Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	56938
Gene name	Basic helix-loop-helix ARNT like 2
Gene symbol	BMAL2
Synonyms (NCBI Gene)	ARNTL2CLIFMOP9PASD9bHLHe6
Chromosome	12
Chromosome location	12p11.23

Show/Hide all (37)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016419	hsa-miR-193b-3p	Microarray	20304954
MIRT019814	hsa-miR-375	Microarray	20215506
MIRT026501	hsa-miR-192-5p	Microarray	19074876
MIRT185714	hsa-miR-204-5p	PAR-CLIP	20371350
MIRT185715	hsa-miR-211-5p	PAR-CLIP	20371350
MIRT185711	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT185712	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT185716	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT185717	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT185713	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT185719	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT562629	hsa-miR-5697	PAR-CLIP	20371350
MIRT185721	hsa-miR-6760-3p	PAR-CLIP	20371350
MIRT562628	hsa-miR-6832-3p	PAR-CLIP	20371350
MIRT562627	hsa-miR-1297	PAR-CLIP	20371350
MIRT562626	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT562625	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT562624	hsa-miR-4465	PAR-CLIP	20371350
MIRT562623	hsa-miR-7703	PAR-CLIP	20371350
MIRT562622	hsa-miR-4325	PAR-CLIP	20371350
MIRT185714	hsa-miR-204-5p	PAR-CLIP	20371350
MIRT185715	hsa-miR-211-5p	PAR-CLIP	20371350
MIRT185711	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT185712	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT185716	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT185717	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT185713	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT185719	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT562629	hsa-miR-5697	PAR-CLIP	20371350
MIRT185721	hsa-miR-6760-3p	PAR-CLIP	20371350
MIRT562628	hsa-miR-6832-3p	PAR-CLIP	20371350
MIRT562627	hsa-miR-1297	PAR-CLIP	20371350
MIRT562626	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT562625	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT562624	hsa-miR-4465	PAR-CLIP	20371350
MIRT562623	hsa-miR-7703	PAR-CLIP	20371350
MIRT562622	hsa-miR-4325	PAR-CLIP	20371350

Show/Hide all (40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	15147242
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	15147242
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	12055078
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	NAS	11018023
GO:0005515	Function	Protein binding	IPI	11018023, 24722188, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	12055078, 12738229
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	11018023
GO:0005654	Component	Nucleoplasm	IDA
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	11018023
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	12055078
GO:0007623	Process	Circadian rhythm	IDA	10864977
GO:0009649	Process	Entrainment of circadian clock	NAS	11018023
GO:0032922	Process	Circadian regulation of gene expression	IDA	10864977
GO:0032922	Process	Circadian regulation of gene expression	IEA
GO:0034751	Component	Aryl hydrocarbon receptor complex	IBA
GO:0042753	Process	Positive regulation of circadian rhythm	IDA	12738229
GO:0042753	Process	Positive regulation of circadian rhythm	IEA
GO:0042753	Process	Positive regulation of circadian rhythm	ISS
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	10864977, 12738229
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	15147242
GO:0046983	Function	Protein dimerization activity	IEA
GO:0048511	Process	Rhythmic process	IEA
GO:0070888	Function	E-box binding	IDA	12738229
GO:0070888	Function	E-box binding	IEA
GO:1990513	Component	CLOCK-BMAL transcription complex	IEA
GO:1990513	Component	CLOCK-BMAL transcription complex	IPI	10864977

MIM	HGNC	e!Ensembl
614517	18984	ENSG00000029153

Q8WYA1

Protein name

Basic helix-loop-helix ARNT-like protein 2 (Aryl hydrocarbon receptor nuclear translocator-like protein 2) (Basic-helix-loop-helix-PAS protein MOP9) (Brain and muscle ARNT-like 2) (CYCLE-like factor) (CLIF) (Class E basic helix-loop-helix protein 6) (bHLH

Protein function

Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in g

PDB

2KDK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00010	HLH	108 → 161	Helix-loop-helix DNA-binding domain	Domain
PF00989	PAS	181 → 287	PAS fold	Domain
PF14598	PAS_11	368 → 477		Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in fetal brain. Highly expressed in brain and placenta. Lower levels in heart, liver, thymus, kidney and lung. Located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN). Also detected in endothelial

Sequence

MAAEEEAAAGGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPRKRKGSDSDPS
QSGIMTEKVVEKLSQNPLTYLLSTRIEISASSGSRVEDGEHQVKMKAFREAHSQTEKRRR
DKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSFLQDN
ELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVK
EQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSFFCRIKSCKISVKEEHGCL
PNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQPYIVPQN
SGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKH
KAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPGE
ASFLPCSSQSSEESSRQSCMSVPGMSTGTVLGAGSIGTDIANEILDLQRLQSSSYLDDSS
PTGLMKDTHTVNCRSMSNKELFPPSPSEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFD
ALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL

Sequence length

636

Interactions

View interactions

	Reactome
			BMAL1:CLOCK,NPAS2 activates circadian gene expression

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Hepatocellular carcinoma	association	rs4964059	RCV005930111
Pulmonary disease, chronic obstructive, susceptibility to	association; protective	rs17497857, rs4964059, rs11048977	RCV002508827 RCV002508828 RCV002508841
Thymoma	Uncertain significance	rs750336615	RCV005931229

BMAL2 (basic helix-loop-helix ARNT like 2)