Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	56977
Gene name	Storkhead box 2
Gene symbol	STOX2
Synonyms (NCBI Gene)	-
Chromosome	4
Chromosome location	4q35.1
Summary	This gene encodes a Storkhead-box_winged-helix domain containing protein. This protein is differentially expressed in decidual tissue and may be involved in the susceptibility to pre-eclampsia with fetal growth restriction. Alternate splicing results in m

207

Show/Hide all (207)

miRTarBase ID	miRNA	Experiments	Reference
MIRT026943	hsa-miR-192-5p	Microarray	19074876
MIRT046669	hsa-miR-222-3p	CLASH	23622248
MIRT045189	hsa-miR-186-5p	CLASH	23622248
MIRT621986	hsa-miR-3657	HITS-CLIP	19536157
MIRT621985	hsa-miR-4669	HITS-CLIP	19536157
MIRT627500	hsa-miR-6867-5p	HITS-CLIP	19536157
MIRT621984	hsa-miR-574-5p	HITS-CLIP	19536157
MIRT621986	hsa-miR-3657	HITS-CLIP	23824327
MIRT621985	hsa-miR-4669	HITS-CLIP	23824327
MIRT621984	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT621986	hsa-miR-3657	HITS-CLIP	23824327
MIRT621985	hsa-miR-4669	HITS-CLIP	23824327
MIRT627500	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT653043	hsa-miR-7843-3p	HITS-CLIP	23824327
MIRT653042	hsa-miR-127-5p	HITS-CLIP	23824327
MIRT621984	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT621986	hsa-miR-3657	HITS-CLIP	23824327
MIRT621985	hsa-miR-4669	HITS-CLIP	23824327
MIRT627500	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT621984	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT621986	hsa-miR-3657	HITS-CLIP	23824327
MIRT621985	hsa-miR-4669	HITS-CLIP	23824327
MIRT627500	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT621984	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT621986	hsa-miR-3657	HITS-CLIP	23824327
MIRT621985	hsa-miR-4669	HITS-CLIP	23824327
MIRT621984	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT546398	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT546397	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT546396	hsa-miR-6088	PAR-CLIP	20371350
MIRT546395	hsa-miR-4770	PAR-CLIP	20371350
MIRT546394	hsa-miR-143-3p	PAR-CLIP	20371350
MIRT546393	hsa-miR-4319	PAR-CLIP	20371350
MIRT546392	hsa-miR-125b-5p	PAR-CLIP	20371350
MIRT546391	hsa-miR-125a-5p	PAR-CLIP	20371350
MIRT546390	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT546389	hsa-miR-576-3p	PAR-CLIP	20371350
MIRT546388	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT546387	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT546383	hsa-miR-4324	PAR-CLIP	20371350
MIRT546382	hsa-miR-4708-5p	PAR-CLIP	20371350
MIRT546381	hsa-miR-1273f	PAR-CLIP	20371350
MIRT546380	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT546379	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT546378	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT546377	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT546376	hsa-miR-1468-3p	PAR-CLIP	20371350
MIRT546375	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT546374	hsa-miR-548aw	PAR-CLIP	20371350
MIRT546373	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT546398	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT546397	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT546396	hsa-miR-6088	PAR-CLIP	21572407
MIRT546395	hsa-miR-4770	PAR-CLIP	21572407
MIRT546394	hsa-miR-143-3p	PAR-CLIP	21572407
MIRT546393	hsa-miR-4319	PAR-CLIP	21572407
MIRT546392	hsa-miR-125b-5p	PAR-CLIP	21572407
MIRT546391	hsa-miR-125a-5p	PAR-CLIP	21572407
MIRT546390	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT546389	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT546388	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT546387	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT546386	hsa-miR-6801-3p	PAR-CLIP	21572407
