CAMK1D (calcium/calmodulin dependent protein kinase ID)

Gene

• Entrez ID: 57118
• Gene name: Calcium/calmodulin dependent protein kinase ID
• Gene symbol: CAMK1D
• Synonyms (NCBI Gene): CKLiK, CaM-K1, CaMKID
• Chromosome: 10
• Chromosome location: 10p13
• Summary: This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT618696	hsa-miR-562	HITS-CLIP	23824327
MIRT618695	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT618694	hsa-miR-5697	HITS-CLIP	23824327
MIRT618693	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT618692	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT618691	hsa-miR-6719-3p	HITS-CLIP	23824327
MIRT618690	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT618696	hsa-miR-562	HITS-CLIP	23824327
MIRT618695	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT618694	hsa-miR-5697	HITS-CLIP	23824327
MIRT618693	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT618692	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT618691	hsa-miR-6719-3p	HITS-CLIP	23824327
MIRT618690	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT860034	hsa-miR-150	CLIP-seq
MIRT860035	hsa-miR-1976	CLIP-seq
MIRT860036	hsa-miR-3130-3p	CLIP-seq
MIRT860037	hsa-miR-3147	CLIP-seq
MIRT860038	hsa-miR-4252	CLIP-seq
MIRT860039	hsa-miR-4425	CLIP-seq
MIRT860040	hsa-miR-4438	CLIP-seq
MIRT860041	hsa-miR-450b-3p	CLIP-seq
MIRT860042	hsa-miR-4690-3p	CLIP-seq
MIRT860043	hsa-miR-4722-3p	CLIP-seq
MIRT860044	hsa-miR-5095	CLIP-seq
MIRT860045	hsa-miR-520g	CLIP-seq
MIRT860046	hsa-miR-520h	CLIP-seq
MIRT860047	hsa-miR-769-3p	CLIP-seq
MIRT860048	hsa-miR-122	CLIP-seq
MIRT860049	hsa-miR-197	CLIP-seq
MIRT860035	hsa-miR-1976	CLIP-seq
MIRT860050	hsa-miR-2355-5p	CLIP-seq
MIRT860051	hsa-miR-2392	CLIP-seq
MIRT860052	hsa-miR-29a	CLIP-seq
MIRT860053	hsa-miR-29b	CLIP-seq
MIRT860054	hsa-miR-29c	CLIP-seq
MIRT860055	hsa-miR-3065-3p	CLIP-seq
MIRT860056	hsa-miR-3120-3p	CLIP-seq
MIRT860057	hsa-miR-3127-3p	CLIP-seq
MIRT860058	hsa-miR-3135b	CLIP-seq
MIRT860059	hsa-miR-3170	CLIP-seq
MIRT860060	hsa-miR-3187-3p	CLIP-seq
MIRT860061	hsa-miR-3194-3p	CLIP-seq
MIRT860062	hsa-miR-3652	CLIP-seq
MIRT860063	hsa-miR-411	CLIP-seq
MIRT860064	hsa-miR-4279	CLIP-seq
MIRT860065	hsa-miR-4283	CLIP-seq
MIRT860066	hsa-miR-431	CLIP-seq
MIRT860067	hsa-miR-4430	CLIP-seq
MIRT860068	hsa-miR-4435	CLIP-seq
MIRT860069	hsa-miR-4454	CLIP-seq
MIRT860070	hsa-miR-4489	CLIP-seq
MIRT860071	hsa-miR-4532	CLIP-seq
MIRT860072	hsa-miR-4695-3p	CLIP-seq
MIRT860073	hsa-miR-4696	CLIP-seq
MIRT860074	hsa-miR-4701-5p	CLIP-seq
MIRT860075	hsa-miR-4708-3p	CLIP-seq
MIRT860076	hsa-miR-4716-5p	CLIP-seq
MIRT860077	hsa-miR-4749-3p	CLIP-seq
MIRT860078	hsa-miR-4761-5p	CLIP-seq
MIRT860079	hsa-miR-4781-3p	CLIP-seq
MIRT860080	hsa-miR-4797-5p	CLIP-seq
MIRT860081	hsa-miR-498	CLIP-seq
MIRT860082	hsa-miR-5096	CLIP-seq
MIRT860083	hsa-miR-548s	CLIP-seq
MIRT860084	hsa-miR-564	CLIP-seq
MIRT860085	hsa-miR-582-5p	CLIP-seq
MIRT860086	hsa-miR-588	CLIP-seq
MIRT860087	hsa-miR-615-5p	CLIP-seq
MIRT860088	hsa-miR-720	CLIP-seq
MIRT860089	hsa-miR-924	CLIP-seq
MIRT860048	hsa-miR-122	CLIP-seq
MIRT1955222	hsa-miR-1297	CLIP-seq
MIRT1955223	hsa-miR-132	CLIP-seq
MIRT1955224	hsa-miR-1343	CLIP-seq
MIRT860034	hsa-miR-150	CLIP-seq
MIRT1955225	hsa-miR-1910	CLIP-seq
MIRT860035	hsa-miR-1976	CLIP-seq
