Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5693
Gene name	Proteasome 20S subunit beta 5
Gene symbol	PSMB5
Synonyms (NCBI Gene)	LMPXMB1
Chromosome	14
Chromosome location	14q11.2
Summary	The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021543	hsa-miR-142-3p	Microarray	17612493
MIRT031323	hsa-miR-18a-5p	Sequencing	20371350
MIRT046973	hsa-miR-221-3p	CLASH	23622248
MIRT044149	hsa-miR-30e-5p	CLASH	23622248
MIRT042548	hsa-miR-423-3p	CLASH	23622248
MIRT654676	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT654675	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT654674	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT654673	hsa-miR-4287	HITS-CLIP	23824327
MIRT654672	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT666802	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT654697	hsa-miR-1470	HITS-CLIP	23824327
MIRT654696	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT654694	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT654695	hsa-miR-5193	HITS-CLIP	23824327
MIRT654693	hsa-miR-3183	HITS-CLIP	23824327
MIRT654692	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT654691	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT654690	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT654689	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT654688	hsa-miR-1248	HITS-CLIP	23824327
MIRT654687	hsa-miR-4469	HITS-CLIP	23824327
MIRT654686	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT654685	hsa-miR-3605-3p	HITS-CLIP	23824327
MIRT654684	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT654683	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT654682	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT654681	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT654680	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT654679	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT654678	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT654677	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT654676	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT654675	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT654674	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT654673	hsa-miR-4287	HITS-CLIP	23824327
MIRT654672	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT654671	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT636306	hsa-miR-651-3p	HITS-CLIP	23824327
MIRT636305	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT137935	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT654670	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT654669	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT636303	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT636302	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT654668	hsa-miR-488-3p	HITS-CLIP	23824327
MIRT636306	hsa-miR-651-3p	HITS-CLIP	23824327
MIRT636305	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT636304	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT137935	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT636303	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT636302	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT630293	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT630292	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT630291	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT630290	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT630289	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT630288	hsa-miR-3666	HITS-CLIP	23824327
MIRT630287	hsa-miR-4295	HITS-CLIP	23824327
MIRT630286	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT630285	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT630284	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT630283	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT630282	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT630281	hsa-miR-767-5p	HITS-CLIP	23824327
MIRT630280	hsa-miR-3135b	HITS-CLIP	23824327
MIRT630279	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT630278	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT630277	hsa-miR-593-5p	HITS-CLIP	23824327
MIRT630276	hsa-miR-3652	HITS-CLIP	23824327
MIRT630275	hsa-miR-4430	HITS-CLIP	23824327
MIRT630274	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT021543	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT021543	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT726853	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT726854	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT726852	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT726851	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT654676	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT654675	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT654674	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT654673	hsa-miR-4287	HITS-CLIP	23824327
MIRT654672	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT666802	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT654697	hsa-miR-1470	HITS-CLIP	23824327
MIRT654696	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT654694	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT654695	hsa-miR-5193	HITS-CLIP	23824327
MIRT654693	hsa-miR-3183	HITS-CLIP	23824327
MIRT654692	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT654691	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT654690	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT654689	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT654688	hsa-miR-1248	HITS-CLIP	23824327
MIRT654687	hsa-miR-4469	HITS-CLIP	23824327
MIRT654686	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT654685	hsa-miR-3605-3p	HITS-CLIP	23824327
MIRT654684	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT654683	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT654682	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT654681	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT654680	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT654679	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT654678	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT654677	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT654676	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT654675	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT654674	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT654673	hsa-miR-4287	HITS-CLIP	23824327
MIRT654672	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT654671	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT636306	hsa-miR-651-3p	HITS-CLIP	23824327
MIRT636305	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT137935	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT654670	hsa-miR-124-3p	HITS-CLIP	23824327
