Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57101
Gene name Gene Name - the full gene name approved by the HGNC.	Anoctamin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ANO2
Synonyms (NCBI Gene) Gene synonyms aliases	C12orf3, TMEM16B
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12p13.31
Summary Summary of gene provided in NCBI Entrez Gene.	ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 [PubMed 19015192]).[supplied by OMIM, Jan 2011]

Show/Hide all(35)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029442	hsa-miR-26b-5p	Microarray	19088304
MIRT785663	hsa-miR-2276	CLIP-seq
MIRT785664	hsa-miR-4286	CLIP-seq
MIRT785665	hsa-miR-4323	CLIP-seq
MIRT785666	hsa-miR-4328	CLIP-seq
MIRT785667	hsa-miR-4758-3p	CLIP-seq
MIRT785668	hsa-miR-578	CLIP-seq
MIRT1931765	hsa-miR-3672	CLIP-seq
MIRT1931766	hsa-miR-3688-5p	CLIP-seq
MIRT1931767	hsa-miR-4318	CLIP-seq
MIRT1931768	hsa-miR-885-3p	CLIP-seq
MIRT2172231	hsa-miR-1236	CLIP-seq
MIRT2172232	hsa-miR-1324	CLIP-seq
MIRT2172233	hsa-miR-3130-3p	CLIP-seq
MIRT2172234	hsa-miR-3157-5p	CLIP-seq
MIRT2172235	hsa-miR-3158-5p	CLIP-seq
MIRT2172236	hsa-miR-3166	CLIP-seq
MIRT2172237	hsa-miR-3667-3p	CLIP-seq
MIRT2172238	hsa-miR-3685	CLIP-seq
MIRT2172239	hsa-miR-4738-5p	CLIP-seq
MIRT2172240	hsa-miR-4753-3p	CLIP-seq
MIRT2172241	hsa-miR-4768-5p	CLIP-seq
MIRT2172242	hsa-miR-4771	CLIP-seq
MIRT2172243	hsa-miR-767-5p	CLIP-seq
MIRT2384235	hsa-miR-142-5p	CLIP-seq
MIRT2384236	hsa-miR-186	CLIP-seq
MIRT785663	hsa-miR-2276	CLIP-seq
MIRT2384237	hsa-miR-3133	CLIP-seq
MIRT2384238	hsa-miR-340	CLIP-seq
MIRT2384239	hsa-miR-3657	CLIP-seq
MIRT785664	hsa-miR-4286	CLIP-seq
MIRT785665	hsa-miR-4323	CLIP-seq
MIRT785666	hsa-miR-4328	CLIP-seq
MIRT2384240	hsa-miR-4669	CLIP-seq
MIRT785667	hsa-miR-4758-3p	CLIP-seq

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005229	Function	Intracellularly calcium-gated chloride channel activity	IBA
GO:0005229	Function	Intracellularly calcium-gated chloride channel activity	IDA	19474308, 21984732
GO:0005254	Function	Chloride channel activity	IEA
GO:0005254	Function	Chloride channel activity	TAS
GO:0005515	Function	Protein binding	IPI	30126976
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006821	Process	Chloride transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	TAS
GO:0034707	Component	Chloride channel complex	IEA
GO:0046983	Function	Protein dimerization activity	IDA	23576756
GO:0046983	Function	Protein dimerization activity	IEA
GO:1902476	Process	Chloride transmembrane transport	IBA

MIM	HGNC	e!Ensembl
610109	1183	ENSG00000047617

Protein

UniProt ID

Q9NQ90

Protein name

Anoctamin-2 (Transmembrane protein 16B)

Protein function

Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the de

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16178	Anoct_dimer	91 → 349	Dimerisation domain of Ca+-activated chloride-channel, anoctamin	Family
PF04547	Anoctamin	352 → 942	Calcium-activated chloride channel	Family

Tissue specificity

TISSUE SPECIFICITY: Retina, especially in the photoreceptor synaptic terminals. {ECO:0000269|PubMed:19474308}.

Sequence

MATPGPRDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPC
GGESTRSSSVINNYLDANEPVSLEARLSRMHFHDSQRKVDYVLAYHYRKRGVHLAQGFPG
HSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENK
SQGSIFVRIHAPWQVLAREAEFLKIKVPTKKEMYEIKAGGSIAKKFSAALQKLSSHLQPR
VPEHSNNKMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGI
NSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKI
GLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDY
WNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEE
RAQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFA
SILFMIALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIY
GAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVF
DGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETD
SAHSKHPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRL
DAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSH
NGTLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYW
FILSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKL
MDEPALRSPGGGDRSRSRAASSAPSGQSQLGSMMSSGSQHTNV

Sequence length

1003

Interactions

View interactions

	KEGG		Reactome
	Olfactory transduction		Stimuli-sensing channels

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Panic Disorder	Panic disorder	N/A	N/A	GWAS

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Cystitis Interstitial	Associate	30973927
Multiple Sclerosis	Associate	26862169, 31375628
Olfaction Disorders	Associate	25635880
Urinary Bladder Diseases	Associate	23018769
von Willebrand Disease Type 3	Associate	17371490, 25635880

ANO2 (anoctamin 2)