PRTFDC1 (phosphoribosyl transferase domain containing 1)

Gene

• Entrez ID: 56952
• Gene name: Phosphoribosyl transferase domain containing 1
• Gene symbol: PRTFDC1
• Synonyms (NCBI Gene): HHGP
• Chromosome: 10
• Chromosome location: 10p12.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1268636	hsa-miR-1323	CLIP-seq
MIRT1268637	hsa-miR-548o	CLIP-seq
MIRT1268638	hsa-miR-943	CLIP-seq
MIRT2305206	hsa-miR-2355-5p	CLIP-seq
MIRT2305207	hsa-miR-3163	CLIP-seq
MIRT2305208	hsa-miR-889	CLIP-seq
MIRT2602265	hsa-miR-1207-3p	CLIP-seq
MIRT2602266	hsa-miR-1225-3p	CLIP-seq
MIRT2602267	hsa-miR-1272	CLIP-seq
MIRT2602268	hsa-miR-1322	CLIP-seq
MIRT2602269	hsa-miR-2277-3p	CLIP-seq
MIRT2602270	hsa-miR-3150a-5p	CLIP-seq
MIRT2602271	hsa-miR-3150b-5p	CLIP-seq
MIRT2602272	hsa-miR-335	CLIP-seq
MIRT2602273	hsa-miR-4438	CLIP-seq
MIRT2602274	hsa-miR-4517	CLIP-seq
MIRT2602275	hsa-miR-5095	CLIP-seq
MIRT2602276	hsa-miR-579	CLIP-seq
MIRT2602277	hsa-miR-656	CLIP-seq
MIRT2602265	hsa-miR-1207-3p	CLIP-seq
MIRT2602266	hsa-miR-1225-3p	CLIP-seq
MIRT2602267	hsa-miR-1272	CLIP-seq
MIRT2602268	hsa-miR-1322	CLIP-seq
MIRT2602269	hsa-miR-2277-3p	CLIP-seq
MIRT2688788	hsa-miR-3126-3p	CLIP-seq
MIRT2602270	hsa-miR-3150a-5p	CLIP-seq
MIRT2602271	hsa-miR-3150b-5p	CLIP-seq
MIRT2688789	hsa-miR-3192	CLIP-seq
MIRT2688790	hsa-miR-3199	CLIP-seq
MIRT2602272	hsa-miR-335	CLIP-seq
MIRT2688791	hsa-miR-4314	CLIP-seq
MIRT2602273	hsa-miR-4438	CLIP-seq
MIRT2602274	hsa-miR-4517	CLIP-seq
MIRT2688792	hsa-miR-4646-5p	CLIP-seq
MIRT2602275	hsa-miR-5095	CLIP-seq
MIRT2602277	hsa-miR-656	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	TAS	21054786
GO:0004422	Function	Hypoxanthine phosphoribosyltransferase activity	IDA	21054786
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 25910212, 26871637, 31515488, 32296183, 33961781
GO:0005829	Component	Cytosol	IBA
GO:0006166	Process	Purine ribonucleoside salvage	IEA
GO:0006178	Process	Guanine salvage	IDA	21054786
GO:0042803	Function	Protein homodimerization activity	IPI	21054786
GO:0046038	Process	GMP catabolic process	IDA	21054786
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 610751
• HGNC: 23333
• e!Ensembl: ENSG00000099256

Protein

• UniProt ID: Q9NRG1
• Protein name: Phosphoribosyltransferase domain-containing protein 1
• Protein function: Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage.
• PDB: 2JBH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00156	Pribosyltran	43 → 203	Phosphoribosyl transferase domain	Domain

• Sequence:

  MAGSSEEAPDYGRGVVIMDDWPGYDLNLFTYPQHYYGDLEYVLIPHGIIVDRIERLAKDI
  MKDIGYSDIMVLCVLKGGYKFCADLVEHLKNISRNSDRFVSMKVDFIRLKSYRNDQSMGE
  MQIIGGDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDG
  FRPDYAGFEIPNLFVVGYALDYNEYFRDLNHICVINEHGKEKYRV

• Sequence length: 225