KLK10 (kallikrein related peptidase 10)

Gene

• Entrez ID: 5655
• Gene name: Kallikrein related peptidase 10
• Gene symbol: KLK10
• Synonyms (NCBI Gene): NES1, PRSSL1
• Chromosome: 19
• Chromosome location: 19q13.41
• Summary: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000455	hsa-let-7f-5p	qRT-PCR, Luciferase reporter assay	20354523
MIRT000454	hsa-miR-224-5p	qRT-PCR, Luciferase reporter assay	20354523
MIRT000455	hsa-let-7f-5p	ELISA, Luciferase reporter assay, qRT-PCR	18627289
MIRT019672	hsa-miR-375	Microarray	20215506
MIRT569877	hsa-miR-2392	PAR-CLIP	20371350
MIRT569876	hsa-miR-4667-5p	PAR-CLIP	20371350
MIRT569874	hsa-miR-4700-5p	PAR-CLIP	20371350
MIRT569875	hsa-miR-8089	PAR-CLIP	20371350
MIRT569873	hsa-miR-3605-5p	PAR-CLIP	20371350
MIRT569872	hsa-miR-4534	PAR-CLIP	20371350
MIRT569871	hsa-miR-8082	PAR-CLIP	20371350
MIRT569870	hsa-miR-6077	PAR-CLIP	20371350
MIRT569869	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT569868	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT569867	hsa-miR-3175	PAR-CLIP	20371350
MIRT569866	hsa-miR-1343-5p	PAR-CLIP	20371350
MIRT569865	hsa-miR-939-5p	PAR-CLIP	20371350
MIRT569863	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT569864	hsa-miR-3150a-3p	PAR-CLIP	20371350
MIRT569862	hsa-miR-6763-5p	PAR-CLIP	20371350
MIRT569861	hsa-miR-6880-5p	PAR-CLIP	20371350
MIRT474394	hsa-miR-140-5p	PAR-CLIP	23592263
MIRT474393	hsa-miR-194-3p	PAR-CLIP	23592263
MIRT474392	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT474391	hsa-miR-4795-5p	PAR-CLIP	23592263
MIRT474390	hsa-miR-1253	PAR-CLIP	23592263
MIRT474389	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT474387	hsa-miR-143-3p	PAR-CLIP	23592263
MIRT474388	hsa-miR-4770	PAR-CLIP	23592263
MIRT474386	hsa-miR-6088	PAR-CLIP	23592263
MIRT474385	hsa-miR-4261	PAR-CLIP	23592263
MIRT474384	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT474383	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT474382	hsa-miR-8085	PAR-CLIP	23592263
MIRT474381	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT474380	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT474379	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT474378	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT474376	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT569877	hsa-miR-2392	PAR-CLIP	20371350
MIRT569876	hsa-miR-4667-5p	PAR-CLIP	20371350
MIRT569874	hsa-miR-4700-5p	PAR-CLIP	20371350
MIRT569875	hsa-miR-8089	PAR-CLIP	20371350
MIRT569873	hsa-miR-3605-5p	PAR-CLIP	20371350
MIRT569872	hsa-miR-4534	PAR-CLIP	20371350
MIRT569871	hsa-miR-8082	PAR-CLIP	20371350
MIRT569870	hsa-miR-6077	PAR-CLIP	20371350
MIRT569869	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT569868	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT569867	hsa-miR-3175	PAR-CLIP	20371350
MIRT569866	hsa-miR-1343-5p	PAR-CLIP	20371350
MIRT569865	hsa-miR-939-5p	PAR-CLIP	20371350
MIRT569863	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT569864	hsa-miR-3150a-3p	PAR-CLIP	20371350
MIRT569862	hsa-miR-6763-5p	PAR-CLIP	20371350
MIRT569861	hsa-miR-6880-5p	PAR-CLIP	20371350
MIRT474394	hsa-miR-140-5p	PAR-CLIP	23592263
MIRT474393	hsa-miR-194-3p	PAR-CLIP	23592263
MIRT474392	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT474391	hsa-miR-4795-5p	PAR-CLIP	23592263
MIRT474390	hsa-miR-1253	PAR-CLIP	23592263
MIRT474389	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT474387	hsa-miR-143-3p	PAR-CLIP	23592263
MIRT474388	hsa-miR-4770	PAR-CLIP	23592263
MIRT474386	hsa-miR-6088	PAR-CLIP	23592263
MIRT474385	hsa-miR-4261	PAR-CLIP	23592263
MIRT474384	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT474383	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT474382	hsa-miR-8085	PAR-CLIP	23592263
MIRT474381	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT474380	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT474379	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT474378	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT474376	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT1098964	hsa-miR-1254	CLIP-seq
