Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5635
Gene name Gene Name - the full gene name approved by the HGNC.	Phosphoribosyl pyrophosphate synthetase associated protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PRPSAP1
Synonyms (NCBI Gene) Gene synonyms aliases	PAP39
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q25.1

Show/Hide all(119)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021127	hsa-miR-186-5p	Sequencing	20371350
MIRT031682	hsa-miR-16-5p	Proteomics	18668040
MIRT031682	hsa-miR-16-5p	CLASH	23622248
MIRT039657	hsa-miR-615-3p	CLASH	23622248
MIRT039657	hsa-miR-615-3p	CLASH	23622248
MIRT661827	hsa-miR-5193	HITS-CLIP	23824327
MIRT661826	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT661825	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT661824	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT661823	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT661822	hsa-miR-6841-3p	HITS-CLIP	23824327
MIRT661821	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT661820	hsa-miR-378g	HITS-CLIP	23824327
MIRT661819	hsa-miR-4437	HITS-CLIP	23824327
MIRT661818	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT661817	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT661816	hsa-miR-502-5p	HITS-CLIP	23824327
MIRT661815	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT661814	hsa-miR-4674	HITS-CLIP	23824327
MIRT661813	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT661827	hsa-miR-5193	HITS-CLIP	23824327
MIRT661826	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT661825	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT661824	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT661823	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT661822	hsa-miR-6841-3p	HITS-CLIP	23824327
MIRT661821	hsa-miR-1915-5p	HITS-CLIP	23824327
MIRT661820	hsa-miR-378g	HITS-CLIP	23824327
MIRT661819	hsa-miR-4437	HITS-CLIP	23824327
MIRT661818	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT661817	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT661816	hsa-miR-502-5p	HITS-CLIP	23824327
MIRT661815	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT661814	hsa-miR-4674	HITS-CLIP	23824327
MIRT661813	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT1266073	hsa-miR-3182	CLIP-seq
MIRT1266074	hsa-miR-421	CLIP-seq
MIRT1266075	hsa-miR-4433	CLIP-seq
MIRT1266076	hsa-miR-4459	CLIP-seq
MIRT1266077	hsa-miR-4685-5p	CLIP-seq
MIRT1266078	hsa-miR-4768-3p	CLIP-seq
MIRT1266079	hsa-miR-626	CLIP-seq
MIRT1266074	hsa-miR-421	CLIP-seq
MIRT2078208	hsa-miR-455-5p	CLIP-seq
MIRT2078209	hsa-miR-4716-5p	CLIP-seq
MIRT2078210	hsa-miR-4764-3p	CLIP-seq
MIRT2078211	hsa-miR-550a	CLIP-seq
MIRT2078212	hsa-miR-7	CLIP-seq
MIRT2304670	hsa-miR-101	CLIP-seq
MIRT2304671	hsa-miR-144	CLIP-seq
MIRT2304672	hsa-miR-3065-5p	CLIP-seq
MIRT1266074	hsa-miR-421	CLIP-seq
MIRT2304673	hsa-miR-4272	CLIP-seq
MIRT2304674	hsa-miR-4444	CLIP-seq
MIRT2304675	hsa-miR-4645-5p	CLIP-seq
MIRT2304676	hsa-miR-4673	CLIP-seq
MIRT2304677	hsa-miR-4687-3p	CLIP-seq
MIRT2078210	hsa-miR-4764-3p	CLIP-seq
MIRT2304678	hsa-miR-508-5p	CLIP-seq
MIRT2601717	hsa-miR-1305	CLIP-seq
MIRT2601718	hsa-miR-194	CLIP-seq
MIRT2601719	hsa-miR-208a	CLIP-seq
MIRT2601720	hsa-miR-208b	CLIP-seq
MIRT1266073	hsa-miR-3182	CLIP-seq
MIRT2601721	hsa-miR-3189-3p	CLIP-seq
MIRT2601722	hsa-miR-362-5p	CLIP-seq
MIRT2601723	hsa-miR-3646	CLIP-seq
MIRT2601724	hsa-miR-3653	CLIP-seq
MIRT2601725	hsa-miR-3658	CLIP-seq
MIRT2601726	hsa-miR-3713	CLIP-seq
MIRT2601727	hsa-miR-3913-3p	CLIP-seq
