Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	56890
Gene name	Mdm1 nuclear protein
Gene symbol	MDM1
Synonyms (NCBI Gene)	-
Chromosome	12
Chromosome location	12q15
Summary	This gene encodes a microtubule-binding nuclear protein that localizes to the centrioles of dividing cells and differentiating multiciliated cells and negatively regulates centriole duplication. The encoded protein is closely associated with the centriole

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029287	hsa-miR-26b-5p	Microarray	19088304
MIRT1138670	hsa-miR-1305	CLIP-seq
MIRT1138671	hsa-miR-3163	CLIP-seq
MIRT1138672	hsa-miR-3617	CLIP-seq
MIRT1138673	hsa-miR-421	CLIP-seq
MIRT1138674	hsa-miR-4282	CLIP-seq
MIRT1138675	hsa-miR-4668-3p	CLIP-seq
MIRT1138676	hsa-miR-4803	CLIP-seq
MIRT1138677	hsa-miR-513a-3p	CLIP-seq
MIRT1138678	hsa-miR-548c-3p	CLIP-seq
MIRT1138679	hsa-miR-641	CLIP-seq
MIRT1138680	hsa-miR-888	CLIP-seq
MIRT1138681	hsa-miR-142-5p	CLIP-seq
MIRT1138682	hsa-miR-3074-3p	CLIP-seq
MIRT1138683	hsa-miR-340	CLIP-seq
MIRT1138684	hsa-miR-4762-5p	CLIP-seq
MIRT1138685	hsa-miR-1197	CLIP-seq
MIRT1138686	hsa-miR-1265	CLIP-seq
MIRT1138687	hsa-miR-144	CLIP-seq
MIRT1138688	hsa-miR-2392	CLIP-seq
MIRT1138689	hsa-miR-3135	CLIP-seq
MIRT1138690	hsa-miR-369-3p	CLIP-seq
MIRT1138691	hsa-miR-374a	CLIP-seq
MIRT1138692	hsa-miR-374b	CLIP-seq
MIRT1138693	hsa-miR-4645-3p	CLIP-seq
MIRT1138694	hsa-miR-4766-3p	CLIP-seq
MIRT1138695	hsa-miR-548p	CLIP-seq
MIRT2039338	hsa-miR-545	CLIP-seq
MIRT2269423	hsa-miR-3074-5p	CLIP-seq
MIRT2465622	hsa-miR-4659a-3p	CLIP-seq
MIRT2465623	hsa-miR-4659b-3p	CLIP-seq
MIRT2465624	hsa-miR-515-5p	CLIP-seq
MIRT2465625	hsa-miR-548v	CLIP-seq
MIRT2465626	hsa-miR-942	CLIP-seq
MIRT2568596	hsa-miR-1207-3p	CLIP-seq
MIRT1138670	hsa-miR-1305	CLIP-seq
MIRT2568597	hsa-miR-138	CLIP-seq
MIRT2568598	hsa-miR-186	CLIP-seq
MIRT2568599	hsa-miR-3121-3p	CLIP-seq
MIRT2568600	hsa-miR-3149	CLIP-seq
MIRT2568601	hsa-miR-3185	CLIP-seq
MIRT2568602	hsa-miR-3192	CLIP-seq
MIRT2568603	hsa-miR-326	CLIP-seq
MIRT2568604	hsa-miR-330-5p	CLIP-seq
MIRT2568605	hsa-miR-3607-5p	CLIP-seq
MIRT2568606	hsa-miR-3611	CLIP-seq
MIRT2568607	hsa-miR-3613-3p	CLIP-seq
MIRT2568608	hsa-miR-3664-5p	CLIP-seq
MIRT2568609	hsa-miR-3941	CLIP-seq
MIRT2568610	hsa-miR-3973	CLIP-seq
MIRT2568611	hsa-miR-4291	CLIP-seq
MIRT2568612	hsa-miR-4314	CLIP-seq
MIRT2568613	hsa-miR-4495	CLIP-seq
MIRT2568614	hsa-miR-4646-5p	CLIP-seq
MIRT2568615	hsa-miR-466	CLIP-seq
MIRT2568616	hsa-miR-4666-5p	CLIP-seq
MIRT2568617	hsa-miR-4672	CLIP-seq
MIRT2568618	hsa-miR-4694-5p	CLIP-seq
MIRT2568619	hsa-miR-4714-5p	CLIP-seq
MIRT2568620	hsa-miR-4719	CLIP-seq
MIRT2568621	hsa-miR-4731-3p	CLIP-seq
MIRT2568622	hsa-miR-4801	CLIP-seq
MIRT1138677	hsa-miR-513a-3p	CLIP-seq
MIRT2568623	hsa-miR-520g	CLIP-seq
MIRT2568624	hsa-miR-520h	CLIP-seq
MIRT2039338	hsa-miR-545	CLIP-seq
MIRT2568625	hsa-miR-548k	CLIP-seq
MIRT2568626	hsa-miR-548n	CLIP-seq
MIRT2568627	hsa-miR-548t	CLIP-seq
MIRT2568628	hsa-miR-568	CLIP-seq
MIRT2568629	hsa-miR-576-3p	CLIP-seq
MIRT2568630	hsa-miR-607	CLIP-seq
MIRT1138680	hsa-miR-888	CLIP-seq
MIRT2568598	hsa-miR-186	CLIP-seq
MIRT2568599	hsa-miR-3121-3p	CLIP-seq
MIRT2568601	hsa-miR-3185	CLIP-seq
MIRT2568602	hsa-miR-3192	CLIP-seq
MIRT2568603	hsa-miR-326	CLIP-seq
MIRT2568604	hsa-miR-330-5p	CLIP-seq
MIRT2568605	hsa-miR-3607-5p	CLIP-seq
MIRT2568606	hsa-miR-3611	CLIP-seq
MIRT2568607	hsa-miR-3613-3p	CLIP-seq
MIRT2568608	hsa-miR-3664-5p	CLIP-seq
MIRT2568609	hsa-miR-3941	CLIP-seq
MIRT2568611	hsa-miR-4291	CLIP-seq
MIRT2568612	hsa-miR-4314	CLIP-seq
MIRT2568613	hsa-miR-4495	CLIP-seq
MIRT2568614	hsa-miR-4646-5p	CLIP-seq
MIRT2568615	hsa-miR-466	CLIP-seq
MIRT2568616	hsa-miR-4666-5p	CLIP-seq
MIRT2568617	hsa-miR-4672	CLIP-seq
MIRT2568619	hsa-miR-4714-5p	CLIP-seq
MIRT2568620	hsa-miR-4719	CLIP-seq
MIRT2568621	hsa-miR-4731-3p	CLIP-seq
MIRT2568622	hsa-miR-4801	CLIP-seq
MIRT2039338	hsa-miR-545	CLIP-seq
MIRT2568629	hsa-miR-576-3p	CLIP-seq
MIRT1138680	hsa-miR-888	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	26337392
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	26337392
GO:0005813	Component	Centrosome	IEA
GO:0005814	Component	Centriole	IDA	26337392
GO:0005814	Component	Centriole	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0008017	Function	Microtubule binding	IEA
GO:0008017	Function	Microtubule binding	IMP	26337392
GO:0034451	Component	Centriolar satellite	IDA
GO:0046600	Process	Negative regulation of centriole replication	IEA
GO:0046600	Process	Negative regulation of centriole replication	IMP	26337392
GO:0060041	Process	Retina development in camera-type eye	IBA