MIRT1955226	hsa-miR-212	CLIP-seq
MIRT1955227	hsa-miR-26a	CLIP-seq
MIRT1955228	hsa-miR-26b	CLIP-seq
MIRT860058	hsa-miR-3135b	CLIP-seq
MIRT1955229	hsa-miR-3650	CLIP-seq
MIRT860062	hsa-miR-3652	CLIP-seq
MIRT1955230	hsa-miR-3907	CLIP-seq
MIRT860067	hsa-miR-4430	CLIP-seq
MIRT1955231	hsa-miR-4465	CLIP-seq
MIRT860072	hsa-miR-4695-3p	CLIP-seq
MIRT860043	hsa-miR-4722-3p	CLIP-seq
MIRT1955232	hsa-miR-516a-3p	CLIP-seq
MIRT860045	hsa-miR-520g	CLIP-seq
MIRT860046	hsa-miR-520h	CLIP-seq
MIRT860048	hsa-miR-122	CLIP-seq
MIRT2192941	hsa-miR-1227	CLIP-seq
MIRT860035	hsa-miR-1976	CLIP-seq
MIRT2192942	hsa-miR-2964a-3p	CLIP-seq
MIRT860058	hsa-miR-3135b	CLIP-seq
MIRT1955229	hsa-miR-3650	CLIP-seq
MIRT860062	hsa-miR-3652	CLIP-seq
MIRT2192943	hsa-miR-3934	CLIP-seq
MIRT860064	hsa-miR-4279	CLIP-seq
MIRT860067	hsa-miR-4430	CLIP-seq
MIRT860040	hsa-miR-4438	CLIP-seq
MIRT860069	hsa-miR-4454	CLIP-seq
MIRT860071	hsa-miR-4532	CLIP-seq
MIRT860072	hsa-miR-4695-3p	CLIP-seq
MIRT2192944	hsa-miR-4715-3p	CLIP-seq
MIRT860043	hsa-miR-4722-3p	CLIP-seq
MIRT2192945	hsa-miR-4731-5p	CLIP-seq
MIRT2192946	hsa-miR-4740-3p	CLIP-seq
MIRT2192947	hsa-miR-4772-3p	CLIP-seq
MIRT860081	hsa-miR-498	CLIP-seq
MIRT860044	hsa-miR-5095	CLIP-seq
MIRT2192948	hsa-miR-552	CLIP-seq
MIRT860084	hsa-miR-564	CLIP-seq
MIRT2192949	hsa-miR-616	CLIP-seq
MIRT2192950	hsa-miR-936	CLIP-seq
MIRT860048	hsa-miR-122	CLIP-seq
MIRT1955222	hsa-miR-1297	CLIP-seq
MIRT1955224	hsa-miR-1343	CLIP-seq
MIRT1955227	hsa-miR-26a	CLIP-seq
MIRT1955228	hsa-miR-26b	CLIP-seq
MIRT860058	hsa-miR-3135b	CLIP-seq
MIRT1955229	hsa-miR-3650	CLIP-seq
MIRT860062	hsa-miR-3652	CLIP-seq
MIRT860067	hsa-miR-4430	CLIP-seq
MIRT1955231	hsa-miR-4465	CLIP-seq
MIRT860072	hsa-miR-4695-3p	CLIP-seq
MIRT1955232	hsa-miR-516a-3p	CLIP-seq
MIRT2496002	hsa-miR-941	CLIP-seq
MIRT1955222	hsa-miR-1297	CLIP-seq
MIRT1955224	hsa-miR-1343	CLIP-seq
MIRT860035	hsa-miR-1976	CLIP-seq
MIRT1955227	hsa-miR-26a	CLIP-seq
MIRT1955228	hsa-miR-26b	CLIP-seq
MIRT860064	hsa-miR-4279	CLIP-seq
MIRT1955231	hsa-miR-4465	CLIP-seq
MIRT860043	hsa-miR-4722-3p	CLIP-seq
MIRT1955232	hsa-miR-516a-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004683	Function	Calmodulin-dependent protein kinase activity	IBA	21873635
GO:0004683	Function	Calmodulin-dependent protein kinase activity	IDA	11050006
GO:0005516	Function	Calmodulin binding	IBA	21873635
GO:0005524	Function	ATP binding	IEA
GO:0005622	Component	Intracellular anatomical structure	IBA	21873635
GO:0005634	Component	Nucleus	IDA	16324104
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	11050006, 16324104
GO:0006954	Process	Inflammatory response	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0010976	Process	Positive regulation of neuron projection development	ISS
GO:0018105	Process	Peptidyl-serine phosphorylation	IBA	21873635
GO:0032793	Process	Positive regulation of CREB transcription factor activity	IDA	16324104
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0050766	Process	Positive regulation of phagocytosis	IMP	15840691
GO:0050773	Process	Regulation of dendrite development	IMP	17056143
GO:0060267	Process	Positive regulation of respiratory burst	IMP	15840691
GO:0071622	Process	Regulation of granulocyte chemotaxis	IMP	15840691
GO:0090023	Process	Positive regulation of neutrophil chemotaxis	ISS