MIRT654669	hsa-miR-506-3p	HITS-CLIP	23824327
MIRT636303	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT636302	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT654668	hsa-miR-488-3p	HITS-CLIP	23824327
MIRT636306	hsa-miR-651-3p	HITS-CLIP	23824327
MIRT636305	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT636304	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT137935	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT636303	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT636302	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT630293	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT630292	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT630291	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT630290	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT630289	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT630288	hsa-miR-3666	HITS-CLIP	23824327
MIRT630287	hsa-miR-4295	HITS-CLIP	23824327
MIRT630286	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT630285	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT630284	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT630283	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT630282	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT630281	hsa-miR-767-5p	HITS-CLIP	23824327
MIRT630280	hsa-miR-3135b	HITS-CLIP	23824327
MIRT630279	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT630278	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT630277	hsa-miR-593-5p	HITS-CLIP	23824327
MIRT630276	hsa-miR-3652	HITS-CLIP	23824327
MIRT630275	hsa-miR-4430	HITS-CLIP	23824327
MIRT630274	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT1270254	hsa-miR-103a	CLIP-seq
MIRT1270255	hsa-miR-107	CLIP-seq
MIRT1270256	hsa-miR-1184	CLIP-seq
MIRT1270257	hsa-miR-1205	CLIP-seq
MIRT1270258	hsa-miR-1265	CLIP-seq
MIRT1270259	hsa-miR-2392	CLIP-seq
MIRT1270260	hsa-miR-3121-3p	CLIP-seq
MIRT1270261	hsa-miR-3143	CLIP-seq
MIRT1270262	hsa-miR-3158-5p	CLIP-seq
MIRT1270263	hsa-miR-324-5p	CLIP-seq
MIRT1270264	hsa-miR-3605-5p	CLIP-seq
MIRT1270265	hsa-miR-4436b-5p	CLIP-seq
MIRT1270266	hsa-miR-4490	CLIP-seq
MIRT1270267	hsa-miR-4493	CLIP-seq
MIRT1270268	hsa-miR-4534	CLIP-seq
MIRT1270269	hsa-miR-4660	CLIP-seq
MIRT1270270	hsa-miR-4666-3p	CLIP-seq
MIRT1270271	hsa-miR-4731-3p	CLIP-seq
MIRT1270272	hsa-miR-4801	CLIP-seq
MIRT1270273	hsa-miR-4802-5p	CLIP-seq
MIRT1270274	hsa-miR-548a-5p	CLIP-seq
MIRT1270275	hsa-miR-548ab	CLIP-seq
MIRT1270276	hsa-miR-548ak	CLIP-seq
MIRT1270277	hsa-miR-548b-5p	CLIP-seq
MIRT1270278	hsa-miR-548c-5p	CLIP-seq
MIRT1270279	hsa-miR-548d-5p	CLIP-seq
MIRT1270280	hsa-miR-548h	CLIP-seq
MIRT1270281	hsa-miR-548i	CLIP-seq
MIRT1270282	hsa-miR-548j	CLIP-seq
MIRT1270283	hsa-miR-548w	CLIP-seq
MIRT1270284	hsa-miR-548y	CLIP-seq
MIRT1270285	hsa-miR-559	CLIP-seq
MIRT1270286	hsa-miR-646	CLIP-seq
MIRT1270287	hsa-miR-765	CLIP-seq
MIRT1270258	hsa-miR-1265	CLIP-seq
MIRT1270259	hsa-miR-2392	CLIP-seq
MIRT1270260	hsa-miR-3121-3p	CLIP-seq
MIRT1270265	hsa-miR-4436b-5p	CLIP-seq
MIRT1270267	hsa-miR-4493	CLIP-seq
MIRT1270270	hsa-miR-4666-3p	CLIP-seq
MIRT2079441	hsa-miR-1208	CLIP-seq
MIRT1270258	hsa-miR-1265	CLIP-seq
MIRT1270259	hsa-miR-2392	CLIP-seq
MIRT1270260	hsa-miR-3121-3p	CLIP-seq
MIRT1270263	hsa-miR-324-5p	CLIP-seq
MIRT1270264	hsa-miR-3605-5p	CLIP-seq
MIRT2079442	hsa-miR-3657	CLIP-seq
MIRT1270265	hsa-miR-4436b-5p	CLIP-seq
MIRT1270268	hsa-miR-4534	CLIP-seq
MIRT2079443	hsa-miR-4645-3p	CLIP-seq
MIRT2079444	hsa-miR-4669	CLIP-seq
MIRT2079445	hsa-miR-4704-3p	CLIP-seq
MIRT1270271	hsa-miR-4731-3p	CLIP-seq
MIRT1270272	hsa-miR-4801	CLIP-seq
MIRT1270273	hsa-miR-4802-5p	CLIP-seq
MIRT2079446	hsa-miR-556-3p	CLIP-seq
MIRT1270286	hsa-miR-646	CLIP-seq
MIRT1270287	hsa-miR-765	CLIP-seq
MIRT2079447	hsa-miR-892a	CLIP-seq
MIRT1270254	hsa-miR-103a	CLIP-seq
MIRT1270255	hsa-miR-107	CLIP-seq
MIRT1270256	hsa-miR-1184	CLIP-seq
MIRT1270257	hsa-miR-1205	CLIP-seq
MIRT2079441	hsa-miR-1208	CLIP-seq
MIRT1270258	hsa-miR-1265	CLIP-seq
MIRT1270259	hsa-miR-2392	CLIP-seq
MIRT1270260	hsa-miR-3121-3p	CLIP-seq
MIRT1270261	hsa-miR-3143	CLIP-seq
MIRT1270262	hsa-miR-3158-5p	CLIP-seq
MIRT1270263	hsa-miR-324-5p	CLIP-seq
MIRT1270264	hsa-miR-3605-5p	CLIP-seq
MIRT2079442	hsa-miR-3657	CLIP-seq
MIRT2305737	hsa-miR-376c	CLIP-seq
MIRT1270265	hsa-miR-4436b-5p	CLIP-seq
MIRT1270266	hsa-miR-4490	CLIP-seq
MIRT1270267	hsa-miR-4493	CLIP-seq
MIRT1270268	hsa-miR-4534	CLIP-seq
MIRT2079443	hsa-miR-4645-3p	CLIP-seq
MIRT1270269	hsa-miR-4660	CLIP-seq
MIRT1270270	hsa-miR-4666-3p	CLIP-seq
MIRT2079444	hsa-miR-4669	CLIP-seq
MIRT2079445	hsa-miR-4704-3p	CLIP-seq
MIRT1270271	hsa-miR-4731-3p	CLIP-seq
MIRT2305738	hsa-miR-4789-3p	CLIP-seq
MIRT1270272	hsa-miR-4801	CLIP-seq
MIRT1270273	hsa-miR-4802-5p	CLIP-seq
MIRT1270274	hsa-miR-548a-5p	CLIP-seq
MIRT1270275	hsa-miR-548ab	CLIP-seq
MIRT1270276	hsa-miR-548ak	CLIP-seq
MIRT1270277	hsa-miR-548b-5p	CLIP-seq
MIRT1270278	hsa-miR-548c-5p	CLIP-seq
MIRT1270279	hsa-miR-548d-5p	CLIP-seq
MIRT1270280	hsa-miR-548h	CLIP-seq
MIRT1270281	hsa-miR-548i	CLIP-seq
MIRT1270282	hsa-miR-548j	CLIP-seq
MIRT1270283	hsa-miR-548w	CLIP-seq
MIRT1270284	hsa-miR-548y	CLIP-seq
MIRT2079446	hsa-miR-556-3p	CLIP-seq
MIRT1270285	hsa-miR-559	CLIP-seq
MIRT1270286	hsa-miR-646	CLIP-seq
MIRT1270287	hsa-miR-765	CLIP-seq
MIRT2079447	hsa-miR-892a	CLIP-seq
MIRT2079441	hsa-miR-1208	CLIP-seq
MIRT1270258	hsa-miR-1265	CLIP-seq
MIRT1270259	hsa-miR-2392	CLIP-seq
MIRT1270260	hsa-miR-3121-3p	CLIP-seq
MIRT1270263	hsa-miR-324-5p	CLIP-seq
MIRT1270264	hsa-miR-3605-5p	CLIP-seq
MIRT2079442	hsa-miR-3657	CLIP-seq
MIRT1270265	hsa-miR-4436b-5p	CLIP-seq
MIRT1270267	hsa-miR-4493	CLIP-seq
MIRT1270268	hsa-miR-4534	CLIP-seq
MIRT2079443	hsa-miR-4645-3p	CLIP-seq
MIRT1270270	hsa-miR-4666-3p	CLIP-seq
MIRT2079444	hsa-miR-4669	CLIP-seq
MIRT2079445	hsa-miR-4704-3p	CLIP-seq
MIRT1270271	hsa-miR-4731-3p	CLIP-seq
MIRT1270272	hsa-miR-4801	CLIP-seq
MIRT1270273	hsa-miR-4802-5p	CLIP-seq
MIRT2079446	hsa-miR-556-3p	CLIP-seq
MIRT1270286	hsa-miR-646	CLIP-seq
MIRT1270287	hsa-miR-765	CLIP-seq
MIRT2079447	hsa-miR-892a	CLIP-seq
MIRT2079441	hsa-miR-1208	CLIP-seq
MIRT1270258	hsa-miR-1265	CLIP-seq
MIRT1270259	hsa-miR-2392	CLIP-seq
MIRT1270260	hsa-miR-3121-3p	CLIP-seq
MIRT1270263	hsa-miR-324-5p	CLIP-seq
MIRT1270264	hsa-miR-3605-5p	CLIP-seq
MIRT2079442	hsa-miR-3657	CLIP-seq
MIRT1270265	hsa-miR-4436b-5p	CLIP-seq
MIRT1270267	hsa-miR-4493	CLIP-seq
MIRT1270268	hsa-miR-4534	CLIP-seq
MIRT2079443	hsa-miR-4645-3p	CLIP-seq
MIRT1270270	hsa-miR-4666-3p	CLIP-seq
MIRT2079444	hsa-miR-4669	CLIP-seq
MIRT2079445	hsa-miR-4704-3p	CLIP-seq
MIRT1270271	hsa-miR-4731-3p	CLIP-seq
MIRT1270272	hsa-miR-4801	CLIP-seq
MIRT1270273	hsa-miR-4802-5p	CLIP-seq
MIRT2079446	hsa-miR-556-3p	CLIP-seq
MIRT1270286	hsa-miR-646	CLIP-seq
MIRT1270287	hsa-miR-765	CLIP-seq
MIRT2079447	hsa-miR-892a	CLIP-seq

