Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5635
Gene name Gene Name - the full gene name approved by the HGNC.	Phosphoribosyl pyrophosphate synthetase associated protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PRPSAP1
Synonyms (NCBI Gene) Gene synonyms aliases	PAP39
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q25.1

Show/Hide all(119)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021127	hsa-miR-186-5p	Sequencing	20371350
MIRT031682	hsa-miR-16-5p	Proteomics	18668040
MIRT031682	hsa-miR-16-5p	CLASH	23622248
MIRT039657	hsa-miR-615-3p	CLASH	23622248
MIRT039657	hsa-miR-615-3p	CLASH	23622248
MIRT661827	hsa-miR-5193	HITS-CLIP	23824327
MIRT661826	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT661825	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT661824	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT661823	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT661822	hsa-miR-6841-3p	HITS-CLIP	23824327
MIRT661821	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT661820	hsa-miR-378g	HITS-CLIP	23824327
MIRT661819	hsa-miR-4437	HITS-CLIP	23824327
MIRT661818	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT661817	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT661816	hsa-miR-502-5p	HITS-CLIP	23824327
MIRT661815	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT661814	hsa-miR-4674	HITS-CLIP	23824327
MIRT661813	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT661827	hsa-miR-5193	HITS-CLIP	23824327
MIRT661826	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT661825	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT661824	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT661823	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT661822	hsa-miR-6841-3p	HITS-CLIP	23824327
MIRT661821	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT661820	hsa-miR-378g	HITS-CLIP	23824327
MIRT661819	hsa-miR-4437	HITS-CLIP	23824327
MIRT661818	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT661817	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT661816	hsa-miR-502-5p	HITS-CLIP	23824327
MIRT661815	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT661814	hsa-miR-4674	HITS-CLIP	23824327
MIRT661813	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT1266073	hsa-miR-3182	CLIP-seq
MIRT1266074	hsa-miR-421	CLIP-seq
MIRT1266075	hsa-miR-4433	CLIP-seq
MIRT1266076	hsa-miR-4459	CLIP-seq
MIRT1266077	hsa-miR-4685-5p	CLIP-seq
MIRT1266078	hsa-miR-4768-3p	CLIP-seq
MIRT1266079	hsa-miR-626	CLIP-seq
MIRT1266074	hsa-miR-421	CLIP-seq
MIRT2078208	hsa-miR-455-5p	CLIP-seq
MIRT2078209	hsa-miR-4716-5p	CLIP-seq
MIRT2078210	hsa-miR-4764-3p	CLIP-seq
MIRT2078211	hsa-miR-550a	CLIP-seq
MIRT2078212	hsa-miR-7	CLIP-seq
MIRT2304670	hsa-miR-101	CLIP-seq
MIRT2304671	hsa-miR-144	CLIP-seq
MIRT2304672	hsa-miR-3065-5p	CLIP-seq
MIRT1266074	hsa-miR-421	CLIP-seq
MIRT2304673	hsa-miR-4272	CLIP-seq
MIRT2304674	hsa-miR-4444	CLIP-seq
MIRT2304675	hsa-miR-4645-5p	CLIP-seq
MIRT2304676	hsa-miR-4673	CLIP-seq
MIRT2304677	hsa-miR-4687-3p	CLIP-seq
MIRT2078210	hsa-miR-4764-3p	CLIP-seq
MIRT2304678	hsa-miR-508-5p	CLIP-seq
MIRT2601717	hsa-miR-1305	CLIP-seq
MIRT2601718	hsa-miR-194	CLIP-seq
MIRT2601719	hsa-miR-208a	CLIP-seq
MIRT2601720	hsa-miR-208b	CLIP-seq
MIRT1266073	hsa-miR-3182	CLIP-seq
MIRT2601721	hsa-miR-3189-3p	CLIP-seq
MIRT2601722	hsa-miR-362-5p	CLIP-seq
MIRT2601723	hsa-miR-3646	CLIP-seq
MIRT2601724	hsa-miR-3653	CLIP-seq
MIRT2601725	hsa-miR-3658	CLIP-seq
MIRT2601726	hsa-miR-3713	CLIP-seq
MIRT2601727	hsa-miR-3913-3p	CLIP-seq
MIRT2601728	hsa-miR-3942-3p	CLIP-seq
MIRT2601729	hsa-miR-3976	CLIP-seq
MIRT2601730	hsa-miR-3977	CLIP-seq
MIRT2601731	hsa-miR-4424	CLIP-seq
MIRT2601732	hsa-miR-4432	CLIP-seq
MIRT2601733	hsa-miR-4528	CLIP-seq
MIRT2078208	hsa-miR-455-5p	CLIP-seq
MIRT2304677	hsa-miR-4687-3p	CLIP-seq
MIRT2601734	hsa-miR-4762-3p	CLIP-seq
MIRT2078210	hsa-miR-4764-3p	CLIP-seq
MIRT2601735	hsa-miR-4766-5p	CLIP-seq
MIRT2601736	hsa-miR-489	CLIP-seq
MIRT2601737	hsa-miR-494	CLIP-seq
MIRT2601738	hsa-miR-499-5p	CLIP-seq
MIRT2601739	hsa-miR-500b	CLIP-seq
MIRT2078211	hsa-miR-550a	CLIP-seq
MIRT2601740	hsa-miR-579	CLIP-seq
MIRT1266079	hsa-miR-626	CLIP-seq
MIRT2078212	hsa-miR-7	CLIP-seq
MIRT2601717	hsa-miR-1305	CLIP-seq
MIRT2688727	hsa-miR-1470	CLIP-seq
MIRT2601718	hsa-miR-194	CLIP-seq
MIRT2601719	hsa-miR-208a	CLIP-seq
MIRT2601720	hsa-miR-208b	CLIP-seq
MIRT2601721	hsa-miR-3189-3p	CLIP-seq
MIRT2601722	hsa-miR-362-5p	CLIP-seq
MIRT2601723	hsa-miR-3646	CLIP-seq
MIRT2601727	hsa-miR-3913-3p	CLIP-seq
MIRT2601729	hsa-miR-3976	CLIP-seq
MIRT2601730	hsa-miR-3977	CLIP-seq
MIRT2601731	hsa-miR-4424	CLIP-seq
MIRT2601732	hsa-miR-4432	CLIP-seq
MIRT2688728	hsa-miR-4522	CLIP-seq
MIRT2601733	hsa-miR-4528	CLIP-seq
MIRT2078208	hsa-miR-455-5p	CLIP-seq
MIRT2688729	hsa-miR-4667-3p	CLIP-seq
MIRT2688730	hsa-miR-4684-5p	CLIP-seq
MIRT2304677	hsa-miR-4687-3p	CLIP-seq
MIRT2601734	hsa-miR-4762-3p	CLIP-seq
MIRT2078210	hsa-miR-4764-3p	CLIP-seq
MIRT2601735	hsa-miR-4766-5p	CLIP-seq
MIRT2601736	hsa-miR-489	CLIP-seq
MIRT2601737	hsa-miR-494	CLIP-seq
MIRT2601738	hsa-miR-499-5p	CLIP-seq
MIRT2601739	hsa-miR-500b	CLIP-seq
MIRT2078211	hsa-miR-550a	CLIP-seq
MIRT2601740	hsa-miR-579	CLIP-seq
MIRT2078212	hsa-miR-7	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0002189	Component	Ribose phosphate diphosphokinase complex	IBA	21873635
GO:0004749	Function	Ribose phosphate diphosphokinase activity	IBA	21873635
GO:0004857	Function	Enzyme inhibitor activity	TAS	8132556
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 25910212, 31515488, 32296183
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0006015	Process	5-phosphoribose 1-diphosphate biosynthetic process	IBA	21873635
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	8611620
GO:0006164	Process	Purine nucleotide biosynthetic process	IBA	21873635
GO:0042802	Function	Identical protein binding	IPI	16189514, 19447967, 32296183
GO:0043086	Process	Negative regulation of catalytic activity	IEA

MIM	HGNC	e!Ensembl
601249	9466	ENSG00000161542

Protein

UniProt ID

Q14558

Protein name

Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39)

Protein function

Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.

PDB

2C4K

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13793	Pribosyltran_N	9 → 126	N-terminal domain of ribose phosphate pyrophosphokinase	Domain
PF14572	Pribosyl_synth	167 → 350	Phosphoribosyl synthetase-associated domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MNAARTGYRVFSANSTAACTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDI
FIIQTIPRDVNTAVMELLIMAYALKTACARNIIGVIPYFPYSKQSKMRKRGSIVCKLLAS
MLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIPNYRNAVIVAKSPDA
AKRAQSYAERLRLGLAVIHGEAQCTELDMDDGRHSPPMVKNATVHPGLELPLMMAKEKPP
ITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEES
SVDEVVVTNTVPHEVQKLQCPKIKTVDISLILSEAIRRIHNGESMAYLFRNITVDD

Sequence length

356

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Gout	Gout			GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Hepatocellular	Inhibit	28732507
Ovarian Neoplasms	Associate	31469419

PRPSAP1 (phosphoribosyl pyrophosphate synthetase associated protein 1)