Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	57161
Gene name	Pellino E3 ubiquitin protein ligase family member 2
Gene symbol	PELI2
Synonyms (NCBI Gene)	-
Chromosome	14
Chromosome location	14q22.3

243

Show/Hide all (243)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019058	hsa-miR-335-5p	Microarray	18185580
MIRT019524	hsa-miR-151a-5p	Sequencing	20371350
MIRT046700	hsa-miR-222-3p	CLASH	23622248
MIRT655288	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT655287	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT655286	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT655285	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT070503	hsa-miR-498	HITS-CLIP	23824327
MIRT655288	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT655287	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT655286	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT655285	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT070503	hsa-miR-498	HITS-CLIP	23824327
MIRT1224822	hsa-miR-1179	CLIP-seq
MIRT1224823	hsa-miR-1228	CLIP-seq
MIRT1224824	hsa-miR-1246	CLIP-seq
MIRT1224825	hsa-miR-127-5p	CLIP-seq
MIRT1224826	hsa-miR-1297	CLIP-seq
MIRT1224827	hsa-miR-203	CLIP-seq
MIRT1224828	hsa-miR-2117	CLIP-seq
MIRT1224829	hsa-miR-26a	CLIP-seq
MIRT1224830	hsa-miR-26b	CLIP-seq
MIRT1224831	hsa-miR-28-5p	CLIP-seq
MIRT1224832	hsa-miR-31	CLIP-seq
MIRT1224833	hsa-miR-3139	CLIP-seq
MIRT1224834	hsa-miR-3144-3p	CLIP-seq
MIRT1224835	hsa-miR-3148	CLIP-seq
MIRT1224836	hsa-miR-3201	CLIP-seq
MIRT1224837	hsa-miR-3609	CLIP-seq
MIRT1224838	hsa-miR-3617	CLIP-seq
MIRT1224839	hsa-miR-3647-3p	CLIP-seq
MIRT1224840	hsa-miR-3688-3p	CLIP-seq
MIRT1224841	hsa-miR-377	CLIP-seq
MIRT1224842	hsa-miR-4273	CLIP-seq
MIRT1224843	hsa-miR-4465	CLIP-seq
MIRT1224844	hsa-miR-4519	CLIP-seq
MIRT1224845	hsa-miR-4684-5p	CLIP-seq
MIRT1224846	hsa-miR-4694-3p	CLIP-seq
MIRT1224847	hsa-miR-4696	CLIP-seq
MIRT1224848	hsa-miR-4724-3p	CLIP-seq
MIRT1224849	hsa-miR-4744	CLIP-seq
MIRT1224850	hsa-miR-4791	CLIP-seq
MIRT1224851	hsa-miR-5096	CLIP-seq
MIRT1224852	hsa-miR-548ah	CLIP-seq
MIRT1224853	hsa-miR-556-3p	CLIP-seq
MIRT1224854	hsa-miR-605	CLIP-seq
MIRT1224855	hsa-miR-641	CLIP-seq
MIRT1224856	hsa-miR-656	CLIP-seq
MIRT1224857	hsa-miR-708	CLIP-seq
MIRT1224858	hsa-miR-875-5p	CLIP-seq
MIRT1224859	hsa-miR-944	CLIP-seq
MIRT2065564	hsa-miR-1205	CLIP-seq
MIRT2065565	hsa-miR-1299	CLIP-seq
MIRT2065566	hsa-miR-1323	CLIP-seq
MIRT1224835	hsa-miR-3148	CLIP-seq
MIRT2065567	hsa-miR-3682-5p	CLIP-seq
MIRT2065568	hsa-miR-3978	CLIP-seq
MIRT2065569	hsa-miR-4782-5p	CLIP-seq
MIRT2065570	hsa-miR-516b	CLIP-seq
MIRT2065571	hsa-miR-518a-5p	CLIP-seq
MIRT2065572	hsa-miR-527	CLIP-seq
MIRT2065573	hsa-miR-545	CLIP-seq
MIRT2065574	hsa-miR-548a-3p	CLIP-seq
MIRT2065575	hsa-miR-548e	CLIP-seq
MIRT2065576	hsa-miR-548f	CLIP-seq
MIRT2065577	hsa-miR-548o	CLIP-seq
MIRT2065578	hsa-miR-548p	CLIP-seq
MIRT2065579	hsa-miR-579	CLIP-seq
MIRT2065580	hsa-miR-875-3p	CLIP-seq
MIRT1224859	hsa-miR-944	CLIP-seq
MIRT2293425	hsa-miR-1184	CLIP-seq
MIRT2065564	hsa-miR-1205	CLIP-seq
MIRT2293426	hsa-miR-3158-5p	CLIP-seq
MIRT2065579	hsa-miR-579	CLIP-seq
MIRT2392396	hsa-miR-4699-5p	CLIP-seq
MIRT2591437	hsa-miR-1202	CLIP-seq
MIRT2591438	hsa-miR-1208	CLIP-seq