MIRT546385	hsa-miR-6810-3p	PAR-CLIP	21572407
MIRT546384	hsa-miR-331-3p	PAR-CLIP	21572407
MIRT546383	hsa-miR-4324	PAR-CLIP	21572407
MIRT546382	hsa-miR-4708-5p	PAR-CLIP	21572407
MIRT546381	hsa-miR-1273f	PAR-CLIP	21572407
MIRT546380	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT546379	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT546378	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT546377	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT546376	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT546375	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT546374	hsa-miR-548aw	PAR-CLIP	21572407
MIRT546373	hsa-miR-6505-5p	PAR-CLIP	21572407
MIRT447003	hsa-miR-142-5p	PAR-CLIP	22100165
MIRT447002	hsa-miR-5590-3p	PAR-CLIP	22100165
MIRT447001	hsa-miR-383-3p	PAR-CLIP	22100165
MIRT447000	hsa-miR-4709-3p	PAR-CLIP	22100165
MIRT446999	hsa-miR-3161	PAR-CLIP	22100165
MIRT446997	hsa-miR-3611	PAR-CLIP	22100165
MIRT446998	hsa-miR-599	PAR-CLIP	22100165
MIRT447003	hsa-miR-142-5p	PAR-CLIP	22100165
MIRT447002	hsa-miR-5590-3p	PAR-CLIP	22100165
MIRT447001	hsa-miR-383-3p	PAR-CLIP	22100165
MIRT447000	hsa-miR-4709-3p	PAR-CLIP	22100165
MIRT446999	hsa-miR-3161	PAR-CLIP	22100165
MIRT446997	hsa-miR-3611	PAR-CLIP	22100165
MIRT446998	hsa-miR-599	PAR-CLIP	22100165
MIRT621986	hsa-miR-3657	HITS-CLIP	19536157
MIRT621985	hsa-miR-4669	HITS-CLIP	19536157
MIRT627500	hsa-miR-6867-5p	HITS-CLIP	19536157
MIRT621984	hsa-miR-574-5p	HITS-CLIP	19536157
MIRT621986	hsa-miR-3657	HITS-CLIP	23824327
MIRT621985	hsa-miR-4669	HITS-CLIP	23824327
MIRT621984	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT621986	hsa-miR-3657	HITS-CLIP	23824327
MIRT621985	hsa-miR-4669	HITS-CLIP	23824327
MIRT627500	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT653043	hsa-miR-7843-3p	HITS-CLIP	23824327
MIRT653042	hsa-miR-127-5p	HITS-CLIP	23824327
MIRT621984	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT621986	hsa-miR-3657	HITS-CLIP	23824327
MIRT621985	hsa-miR-4669	HITS-CLIP	23824327
MIRT627500	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT621984	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT621986	hsa-miR-3657	HITS-CLIP	23824327
MIRT621985	hsa-miR-4669	HITS-CLIP	23824327
MIRT627500	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT621984	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT621986	hsa-miR-3657	HITS-CLIP	23824327
MIRT621985	hsa-miR-4669	HITS-CLIP	23824327
MIRT621984	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT546398	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT546397	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT546396	hsa-miR-6088	PAR-CLIP	20371350
MIRT546395	hsa-miR-4770	PAR-CLIP	20371350
MIRT546394	hsa-miR-143-3p	PAR-CLIP	20371350
MIRT546393	hsa-miR-4319	PAR-CLIP	20371350
MIRT546392	hsa-miR-125b-5p	PAR-CLIP	20371350
MIRT546391	hsa-miR-125a-5p	PAR-CLIP	20371350
MIRT546390	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT546389	hsa-miR-576-3p	PAR-CLIP	20371350
MIRT546388	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT546387	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT546383	hsa-miR-4324	PAR-CLIP	20371350
MIRT546382	hsa-miR-4708-5p	PAR-CLIP	20371350
MIRT546381	hsa-miR-1273f	PAR-CLIP	20371350
MIRT546380	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT546379	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT546378	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT546377	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT546376	hsa-miR-1468-3p	PAR-CLIP	20371350
