Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5639
Gene name Gene Name - the full gene name approved by the HGNC.	Proline rich and Gla domain 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PRRG2
Synonyms (NCBI Gene) Gene synonyms aliases	PRGP2
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.33
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017531	hsa-miR-335-5p	Microarray	18185580
MIRT1267915	hsa-miR-2909	CLIP-seq
MIRT1267916	hsa-miR-4267	CLIP-seq
MIRT1267917	hsa-miR-4278	CLIP-seq
MIRT1267918	hsa-miR-508-5p	CLIP-seq
MIRT1267919	hsa-miR-766	CLIP-seq
MIRT2078782	hsa-miR-2355-5p	CLIP-seq
MIRT2078783	hsa-miR-3145-5p	CLIP-seq
MIRT2078784	hsa-miR-3691-3p	CLIP-seq
MIRT1267916	hsa-miR-4267	CLIP-seq
MIRT2078785	hsa-miR-4286	CLIP-seq
MIRT2602180	hsa-miR-1343	CLIP-seq
MIRT2602181	hsa-miR-378g	CLIP-seq
MIRT2602182	hsa-miR-4437	CLIP-seq
MIRT2602183	hsa-miR-4492	CLIP-seq
MIRT2602184	hsa-miR-4498	CLIP-seq
MIRT2602185	hsa-miR-4505	CLIP-seq
MIRT2602186	hsa-miR-4508	CLIP-seq
MIRT2602187	hsa-miR-4674	CLIP-seq
MIRT2602188	hsa-miR-762	CLIP-seq
MIRT2602180	hsa-miR-1343	CLIP-seq
MIRT2602181	hsa-miR-378g	CLIP-seq
MIRT2602182	hsa-miR-4437	CLIP-seq
MIRT2602183	hsa-miR-4492	CLIP-seq
MIRT2602184	hsa-miR-4498	CLIP-seq
MIRT2602185	hsa-miR-4505	CLIP-seq
MIRT2602186	hsa-miR-4508	CLIP-seq
MIRT2602187	hsa-miR-4674	CLIP-seq
MIRT2602188	hsa-miR-762	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004252	Function	Serine-type endopeptidase activity	IBA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	17502622, 23873930, 25283809
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	17502622
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9256434
GO:0006508	Process	Proteolysis	IBA
GO:0007596	Process	Blood coagulation	IBA
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
604429	9470	ENSG00000126460

Protein

UniProt ID

O14669

Protein name

Transmembrane gamma-carboxyglutamic acid protein 2 (Proline-rich gamma-carboxyglutamic acid protein 2) (Proline-rich Gla protein 2)

PDB

9BVP , 9BVQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00594	Gla	55 → 95	Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with highest levels in kidney (PubMed:23873930). Also highly expressed in the thyroid (PubMed:23873930, PubMed:9256434). {ECO:0000269|PubMed:23873930, ECO:0000269|PubMed:9256434}.

Sequence

MRGHPSLLLLYMALTTCLDTSPSEETDQEVFLGPPEAQSFLSSHTRIPRANHWDLELLTP
GNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGKGGRGRVDVASLAVGLTGGILL
IVLAGLGAFWYLRWRQHRGQQPCPQEAGLISPLSPLNPLGPPTPLPPPPPPPPGLPTYEQ
ALAASGVHDAPPPPYTSLRRPH

Sequence length

202

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

PRRG2 (proline rich and Gla domain 2)