PRRG2 (proline rich and Gla domain 2)

Gene

• Entrez ID: 5639
• Gene name: Proline rich and Gla domain 2
• Gene symbol: PRRG2
• Synonyms (NCBI Gene): PRGP2
• Chromosome: 19
• Chromosome location: 19q13.33
• Summary: The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017531	hsa-miR-335-5p	Microarray	18185580
MIRT1267915	hsa-miR-2909	CLIP-seq
MIRT1267916	hsa-miR-4267	CLIP-seq
MIRT1267917	hsa-miR-4278	CLIP-seq
MIRT1267918	hsa-miR-508-5p	CLIP-seq
MIRT1267919	hsa-miR-766	CLIP-seq
MIRT2078782	hsa-miR-2355-5p	CLIP-seq
MIRT2078783	hsa-miR-3145-5p	CLIP-seq
MIRT2078784	hsa-miR-3691-3p	CLIP-seq
MIRT1267916	hsa-miR-4267	CLIP-seq
MIRT2078785	hsa-miR-4286	CLIP-seq
MIRT2602180	hsa-miR-1343	CLIP-seq
MIRT2602181	hsa-miR-378g	CLIP-seq
MIRT2602182	hsa-miR-4437	CLIP-seq
MIRT2602183	hsa-miR-4492	CLIP-seq
MIRT2602184	hsa-miR-4498	CLIP-seq
MIRT2602185	hsa-miR-4505	CLIP-seq
MIRT2602186	hsa-miR-4508	CLIP-seq
MIRT2602187	hsa-miR-4674	CLIP-seq
MIRT2602188	hsa-miR-762	CLIP-seq
MIRT2602180	hsa-miR-1343	CLIP-seq
MIRT2602181	hsa-miR-378g	CLIP-seq
MIRT2602182	hsa-miR-4437	CLIP-seq
MIRT2602183	hsa-miR-4492	CLIP-seq
MIRT2602184	hsa-miR-4498	CLIP-seq
MIRT2602185	hsa-miR-4505	CLIP-seq
MIRT2602186	hsa-miR-4508	CLIP-seq
MIRT2602187	hsa-miR-4674	CLIP-seq
MIRT2602188	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004252	Function	Serine-type endopeptidase activity	IBA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	17502622, 23873930, 25283809
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	17502622
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9256434
GO:0006508	Process	Proteolysis	IBA
GO:0007596	Process	Blood coagulation	IBA
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: 604429
• HGNC: 9470
• e!Ensembl: ENSG00000126460

Protein

• UniProt ID: O14669
• Protein name: Transmembrane gamma-carboxyglutamic acid protein 2 (Proline-rich gamma-carboxyglutamic acid protein 2) (Proline-rich Gla protein 2)
• PDB: 9BVP, 9BVQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00594	Gla	55 → 95	Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed with highest levels in kidney (PubMed:23873930). Also highly expressed in the thyroid (PubMed:23873930, PubMed:9256434). {ECO:0000269|PubMed:23873930, ECO:0000269|PubMed:9256434}.
• Sequence:

  MRGHPSLLLLYMALTTCLDTSPSEETDQEVFLGPPEAQSFLSSHTRIPRANHWDLELLTP
  GNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGKGGRGRVDVASLAVGLTGGILL
  IVLAGLGAFWYLRWRQHRGQQPCPQEAGLISPLSPLNPLGPPTPLPPPPPPPPGLPTYEQ
  ALAASGVHDAPPPPYTSLRRPH

• Sequence length: 202

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Adrenocortical carcinoma, hereditary	-	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	-	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations