Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	56474
Gene name	CTP synthase 2
Gene symbol	CTPS2
Synonyms (NCBI Gene)	GATD5B
Chromosome	X
Chromosome location	Xp22.2
Summary	The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various

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miRTarBase ID	miRNA	Experiments	Reference
MIRT026439	hsa-miR-192-5p	Microarray	19074876
MIRT482933	hsa-miR-4475	PAR-CLIP	23592263
MIRT482932	hsa-miR-512-5p	PAR-CLIP	23592263
MIRT482931	hsa-miR-510-5p	PAR-CLIP	23592263
MIRT482930	hsa-miR-4494	PAR-CLIP	23592263
MIRT482929	hsa-miR-499b-5p	PAR-CLIP	23592263
MIRT482928	hsa-miR-4742-3p	PAR-CLIP	23592263
MIRT482927	hsa-miR-6892-5p	PAR-CLIP	23592263
MIRT482926	hsa-miR-137	PAR-CLIP	23592263
MIRT486594	hsa-miR-628-5p	PAR-CLIP	23592263
MIRT482933	hsa-miR-4475	PAR-CLIP	23592263
MIRT482932	hsa-miR-512-5p	PAR-CLIP	23592263
MIRT482931	hsa-miR-510-5p	PAR-CLIP	23592263
MIRT482930	hsa-miR-4494	PAR-CLIP	23592263
MIRT482929	hsa-miR-499b-5p	PAR-CLIP	23592263
MIRT482928	hsa-miR-4742-3p	PAR-CLIP	23592263
MIRT482927	hsa-miR-6892-5p	PAR-CLIP	23592263
MIRT482926	hsa-miR-137	PAR-CLIP	23592263
MIRT482933	hsa-miR-4475	PAR-CLIP	23592263
MIRT482932	hsa-miR-512-5p	PAR-CLIP	23592263
MIRT482931	hsa-miR-510-5p	PAR-CLIP	23592263
MIRT482930	hsa-miR-4494	PAR-CLIP	23592263
MIRT482929	hsa-miR-499b-5p	PAR-CLIP	23592263
MIRT482928	hsa-miR-4742-3p	PAR-CLIP	23592263
MIRT482927	hsa-miR-6892-5p	PAR-CLIP	23592263
MIRT482926	hsa-miR-137	PAR-CLIP	23592263
MIRT486594	hsa-miR-628-5p	PAR-CLIP	23592263
MIRT482933	hsa-miR-4475	PAR-CLIP	23592263
MIRT482932	hsa-miR-512-5p	PAR-CLIP	23592263
MIRT482931	hsa-miR-510-5p	PAR-CLIP	23592263
MIRT482930	hsa-miR-4494	PAR-CLIP	23592263
MIRT482929	hsa-miR-499b-5p	PAR-CLIP	23592263
MIRT482928	hsa-miR-4742-3p	PAR-CLIP	23592263
MIRT482927	hsa-miR-6892-5p	PAR-CLIP	23592263
MIRT482926	hsa-miR-137	PAR-CLIP	23592263
MIRT915296	hsa-let-7a	CLIP-seq
MIRT915297	hsa-let-7b	CLIP-seq
MIRT915298	hsa-let-7c	CLIP-seq
MIRT915299	hsa-let-7d	CLIP-seq
MIRT915300	hsa-let-7e	CLIP-seq
MIRT915301	hsa-let-7f	CLIP-seq
MIRT915302	hsa-let-7g	CLIP-seq
MIRT915303	hsa-let-7i	CLIP-seq
MIRT915304	hsa-miR-1244	CLIP-seq
MIRT915305	hsa-miR-196a	CLIP-seq
MIRT915306	hsa-miR-196b	CLIP-seq
MIRT915307	hsa-miR-202	CLIP-seq
MIRT915308	hsa-miR-2113	CLIP-seq
MIRT915309	hsa-miR-297	CLIP-seq
MIRT915310	hsa-miR-3115	CLIP-seq
MIRT915311	hsa-miR-3149	CLIP-seq
MIRT915312	hsa-miR-383	CLIP-seq
MIRT915313	hsa-miR-4436b-5p	CLIP-seq
MIRT915314	hsa-miR-4458	CLIP-seq
MIRT915315	hsa-miR-4500	CLIP-seq
MIRT915316	hsa-miR-4524	CLIP-seq
MIRT915317	hsa-miR-4690-5p	CLIP-seq
MIRT915318	hsa-miR-4772-5p	CLIP-seq
MIRT915319	hsa-miR-629	CLIP-seq
MIRT915320	hsa-miR-758	CLIP-seq
MIRT915321	hsa-miR-98	CLIP-seq
MIRT915296	hsa-let-7a	CLIP-seq
MIRT915297	hsa-let-7b	CLIP-seq
MIRT915298	hsa-let-7c	CLIP-seq
MIRT915299	hsa-let-7d	CLIP-seq
MIRT915300	hsa-let-7e	CLIP-seq
