Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57054
Gene name Gene Name - the full gene name approved by the HGNC.	Deleted in azoospermia 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DAZ3
Synonyms (NCBI Gene) Gene synonyms aliases	pDP1679
Chromosome Chromosome number	Y
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Yq11.23
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important

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miRTarBase ID	miRNA	Experiments
MIRT923387	hsa-let-7a	CLIP-seq
MIRT923388	hsa-let-7b	CLIP-seq
MIRT923389	hsa-let-7c	CLIP-seq
MIRT923390	hsa-let-7d	CLIP-seq
MIRT923391	hsa-let-7e	CLIP-seq
MIRT923392	hsa-let-7f	CLIP-seq
MIRT923393	hsa-let-7g	CLIP-seq
MIRT923394	hsa-let-7i	CLIP-seq
MIRT923395	hsa-miR-1270	CLIP-seq
MIRT923396	hsa-miR-1304	CLIP-seq
MIRT923397	hsa-miR-202	CLIP-seq
MIRT923398	hsa-miR-203	CLIP-seq
MIRT923399	hsa-miR-3140-3p	CLIP-seq
MIRT923400	hsa-miR-3140-5p	CLIP-seq
MIRT923401	hsa-miR-3682-5p	CLIP-seq
MIRT923402	hsa-miR-3923	CLIP-seq
MIRT923403	hsa-miR-4276	CLIP-seq
MIRT923404	hsa-miR-4302	CLIP-seq
MIRT923405	hsa-miR-432	CLIP-seq
MIRT923406	hsa-miR-4434	CLIP-seq
MIRT923407	hsa-miR-4458	CLIP-seq
MIRT923408	hsa-miR-4500	CLIP-seq
MIRT923409	hsa-miR-4516	CLIP-seq
MIRT923410	hsa-miR-4531	CLIP-seq
MIRT923411	hsa-miR-4733-5p	CLIP-seq
MIRT923412	hsa-miR-4766-5p	CLIP-seq
MIRT923413	hsa-miR-4777-5p	CLIP-seq
MIRT923414	hsa-miR-513a-3p	CLIP-seq
MIRT923415	hsa-miR-518d-5p	CLIP-seq
MIRT923416	hsa-miR-519b-5p	CLIP-seq
MIRT923417	hsa-miR-519c-5p	CLIP-seq
MIRT923418	hsa-miR-520c-5p	CLIP-seq
MIRT923419	hsa-miR-526a	CLIP-seq
MIRT923420	hsa-miR-548u	CLIP-seq
MIRT923421	hsa-miR-561	CLIP-seq
MIRT923422	hsa-miR-606	CLIP-seq
MIRT923423	hsa-miR-620	CLIP-seq
MIRT923424	hsa-miR-628-3p	CLIP-seq
MIRT923425	hsa-miR-98	CLIP-seq
MIRT923403	hsa-miR-4276	CLIP-seq
MIRT923404	hsa-miR-4302	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003730	Function	MRNA 3'-UTR binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	10857750
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0007275	Process	Multicellular organism development	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0008494	Function	Translation activator activity	IBA	21873635
GO:0030154	Process	Cell differentiation	IEA
GO:0032991	Component	Protein-containing complex	IDA	10857750
GO:0045948	Process	Positive regulation of translational initiation	IBA	21873635
GO:0070935	Process	3'-UTR-mediated mRNA stabilization	IBA	21873635

MIM	HGNC	e!Ensembl
400027	15965	ENSG00000187191

Protein

UniProt ID

Q9NR90

Protein name

Deleted in azoospermia protein 3

Protein function

RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	42 → 109	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF18872	Daz	170 → 190	Daz repeat	Repeat
PF18872	Daz	194 → 214	Daz repeat	Repeat
PF18872	Daz	218 → 238	Daz repeat	Repeat
PF18872	Daz	242 → 262	Daz repeat	Repeat
PF18872	Daz	266 → 286	Daz repeat	Repeat
PF18872	Daz	290 → 310	Daz repeat	Repeat
PF18872	Daz	314 → 334	Daz repeat	Repeat
PF18872	Daz	338 → 358	Daz repeat	Repeat
PF18872	Daz	362 → 382	Daz repeat	Repeat
PF18872	Daz	386 → 406	Daz repeat	Repeat
PF18872	Daz	410 → 430	Daz repeat	Repeat
PF18872	Daz	434 → 454	Daz repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Testis specific. {ECO:0000269|PubMed:10936047}.

Sequence

MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCF
GRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLC
ARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVIT
GCQLLVYNYQEYPTYPDSAFQVTTGYQLPVYNYQPFPAYPRSPFQVTAGYQLPVYNYQAF
PAYPNSPFQVATGYQFPVYNYQPFPAYPSSPFQVTAGYQLPVYNYQAFPAYPNSPFQVAT
GYQFPVYNYQAFPAYPNSPVQVTTGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQAF
PAYPNSPVQVTTGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQAFPAYPNSPVQVTT
GYQLPVYNYQAFPAYPNSAVQVTTGYQFHVYNYQMPPQCPVGEQRRNLWTEAYKWWYLVC
LIQRRD

Sequence length

486

Interactions

View interactions

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID
Causal
Azoospermia	Azoospermia	rs200969445, rs144567652, rs765353898
Cryptorchidism	Cryptorchidism	rs121912555, rs104894697, rs104894698, rs398122886
Non-obstructive azoospermia	Non-obstructive azoospermia	rs587777872, rs879253743, rs1600840291, rs1600877766, rs753462162, rs1588618614, rs1602684496, rs377712900
Oligospermia	Oligospermia	rs1602125411, rs377712900

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining
Arrest of spermatogenesis	Associate	20823911
Azoospermia	Associate	33093613
Cardiomyopathy Dilated	Associate	33093613
Infertility	Associate	15520406
Infertility Male	Associate	37365340
Oligospermia	Associate	20823911

DAZ3 (deleted in azoospermia 3)