Other IDs

• MIM: 607957
• HGNC: 19341
• e!Ensembl: ENSG00000183049

Protein

• UniProt ID: Q8IU85
• Protein name: Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase I delta) (CaM kinase ID) (CaM-KI delta) (CaMKI delta) (CaMKID) (CaMKI-like protein kinase) (CKLiK)
• Protein function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respirato
• PDB: 2JC6, 6QP5, 6T28, 6T29, 6T6F, 8BFM, 8BFS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	23 → 279	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. {ECO:0000269|PubMed:11050006, ECO:000026
• Sequence:

  MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK
  GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKD
  ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST
  ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF
  DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN
  FAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSS
  SGVSGVGAERRPRPTTVTAVHSGSK

• Sequence length: 385

Pathways

KEGG:

Calcium signaling pathway
Oxytocin signaling pathway
Aldosterone synthesis and secretion
Glioma

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	30718926
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	31374203

Unknown
Disease term	Disease name	Evidence	References	Source
Anorexia	Anorexia			GWAS
Eating Disorders	Eating Disorders			GWAS
Bipolar Disorder	Bipolar Disorder			GWAS
Diabetes	Diabetes			GWAS
Frontal Fibrosing Alopecia	Frontal Fibrosing Alopecia			GWAS
Borderline personality disorder	Borderline personality disorder			GWAS
Dementia	Dementia			GWAS
Alzheimer disease	Alzheimer disease			GWAS
Oligodendroglioma	Oligodendroglioma			GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus			GWAS
Insomnia	Insomnia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	33660800
Breast Neoplasms	Associate	19383354, 20418484
Coronary Artery Disease	Associate	35246263
Diabetes Mellitus	Associate	18567820, 19833888, 24135527
Diabetes Mellitus Type 2	Associate	18567820, 19833888, 22923468, 23840313, 26599349, 27281091, 38353623
Essential Hypertension	Associate	28682143
Insulin Resistance	Associate	34745571
Metabolic Syndrome	Associate	26599349
Narcolepsy	Associate	34745571
Neoplasm Invasiveness	Stimulate	19383354
Neoplasms	Associate	19383354
Obesity	Associate	18567820
Parkinson Disease	Associate	34745571
Postoperative Nausea and Vomiting	Associate	34320404
Pulmonary Disease Chronic Obstructive	Associate	25366777
Sleep Apnea Obstructive	Associate	33243845