RETN (resistin)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
56729
Gene name Gene Name - the full gene name approved by the HGNC.
Resistin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RETN
Synonyms (NCBI Gene) Gene synonyms aliases
ADSF, FIZZ3, RENT, RETN1, RSTN, XCP1
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may b
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT1301086 hsa-miR-3925-3p CLIP-seq
MIRT1301087 hsa-miR-766 CLIP-seq
MIRT1301086 hsa-miR-3925-3p CLIP-seq
MIRT1301087 hsa-miR-766 CLIP-seq
MIRT1301086 hsa-miR-3925-3p CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
ATF2 Activation 20360975
PPARG Activation 20360975
PPARG Unknown 12504108
SP1 Activation 20360975
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0005179 Function Hormone activity IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA 21873635
GO:0005634 Component Nucleus IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
605565 20389 ENSG00000104918
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9HD89
Protein name Resistin (Adipose tissue-specific secretory factor) (ADSF) (C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein) (Cysteine-rich secreted protein A12-alpha-like 2) (Cysteine-rich secreted protein FIZZ3)
Protein function Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis in myeloid cells (PubMed:15064728). {ECO:0000250|UniProtKB:
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06954 Resistin 20 → 106 Resistin Family
Tissue specificity TISSUE SPECIFICITY: Expressed in white adipose tissue (at protein level) (PubMed:11201732). Widely expressed, with particularly strong expression in lung, bone marrow, breast and peripheral blood (PubMed:15248836). Expressed strongly in bone marrow and at
Sequence
Sequence length 108
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (4)
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
Kidney disease Chronic Kidney Diseases rs74315342, rs749740335, rs757649673, rs112417755, rs35138315 22421264
Metabolic syndrome Metabolic Syndrome X rs367643250, rs587777380, rs777736953 18328350
Renal insufficiency Chronic Kidney Insufficiency rs1596536873 22421264
Show/Hide Unknown Diseases (5)
Unknown
Disease term Disease name Evidence References Source
Congestive heart failure Congestive heart failure 26670611 ClinVar
Heart failure Heart failure, Left-Sided Heart Failure, Heart Failure, Right-Sided 26670611 ClinVar
Myocardial infarction Myocardial Failure 26670611 ClinVar
Diabetes Mellitus diabetes mellitus, noninsulin-dependent GenCC
Show/Hide Text Mining Associations (177)
Associations from Text Mining
Disease Name Relationship Type References
Abortion Habitual Stimulate 25935494
Acute Coronary Syndrome Stimulate 18654008, 20061546, 26110037
Adenocarcinoma of Lung Associate 29927028, 37532692
Alzheimer Disease Associate 38527854
Anorexia Nervosa Associate 17705672, 34292570
Anorexia Nervosa Inhibit 34292570
Aortic Aneurysm Abdominal Associate 37897936
Arthritis Associate 19770005
Arthritis Psoriatic Stimulate 25196858
Arthritis Rheumatoid Associate 17040961, 29561430, 29978502