ANO2 (anoctamin 2)

Gene

• Entrez ID: 57101
• Gene name: Anoctamin 2
• Gene symbol: ANO2
• Synonyms (NCBI Gene): C12orf3, TMEM16B
• Chromosome: 12
• Chromosome location: 12p13.31
• Summary: ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 [PubMed 19015192]).[supplied by OMIM, Jan 2011]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029442	hsa-miR-26b-5p	Microarray	19088304
MIRT785663	hsa-miR-2276	CLIP-seq
MIRT785664	hsa-miR-4286	CLIP-seq
MIRT785665	hsa-miR-4323	CLIP-seq
MIRT785666	hsa-miR-4328	CLIP-seq
MIRT785667	hsa-miR-4758-3p	CLIP-seq
MIRT785668	hsa-miR-578	CLIP-seq
MIRT1931765	hsa-miR-3672	CLIP-seq
MIRT1931766	hsa-miR-3688-5p	CLIP-seq
MIRT1931767	hsa-miR-4318	CLIP-seq
MIRT1931768	hsa-miR-885-3p	CLIP-seq
MIRT2172231	hsa-miR-1236	CLIP-seq
MIRT2172232	hsa-miR-1324	CLIP-seq
MIRT2172233	hsa-miR-3130-3p	CLIP-seq
MIRT2172234	hsa-miR-3157-5p	CLIP-seq
MIRT2172235	hsa-miR-3158-5p	CLIP-seq
MIRT2172236	hsa-miR-3166	CLIP-seq
MIRT2172237	hsa-miR-3667-3p	CLIP-seq
MIRT2172238	hsa-miR-3685	CLIP-seq
MIRT2172239	hsa-miR-4738-5p	CLIP-seq
MIRT2172240	hsa-miR-4753-3p	CLIP-seq
MIRT2172241	hsa-miR-4768-5p	CLIP-seq
MIRT2172242	hsa-miR-4771	CLIP-seq
MIRT2172243	hsa-miR-767-5p	CLIP-seq
MIRT2384235	hsa-miR-142-5p	CLIP-seq
MIRT2384236	hsa-miR-186	CLIP-seq
MIRT785663	hsa-miR-2276	CLIP-seq
MIRT2384237	hsa-miR-3133	CLIP-seq
MIRT2384238	hsa-miR-340	CLIP-seq
MIRT2384239	hsa-miR-3657	CLIP-seq
MIRT785664	hsa-miR-4286	CLIP-seq
MIRT785665	hsa-miR-4323	CLIP-seq
MIRT785666	hsa-miR-4328	CLIP-seq
MIRT2384240	hsa-miR-4669	CLIP-seq
MIRT785667	hsa-miR-4758-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005229	Function	Intracellularly calcium-gated chloride channel activity	IBA
GO:0005229	Function	Intracellularly calcium-gated chloride channel activity	IDA	19474308, 21984732
GO:0005254	Function	Chloride channel activity	IEA
GO:0005254	Function	Chloride channel activity	TAS
GO:0005515	Function	Protein binding	IPI	30126976
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006821	Process	Chloride transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	TAS
GO:0034707	Component	Chloride channel complex	IEA
GO:0046983	Function	Protein dimerization activity	IDA	23576756
GO:0046983	Function	Protein dimerization activity	IEA
GO:1902476	Process	Chloride transmembrane transport	IBA

Other IDs

• MIM: 610109
• HGNC: 1183
• e!Ensembl: ENSG00000047617

Protein

• UniProt ID: Q9NQ90
• Protein name: Anoctamin-2 (Transmembrane protein 16B)
• Protein function: Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the de
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16178	Anoct_dimer	91 → 349	Dimerisation domain of Ca+-activated chloride-channel, anoctamin	Family
  PF04547	Anoctamin	352 → 942	Calcium-activated chloride channel	Family

• Tissue specificity: TISSUE SPECIFICITY: Retina, especially in the photoreceptor synaptic terminals. {ECO:0000269|PubMed:19474308}.
• Sequence:

  MATPGPRDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPC
  GGESTRSSSVINNYLDANEPVSLEARLSRMHFHDSQRKVDYVLAYHYRKRGVHLAQGFPG
  HSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENK
  SQGSIFVRIHAPWQVLAREAEFLKIKVPTKKEMYEIKAGGSIAKKFSAALQKLSSHLQPR
  VPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGI
  NSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKI
  GLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDY
  WNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEE
  RAQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFA
  SILFMIALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIY
  GAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVF
  DGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETD
  SAHSKHPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRL
  DAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSH
  NGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYW
  FILSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKL
  MDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMSSGSQHTNV

• Sequence length: 1003

Pathways

KEGG:

Olfactory transduction

Reactome:

Stimuli-sensing channels

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Cervical cancer	Likely benign	rs71582855	RCV005933056
Ovarian serous cystadenocarcinoma	Likely benign	rs71582855	RCV005933057
Thymoma	Likely benign	rs71582855	RCV005933058

Associations from Text Mining
Disease Name	Relationship Type	References
Cystitis Interstitial	Associate	30973927
Multiple Sclerosis	Associate	26862169, 31375628
Olfaction Disorders	Associate	25635880
Urinary Bladder Diseases	Associate	23018769
von Willebrand Disease Type 3	Associate	17371490, 25635880