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Transcription factor	Regulation	Reference
STAT3	Activation	24627483

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000502	Component	Proteasome complex	IDA	17323924
GO:0000502	Component	Proteasome complex	IEA
GO:0000502	Component	Proteasome complex	NAS	29636472
GO:0000502	Component	Proteasome complex	TAS	8811196
GO:0004175	Function	Endopeptidase activity	IBA
GO:0004175	Function	Endopeptidase activity	TAS
GO:0004298	Function	Threonine-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	14733938, 15231747, 17948026, 20723761, 28514442, 31473102, 32296183, 33961781, 35271311, 35858375
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	34711951
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	34711951
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005839	Component	Proteasome core complex	IDA	34711951
GO:0005839	Component	Proteasome core complex	IEA
GO:0005839	Component	Proteasome core complex	ISS
GO:0006508	Process	Proteolysis	IDA	17540904
GO:0006508	Process	Proteolysis	IEA
GO:0006979	Process	Response to oxidative stress	IEA
GO:0008233	Function	Peptidase activity	IDA	17540904
GO:0008233	Function	Peptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019774	Component	Proteasome core complex, beta-subunit complex	IBA
GO:0019774	Component	Proteasome core complex, beta-subunit complex	ISS
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	NAS	19489727
GO:0043248	Process	Proteasome assembly	TAS
GO:0051603	Process	Proteolysis involved in protein catabolic process	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867

