Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
56957
Gene name Gene Name - the full gene name approved by the HGNC.
OTU deubiquitinase 7B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
OTUD7B
Synonyms (NCBI Gene) Gene synonyms aliases
CEZANNE, ZA20D1
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT051066 hsa-miR-16-5p CLASH 23622248
MIRT042784 hsa-miR-339-5p CLASH 23622248
MIRT037334 hsa-miR-877-5p CLASH 23622248
MIRT036370 hsa-miR-1229-3p CLASH 23622248
MIRT054272 hsa-miR-500a-5p Immunoprecipitaion, Luciferase reporter assay, qRT-PCR, Western blot 25595906
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 21097510
GO:0001701 Process In utero embryonic development IEA
GO:0002250 Process Adaptive immune response IEA
GO:0002385 Process Mucosal immune response ISS
GO:0003677 Function DNA binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
611748 16683 ENSG00000264522
Protein
UniProt ID Q6GQQ9
Protein name OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne)
Protein function Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:18178551). In response to non
PDB 5LRU , 5LRV , 5LRW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14555 UBA_4 6 41 Domain
PF02338 OTU 189 359 OTU-like cysteine protease Family
PF01754 zf-A20 800 824 A20-like zinc finger Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the mature cells. {ECO:0000269|PubM
Sequence
MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGS
GGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGG
GGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTS
QRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQ
QNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVF
VLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHF
S
ALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEV
KLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPRSTPESGDSDKESVGSSSTSNE
GGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSKPGGVGTGLG
GSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQEVMQSLSILR
TAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERKIMNGGIGGG
PPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEPRRQLAGGPC
VGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRVADSYSNGYR
EPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRREREPDGELLV
HRF
Sequence length 843
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ovarian tumor domain proteases
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
25751625, 29059683
Unknown
Disease term Disease name Evidence References Source
Eczema Eczema GWAS
Schizophrenia Schizophrenia GWAS
Coronary artery disease Coronary artery disease GWAS
Breast cancer Breast cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Psoriatic Inhibit 37893484
Carcinoma Hepatocellular Associate 25638165
Familial cylindromatosis Associate 37893484
Inflammation Inhibit 18178551, 35025147, 37893484
Neoplasms Inhibit 25638165
Neoplasms Associate 29973362, 37371581
Polycythemia Vera Inhibit 35025147
Psoriasis Associate 37893484