Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57140
Gene name Gene Name - the full gene name approved by the HGNC.	Arginyl aminopeptidase like 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RNPEPL1
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q37.3

Show/Hide all(109)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002699	hsa-miR-124-3p	Microarray	15685193
MIRT002699	hsa-miR-124-3p	Microarray	18668037
MIRT002699	hsa-miR-124-3p	Microarray	15685193
MIRT724346	hsa-miR-4308	HITS-CLIP	19536157
MIRT724345	hsa-miR-4292	HITS-CLIP	19536157
MIRT724344	hsa-miR-6791-5p	HITS-CLIP	19536157
MIRT724343	hsa-miR-339-5p	HITS-CLIP	19536157
MIRT724342	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT724341	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT724340	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT724339	hsa-miR-1266-3p	HITS-CLIP	19536157
MIRT724338	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT724337	hsa-miR-26b-3p	HITS-CLIP	19536157
MIRT724336	hsa-miR-3199	HITS-CLIP	19536157
MIRT724335	hsa-miR-8052	HITS-CLIP	19536157
MIRT724334	hsa-miR-365a-5p	HITS-CLIP	19536157
MIRT724333	hsa-miR-365b-5p	HITS-CLIP	19536157
MIRT724332	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT724331	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT724346	hsa-miR-4308	HITS-CLIP	19536157
MIRT724345	hsa-miR-4292	HITS-CLIP	19536157
MIRT724344	hsa-miR-6791-5p	HITS-CLIP	19536157
MIRT724343	hsa-miR-339-5p	HITS-CLIP	19536157
MIRT724342	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT724341	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT724340	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT724339	hsa-miR-1266-3p	HITS-CLIP	19536157
MIRT724338	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT724337	hsa-miR-26b-3p	HITS-CLIP	19536157
MIRT724336	hsa-miR-3199	HITS-CLIP	19536157
MIRT724335	hsa-miR-8052	HITS-CLIP	19536157
MIRT724334	hsa-miR-365a-5p	HITS-CLIP	19536157
MIRT724333	hsa-miR-365b-5p	HITS-CLIP	19536157
MIRT724332	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT724331	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT1314370	hsa-miR-1205	CLIP-seq
MIRT1314371	hsa-miR-1254	CLIP-seq
MIRT1314372	hsa-miR-1343	CLIP-seq
MIRT1314373	hsa-miR-1909	CLIP-seq
MIRT1314374	hsa-miR-296-5p	CLIP-seq
MIRT1314375	hsa-miR-3116	CLIP-seq
MIRT1314376	hsa-miR-3155	CLIP-seq
MIRT1314377	hsa-miR-3155b	CLIP-seq
MIRT1314378	hsa-miR-3176	CLIP-seq
MIRT1314379	hsa-miR-3184	CLIP-seq
MIRT1314380	hsa-miR-3922-3p	CLIP-seq
MIRT1314381	hsa-miR-423-5p	CLIP-seq
MIRT1314382	hsa-miR-4287	CLIP-seq
MIRT1314383	hsa-miR-4423-5p	CLIP-seq
MIRT1314384	hsa-miR-4469	CLIP-seq
MIRT1314385	hsa-miR-4489	CLIP-seq
MIRT1314386	hsa-miR-4640-5p	CLIP-seq
MIRT1314387	hsa-miR-4685-3p	CLIP-seq
MIRT1314388	hsa-miR-4726-5p	CLIP-seq
MIRT1314389	hsa-miR-484	CLIP-seq
MIRT1314390	hsa-miR-661	CLIP-seq
MIRT1314391	hsa-miR-760	CLIP-seq
MIRT2093526	hsa-miR-1226	CLIP-seq
MIRT1314371	hsa-miR-1254	CLIP-seq
MIRT2093527	hsa-miR-147b	CLIP-seq
MIRT2093528	hsa-miR-1915	CLIP-seq
MIRT2093529	hsa-miR-2861	CLIP-seq
MIRT2093530	hsa-miR-29a	CLIP-seq
MIRT2093531	hsa-miR-29b	CLIP-seq
MIRT2093532	hsa-miR-29c	CLIP-seq
MIRT2093533	hsa-miR-3065-3p	CLIP-seq
MIRT1314375	hsa-miR-3116	CLIP-seq
MIRT2093534	hsa-miR-3156-3p	CLIP-seq
MIRT1314379	hsa-miR-3184	CLIP-seq
MIRT2093535	hsa-miR-3192	CLIP-seq
MIRT2093536	hsa-miR-3657	CLIP-seq
MIRT1314381	hsa-miR-423-5p	CLIP-seq
MIRT2093537	hsa-miR-4301	CLIP-seq
MIRT1314383	hsa-miR-4423-5p	CLIP-seq
MIRT2093538	hsa-miR-4457	CLIP-seq
MIRT1314385	hsa-miR-4489	CLIP-seq
MIRT1314386	hsa-miR-4640-5p	CLIP-seq
MIRT2093539	hsa-miR-4669	CLIP-seq
MIRT1314388	hsa-miR-4726-5p	CLIP-seq
MIRT2093540	hsa-miR-4727-5p	CLIP-seq
MIRT2093541	hsa-miR-4728-5p	CLIP-seq
MIRT2093542	hsa-miR-4731-3p	CLIP-seq
MIRT2093543	hsa-miR-4769-3p	CLIP-seq
MIRT2093544	hsa-miR-4801	CLIP-seq
MIRT2093545	hsa-miR-532-3p	CLIP-seq
MIRT2093546	hsa-miR-593	CLIP-seq
MIRT2093547	hsa-miR-634	CLIP-seq
MIRT1314390	hsa-miR-661	CLIP-seq
MIRT2318074	hsa-miR-1231	CLIP-seq
MIRT2318075	hsa-miR-124	CLIP-seq
MIRT2318076	hsa-miR-1913	CLIP-seq
MIRT2093535	hsa-miR-3192	CLIP-seq
MIRT2318077	hsa-miR-324-3p	CLIP-seq
MIRT2318078	hsa-miR-331-3p	CLIP-seq
MIRT2093536	hsa-miR-3657	CLIP-seq
MIRT2318079	hsa-miR-3689a-3p	CLIP-seq
MIRT2318080	hsa-miR-3689c	CLIP-seq
MIRT2318081	hsa-miR-4258	CLIP-seq
MIRT1314382	hsa-miR-4287	CLIP-seq
MIRT2318082	hsa-miR-4313	CLIP-seq
MIRT2318083	hsa-miR-4314	CLIP-seq
MIRT1314384	hsa-miR-4469	CLIP-seq
MIRT2318084	hsa-miR-4646-5p	CLIP-seq
MIRT2093539	hsa-miR-4669	CLIP-seq
MIRT1314387	hsa-miR-4685-3p	CLIP-seq
MIRT2318085	hsa-miR-4690-3p	CLIP-seq
MIRT2318086	hsa-miR-4707-3p	CLIP-seq
MIRT2093541	hsa-miR-4728-5p	CLIP-seq
MIRT2318087	hsa-miR-506	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0006508	Process	Proteolysis	IBA	21873635
GO:0006508	Process	Proteolysis	IDA	11017071
GO:0008270	Function	Zinc ion binding	IEA
GO:0070006	Function	Metalloaminopeptidase activity	IBA	21873635
GO:0070006	Function	Metalloaminopeptidase activity	IDA	11017071

