVPVKASGSSHCRAGQTGVCLIM

• Sequence length: 476

Pathways

KEGG:

Calcium signaling pathway
Oxytocin signaling pathway
Aldosterone synthesis and secretion
Glioma

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Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	N/A	N/A	GWAS
Restless Legs Syndrome	Restless legs syndrome	N/A	N/A	GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma	Associate	32509861