MIRT915301	hsa-let-7f	CLIP-seq
MIRT915302	hsa-let-7g	CLIP-seq
MIRT915303	hsa-let-7i	CLIP-seq
MIRT915304	hsa-miR-1244	CLIP-seq
MIRT915322	hsa-miR-1294	CLIP-seq
MIRT915323	hsa-miR-1587	CLIP-seq
MIRT915305	hsa-miR-196a	CLIP-seq
MIRT915306	hsa-miR-196b	CLIP-seq
MIRT915307	hsa-miR-202	CLIP-seq
MIRT915324	hsa-miR-221	CLIP-seq
MIRT915325	hsa-miR-222	CLIP-seq
MIRT915326	hsa-miR-2355-5p	CLIP-seq
MIRT915309	hsa-miR-297	CLIP-seq
MIRT915327	hsa-miR-3136-5p	CLIP-seq
MIRT915328	hsa-miR-3147	CLIP-seq
MIRT915329	hsa-miR-3148	CLIP-seq
MIRT915311	hsa-miR-3149	CLIP-seq
MIRT915330	hsa-miR-3153	CLIP-seq
MIRT915331	hsa-miR-3157-5p	CLIP-seq
MIRT915332	hsa-miR-3177-5p	CLIP-seq
MIRT915333	hsa-miR-3660	CLIP-seq
MIRT915334	hsa-miR-4256	CLIP-seq
MIRT915335	hsa-miR-4283	CLIP-seq
MIRT915336	hsa-miR-4293	CLIP-seq
MIRT915337	hsa-miR-4425	CLIP-seq
MIRT915313	hsa-miR-4436b-5p	CLIP-seq
MIRT915338	hsa-miR-4437	CLIP-seq
MIRT915339	hsa-miR-4438	CLIP-seq
MIRT915340	hsa-miR-4439	CLIP-seq
MIRT915314	hsa-miR-4458	CLIP-seq
MIRT915315	hsa-miR-4500	CLIP-seq
MIRT915341	hsa-miR-4513	CLIP-seq
MIRT915316	hsa-miR-4524	CLIP-seq
MIRT915342	hsa-miR-4526	CLIP-seq
MIRT915343	hsa-miR-4536	CLIP-seq
MIRT915344	hsa-miR-4643	CLIP-seq
MIRT915345	hsa-miR-4666-3p	CLIP-seq
MIRT915346	hsa-miR-4668-5p	CLIP-seq
MIRT915347	hsa-miR-4674	CLIP-seq
MIRT915317	hsa-miR-4690-5p	CLIP-seq
MIRT915348	hsa-miR-4691-3p	CLIP-seq
MIRT915349	hsa-miR-4694-3p	CLIP-seq
MIRT915350	hsa-miR-4729	CLIP-seq
MIRT915351	hsa-miR-485-3p	CLIP-seq
MIRT915352	hsa-miR-5095	CLIP-seq
MIRT915353	hsa-miR-522	CLIP-seq
MIRT915354	hsa-miR-548v	CLIP-seq
MIRT915355	hsa-miR-555	CLIP-seq
MIRT915356	hsa-miR-590-3p	CLIP-seq
MIRT915357	hsa-miR-635	CLIP-seq
MIRT915358	hsa-miR-642b	CLIP-seq
MIRT915359	hsa-miR-648	CLIP-seq
MIRT915360	hsa-miR-664	CLIP-seq
MIRT915361	hsa-miR-671-5p	CLIP-seq
MIRT915321	hsa-miR-98	CLIP-seq
MIRT915362	hsa-miR-1178	CLIP-seq
MIRT915363	hsa-miR-1245	CLIP-seq
MIRT915364	hsa-miR-1273g	CLIP-seq
MIRT915365	hsa-miR-142-3p	CLIP-seq
MIRT915323	hsa-miR-1587	CLIP-seq
MIRT915324	hsa-miR-221	CLIP-seq
MIRT915325	hsa-miR-222	CLIP-seq
MIRT915366	hsa-miR-3185	CLIP-seq
MIRT915367	hsa-miR-323-5p	CLIP-seq
MIRT915368	hsa-miR-3675-5p	CLIP-seq
MIRT915369	hsa-miR-3942-3p	CLIP-seq
MIRT915370	hsa-miR-4280	CLIP-seq
MIRT915335	hsa-miR-4283	CLIP-seq
MIRT915338	hsa-miR-4437	CLIP-seq
MIRT915344	hsa-miR-4643	CLIP-seq
MIRT915371	hsa-miR-4659a-3p	CLIP-seq
MIRT915372	hsa-miR-4659b-3p	CLIP-seq
MIRT915347	hsa-miR-4674	CLIP-seq
MIRT915373	hsa-miR-4738-3p	CLIP-seq
MIRT915374	hsa-miR-4753-5p	CLIP-seq
MIRT915375	hsa-miR-4786-3p	CLIP-seq
MIRT915376	hsa-miR-548m	CLIP-seq
MIRT915354	hsa-miR-548v	CLIP-seq
MIRT915355	hsa-miR-555	CLIP-seq
MIRT915357	hsa-miR-635	CLIP-seq
MIRT915358	hsa-miR-642b	CLIP-seq
MIRT915377	hsa-miR-876-3p	CLIP-seq
MIRT1971472	hsa-miR-129-5p	CLIP-seq
MIRT915323	hsa-miR-1587	CLIP-seq
MIRT915324	hsa-miR-221	CLIP-seq
