Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
57134
Gene name Gene Name - the full gene name approved by the HGNC.
Mannosidase alpha class 1C member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MAN1C1
Synonyms (NCBI Gene) Gene synonyms aliases
HMIC, MAN1A3, MAN1C, pp6318
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p36.11
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020204 hsa-miR-130b-3p Sequencing 20371350
MIRT028164 hsa-miR-93-5p Sequencing 20371350
MIRT050567 hsa-miR-20a-5p CLASH 23622248
MIRT623327 hsa-miR-552-3p HITS-CLIP 19536157
MIRT709826 hsa-miR-6871-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IBA 21873635
GO:0000139 Component Golgi membrane TAS
GO:0004571 Function Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA 21873635
GO:0004571 Function Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity TAS 10915796
GO:0005509 Function Calcium ion binding TAS 10915796
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
616772 19080 ENSG00000117643
Protein
UniProt ID Q9NR34
Protein name Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (HMIC) (Mannosidase alpha class 1C member 1) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC)
Protein function Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01532 Glyco_hydro_47 181 617 Glycosyl hydrolase family 47 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in most tissues with the exception of lung, muscle and pancreas. Highly expressed in placenta.
Sequence
Sequence length 630
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  N-Glycan biosynthesis
Various types of N-glycan biosynthesis
Metabolic pathways
Protein processing in endoplasmic reticulum
  Intra-Golgi traffic
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Common variable immunodeficiency Common Variable Immunodeficiency rs72553883, rs121908379, rs104894650, rs587776775, rs398122863, rs398122864, rs397514332, rs397514331, rs727502786, rs727502787, rs72553882, rs869320688, rs869320689, rs869320754, rs773694113
View all (35 more)
21497890
Associations from Text Mining
Disease Name Relationship Type References
Aging Premature Associate 21966431
Carcinogenesis Associate 38117655
Cholangiocarcinoma Associate 38117655
Emphysema Associate 24383474
Glioblastoma Associate 39333557
Glioma Associate 39333557
Inflammation Stimulate 39333557
Neoplasms Associate 35065254
Ovarian Neoplasms Associate 39972314
Parkinson Disease Associate 26510930