PSG5 (pregnancy specific beta-1-glycoprotein 5)

Gene

• Entrez ID: 5673
• Gene name: Pregnancy specific beta-1-glycoprotein 5
• Gene symbol: PSG5
• Synonyms (NCBI Gene): FL-NCA-3, PSG
• Chromosome: 19
• Chromosome location: 19q13.31
• Summary: The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunog

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1269731	hsa-miR-4314	CLIP-seq
MIRT1269732	hsa-miR-4667-5p	CLIP-seq
MIRT1269733	hsa-miR-4700-5p	CLIP-seq
MIRT1269734	hsa-miR-637	CLIP-seq
MIRT2305616	hsa-miR-335	CLIP-seq
MIRT2305617	hsa-miR-361-5p	CLIP-seq
MIRT2305618	hsa-miR-4272	CLIP-seq
MIRT2305619	hsa-miR-630	CLIP-seq
MIRT2305620	hsa-miR-643	CLIP-seq
MIRT2305621	hsa-miR-873	CLIP-seq
MIRT2305616	hsa-miR-335	CLIP-seq
MIRT2305617	hsa-miR-361-5p	CLIP-seq
MIRT2305618	hsa-miR-4272	CLIP-seq
MIRT2305619	hsa-miR-630	CLIP-seq
MIRT2305620	hsa-miR-643	CLIP-seq
MIRT2305621	hsa-miR-873	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
KLF6	Activation	21799854;23418492
KLF6	Unknown	9083102

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21982860
GO:0005576	Component	Extracellular region	IEA
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA
GO:0007565	Process	Female pregnancy	TAS	1690992
GO:0009986	Component	Cell surface	IBA

Other IDs

• MIM: 176394
• HGNC: 9522
• e!Ensembl: ENSG00000204941

Protein

• UniProt ID: Q15238
• Protein name: Pregnancy-specific beta-1-glycoprotein 5 (PS-beta-G-5) (PSBG-5) (Pregnancy-specific glycoprotein 5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	39 → 139	Immunoglobulin V-set domain	Domain
  PF13895	Ig_2	148 → 235	Immunoglobulin domain	Domain
  PF13895	Ig_2	241 → 320	Immunoglobulin domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Synthesized by syncytiotrophoblast of the placenta.
• Sequence:

  MGPLSAPPCTQHITWKGLLLTASLLNFWNLPITAQVTIEALPPKVSEGKDVLLLVHNLPQ
  NLAGYIWYKGQLMDLYHYITSYVVDGQINIYGPAYTGRETVYSNASLLIQNVTREDAGSY
  TLHIIKRGDRTRGVTGYFTFNLYLKLPKPYITINNSKPRENKDVLAFTCEPKSENYTYIW
  WLNGQSLPVSPRVKRPIENRILILPSVTRNETGPYECEIRDRDGGMRSDPVTLNVLYGPD
  LPSIYPSFTYYRSGENLYLSCFAESNPPAEYFWTINGKFQQSGQKLSIPQITTKHRGLYT
  CSVRNSATGKESSKSMTVEVSAPSGIGRLPLLNPI

• Sequence length: 335

Pathways

Reactome:

Cell surface interactions at the vascular wall