MIRT1224824	hsa-miR-1246	CLIP-seq
MIRT2591439	hsa-miR-1270	CLIP-seq
MIRT2591440	hsa-miR-1273f	CLIP-seq
MIRT2591441	hsa-miR-1273g	CLIP-seq
MIRT2591442	hsa-miR-1290	CLIP-seq
MIRT1224826	hsa-miR-1297	CLIP-seq
MIRT2065566	hsa-miR-1323	CLIP-seq
MIRT2591443	hsa-miR-135a	CLIP-seq
MIRT2591444	hsa-miR-135b	CLIP-seq
MIRT2591445	hsa-miR-15a	CLIP-seq
MIRT2591446	hsa-miR-15b	CLIP-seq
MIRT2591447	hsa-miR-16	CLIP-seq
MIRT2591448	hsa-miR-1827	CLIP-seq
MIRT2591449	hsa-miR-1912	CLIP-seq
MIRT2591450	hsa-miR-1914	CLIP-seq
MIRT2591451	hsa-miR-195	CLIP-seq
MIRT2591452	hsa-miR-2276	CLIP-seq
MIRT1224829	hsa-miR-26a	CLIP-seq
MIRT1224830	hsa-miR-26b	CLIP-seq
MIRT2591453	hsa-miR-3119	CLIP-seq
MIRT2591454	hsa-miR-3130-5p	CLIP-seq
MIRT2591455	hsa-miR-3134	CLIP-seq
MIRT1224835	hsa-miR-3148	CLIP-seq
MIRT2591456	hsa-miR-3160-5p	CLIP-seq
MIRT2591457	hsa-miR-3167	CLIP-seq
MIRT1224836	hsa-miR-3201	CLIP-seq
MIRT2591458	hsa-miR-323-3p	CLIP-seq
MIRT2591459	hsa-miR-324-5p	CLIP-seq
MIRT2591460	hsa-miR-335	CLIP-seq
MIRT2591461	hsa-miR-338-3p	CLIP-seq
MIRT2591462	hsa-miR-34c-3p	CLIP-seq
MIRT2591463	hsa-miR-361-5p	CLIP-seq
MIRT2591464	hsa-miR-3616-3p	CLIP-seq
MIRT1224839	hsa-miR-3647-3p	CLIP-seq
MIRT2591465	hsa-miR-3929	CLIP-seq
MIRT2591466	hsa-miR-3972	CLIP-seq
MIRT2591467	hsa-miR-3973	CLIP-seq
MIRT2591468	hsa-miR-424	CLIP-seq
MIRT2591469	hsa-miR-4279	CLIP-seq
MIRT2591470	hsa-miR-4310	CLIP-seq
MIRT2591471	hsa-miR-4320	CLIP-seq
MIRT2591472	hsa-miR-433	CLIP-seq
MIRT2591473	hsa-miR-4419b	CLIP-seq
MIRT2591474	hsa-miR-4436b-5p	CLIP-seq
MIRT1224843	hsa-miR-4465	CLIP-seq
MIRT2591475	hsa-miR-4474-5p	CLIP-seq
MIRT2591476	hsa-miR-4478	CLIP-seq
MIRT2591477	hsa-miR-4482	CLIP-seq
MIRT2591478	hsa-miR-4503	CLIP-seq
MIRT2591479	hsa-miR-4534	CLIP-seq
MIRT2591480	hsa-miR-4539	CLIP-seq
MIRT2591481	hsa-miR-4645-3p	CLIP-seq
MIRT2591482	hsa-miR-4662a-3p	CLIP-seq
MIRT2591483	hsa-miR-4668-3p	CLIP-seq
MIRT2591484	hsa-miR-4683	CLIP-seq
MIRT1224847	hsa-miR-4696	CLIP-seq
MIRT2591485	hsa-miR-4708-3p	CLIP-seq
MIRT2591486	hsa-miR-4721	CLIP-seq
MIRT2591487	hsa-miR-4728-3p	CLIP-seq
MIRT2591488	hsa-miR-4776-3p	CLIP-seq
MIRT1224850	hsa-miR-4791	CLIP-seq
MIRT2591489	hsa-miR-4796-5p	CLIP-seq
MIRT2591490	hsa-miR-485-5p	CLIP-seq
MIRT2591491	hsa-miR-487b	CLIP-seq
MIRT2591492	hsa-miR-497	CLIP-seq
MIRT2591493	hsa-miR-499-3p	CLIP-seq
MIRT2591494	hsa-miR-499a-3p	CLIP-seq
MIRT2591495	hsa-miR-520g	CLIP-seq
MIRT2591496	hsa-miR-520h	CLIP-seq
MIRT2591497	hsa-miR-544	CLIP-seq
MIRT2065574	hsa-miR-548a-3p	CLIP-seq
MIRT2591498	hsa-miR-548aa	CLIP-seq
MIRT2591499	hsa-miR-548ac	CLIP-seq
MIRT2591500	hsa-miR-548d-3p	CLIP-seq
MIRT2065575	hsa-miR-548e	CLIP-seq
MIRT2065576	hsa-miR-548f	CLIP-seq
MIRT2065577	hsa-miR-548o	CLIP-seq
MIRT2065578	hsa-miR-548p	CLIP-seq
MIRT2591501	hsa-miR-548u	CLIP-seq
MIRT2591502	hsa-miR-548z	CLIP-seq
MIRT2591503	hsa-miR-620	CLIP-seq
MIRT1224856	hsa-miR-656	CLIP-seq
MIRT2591504	hsa-miR-664	CLIP-seq
MIRT2065580	hsa-miR-875-3p	CLIP-seq
MIRT2591505	hsa-miR-876-5p	CLIP-seq
MIRT2591437	hsa-miR-1202	CLIP-seq
MIRT2591438	hsa-miR-1208	CLIP-seq
MIRT1224824	hsa-miR-1246	CLIP-seq
MIRT2687566	hsa-miR-1265	CLIP-seq
MIRT2591439	hsa-miR-1270	CLIP-seq
MIRT2591440	hsa-miR-1273f	CLIP-seq
MIRT2591441	hsa-miR-1273g	CLIP-seq
