TRPC7 (transient receptor potential cation channel subfamily C member 7)

Gene

• Entrez ID: 57113
• Gene name: Transient receptor potential cation channel subfamily C member 7
• Gene symbol: TRPC7
• Synonyms (NCBI Gene): TRP7
• Chromosome: 5
• Chromosome location: 5q31.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029163	hsa-miR-26b-5p	Microarray	19088304
MIRT1457288	hsa-miR-138	CLIP-seq
MIRT1457289	hsa-miR-224	CLIP-seq
MIRT1457290	hsa-miR-3529	CLIP-seq
MIRT1457291	hsa-miR-379	CLIP-seq
MIRT1457292	hsa-miR-4451	CLIP-seq
MIRT1457293	hsa-miR-4650-3p	CLIP-seq
MIRT2462418	hsa-miR-1587	CLIP-seq
MIRT2462419	hsa-miR-299-3p	CLIP-seq
MIRT2462420	hsa-miR-4265	CLIP-seq
MIRT2462421	hsa-miR-4296	CLIP-seq
MIRT2462422	hsa-miR-4322	CLIP-seq
MIRT2462423	hsa-miR-4417	CLIP-seq
MIRT2462424	hsa-miR-4492	CLIP-seq
MIRT2462425	hsa-miR-4498	CLIP-seq
MIRT2462426	hsa-miR-4656	CLIP-seq
MIRT2462427	hsa-miR-4675	CLIP-seq
MIRT2462428	hsa-miR-4741	CLIP-seq
MIRT2462429	hsa-miR-762	CLIP-seq
MIRT2462418	hsa-miR-1587	CLIP-seq
MIRT2462419	hsa-miR-299-3p	CLIP-seq
MIRT2462420	hsa-miR-4265	CLIP-seq
MIRT2462421	hsa-miR-4296	CLIP-seq
MIRT2462422	hsa-miR-4322	CLIP-seq
MIRT2462423	hsa-miR-4417	CLIP-seq
MIRT2462424	hsa-miR-4492	CLIP-seq
MIRT2462425	hsa-miR-4498	CLIP-seq
MIRT2462426	hsa-miR-4656	CLIP-seq
MIRT2462427	hsa-miR-4675	CLIP-seq
MIRT2462428	hsa-miR-4741	CLIP-seq
MIRT2462429	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21402151
GO:0005635	Component	Nuclear envelope	IEA
GO:0005801	Component	Cis-Golgi network	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0006828	Process	Manganese ion transport	IBA	21873635
GO:0007338	Process	Single fertilization	IBA	21873635
GO:0015279	Function	Store-operated calcium channel activity	IBA	21873635
GO:0030168	Process	Platelet activation	TAS
GO:0034703	Component	Cation channel complex	IBA	21873635
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051480	Process	Regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0070588	Process	Calcium ion transmembrane transport	IBA	21873635
GO:0070588	Process	Calcium ion transmembrane transport	TAS
GO:0070679	Function	Inositol 1,4,5 trisphosphate binding	IBA	21873635

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9HCX4
• Protein name: Short transient receptor potential channel 7 (TrpC7) (Transient receptor protein 7) (TRP-7) (hTRP7)
• Protein function: Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12796	Ank_2	47 → 139	Ankyrin repeats (3 copies)	Repeat
  PF08344	TRP_2	198 → 260	Transient receptor ion channel II	Family
  PF00520	Ion_trans	386 → 684	Ion transport protein	Family

• Sequence:

  MLRNSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVR
  KMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVR
  IVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIV
  HILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVL
  TALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNFQVW
  SDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSI
  GLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNET
  FTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLS
  IFVASFTARFMAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIIS
  EGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNL
  YSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTM
  VVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYY
  LIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFKKTRYQAGMRNSENLTANNTLSKPTRY
  QKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQ
  LSEKFGKNLNKDHLRVNKGKDI

• Sequence length: 862

Pathways

Reactome:

Effects of PIP2 hydrolysis
Elevation of cytosolic Ca2+ levels
TRP channels

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Insomnia	Insomnia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Atrial Fibrillation	Associate	28839241
Carcinoma Hepatocellular	Associate	38320625
Coronary Artery Disease	Associate	31881747
Kabuki syndrome	Associate	33674768
Ovarian Neoplasms	Associate	30786925