Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5657
Gene name Gene Name - the full gene name approved by the HGNC.	Proteinase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PRTN3
Synonyms (NCBI Gene) Gene synonyms aliases	ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.3

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miRTarBase ID	miRNA	Experiments
MIRT1268885	hsa-miR-342-5p	CLIP-seq
MIRT1268886	hsa-miR-4461	CLIP-seq
MIRT1268887	hsa-miR-4651	CLIP-seq
MIRT1268888	hsa-miR-4664-5p	CLIP-seq
MIRT1268889	hsa-miR-608	CLIP-seq
MIRT2078995	hsa-miR-4449	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
SPI1	Unknown	10677505

Show/Hide all(42)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004252	Function	Serine-type endopeptidase activity	EXP	11389039
GO:0004252	Function	Serine-type endopeptidase activity	IBA
GO:0004252	Function	Serine-type endopeptidase activity	IDA	28240246
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0004252	Function	Serine-type endopeptidase activity	IMP	22266279, 23202369
GO:0005102	Function	Signaling receptor binding	IPI	17244676
GO:0005515	Function	Protein binding	IPI	16488976, 28240246, 30692621
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA
GO:0005829	Component	Cytosol	IDA	17712045
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	17244676, 18462208, 21193407, 22266279, 28240246
GO:0005886	Component	Plasma membrane	IDA	17712045
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IDA	28240246
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	IMP	22266279
GO:0006509	Process	Membrane protein ectodomain proteolysis	IMP	23202369
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	TAS	2679910
GO:0008284	Process	Positive regulation of cell population proliferation	TAS	2598267
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019730	Process	Antimicrobial humoral response	TAS
GO:0019899	Function	Enzyme binding	IPI	17712045
GO:0030574	Process	Collagen catabolic process	IEA
GO:0031012	Component	Extracellular matrix	HDA	20551380
GO:0035578	Component	Azurophil granule lumen	IDA	18462208
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0043547	Process	Positive regulation of GTPase activity	IMP	23202369
GO:0044853	Component	Plasma membrane raft	IDA	21193407
GO:0045121	Component	Membrane raft	IEA
GO:0045217	Process	Cell-cell junction maintenance	IMP	23202369
GO:0050765	Process	Negative regulation of phagocytosis	IDA	17712045
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0072672	Process	Neutrophil extravasation	IMP	22266279
GO:0097029	Process	Mature conventional dendritic cell differentiation	IDA	16478888

MIM	HGNC	e!Ensembl
177020	9495	ENSG00000196415

Protein

UniProt ID

P24158

Protein name

Myeloblastin (EC 3.4.21.76) (AGP7) (C-ANCA antigen) (Leukocyte proteinase 3) (PR-3) (PR3) (Neutrophil proteinase 4) (NP-4) (P29) (Wegener autoantigen)

Protein function

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:2033050, PubMed:28240246, PubMed:3198760). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell

PDB

1FUJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00089	Trypsin	28 → 243	Trypsin	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in polymorphonuclear leukocytes (at protein level) (PubMed:2033050, PubMed:3198760, PubMed:7897245). Expressed in neutrophils (at protein level) (PubMed:17244676, PubMed:18462208, PubMed:21193407, PubMed:22266279, PubMed:2824

Sequence

MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTL
IHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVL
LIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTF
FCRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYV
DWIRSTLRRVEAKGRP

Sequence length

256

Interactions

View interactions

	Reactome
			Common Pathway of Fibrin Clot Formation Other interleukin signaling Neutrophil degranulation Antimicrobial peptides

PRTN3 (proteinase 3)