RETN (resistin)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 56729
Gene name Resistin
Gene symbol RETN
Synonyms (NCBI Gene)
ADSFFIZZ3RENTRETN1RSTNXCP1
Chromosome 19
Chromosome location 19p13.2
Summary This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may b
miRNA miRNA information provided by mirtarbase database.
8
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (8)
miRTarBase ID miRNA Experiments Reference
MIRT1301086 hsa-miR-3925-3p CLIP-seq
MIRT1301087 hsa-miR-766 CLIP-seq
MIRT1301086 hsa-miR-3925-3p CLIP-seq
MIRT1301087 hsa-miR-766 CLIP-seq
MIRT1301086 hsa-miR-3925-3p CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (4)
Transcription factor Regulation Reference
ATF2 Activation 20360975
PPARG Activation 20360975
PPARG Unknown 12504108
SP1 Activation 20360975
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (16)
GO ID Ontology Definition Evidence Reference
GO:0005179 Function Hormone activity IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
605565 20389 ENSG00000104918
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9HD89
Protein name Resistin (Adipose tissue-specific secretory factor) (ADSF) (C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein) (Cysteine-rich secreted protein A12-alpha-like 2) (Cysteine-rich secreted protein FIZZ3)
Protein function Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis in myeloid cells (PubMed:15064728). {ECO:0000250|UniProtKB:
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06954 Resistin 20 → 106 Resistin Family
Tissue specificity TISSUE SPECIFICITY: Expressed in white adipose tissue (at protein level) (PubMed:11201732). Widely expressed, with particularly strong expression in lung, bone marrow, breast and peripheral blood (PubMed:15248836). Expressed strongly in bone marrow and at
Sequence
Sequence length 108
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Neutrophil degranulation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Diabetes mellitus type 2, susceptibility to risk factor rs3745368 RCV000005160
HYPERTENSION, INSULIN RESISTANCE-RELATED, SUSCEPTIBILITY TO risk factor rs3745368 RCV000005161
RETN-related disorder Likely benign rs143039347 RCV003971796
Show/Hide Text Mining Associations (177)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Habitual Stimulate 25935494
Acute Coronary Syndrome Stimulate 18654008, 20061546, 26110037
Adenocarcinoma of Lung Associate 29927028, 37532692
Alzheimer Disease Associate 38527854
Anorexia Nervosa Associate 17705672, 34292570
Anorexia Nervosa Inhibit 34292570
Aortic Aneurysm Abdominal Associate 37897936
Arthritis Associate 19770005
Arthritis Psoriatic Stimulate 25196858
Arthritis Rheumatoid Associate 17040961, 29561430, 29978502