MIRT1098965	hsa-miR-1262	CLIP-seq
MIRT1098966	hsa-miR-1293	CLIP-seq
MIRT1098967	hsa-miR-214	CLIP-seq
MIRT1098968	hsa-miR-216a	CLIP-seq
MIRT1098969	hsa-miR-3116	CLIP-seq
MIRT1098970	hsa-miR-3147	CLIP-seq
MIRT1098971	hsa-miR-3149	CLIP-seq
MIRT1098972	hsa-miR-342-3p	CLIP-seq
MIRT1098973	hsa-miR-3619-5p	CLIP-seq
MIRT1098974	hsa-miR-4291	CLIP-seq
MIRT1098975	hsa-miR-4425	CLIP-seq
MIRT1098976	hsa-miR-4483	CLIP-seq
MIRT1098977	hsa-miR-4694-5p	CLIP-seq
MIRT1098978	hsa-miR-4701-3p	CLIP-seq
MIRT1098979	hsa-miR-4715-3p	CLIP-seq
MIRT1098980	hsa-miR-4722-3p	CLIP-seq
MIRT1098981	hsa-miR-4722-5p	CLIP-seq
MIRT1098982	hsa-miR-4763-5p	CLIP-seq
MIRT1098983	hsa-miR-4782-5p	CLIP-seq
MIRT1098984	hsa-miR-4794	CLIP-seq
MIRT1098985	hsa-miR-582-3p	CLIP-seq
MIRT1098986	hsa-miR-661	CLIP-seq
MIRT1098987	hsa-miR-761	CLIP-seq
MIRT1098988	hsa-miR-922	CLIP-seq
MIRT1098989	hsa-miR-1245b-3p	CLIP-seq
MIRT1098990	hsa-miR-1273f	CLIP-seq
MIRT1098991	hsa-miR-127-5p	CLIP-seq
MIRT1098992	hsa-miR-197	CLIP-seq
MIRT1098993	hsa-miR-3074-5p	CLIP-seq
MIRT1098994	hsa-miR-3167	CLIP-seq
MIRT1098995	hsa-miR-3187-3p	CLIP-seq
MIRT1098996	hsa-miR-3614-3p	CLIP-seq
MIRT1098997	hsa-miR-3663-5p	CLIP-seq
MIRT1098998	hsa-miR-3678-3p	CLIP-seq
MIRT1098999	hsa-miR-3915	CLIP-seq
MIRT1099000	hsa-miR-3928	CLIP-seq
MIRT1099001	hsa-miR-412	CLIP-seq
MIRT1099002	hsa-miR-4435	CLIP-seq
MIRT1099003	hsa-miR-4496	CLIP-seq
MIRT1099004	hsa-miR-450b-5p	CLIP-seq
MIRT1099005	hsa-miR-4640-3p	CLIP-seq
MIRT1099006	hsa-miR-4701-5p	CLIP-seq
MIRT1098979	hsa-miR-4715-3p	CLIP-seq
MIRT1099007	hsa-miR-4738-3p	CLIP-seq
MIRT1099008	hsa-miR-4766-5p	CLIP-seq
MIRT1099009	hsa-miR-488	CLIP-seq
MIRT1099010	hsa-miR-495	CLIP-seq
MIRT1099011	hsa-miR-507	CLIP-seq
MIRT1099012	hsa-miR-5096	CLIP-seq
MIRT1099013	hsa-miR-548s	CLIP-seq
MIRT1099014	hsa-miR-557	CLIP-seq
MIRT1099015	hsa-miR-588	CLIP-seq
MIRT1099016	hsa-miR-876-5p	CLIP-seq
MIRT1098964	hsa-miR-1254	CLIP-seq
MIRT1098969	hsa-miR-3116	CLIP-seq
MIRT1098971	hsa-miR-3149	CLIP-seq
MIRT1098979	hsa-miR-4715-3p	CLIP-seq
MIRT1098980	hsa-miR-4722-3p	CLIP-seq
MIRT1098982	hsa-miR-4763-5p	CLIP-seq
MIRT1098984	hsa-miR-4794	CLIP-seq
MIRT1098986	hsa-miR-661	CLIP-seq
MIRT2389985	hsa-miR-1184	CLIP-seq
MIRT2389986	hsa-miR-1205	CLIP-seq
MIRT2389987	hsa-miR-1275	CLIP-seq
MIRT2389988	hsa-miR-150	CLIP-seq
MIRT2389989	hsa-miR-1909	CLIP-seq
MIRT2389990	hsa-miR-3144-5p	CLIP-seq
MIRT2389991	hsa-miR-3158-5p	CLIP-seq
MIRT2389992	hsa-miR-3194-3p	CLIP-seq
MIRT2389993	hsa-miR-3649	CLIP-seq
MIRT2389994	hsa-miR-4289	CLIP-seq
MIRT2389995	hsa-miR-4437	CLIP-seq
MIRT2389996	hsa-miR-4447	CLIP-seq
MIRT2389997	hsa-miR-4472	CLIP-seq
MIRT2389998	hsa-miR-4525	CLIP-seq
MIRT2389999	hsa-miR-4665-5p	CLIP-seq
MIRT2390000	hsa-miR-4674	CLIP-seq
MIRT2390001	hsa-miR-4723-5p	CLIP-seq
MIRT2390002	hsa-miR-625	CLIP-seq
MIRT2390003	hsa-miR-760	CLIP-seq
MIRT2452697	hsa-miR-1321	CLIP-seq
MIRT2452698	hsa-miR-3679-3p	CLIP-seq
MIRT2452699	hsa-miR-4257	CLIP-seq
MIRT2452700	hsa-miR-4419a	CLIP-seq
MIRT2452701	hsa-miR-4510	CLIP-seq
MIRT2452702	hsa-miR-4739	CLIP-seq
MIRT2452703	hsa-miR-4756-5p	CLIP-seq
MIRT2452697	hsa-miR-1321	CLIP-seq
MIRT2452698	hsa-miR-3679-3p	CLIP-seq
MIRT2452699	hsa-miR-4257	CLIP-seq
MIRT2452700	hsa-miR-4419a	CLIP-seq
MIRT2452701	hsa-miR-4510	CLIP-seq
MIRT2452702	hsa-miR-4739	CLIP-seq
MIRT2452703	hsa-miR-4756-5p	CLIP-seq
MIRT1098964	hsa-miR-1254	CLIP-seq
MIRT2559109	hsa-miR-1297	CLIP-seq
MIRT2559110	hsa-miR-1913	CLIP-seq
MIRT2559111	hsa-miR-26a	CLIP-seq
MIRT2559112	hsa-miR-26b	CLIP-seq
MIRT1098969	hsa-miR-3116	CLIP-seq
MIRT1098971	hsa-miR-3149	CLIP-seq
MIRT2559113	hsa-miR-324-3p	CLIP-seq
MIRT2559114	hsa-miR-4313	CLIP-seq
MIRT2559115	hsa-miR-4465	CLIP-seq
MIRT1098979	hsa-miR-4715-3p	CLIP-seq
MIRT1098984	hsa-miR-4794	CLIP-seq
MIRT1098986	hsa-miR-661	CLIP-seq
MIRT1098964	hsa-miR-1254	CLIP-seq
MIRT1098969	hsa-miR-3116	CLIP-seq
MIRT1098971	hsa-miR-3149	CLIP-seq
MIRT1098979	hsa-miR-4715-3p	CLIP-seq
MIRT1098984	hsa-miR-4794	CLIP-seq
MIRT1098986	hsa-miR-661	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
MBD2	Unknown	21693597