MIRT2591442	hsa-miR-1290	CLIP-seq
MIRT1224826	hsa-miR-1297	CLIP-seq
MIRT2065566	hsa-miR-1323	CLIP-seq
MIRT2591443	hsa-miR-135a	CLIP-seq
MIRT2591444	hsa-miR-135b	CLIP-seq
MIRT2591445	hsa-miR-15a	CLIP-seq
MIRT2591446	hsa-miR-15b	CLIP-seq
MIRT2591447	hsa-miR-16	CLIP-seq
MIRT2591448	hsa-miR-1827	CLIP-seq
MIRT2591449	hsa-miR-1912	CLIP-seq
MIRT2591450	hsa-miR-1914	CLIP-seq
MIRT2591451	hsa-miR-195	CLIP-seq
MIRT2591452	hsa-miR-2276	CLIP-seq
MIRT1224829	hsa-miR-26a	CLIP-seq
MIRT1224830	hsa-miR-26b	CLIP-seq
MIRT2591453	hsa-miR-3119	CLIP-seq
MIRT2591454	hsa-miR-3130-5p	CLIP-seq
MIRT2591455	hsa-miR-3134	CLIP-seq
MIRT1224835	hsa-miR-3148	CLIP-seq
MIRT2591456	hsa-miR-3160-5p	CLIP-seq
MIRT2591457	hsa-miR-3167	CLIP-seq
MIRT2591459	hsa-miR-324-5p	CLIP-seq
MIRT2591461	hsa-miR-338-3p	CLIP-seq
MIRT2591463	hsa-miR-361-5p	CLIP-seq
MIRT2591464	hsa-miR-3616-3p	CLIP-seq
MIRT1224839	hsa-miR-3647-3p	CLIP-seq
MIRT2591465	hsa-miR-3929	CLIP-seq
MIRT2591466	hsa-miR-3972	CLIP-seq
MIRT2591467	hsa-miR-3973	CLIP-seq
MIRT2591468	hsa-miR-424	CLIP-seq
MIRT2591469	hsa-miR-4279	CLIP-seq
MIRT2591470	hsa-miR-4310	CLIP-seq
MIRT2591471	hsa-miR-4320	CLIP-seq
MIRT2591472	hsa-miR-433	CLIP-seq
MIRT2591473	hsa-miR-4419b	CLIP-seq
MIRT2591474	hsa-miR-4436b-5p	CLIP-seq
MIRT1224843	hsa-miR-4465	CLIP-seq
MIRT2591475	hsa-miR-4474-5p	CLIP-seq
MIRT2591476	hsa-miR-4478	CLIP-seq
MIRT2591477	hsa-miR-4482	CLIP-seq
MIRT2591478	hsa-miR-4503	CLIP-seq
MIRT2591479	hsa-miR-4534	CLIP-seq
MIRT2591480	hsa-miR-4539	CLIP-seq
MIRT2591481	hsa-miR-4645-3p	CLIP-seq
MIRT2591482	hsa-miR-4662a-3p	CLIP-seq
MIRT2591483	hsa-miR-4668-3p	CLIP-seq
MIRT2591484	hsa-miR-4683	CLIP-seq
MIRT1224847	hsa-miR-4696	CLIP-seq
MIRT2591485	hsa-miR-4708-3p	CLIP-seq
MIRT2591486	hsa-miR-4721	CLIP-seq
MIRT2591488	hsa-miR-4776-3p	CLIP-seq
MIRT2591489	hsa-miR-4796-5p	CLIP-seq
MIRT2591490	hsa-miR-485-5p	CLIP-seq
MIRT2687567	hsa-miR-488	CLIP-seq
MIRT2591492	hsa-miR-497	CLIP-seq
MIRT2591493	hsa-miR-499-3p	CLIP-seq
MIRT2591494	hsa-miR-499a-3p	CLIP-seq
MIRT2591495	hsa-miR-520g	CLIP-seq
MIRT2591496	hsa-miR-520h	CLIP-seq
MIRT2591497	hsa-miR-544	CLIP-seq
MIRT2065574	hsa-miR-548a-3p	CLIP-seq
MIRT2591498	hsa-miR-548aa	CLIP-seq
MIRT2591499	hsa-miR-548ac	CLIP-seq
MIRT2591500	hsa-miR-548d-3p	CLIP-seq
MIRT2065575	hsa-miR-548e	CLIP-seq
MIRT2065576	hsa-miR-548f	CLIP-seq
MIRT2065577	hsa-miR-548o	CLIP-seq
MIRT2065578	hsa-miR-548p	CLIP-seq
MIRT2591501	hsa-miR-548u	CLIP-seq
MIRT2591502	hsa-miR-548z	CLIP-seq
MIRT2591503	hsa-miR-620	CLIP-seq
MIRT2591504	hsa-miR-664	CLIP-seq
MIRT2065580	hsa-miR-875-3p	CLIP-seq
MIRT2591505	hsa-miR-876-5p	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IBA
GO:0000209	Process	Protein polyubiquitination	IEA
GO:0001934	Process	Positive regulation of protein phosphorylation	IDA	12804775
GO:0005515	Function	Protein binding	IPI	12860405, 16884718, 19081057, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0008592	Process	Regulation of Toll signaling pathway	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0034450	Function	Ubiquitin-ubiquitin ligase activity	TAS
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	TAS
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	12804775
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

