CASS4 (Cas scaffold protein family member 4)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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57091 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Cas scaffold protein family member 4 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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CASS4 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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C20orf32, CAS4, HEFL, HEPL |
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Chromosome
Chromosome number
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20 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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20q13.31 |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | Q9NQ75 | ||||||||||||||||||||
| Protein name | Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL) | ||||||||||||||||||||
| Protein function | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. | ||||||||||||||||||||
| PDB | 2CRE | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed abundantly in lung and spleen. Also highly expressed in ovarian and leukemia cell lines. {ECO:0000269|PubMed:18256281}. | ||||||||||||||||||||
| Sequence |
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| Sequence length | 786 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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