Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	56992
Gene name	Kinesin family member 15
Gene symbol	KIF15
Synonyms (NCBI Gene)	BRDCS2HKLP2KLP2KNSL7NY-BR-62
Chromosome	3
Chromosome location	3p21.31

Show/Hide all (30)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016562	hsa-miR-193b-3p	Microarray	20304954
MIRT024287	hsa-miR-215-5p	Microarray	19074876
MIRT026795	hsa-miR-192-5p	Microarray	19074876
MIRT440373	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440373	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1093418	hsa-miR-1246	CLIP-seq
MIRT1093419	hsa-miR-183	CLIP-seq
MIRT1093420	hsa-miR-4428	CLIP-seq
MIRT1093421	hsa-miR-513a-5p	CLIP-seq
MIRT1093422	hsa-miR-628-5p	CLIP-seq
MIRT1093423	hsa-miR-943	CLIP-seq
MIRT2025066	hsa-miR-1206	CLIP-seq
MIRT1093418	hsa-miR-1246	CLIP-seq
MIRT1093419	hsa-miR-183	CLIP-seq
MIRT2025067	hsa-miR-298	CLIP-seq
MIRT2025068	hsa-miR-409-5p	CLIP-seq
MIRT1093420	hsa-miR-4428	CLIP-seq
MIRT2025069	hsa-miR-4699-3p	CLIP-seq
MIRT2025070	hsa-miR-490-5p	CLIP-seq
MIRT1093421	hsa-miR-513a-5p	CLIP-seq
MIRT2025071	hsa-miR-582-5p	CLIP-seq
MIRT2025072	hsa-miR-876-3p	CLIP-seq
MIRT1093419	hsa-miR-183	CLIP-seq
MIRT1093420	hsa-miR-4428	CLIP-seq
MIRT2025066	hsa-miR-1206	CLIP-seq
MIRT1093418	hsa-miR-1246	CLIP-seq
MIRT1093419	hsa-miR-183	CLIP-seq
MIRT2025067	hsa-miR-298	CLIP-seq
MIRT1093420	hsa-miR-4428	CLIP-seq
MIRT1093421	hsa-miR-513a-5p	CLIP-seq

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000278	Process	Mitotic cell cycle	IEA
GO:0000278	Process	Mitotic cell cycle	TAS	10878014
GO:0000922	Component	Spindle pole	ISS
GO:0003774	Function	Cytoskeletal motor activity	IEA
GO:0003774	Function	Cytoskeletal motor activity	TAS	10878014
GO:0003777	Function	Microtubule motor activity	IBA
GO:0003777	Function	Microtubule motor activity	IEA
GO:0005515	Function	Protein binding	IPI	10878014
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005813	Component	Centrosome	TAS	10878014
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005871	Component	Kinesin complex	IBA
GO:0005873	Component	Plus-end kinesin complex	TAS	10878014
GO:0005874	Component	Microtubule	IBA
GO:0005874	Component	Microtubule	IEA
GO:0007018	Process	Microtubule-based movement	IBA
GO:0007018	Process	Microtubule-based movement	IEA
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IEA
GO:0008574	Function	Plus-end-directed microtubule motor activity	ISS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0051299	Process	Centrosome separation	ISS
GO:0090307	Process	Mitotic spindle assembly	ISS

MIM	HGNC	e!Ensembl
617569	17273	ENSG00000163808

Q9NS87

Protein name

Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62)

Protein function

Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.

PDB

4BN2 , 6ZPH , 6ZPI , 7RYP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00225	Kinesin	32 → 363	Kinesin motor domain	Domain
PF15908	HMMR_C	1266 → 1388	Hyaluronan mediated motility receptor C-terminal	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: Expressed in testis, colon, thymus and in breast cancer. {ECO:0000269|PubMed:12747765}.

Sequence

MAPGCKTELRSVTNGQSNQPSNEGDAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLR
LHSNPEPKTFTFDHVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMM
GPSESDNFSHNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDS
ASAGLYLREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVF
TITIESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVIT
ALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRA
KLIKNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQE
AMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGG
FLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMD
AQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQ
EYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETLKIIT
TPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELR
TVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLN
VLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHM
HVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLN
NLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLE
ESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYN
SALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASK
KHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQ
SPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLRE
MENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIV
EEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERE
RTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLRAENVFL
KEKKRSES

Sequence length

1388

Interactions

View interactions

	KEGG		Reactome
	Motor proteins		MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Kinesins

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Braddock-carey syndrome 2	Pathogenic; Likely pathogenic	rs1002572191, rs2529223639	RCV002271732 RCV003990746

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Gastric cancer	Benign	rs34791294	RCV005903309
Ovarian serous cystadenocarcinoma	Benign	rs34791294	RCV005903310
Pulmonary fibrosis	Likely risk allele	rs777570812, rs1296637776, rs2529061466, rs2529198611, rs1182846113, rs779615762, rs201923210, rs2528970315, rs549556281, rs1247963130, rs758022463	RCV002509770 RCV002509780 RCV002509781 RCV002509782 RCV002509783 RCV002509817 RCV002509818 RCV002509819 RCV002509820 RCV002509821 RCV002509822
Sarcoma	Benign	rs34791294	RCV005903308

Show/Hide Text Mining Associations (19)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	37266661, 37752167
Adenocarcinoma of Lung	Stimulate	37330525
Breast Neoplasms	Associate	18408141, 24391143, 30593585, 32549756, 36726984
Carcinoma Hepatocellular	Associate	28901309, 32108036, 32703154, 36137220
Colorectal Neoplasms	Associate	33011740
COVID 19	Associate	37426642
Death	Associate	37777755
Idiopathic Pulmonary Fibrosis	Associate	31710517, 35417304, 37777755
Inflammation	Associate	32108036, 37426642
Lupus Erythematosus Systemic	Associate	36726984, 37426642
Neoplasms	Associate	24391143, 32108036, 36137220, 39271768
Neoplasms	Stimulate	33011740
Neurodegenerative Diseases	Associate	40229714
Ovarian Neoplasms	Associate	31729978
Pancreatic Neoplasms	Associate	36807568
Sleep Deprivation	Associate	40229714
Sleep Wake Disorders	Associate	40229714
Thyroid Carcinoma Anaplastic	Associate	33455115
Triple Negative Breast Neoplasms	Associate	39271768

KIF15 (kinesin family member 15)