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004252	Function	Serine-type endopeptidase activity	IBA
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS	8764136
GO:0005615	Component	Extracellular space	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	TAS	8764136
GO:0016787	Function	Hydrolase activity	IEA
GO:0030141	Component	Secretory granule	IBA
GO:0051604	Process	Protein maturation	IBA

Other IDs

• MIM: 602673
• HGNC: 6358
• e!Ensembl: ENSG00000129451

Protein

• UniProt ID: O43240
• Protein name: Kallikrein-10 (EC 3.4.21.-) (Normal epithelial cell-specific 1) (Protease serine-like 1)
• Protein function: Has a tumor-suppressor role for NES1 in breast and prostate cancer.
• PDB: 5LPE, 5LPF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00089	Trypsin	47 → 269	Trypsin	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in breast, ovary and prostate.
• Sequence:

  MRAPHLHLSAASGARALAKLLPLLMAQLWAAEAALLPQNDTRLDPEAYGSPCARGSQPWQ
  VSLFNGLSFHCAGVLVDQSWVLTAAHCGNKPLWARVGDDHLLLLQGEQLRRTTRSVVHPK
  YHQGSGPILPRRTDEHDLMLLKLARPVVLGPRVRALQLPYRCAQPGDQCQVAGWGTTAAR
  RVKYNKGLTCSSITILSPKECEVFYPGVVTNNMICAGLDRGQDPCQSDSGGPLVCDETLQ
  GILSWGVYPCGSAQHPAVYTQICKYMSWINKVIRSN

• Sequence length: 276