Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	56965
Gene name Gene Name - the full gene name approved by the HGNC.	Poly(ADP-ribose) polymerase family member 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PARP6
Synonyms (NCBI Gene) Gene synonyms aliases	ARTD17, PARP-6-B1, PARP-6-C, pART17
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q23

Show/Hide all(13)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029594	hsa-miR-26b-5p	Microarray	19088304
MIRT039144	hsa-miR-769-5p	CLASH	23622248
MIRT2061758	hsa-miR-1343	CLIP-seq
MIRT2061759	hsa-miR-3134	CLIP-seq
MIRT2061760	hsa-miR-3616-3p	CLIP-seq
MIRT2061761	hsa-miR-4436b-3p	CLIP-seq
MIRT2061762	hsa-miR-4721	CLIP-seq
MIRT2290144	hsa-miR-1244	CLIP-seq
MIRT2290145	hsa-miR-3168	CLIP-seq
MIRT2290146	hsa-miR-4699-3p	CLIP-seq
MIRT2290147	hsa-miR-520d-5p	CLIP-seq
MIRT2290148	hsa-miR-524-5p	CLIP-seq
MIRT2455940	hsa-miR-3153	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IBA
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IEA
GO:0005635	Component	Nuclear envelope	IBA
GO:0016020	Component	Membrane	IBA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0019900	Function	Kinase binding	IBA
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	IBA
GO:0043539	Function	Protein serine/threonine kinase activator activity	IBA
GO:0050775	Process	Positive regulation of dendrite morphogenesis	IEA
GO:0070213	Process	Protein auto-ADP-ribosylation	IDA	25043379
GO:0071782	Component	Endoplasmic reticulum tubular network	IBA
GO:0140803	Function	NAD+-protein-cysteine ADP-ribosyltransferase activity	IDA	25043379
GO:0140803	Function	NAD+-protein-cysteine ADP-ribosyltransferase activity	IEA
GO:0140806	Function	NAD+-protein-aspartate ADP-ribosyltransferase activity	IDA	25043379
GO:0140806	Function	NAD+-protein-aspartate ADP-ribosyltransferase activity	IEA

MIM	HGNC	e!Ensembl
619439	26921	ENSG00000137817

Protein

UniProt ID

Q2NL67

Protein name

Protein mono-ADP-ribosyltransferase PARP6 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 17) (ARTD17) (Poly [ADP-ribose] polymerase 6) (PARP-6)

Protein function

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00644	PARP	450 → 593	Poly(ADP-ribose) polymerase catalytic domain	Family

Sequence

MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIRE
YGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSN
KEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSWFKASGTIKKFRAGLSIFSPI
PKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMKNPKVEVFGYPPSPQAGLLCPQH
VGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAEQRIPTLNEYCVVCDEQHVFQNGSM
LKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVVDLLVAMCRAALESPRKSIIFEPYPS
VVDPTDPKTLAFNPKKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQW
IISSNRSHIVKLPLSRLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFHGSHIENW
HSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGYSGMGKGQHRMPSKDELVQRYN
RMNTIPQTRSIQSRFLQSRNLNCIALCEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYED
GQVGDANINTQDPKIQKEIMRVIGTQVYTN

Sequence length

630

Interactions

View interactions

	Reactome
			Nicotinamide salvaging

PARP6 (poly(ADP-ribose) polymerase family member 6)