Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
56624
Gene name Gene Name - the full gene name approved by the HGNC.
N-acylsphingosine amidohydrolase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ASAH2
Synonyms (NCBI Gene) Gene synonyms aliases
BCDase, HNAC1, LCDase, N-CDase, NCDase
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q11.23
Summary Summary of gene provided in NCBI Entrez Gene.
Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosp
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT607215 hsa-miR-329-3p HITS-CLIP 19536157
MIRT607214 hsa-miR-362-3p HITS-CLIP 19536157
MIRT607213 hsa-miR-8485 HITS-CLIP 19536157
MIRT607212 hsa-miR-6887-3p HITS-CLIP 19536157
MIRT607215 hsa-miR-329-3p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0005509 Function Calcium ion binding IDA 26190575
GO:0005576 Component Extracellular region IBA 21873635
GO:0005739 Component Mitochondrion IDA 10781606
GO:0005794 Component Golgi apparatus IDA 30154232
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
611202 18860 ENSG00000188611
Protein
UniProt ID Q9NR71
Protein name Neutral ceramidase (N-CDase) (NCDase) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 2) (BCDase) (LCDase) (hCD) (N-acylsphingosine amidohydrolase 2) (Non-lysosomal ceramidase) [Cleaved into: Neutral ceramidase soluble form]
Protein function Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:10781606, PubMed:16229686, PubMed:26190575). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphat
PDB 4WGK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04734 Ceramidase_alk 102 608 Neutral/alkaline non-lysosomal ceramidase, N-terminal Domain
PF17048 Ceramidse_alk_C 610 777 Neutral/alkaline non-lysosomal ceramidase, C-terminal Domain
Tissue specificity TISSUE SPECIFICITY: Primarily expressed in intestine (PubMed:17334805). Ubiquitously expressed with higher levels in kidney, skeletal muscle and heart (PubMed:10781606). The ubiquitous expression observed for ASAH2 might be an experimental artifact due to
Sequence
Sequence length 780
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Sphingolipid metabolism
Metabolic pathways
Sphingolipid signaling pathway
  Glycosphingolipid metabolism
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Celiac disease Celiac Disease 30097691 ClinVar
Schizophrenia Schizophrenia GWAS
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Squamous Cell Associate 32036209
Colorectal Neoplasms Associate 30154232
Dermatitis Atopic Associate 24586752
Ovarian Neoplasms Inhibit 39972314