MIRT2601728	hsa-miR-3942-3p	CLIP-seq
MIRT2601729	hsa-miR-3976	CLIP-seq
MIRT2601730	hsa-miR-3977	CLIP-seq
MIRT2601731	hsa-miR-4424	CLIP-seq
MIRT2601732	hsa-miR-4432	CLIP-seq
MIRT2601733	hsa-miR-4528	CLIP-seq
MIRT2078208	hsa-miR-455-5p	CLIP-seq
MIRT2304677	hsa-miR-4687-3p	CLIP-seq
MIRT2601734	hsa-miR-4762-3p	CLIP-seq
MIRT2078210	hsa-miR-4764-3p	CLIP-seq
MIRT2601735	hsa-miR-4766-5p	CLIP-seq
MIRT2601736	hsa-miR-489	CLIP-seq
MIRT2601737	hsa-miR-494	CLIP-seq
MIRT2601738	hsa-miR-499-5p	CLIP-seq
MIRT2601739	hsa-miR-500b	CLIP-seq
MIRT2078211	hsa-miR-550a	CLIP-seq
MIRT2601740	hsa-miR-579	CLIP-seq
MIRT1266079	hsa-miR-626	CLIP-seq
MIRT2078212	hsa-miR-7	CLIP-seq
MIRT2601717	hsa-miR-1305	CLIP-seq
MIRT2688727	hsa-miR-1470	CLIP-seq
MIRT2601718	hsa-miR-194	CLIP-seq
MIRT2601719	hsa-miR-208a	CLIP-seq
MIRT2601720	hsa-miR-208b	CLIP-seq
MIRT2601721	hsa-miR-3189-3p	CLIP-seq
MIRT2601722	hsa-miR-362-5p	CLIP-seq
MIRT2601723	hsa-miR-3646	CLIP-seq
MIRT2601727	hsa-miR-3913-3p	CLIP-seq
MIRT2601729	hsa-miR-3976	CLIP-seq
MIRT2601730	hsa-miR-3977	CLIP-seq
MIRT2601731	hsa-miR-4424	CLIP-seq
MIRT2601732	hsa-miR-4432	CLIP-seq
MIRT2688728	hsa-miR-4522	CLIP-seq
MIRT2601733	hsa-miR-4528	CLIP-seq
MIRT2078208	hsa-miR-455-5p	CLIP-seq
MIRT2688729	hsa-miR-4667-3p	CLIP-seq
MIRT2688730	hsa-miR-4684-5p	CLIP-seq
MIRT2304677	hsa-miR-4687-3p	CLIP-seq
MIRT2601734	hsa-miR-4762-3p	CLIP-seq
MIRT2078210	hsa-miR-4764-3p	CLIP-seq
MIRT2601735	hsa-miR-4766-5p	CLIP-seq
MIRT2601736	hsa-miR-489	CLIP-seq
MIRT2601737	hsa-miR-494	CLIP-seq
MIRT2601738	hsa-miR-499-5p	CLIP-seq
MIRT2601739	hsa-miR-500b	CLIP-seq
MIRT2078211	hsa-miR-550a	CLIP-seq
MIRT2601740	hsa-miR-579	CLIP-seq
MIRT2078212	hsa-miR-7	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0004857	Function	Enzyme inhibitor activity	TAS	8132556
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 25910212, 31515488, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0006015	Process	5-phosphoribose 1-diphosphate biosynthetic process	IBA
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	8611620
GO:0006164	Process	Purine nucleotide biosynthetic process	IBA
GO:0009165	Process	Nucleotide biosynthetic process	IEA
GO:0030234	Function	Enzyme regulator activity	IBA
GO:0042802	Function	Identical protein binding	IPI	16189514, 19447967, 32296183

MIM	HGNC	e!Ensembl
601249	9466	ENSG00000161542

Protein

UniProt ID

Q14558

Protein name

Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39)

Protein function

Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.

PDB

2C4K

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13793	Pribosyltran_N	9 → 126	N-terminal domain of ribose phosphate pyrophosphokinase	Domain
PF14572	Pribosyl_synth	167 → 350	Phosphoribosyl synthetase-associated domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MNAARTGYRVFSANSTAACTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDI
FIIQTIPRDVNTAVMELLIMAYALKTACARNIIGVIPYFPYSKQSKMRKRGSIVCKLLAS
MLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIPNYRNAVIVAKSPDA
AKRAQSYAERLRLGLAVIHGEAQCTELDMDDGRHSPPMVKNATVHPGLELPLMMAKEKPP
ITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEES
SVDEVVVTNTVPHEVQKLQCPKIKTVDISLILSEAIRRIHNGESMAYLFRNITVDD

Sequence length

356

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Gout	Gout	N/A	N/A	GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Carcinoma Hepatocellular	Inhibit	28732507
Ovarian Neoplasms	Associate	31469419

PRPSAP1 (phosphoribosyl pyrophosphate synthetase associated protein 1)