CHPT1 (choline phosphotransferase 1)

Gene

• Entrez ID: 56994
• Gene name: Choline phosphotransferase 1
• Gene symbol: CHPT1
• Synonyms (NCBI Gene): CPT, CPT1
• Chromosome: 12
• Chromosome location: 12q23.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019907	hsa-miR-375	Microarray	20215506
MIRT024793	hsa-miR-215-5p	Microarray	19074876
MIRT026717	hsa-miR-192-5p	Microarray	19074876
MIRT031836	hsa-miR-16-5p	Microarray	21199864
MIRT891413	hsa-miR-3667-3p	CLIP-seq
MIRT891414	hsa-miR-494	CLIP-seq
MIRT891415	hsa-miR-548c-3p	CLIP-seq
MIRT891416	hsa-miR-889	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	12221122
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0001558	Process	Regulation of cell growth	NAS	10893425
GO:0004142	Function	Diacylglycerol cholinephosphotransferase activity	IBA
GO:0004142	Function	Diacylglycerol cholinephosphotransferase activity	IDA	10893425
GO:0004142	Function	Diacylglycerol cholinephosphotransferase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	TAS	10893425
GO:0006656	Process	Phosphatidylcholine biosynthetic process	IDA	10480912
GO:0006656	Process	Phosphatidylcholine biosynthetic process	IDA	10893425
GO:0006656	Process	Phosphatidylcholine biosynthetic process	IEA
GO:0006657	Process	CDP-choline pathway	NAS	10893425
GO:0006663	Process	Platelet activating factor biosynthetic process	IDA	10893425
GO:0008654	Process	Phospholipid biosynthetic process	IEA
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	10893425
GO:0016740	Function	Transferase activity	IEA
GO:0016780	Function	Phosphotransferase activity, for other substituted phosphate groups	IEA
GO:0019992	Function	Diacylglycerol binding	NAS	10893425
GO:0043231	Component	Intracellular membrane-bounded organelle	NAS	10893425
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 616747
• HGNC: 17852
• e!Ensembl: ENSG00000111666

Protein

• UniProt ID: Q8WUD6
• Protein name: Cholinephosphotransferase 1 (hCPT1) (EC 2.7.8.2) (AAPT1-like protein) (Diacylglycerol cholinephosphotransferase 1)
• Protein function: Catalyzes the final step of de novo phosphatidylcholine (PC) synthesis, i.e. the transfer of choline phosphate from CDP-choline to the free hydroxyl of a diacylglycerol (DAG), producing a PC. It thereby plays a central role in the formation and
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01066	CDP-OH_P_transf	61 → 136	CDP-alcohol phosphatidyltransferase	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in testis, colon, small intestine, heart, prostate and spleen. Also detected in kidney, skeletal muscle, pancreas, leukocytes, ovary and thymus. Weakly expressed in the brain, placenta and lung. Overexpressed in cancer
• Sequence:

  MAAGAGAGSAPRWLRALSEPLSAAQLRRLEEHRYSAAGVSLLEPPLQLYWTWLLQWIPLW
  MAPNSITLLGLAVNVVTTLVLISYCPTATEEAPYWTYLLCALGLFIYQSLDAIDGKQARR
  TNSCSPLGELFDHGCDSLSTVFMAVGASIAARLGTYPDWFFFCSFIGMFVFYCAHWQTYV
  SGMLRFGKVDVTEIQIALVIVFVLSAFGGATMWDYTIPILEIKLKILPVLGFLGGVIFSC
  SNYFHVILHGGVGKNGSTIAGTSVLSPGLHIGLIIILAIMIYKKSATDVFEKHPCLYILM
  FGCVFAKVSQKLVVAHMTKSELYLQDTVFLGPGLLFLDQYFNNFIDEYVVLWMAMVISSF
  DMVIYFSALCLQISRHLHLNIFKTACHQAPEQVQVLSSKSHQNNMD

• Sequence length: 406

Pathways

KEGG:

Phosphonate and phosphinate metabolism
Glycerophospholipid metabolism
Ether lipid metabolism
Metabolic pathways
Choline metabolism in cancer

Reactome:

Synthesis of PC