PSG7 (pregnancy specific beta-1-glycoprotein 7)

Gene

• Entrez ID: 5676
• Gene name: Pregnancy specific beta-1-glycoprotein 7
• Gene symbol: PSG7
• Synonyms (NCBI Gene): PS-beta-G-7, PSBG-7, PSG1, PSGGA
• Chromosome: 19
• Chromosome location: 19q13.31
• Summary: This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another c

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1269739	hsa-miR-24	CLIP-seq
MIRT1269740	hsa-miR-4269	CLIP-seq
MIRT1269741	hsa-miR-4284	CLIP-seq
MIRT1269742	hsa-miR-4303	CLIP-seq
MIRT1269743	hsa-miR-4468	CLIP-seq
MIRT1269744	hsa-miR-4481	CLIP-seq
MIRT1269745	hsa-miR-4682	CLIP-seq
MIRT1269746	hsa-miR-4710	CLIP-seq
MIRT1269747	hsa-miR-4745-5p	CLIP-seq
MIRT1269748	hsa-miR-4758-5p	CLIP-seq
MIRT1269749	hsa-miR-4792	CLIP-seq
MIRT1269750	hsa-miR-502-5p	CLIP-seq
MIRT1269751	hsa-miR-582-5p	CLIP-seq
MIRT1269752	hsa-miR-646	CLIP-seq
MIRT2079273	hsa-miR-1253	CLIP-seq
MIRT2079274	hsa-miR-1267	CLIP-seq
MIRT2079275	hsa-miR-3117-5p	CLIP-seq
MIRT2079276	hsa-miR-3200-5p	CLIP-seq
MIRT2079277	hsa-miR-3660	CLIP-seq
MIRT2079278	hsa-miR-3664-5p	CLIP-seq
MIRT2079279	hsa-miR-4426	CLIP-seq
MIRT2079280	hsa-miR-4434	CLIP-seq
MIRT2079281	hsa-miR-4516	CLIP-seq
MIRT2079282	hsa-miR-4526	CLIP-seq
MIRT2079283	hsa-miR-4647	CLIP-seq
MIRT2079284	hsa-miR-4662b	CLIP-seq
MIRT2305622	hsa-miR-1200	CLIP-seq
MIRT2305623	hsa-miR-1238	CLIP-seq
MIRT2305624	hsa-miR-1273f	CLIP-seq
MIRT2305625	hsa-miR-143	CLIP-seq
MIRT2305626	hsa-miR-1827	CLIP-seq
MIRT1269740	hsa-miR-4269	CLIP-seq
MIRT2305627	hsa-miR-4324	CLIP-seq
MIRT2305628	hsa-miR-4691-5p	CLIP-seq
MIRT2305629	hsa-miR-4708-5p	CLIP-seq
MIRT2305630	hsa-miR-4770	CLIP-seq
MIRT2305631	hsa-miR-544b	CLIP-seq
MIRT2305632	hsa-miR-583	CLIP-seq
MIRT2305633	hsa-miR-940	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
FOXF2	Repression	19562724

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	IEA
GO:0007565	Process	Female pregnancy	TAS	1690992

Other IDs

• MIM: 176396
• HGNC: 9524
• e!Ensembl: ENSG00000221878

Protein

• UniProt ID: Q13046
• Protein name: Pregnancy-specific beta-1-glycoprotein 7 (PS-beta-G-7) (PSBG-7) (Pregnancy-specific glycoprotein 7)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	38 → 141	Immunoglobulin V-set domain	Domain
  PF13927	Ig_3	148 → 221		Domain
  PF13895	Ig_2	239 → 328	Immunoglobulin domain	Domain
  PF13895	Ig_2	334 → 413	Immunoglobulin domain	Domain

• Sequence:

  MGPLSAPPCTQHITWKGLLLTASLLNFWNPPTTAQVTIEAQPPKVSEGKDVLLLVHNLPQ
  NLTGYIWYKGQIRDLYHYVTSYIVDGQIIKYGPAYSGRETVYSNASLLIQNVTQEDTGSY
  TLHIIKRGDGTGGVTGRFTFTLYLETPKPSISSSNFNPREATEAVILTCDPETPDASYLW
  WMNGQSLPMTHSLQLSETNRTLYLFGVTNYTAGPYECEIRNPVSASRSDPVTLNLLPKLP
  KPYITINNLNPRENKDVSTFTCEPKSENYTYIWWLNGQSLPVSPRVKRRIENRILILPSV
  TRNETGPYQCEIRDRYGGIRSDPVTLNVLYGPDLPRIYPSFTYYHSGQNLYLSCFADSNP
  PAQYSWTINGKFQLSGQKLSIPQITTKHSGLYACSVRNSATGKESSKSVTVRVSDWTLP

• Sequence length: 419

Pathways

Reactome:

Cell surface interactions at the vascular wall

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTISM SPECTRUM DISORDER	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Pre Eclampsia	Stimulate	35322669	★☆☆☆☆ Found in Text Mining only
Preeclamptic toxemia	Stimulate	35322669	★☆☆☆☆ Found in Text Mining only