MIM	HGNC	e!Ensembl
613813	29917	ENSG00000111554

Q8TC05

Protein name

Nuclear protein MDM1

Protein function

Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15501	MDM1	9 → 548	Nuclear protein MDM1	Family

Sequence

MPVRFKGLSEYQRNFLWKKSYLSESCNSSVGRKYPWAGLRSDQLGITKEPSFISKRRVPY
HDPQISKSLEWNGAISESNVVASPEPEAPETPKSQEAEQKDVTQERVHSLEASRVPKRTR
SHSADSRAEGASDVENNEGVTNHTPVNENVELEHSTKVLSENVDNGLDRLLRKKAGLTVV
PSYNALRNSEYQRQFVWKTSKETAPAFAANQVFHNKSQFVPPFKGNSVIHETEYKRNFKG
LSPVKEPKLRNDLRENRNLETVSPERKSNKIDDRLKLEAEMELKDLHQPKRKLTPWKHQR
LGKVNSEYRAKFLSPAQYLYKAGAWTHVKGNMPNQVKELREKAEFYRKRVQGTHFSRDHL
NQILSDSNCCWDVSSTTSSEGTVSSNIRALDLAGDPTSHKTLQKCPSTEPEEKGNIVEEQ
PQKNTTEKLGVSAPTIPVRRRLAWDTENTSEDVQKQPGEKEEEDDNEEEGDRKTGKQAFM
GEQEKLDVREKSKADKMKEGSDSSVSSEKGGRLPTPKLRELGGIQRTHHDLTTPAVGGAV
LVSPSKMKPPAPEQRKRMTSQDCLETSKNDFTKKESRAVSLLTSPAAGIKTVDPLPLRED
SEDNIHKFAEATLPVSKIPKYPTNPPGQLPSPPHVPSYWHPSRRIQGSLRDPEFQHNVGK
ARMNNLQLPQHEAFNDEDEDRLSEISARSAASSLRAFQTLARAKKRKENFWGKT

Sequence length

714

Interactions

View interactions

MDM1 (Mdm1 nuclear protein)