MIRT546375	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT546374	hsa-miR-548aw	PAR-CLIP	20371350
MIRT546373	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT546398	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT546397	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT546396	hsa-miR-6088	PAR-CLIP	21572407
MIRT546395	hsa-miR-4770	PAR-CLIP	21572407
MIRT546394	hsa-miR-143-3p	PAR-CLIP	21572407
MIRT546393	hsa-miR-4319	PAR-CLIP	21572407
MIRT546392	hsa-miR-125b-5p	PAR-CLIP	21572407
MIRT546391	hsa-miR-125a-5p	PAR-CLIP	21572407
MIRT546390	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT546389	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT546388	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT546387	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT546386	hsa-miR-6801-3p	PAR-CLIP	21572407
MIRT546385	hsa-miR-6810-3p	PAR-CLIP	21572407
MIRT546384	hsa-miR-331-3p	PAR-CLIP	21572407
MIRT546383	hsa-miR-4324	PAR-CLIP	21572407
MIRT546382	hsa-miR-4708-5p	PAR-CLIP	21572407
MIRT546381	hsa-miR-1273f	PAR-CLIP	21572407
MIRT546380	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT546379	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT546378	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT546377	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT546376	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT546375	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT546374	hsa-miR-548aw	PAR-CLIP	21572407
MIRT546373	hsa-miR-6505-5p	PAR-CLIP	21572407
MIRT447003	hsa-miR-142-5p	PAR-CLIP	22100165
MIRT447002	hsa-miR-5590-3p	PAR-CLIP	22100165
MIRT447001	hsa-miR-383-3p	PAR-CLIP	22100165
MIRT447000	hsa-miR-4709-3p	PAR-CLIP	22100165
MIRT446999	hsa-miR-3161	PAR-CLIP	22100165
MIRT446997	hsa-miR-3611	PAR-CLIP	22100165
MIRT446998	hsa-miR-599	PAR-CLIP	22100165
MIRT447003	hsa-miR-142-5p	PAR-CLIP	22100165
MIRT447002	hsa-miR-5590-3p	PAR-CLIP	22100165
MIRT447001	hsa-miR-383-3p	PAR-CLIP	22100165
MIRT447000	hsa-miR-4709-3p	PAR-CLIP	22100165
MIRT446999	hsa-miR-3161	PAR-CLIP	22100165
MIRT446997	hsa-miR-3611	PAR-CLIP	22100165
MIRT446998	hsa-miR-599	PAR-CLIP	22100165
MIRT1399114	hsa-miR-129-5p	CLIP-seq
MIRT1399115	hsa-miR-1910	CLIP-seq
MIRT1399116	hsa-miR-199a-5p	CLIP-seq
MIRT1399117	hsa-miR-199b-5p	CLIP-seq
MIRT1399118	hsa-miR-30a	CLIP-seq
MIRT1399119	hsa-miR-30b	CLIP-seq
MIRT1399120	hsa-miR-30c	CLIP-seq
MIRT1399121	hsa-miR-30d	CLIP-seq
MIRT1399122	hsa-miR-30e	CLIP-seq
MIRT1399123	hsa-miR-3124-3p	CLIP-seq
MIRT1399124	hsa-miR-3157-3p	CLIP-seq
MIRT1399125	hsa-miR-4495	CLIP-seq
MIRT1399126	hsa-miR-455-3p	CLIP-seq
MIRT1399127	hsa-miR-511	CLIP-seq
MIRT1399128	hsa-miR-874	CLIP-seq
MIRT2341786	hsa-miR-1827	CLIP-seq
MIRT2341787	hsa-miR-298	CLIP-seq
MIRT1399118	hsa-miR-30a	CLIP-seq
MIRT1399119	hsa-miR-30b	CLIP-seq
MIRT1399120	hsa-miR-30c	CLIP-seq
MIRT1399121	hsa-miR-30d	CLIP-seq
MIRT1399122	hsa-miR-30e	CLIP-seq
MIRT2341788	hsa-miR-3156-5p	CLIP-seq
MIRT2341789	hsa-miR-3192	CLIP-seq
MIRT2341790	hsa-miR-3200-5p	CLIP-seq
MIRT2341791	hsa-miR-4300	CLIP-seq
MIRT2341792	hsa-miR-4463	CLIP-seq
MIRT2341793	hsa-miR-4494	CLIP-seq
MIRT2341794	hsa-miR-4649-3p	CLIP-seq
MIRT2341795	hsa-miR-920	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0001893	Process	Maternal placenta development	IEP	20643876
GO:0003700	Function	DNA-binding transcription factor activity	NAS	34673265
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	NAS	34673265
GO:0009617	Process	Response to bacterium	IEA
GO:0009792	Process	Embryo development ending in birth or egg hatching	IEP	20643876

