Gene Gene information from NCBI Gene database.
Entrez ID 57085
Gene name Angiotensin II receptor associated protein
Gene symbol AGTRAP
Synonyms (NCBI Gene)
ATRAP
Chromosome 1
Chromosome location 1p36.22
Summary This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of
miRNA miRNA information provided by mirtarbase database.
575
miRTarBase ID miRNA Experiments Reference
MIRT023506 hsa-miR-1-3p Proteomics 18668040
MIRT045764 hsa-miR-125a-5p CLASH 23622248
MIRT692364 hsa-miR-3974 HITS-CLIP 23313552
MIRT692363 hsa-miR-624-3p HITS-CLIP 23313552
MIRT129749 hsa-miR-6808-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0001666 Process Response to hypoxia IEA
GO:0004945 Function Angiotensin type II receptor activity IEA
GO:0005515 Function Protein binding IPI 16189514, 19060904, 21516116, 25416956, 25910212, 26871637, 29892012, 31515488, 32296183
GO:0005783 Component Endoplasmic reticulum IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608729 13539 ENSG00000177674
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6RW13
Protein name Type-1 angiotensin II receptor-associated protein (AT1 receptor-associated protein)
Protein function Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Also induces a decrease in cell proliferatio
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06396 AGTRAP 9 154 Angiotensin II, type I receptor-associated protein (AGTRAP) Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous but more abundant in kidney, heart, pancreas and thyroid. {ECO:0000269|PubMed:11733189}.
Sequence
Sequence length 159
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Signaling by BRAF and RAF fusions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
SCHIZOPHRENIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Acute Kidney Injury Associate 34089082
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 35414770
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 34840632
★☆☆☆☆
Found in Text Mining only
Cognitive Dysfunction Associate 31719572
★☆☆☆☆
Found in Text Mining only
Fibrosis Associate 31719572
★☆☆☆☆
Found in Text Mining only
Neoplasm Metastasis Stimulate 35414770
★☆☆☆☆
Found in Text Mining only
Neoplasms Stimulate 34840632
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 35414770
★☆☆☆☆
Found in Text Mining only
Pulmonary Atelectasis Associate 34089082
★☆☆☆☆
Found in Text Mining only