MIRT915325	hsa-miR-222	CLIP-seq
MIRT915327	hsa-miR-3136-5p	CLIP-seq
MIRT1971473	hsa-miR-3200-3p	CLIP-seq
MIRT1971474	hsa-miR-330-3p	CLIP-seq
MIRT915368	hsa-miR-3675-5p	CLIP-seq
MIRT1971475	hsa-miR-3926	CLIP-seq
MIRT915335	hsa-miR-4283	CLIP-seq
MIRT915336	hsa-miR-4293	CLIP-seq
MIRT915338	hsa-miR-4437	CLIP-seq
MIRT915340	hsa-miR-4439	CLIP-seq
MIRT915341	hsa-miR-4513	CLIP-seq
MIRT915344	hsa-miR-4643	CLIP-seq
MIRT915347	hsa-miR-4674	CLIP-seq
MIRT1971476	hsa-miR-4682	CLIP-seq
MIRT915349	hsa-miR-4694-3p	CLIP-seq
MIRT1971477	hsa-miR-4719	CLIP-seq
MIRT1971478	hsa-miR-518a-5p	CLIP-seq
MIRT915353	hsa-miR-522	CLIP-seq
MIRT1971479	hsa-miR-527	CLIP-seq
MIRT1971480	hsa-miR-548u	CLIP-seq
MIRT915354	hsa-miR-548v	CLIP-seq
MIRT915355	hsa-miR-555	CLIP-seq
MIRT1971481	hsa-miR-617	CLIP-seq
MIRT915357	hsa-miR-635	CLIP-seq
MIRT915358	hsa-miR-642b	CLIP-seq
MIRT915361	hsa-miR-671-5p	CLIP-seq
MIRT1971482	hsa-miR-4698	CLIP-seq
MIRT915369	hsa-miR-3942-3p	CLIP-seq
MIRT915296	hsa-let-7a	CLIP-seq
MIRT915297	hsa-let-7b	CLIP-seq
MIRT915298	hsa-let-7c	CLIP-seq
MIRT915299	hsa-let-7d	CLIP-seq
MIRT915300	hsa-let-7e	CLIP-seq
MIRT915301	hsa-let-7f	CLIP-seq
MIRT915302	hsa-let-7g	CLIP-seq
MIRT915303	hsa-let-7i	CLIP-seq
MIRT2207194	hsa-miR-1185	CLIP-seq
MIRT915304	hsa-miR-1244	CLIP-seq
MIRT2207195	hsa-miR-1287	CLIP-seq
MIRT915322	hsa-miR-1294	CLIP-seq
MIRT2207196	hsa-miR-154	CLIP-seq
MIRT915323	hsa-miR-1587	CLIP-seq
MIRT915305	hsa-miR-196a	CLIP-seq
MIRT915306	hsa-miR-196b	CLIP-seq
MIRT915307	hsa-miR-202	CLIP-seq
MIRT915308	hsa-miR-2113	CLIP-seq
MIRT915324	hsa-miR-221	CLIP-seq
MIRT915325	hsa-miR-222	CLIP-seq
MIRT915326	hsa-miR-2355-5p	CLIP-seq
MIRT2207197	hsa-miR-2467-5p	CLIP-seq
MIRT915310	hsa-miR-3115	CLIP-seq
MIRT2207198	hsa-miR-3125	CLIP-seq
MIRT2207199	hsa-miR-3135b	CLIP-seq
MIRT915327	hsa-miR-3136-5p	CLIP-seq
MIRT915328	hsa-miR-3147	CLIP-seq
MIRT915329	hsa-miR-3148	CLIP-seq
MIRT915330	hsa-miR-3153	CLIP-seq
MIRT2207200	hsa-miR-3176	CLIP-seq
MIRT2207201	hsa-miR-3188	CLIP-seq
MIRT1971473	hsa-miR-3200-3p	CLIP-seq
MIRT915367	hsa-miR-323-5p	CLIP-seq
MIRT2207202	hsa-miR-339-5p	CLIP-seq
MIRT915333	hsa-miR-3660	CLIP-seq
MIRT2207203	hsa-miR-3679-5p	CLIP-seq
MIRT915312	hsa-miR-383	CLIP-seq
MIRT2207204	hsa-miR-3916	CLIP-seq
MIRT2207205	hsa-miR-3922-3p	CLIP-seq
MIRT2207206	hsa-miR-3975	CLIP-seq
MIRT2207207	hsa-miR-4282	CLIP-seq
MIRT915335	hsa-miR-4283	CLIP-seq
MIRT915336	hsa-miR-4293	CLIP-seq
MIRT2207208	hsa-miR-4316	CLIP-seq
MIRT915337	hsa-miR-4425	CLIP-seq
MIRT2207209	hsa-miR-4434	CLIP-seq
MIRT2207210	hsa-miR-4435	CLIP-seq
MIRT915338	hsa-miR-4437	CLIP-seq
MIRT915340	hsa-miR-4439	CLIP-seq
MIRT2207211	hsa-miR-4456	CLIP-seq
MIRT915314	hsa-miR-4458	CLIP-seq
MIRT915315	hsa-miR-4500	CLIP-seq
MIRT2207212	hsa-miR-4506	CLIP-seq
MIRT915341	hsa-miR-4513	CLIP-seq
MIRT2207213	hsa-miR-4516	CLIP-seq
MIRT915316	hsa-miR-4524	CLIP-seq
MIRT915342	hsa-miR-4526	CLIP-seq
MIRT2207214	hsa-miR-4527	CLIP-seq