MIM	HGNC	e!Ensembl
600306	9542	ENSG00000100804

P28074

Protein name

Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X) (Proteasome subunit beta-5) (beta-5

Protein function

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with

PDB

4R3O , 4R67 , 5A0Q , 5GJQ , 5GJR , 5L4G , 5L5W , 5L5X , 5L5Y , 5L5Z , 5L60 , 5L61 , 5L62 , 5L63 , 5L64 , 5LE5 , 5LEX , 5LEY , 5LEZ , 5LF0 , 5LF1 , 5LF3 , 5LF4 , 5LF6 , 5LF7 , 5LN3 , 5M32 , 5T0C , 5T0G , 5T0H , 5T0I , 5T0J , 5VFO , 5VFP , 5VFQ , 5VFR , 5VFS , 5VFT , 5VFU , 6KWY , 6MSB , 6MSD , 6MSE , 6MSG , 6MSH , 6MSJ , 6MSK , 6R70 , 6REY , 6RGQ , 6WJD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00227	Proteasome	56 → 238	Proteasome subunit	Domain

Sequence

MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP

Sequence length

263

Interactions

View interactions

	KEGG		Reactome
	Proteasome Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants that don't undergo autocatalytic processing are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MYOCARDIAL ISCHEMIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Arthritis	Associate	24875235	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Juvenile	Associate	24875235	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	36062301	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Non Small Cell Lung	Associate	37864031	★★★★★ ★☆☆☆☆ Found in Text Mining only
Disease	Associate	38132120	★★★★★ ★☆☆☆☆ Found in Text Mining only
Down Syndrome	Associate	28143565	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	36049539	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Associate	24418325, 27542283	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Cutaneous	Associate	36049539	★★★★★ ★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Associate	36273157	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Stimulate	30954557	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Associate	35246527, 36399828	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	24737138, 36062301, 36273157	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pterygium	Inhibit	30563490	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Stimulate	28623645	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Associate	36562811	★★★★★ ★☆☆☆☆ Found in Text Mining only

PSMB5 (proteasome 20S subunit beta 5)