MIM	HGNC	e!Ensembl
605287	10079	ENSG00000142327

Protein

UniProt ID

Q9HAU8

Protein name

Aminopeptidase RNPEPL1 (EC 3.4.11.-) (Arginyl aminopeptidase-like 1) (Methionyl aminopeptidase) (EC 3.4.11.18)

Protein function

Broad specificity aminopeptidase which preferentially hydrolyzes an N-terminal methionine, citrulline or glutamine.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17900	Peptidase_M1_N	133 → 258		Domain
PF01433	Peptidase_M1	291 → 501	Peptidase family M1 domain	Domain
PF09127	Leuk-A4-hydro_C	560 → 673	Leukotriene A4 hydrolase, C-terminal	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. Expressed at relatively higher levels in heart and skeletal muscle. {ECO:0000269|PubMed:11017071, ECO:0000269|PubMed:19508204}.

Sequence

MAAQCCCRQAPGAEAAPVRPPPEPPPALDVASASSAQLFRLRHLQLGLELRPEARELAGC
LVLELCALRPAPRALVLDAHPALRLHSAAFRRAPAAAAETPCAFAFSAPGPGPAPPPPLP
AFPEAPGSEPACCPLAFRVDPFTDYGSSLTVTLPPELQAHQPFQVILRYTSTDAPAIWWL
DPELTYGCAKPFVFTQGHSVCNRSFFPCFDTPAVKCTYSAVVKAPSGVQVLMSATRSAYM
EEEGVFHFHMEHPVPAYLVALVAGDLKPADIGPRSRVWAEPCLLPTATSKLSGAVEQWLS
AAERLYGPYMWGRYDIVFLPPSFPIVAMENPCLTFIISSILESDEFLVIDVIHEVAHSWF
GNAVTNATWEEMWLSEGLATYAQRRITTETYGAAFTCLETAFRLDALHRQMKLLGEDSPV
SKLQVKLEPGVNPSHLMNLFTYEKGYCFVYYLSQLCGDPQRFDDFLRAYVEKYKFTSVVA
QDLLDSFLSFFPELKEQSVDCRAGLEFERWLNATGPPLAEPDLSQGSSLTRPVEALFQLW
TAEPLDQAAASASAIDISKWRTFQTALFLDRLLDGSPLPQEVVMSLSKCYSSLLDSMNAE
IRIRWLQIVVRNDYYPDLHRVRRFLESQMSRMYTIPLYEDLCTGALKSFALEVFYQTQGR
LHPNLRRAIQQILSQGLGSSTEPASEPSTELGKAEADTDSDAQALLLGDEAPSSAISLRD
VNVSA

Sequence length

725

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800 View all (467 more)

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Bipolar Disorder	Bipolar Disorder			GWAS

RNPEPL1 (arginyl aminopeptidase like 1)