MIRT2207215	hsa-miR-4531	CLIP-seq
MIRT2207216	hsa-miR-4640-5p	CLIP-seq
MIRT915344	hsa-miR-4643	CLIP-seq
MIRT915345	hsa-miR-4666-3p	CLIP-seq
MIRT915346	hsa-miR-4668-5p	CLIP-seq
MIRT915347	hsa-miR-4674	CLIP-seq
MIRT2207217	hsa-miR-4677-3p	CLIP-seq
MIRT915317	hsa-miR-4690-5p	CLIP-seq
MIRT915349	hsa-miR-4694-3p	CLIP-seq
MIRT2207218	hsa-miR-4713-5p	CLIP-seq
MIRT2207219	hsa-miR-4716-5p	CLIP-seq
MIRT2207220	hsa-miR-4726-5p	CLIP-seq
MIRT915318	hsa-miR-4772-5p	CLIP-seq
MIRT2207221	hsa-miR-4773	CLIP-seq
MIRT915351	hsa-miR-485-3p	CLIP-seq
MIRT2207222	hsa-miR-485-5p	CLIP-seq
MIRT2207223	hsa-miR-516a-5p	CLIP-seq
MIRT1971478	hsa-miR-518a-5p	CLIP-seq
MIRT915353	hsa-miR-522	CLIP-seq
MIRT1971479	hsa-miR-527	CLIP-seq
MIRT915354	hsa-miR-548v	CLIP-seq
MIRT915355	hsa-miR-555	CLIP-seq
MIRT915356	hsa-miR-590-3p	CLIP-seq
MIRT2207224	hsa-miR-603	CLIP-seq
MIRT915319	hsa-miR-629	CLIP-seq
MIRT915357	hsa-miR-635	CLIP-seq
MIRT915358	hsa-miR-642b	CLIP-seq
MIRT915360	hsa-miR-664	CLIP-seq
MIRT2207225	hsa-miR-670	CLIP-seq
MIRT915361	hsa-miR-671-5p	CLIP-seq
MIRT915320	hsa-miR-758	CLIP-seq
MIRT915377	hsa-miR-876-3p	CLIP-seq
MIRT2207226	hsa-miR-877	CLIP-seq
MIRT915321	hsa-miR-98	CLIP-seq
MIRT2386574	hsa-miR-205	CLIP-seq
MIRT915324	hsa-miR-221	CLIP-seq
MIRT915325	hsa-miR-222	CLIP-seq
MIRT915344	hsa-miR-4643	CLIP-seq
MIRT915354	hsa-miR-548v	CLIP-seq
MIRT915358	hsa-miR-642b	CLIP-seq
MIRT915324	hsa-miR-221	CLIP-seq
MIRT915325	hsa-miR-222	CLIP-seq
MIRT915344	hsa-miR-4643	CLIP-seq
MIRT915354	hsa-miR-548v	CLIP-seq
MIRT915355	hsa-miR-555	CLIP-seq
MIRT915358	hsa-miR-642b	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003883	Function	CTP synthase activity	IBA
GO:0003883	Function	CTP synthase activity	IDA	16179339, 31873303
GO:0003883	Function	CTP synthase activity	IEA
GO:0003883	Function	CTP synthase activity	TAS	10899599
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 28514442, 32296183, 33961781, 35271311
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	24503052
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	24503052
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005829	Component	Cytosol	TAS
GO:0006220	Process	Pyrimidine nucleotide metabolic process	TAS	10899599
GO:0006221	Process	Pyrimidine nucleotide biosynthetic process	IEA
GO:0006241	Process	CTP biosynthetic process	IBA
GO:0006241	Process	CTP biosynthetic process	IDA	16179339, 31873303
GO:0006241	Process	CTP biosynthetic process	IEA
GO:0016874	Function	Ligase activity	IEA
GO:0019856	Process	Pyrimidine nucleobase biosynthetic process	IBA
GO:0042802	Function	Identical protein binding	IBA
GO:0042802	Function	Identical protein binding	IPI	16189514, 25416956, 31515488, 31873303
GO:0044210	Process	'de novo' CTP biosynthetic process	IEA
GO:0044281	Process	Small molecule metabolic process	IEA
GO:0097268	Component	Cytoophidium	IBA
GO:0097268	Component	Cytoophidium	IDA	24503052

