DAZ4 (deleted in azoospermia 4)

Gene

• Entrez ID: 57135
• Gene name: Deleted in azoospermia 4
• Gene symbol: DAZ4
• Synonyms (NCBI Gene): pDP1680, pDP1681
• Chromosome: Y
• Chromosome location: Yq11.23
• Summary: This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT923426	hsa-let-7a	CLIP-seq
MIRT923427	hsa-let-7b	CLIP-seq
MIRT923428	hsa-let-7c	CLIP-seq
MIRT923429	hsa-let-7d	CLIP-seq
MIRT923430	hsa-let-7e	CLIP-seq
MIRT923431	hsa-let-7f	CLIP-seq
MIRT923432	hsa-let-7g	CLIP-seq
MIRT923433	hsa-let-7i	CLIP-seq
MIRT923434	hsa-miR-1270	CLIP-seq
MIRT923435	hsa-miR-1304	CLIP-seq
MIRT923436	hsa-miR-202	CLIP-seq
MIRT923437	hsa-miR-203	CLIP-seq
MIRT923438	hsa-miR-3140-3p	CLIP-seq
MIRT923439	hsa-miR-3140-5p	CLIP-seq
MIRT923440	hsa-miR-3682-5p	CLIP-seq
MIRT923441	hsa-miR-3923	CLIP-seq
MIRT923442	hsa-miR-4276	CLIP-seq
MIRT923443	hsa-miR-4302	CLIP-seq
MIRT923444	hsa-miR-432	CLIP-seq
MIRT923445	hsa-miR-4434	CLIP-seq
MIRT923446	hsa-miR-4458	CLIP-seq
MIRT923447	hsa-miR-4500	CLIP-seq
MIRT923448	hsa-miR-4516	CLIP-seq
MIRT923449	hsa-miR-4531	CLIP-seq
MIRT923450	hsa-miR-4766-5p	CLIP-seq
MIRT923451	hsa-miR-4777-5p	CLIP-seq
MIRT923452	hsa-miR-513a-3p	CLIP-seq
MIRT923453	hsa-miR-518d-5p	CLIP-seq
MIRT923454	hsa-miR-519b-5p	CLIP-seq
MIRT923455	hsa-miR-519c-5p	CLIP-seq
MIRT923456	hsa-miR-520c-5p	CLIP-seq
MIRT923457	hsa-miR-526a	CLIP-seq
MIRT923458	hsa-miR-548u	CLIP-seq
MIRT923459	hsa-miR-561	CLIP-seq
MIRT923460	hsa-miR-620	CLIP-seq
MIRT923461	hsa-miR-628-3p	CLIP-seq
MIRT923462	hsa-miR-98	CLIP-seq
MIRT923463	hsa-miR-4733-5p	CLIP-seq
MIRT923464	hsa-miR-606	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003730	Function	MRNA 3'-UTR binding	IBA
GO:0003730	Function	MRNA 3'-UTR binding	IEA
GO:0005515	Function	Protein binding	IPI	10857750
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	31429579
GO:0005737	Component	Cytoplasm	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0008494	Function	Translation activator activity	IBA
GO:0030154	Process	Cell differentiation	IEA
GO:0032991	Component	Protein-containing complex	IDA	10857750
GO:0032991	Component	Protein-containing complex	IEA
GO:0045948	Process	Positive regulation of translational initiation	IBA
GO:0070935	Process	3'-UTR-mediated mRNA stabilization	IBA

Other IDs

• MIM: 400048
• HGNC: 15966
• e!Ensembl: ENSG00000205916

Protein

• UniProt ID: Q86SG3
• Protein name: Deleted in azoospermia protein 4
• Protein function: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	42 → 109	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	207 → 274	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF18872	Daz	335 → 355	Daz repeat	Repeat
  PF18872	Daz	359 → 379	Daz repeat	Repeat
  PF18872	Daz	383 → 403	Daz repeat	Repeat
  PF18872	Daz	407 → 427	Daz repeat	Repeat
  PF18872	Daz	431 → 451	Daz repeat	Repeat
  PF18872	Daz	455 → 475	Daz repeat	Repeat
  PF18872	Daz	479 → 499	Daz repeat	Repeat
  PF18872	Daz	503 → 523	Daz repeat	Repeat
  PF18872	Daz	527 → 547	Daz repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Testis-specific. Expression restricted to premeiotic germ cells, particularly in spermatogonia (at protein level). {ECO:0000269|PubMed:10936047, ECO:0000269|PubMed:18385127, ECO:0000269|PubMed:19223287}.
• Sequence:

  MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCF
  GRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLC
  ARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISR
  EASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNR
  TGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPP
  PPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVITGCQLLVYNYQEYPTY
  PDSAFQVTTGYQLPVYNYQPFPAYPRSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQ
  FPVYNYQPFPAYPSSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQAFPAY
  PNSPVQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPNSAVQVTTGYQ
  FHVYNYQMPPQCPVGEQRRNLWTEAYKWWYLVCLIQRRD

• Sequence length: 579