MIM	HGNC	e!Ensembl
614798	8828	ENSG00000139946

Q9HAT8

Protein name

E3 ubiquitin-protein ligase pellino homolog 2 (Pellino-2) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase pellino homolog 2)

Protein function

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1

PDB

3EGA , 3EGB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04710	Pellino	10 → 420	Pellino	Family

Sequence

MFSPGQEEHCAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVH
VISTPQASKAISCKGQHSISYTLSRNQTVVVEYTHDKDTDMFQVGRSTESPIDFVVTDTI
SGSQNTDEAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPDG
HMDGLTTNGVLVMHPRGGFTEESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVL
QDGSLIDLCGATLLWRTADGLFHTPTQKHIEALRQEINAARPQCPVGLNTLAFPSINRKE
VVEEKQPWAYLSCGHVHGYHNWGHRSDTEANERECPMCRTVGPYVPLWLGCEAGFYVDAG
PPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCATQLVGEQNCIKLIFQGPID

Sequence length

420

Interactions

View interactions

	Reactome
			Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER'S DISEASE NEUROPATHOLOGIC CHANGE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, BASAL CELL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIPHERAL ARTERIAL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Keloid	Associate	36776133	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Associate	30075554	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Associate	30971501	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Stimulate	30971501	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Associate	30971501	★★★★★ ★☆☆☆☆ Found in Text Mining only

PELI2 (pellino E3 ubiquitin protein ligase family member 2)