MIM	HGNC	e!Ensembl
300380	2520	ENSG00000047230

Q9NRF8

Protein name

CTP synthase 2 (EC 6.3.4.2) (CTP synthetase 2) (UTP--ammonia ligase 2)

Protein function

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. {ECO:0000269|PubMed:10899599, ECO:0000269|PubMed:161

PDB

2V4U , 2VKT , 3IHL , 6PK4 , 6PK7 , 7MH1 , 7MIH , 7MII

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06418	CTP_synth_N	2 → 272	CTP synthase N-terminus	Domain
PF00117	GATase	309 → 546	Glutamine amidotransferase class-I	Domain

Sequence

MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDPYINIDAGTFSPYEHGEVFV
LNDGGEVDLDLGNYERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDA
VQEWVMNQAKVPVDGNKEEPQICVIELGGTIGDIEGMPFVEAFRQFQFKAKRENFCNIHV
SLVPQLSATGEQKTKPTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQ
VICIHDVSSTYRVPVLLEEQSIVKYFKERLHLPIGDSASNLLFKWRNMADRYERLQKICS
IALVGKYTKLRDCYASVFKALEHSALAINHKLNLMYIDSIDLEKITETEDPVKFHEAWQK
LCKADGILVPGGFGIRGTLGKLQAISWARTKKIPFLGVCLGMQLAVIEFARNCLNLKDAD
STEFRPNAPVPLVIDMPEHNPGNLGGTMRLGIRRTVFKTENSILRKLYGDVPFIEERHRH
RFEVNPNLIKQFEQNDLSFVGQDVDGDRMEIIELANHPYFVGVQFHPEFSSRPMKPSPPY
LGLLLAATGNLNAYLQQGCKLSSSDRYSDASDDSFSEPRIAELEIS

Sequence length

586

Interactions

View interactions

	KEGG		Reactome
	Pyrimidine metabolism Metabolic pathways Nucleotide metabolism Biosynthesis of cofactors		Interconversion of nucleotide di- and triphosphates

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CYTIDINE 5-PRIME TRIPHOSPHATE SYNTHETASE 2 deficiency	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Laterality defects, autosomal dominant	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	34996932	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Foot	Associate	38287255	★★★★★ ★☆☆☆☆ Found in Text Mining only
Epstein Barr Virus Infections	Associate	34281398	★★★★★ ★☆☆☆☆ Found in Text Mining only
Infectious Mononucleosis	Associate	29176466	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Associate	29176466	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoproliferative Disorders	Associate	34281398	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nance Horan syndrome	Associate	35122698	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	31173206	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Associate	31173206	★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary Immunodeficiency Diseases	Associate	29176466	★★★★★ ★☆☆☆☆ Found in Text Mining only

CTPS2 (CTP synthase 2)