Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57084
Gene name Gene Name - the full gene name approved by the HGNC.	Solute carrier family 17 member 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SLC17A6
Synonyms (NCBI Gene) Gene synonyms aliases	DNPI, VGLUT2
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11p14.3

Show/Hide all(36)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029908	hsa-miR-26b-5p	Microarray	19088304
MIRT1353522	hsa-miR-1193	CLIP-seq
MIRT1353523	hsa-miR-1252	CLIP-seq
MIRT1353524	hsa-miR-2052	CLIP-seq
MIRT1353525	hsa-miR-2116	CLIP-seq
MIRT1353526	hsa-miR-25	CLIP-seq
MIRT1353527	hsa-miR-32	CLIP-seq
MIRT1353528	hsa-miR-331-5p	CLIP-seq
MIRT1353529	hsa-miR-33a	CLIP-seq
MIRT1353530	hsa-miR-33b	CLIP-seq
MIRT1353531	hsa-miR-363	CLIP-seq
MIRT1353532	hsa-miR-367	CLIP-seq
MIRT1353533	hsa-miR-4273	CLIP-seq
MIRT1353534	hsa-miR-4477b	CLIP-seq
MIRT1353535	hsa-miR-4677-5p	CLIP-seq
MIRT1353536	hsa-miR-4694-3p	CLIP-seq
MIRT1353537	hsa-miR-522	CLIP-seq
MIRT1353538	hsa-miR-579	CLIP-seq
MIRT1353539	hsa-miR-629	CLIP-seq
MIRT1353540	hsa-miR-7	CLIP-seq
MIRT1353541	hsa-miR-889	CLIP-seq
MIRT1353542	hsa-miR-92a	CLIP-seq
MIRT1353543	hsa-miR-92b	CLIP-seq
MIRT1353544	hsa-miR-944	CLIP-seq
MIRT2104625	hsa-miR-495	CLIP-seq
MIRT2329069	hsa-miR-19a	CLIP-seq
MIRT2329070	hsa-miR-19b	CLIP-seq
MIRT2329071	hsa-miR-2113	CLIP-seq
MIRT2329072	hsa-miR-2278	CLIP-seq
MIRT2329073	hsa-miR-3065-5p	CLIP-seq
MIRT2329074	hsa-miR-3121-3p	CLIP-seq
MIRT1353533	hsa-miR-4273	CLIP-seq
MIRT2329075	hsa-miR-4282	CLIP-seq
MIRT2329076	hsa-miR-4705	CLIP-seq
MIRT2329077	hsa-miR-576-5p	CLIP-seq
MIRT2329078	hsa-miR-633	CLIP-seq

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005313	Function	L-glutamate transmembrane transporter activity	IBA	21873635
GO:0005326	Function	Neurotransmitter transmembrane transporter activity	IBA	21873635
GO:0006811	Process	Ion transport	TAS
GO:0006814	Process	Sodium ion transport	IEA
GO:0006820	Process	Anion transport	IBA	21873635
GO:0015293	Function	Symporter activity	IEA
GO:0015813	Process	L-glutamate transmembrane transport	IEA
GO:0016021	Component	Integral component of membrane	IBA	21873635
GO:0022857	Function	Transmembrane transporter activity	IBA	21873635
GO:0030285	Component	Integral component of synaptic vesicle membrane	IBA	21873635
GO:0030672	Component	Synaptic vesicle membrane	TAS
GO:0035249	Process	Synaptic transmission, glutamatergic	IBA	21873635
GO:0043005	Component	Neuron projection	IEA
GO:0050803	Process	Regulation of synapse structure or activity	IBA	21873635
GO:0060076	Component	Excitatory synapse	IBA	21873635
GO:0098700	Process	Neurotransmitter loading into synaptic vesicle	IBA	21873635
GO:0098700	Process	Neurotransmitter loading into synaptic vesicle	IMP	11698620
GO:1990384	Process	Hyaloid vascular plexus regression	ISS

MIM	HGNC	e!Ensembl
607563	16703	ENSG00000091664

Protein

UniProt ID

Q9P2U8

Protein name

Vesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6)

Protein function

Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:11698620, PubMed:33440152). At the synaptic vesicle membrane, mainly functions as a uniporter whic

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07690	MFS_1	76 → 461	Major Facilitator Superfamily	Family

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in adult brain (PubMed:10820226). Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, tempora

Sequence

MESVKQRILAPGKEGLKNFAGKSLGQIYRVLEKKQDTGETIELTEDGKPLEVPERKAPLC
DCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWD
PETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCV
IFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYT
GWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFK
TPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMT
IIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAV
GFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVF
LIAALVHYGGVIFYAIFASGEKQPWADPEETSEEKCGFIHEDELDEETGDITQNYINYGT
TKSYGATTQANGGWPSGWEKKEEFVQGEVQDSHSYKDRVDYS

Sequence length

582

Interactions

View interactions

	KEGG		Reactome
	Synaptic vesicle cycle Retrograde endocannabinoid signaling Glutamatergic synapse Nicotine addiction		Organic anion transporters

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	19228977, 20541370, 19839996

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Unipolar Depression, Major Depressive Disorder		19839996	ClinVar

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	38552733, 39650656
Colorectal Neoplasms	Associate	37404825
Glioma	Associate	33765507
Parkinson Disease	Associate	16563567
Parkinson Disease	Stimulate	35258081

SLC17A6 (solute carrier family 17 member 6)