MIM	HGNC	e!Ensembl
617359	25450	ENSG00000173320

Q9P2F5

Protein name

Storkhead-box protein 2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10264	Stork_head	63 → 141	Winged helix Storkhead-box1 domain	Family

Sequence

MKKTRSTTLRRAWPSSDFSDRASDRMRSRSEKDYRLHKRFPAAFAPQASRGYMTSGDVSP
ISMSPISQSQFIPLGEILCLAISAMNSARKPVTQEALMEHLTTCFPGVPTPSQEILRHTL
NTLVRERKIYPTPDGYFIVTPQTYFITPSLIRTNSKWYHLDERIPDRSQCTSPQPGTITP
SASGCVRERTLPRNHCDSCHCCREDVHSTHAPTLQRKSAKDCKDPYCPPSLCQVPPTEKS
KSTVNFSYKTETLSKPKDSEKQSKKFGLKLFRLSFKKDKTKQLANFSAQFPPEEWPLRDE
DTPATIPREVEMEIIRRINPDLTVENVMRHTALMKKLEEEKAQRSKAGSSAHHSGRSKKS
RTHRKSHGKSRSHSKTRVSKGDPSDGSHLDIPAEREYDFCDPLTRVPREGCFIIEHKGDN
FIMHSNTNVLESHFPMTPEWDVSGELAKRRTEMPFPEPSRGSSHSKVHRSHSHTQDRRSR
NERSNKAKERSRSMDNSKGPLGASSLGTPEDLAEGCSQDDQTPSQSYIDDSTLRPAQTVS
LQRAHISSTSYKEVCIPEIVSGSKEPSSACSLLEPGKPPESLPSYGELNSCPTKTATDDY
FQCNTSSETVLTAPSPLGKNKEDHDTLTLAEGVKKLSPSDRQVPHSSREPVGHKEESPKG
PGGGPAASGGVAEGIANGRLVQHHGAEPSSLDKRKEIFSKDTLFKPLHSTLSVNSYHKSS
LSLLKSHPKTPADTLPGRCEKLEPSLGTSAAQAMPASQRQQESGGNQEASFDYYNVSDDD
DSEEGANKNTEEEKNREDVGTMQWLLEREKERDLQRKFEKNLTLLAPKETDSSSNQRATH
SARLDSMDSSSITVDSGFNSPRTRESLASNTSSIVESNRRQNPALSPAHGGAGPAFNFRA
SAEPPTNEAEKLQKPSNCLQASVTSV

Sequence length

926

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIFFERENTIATED THYROID CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOOD DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SARCOIDOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Fetal Growth Retardation	Associate	20643876, 27050375	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Inhibit	27050375	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	27050375	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Stimulate	36232621	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pre Eclampsia	Associate	20643876, 27050375	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Associate	27050375	★★★★★ ★☆☆☆☆ Found in Text Mining only

STOX2 (storkhead box 2)