Gene Gene information from NCBI Gene database.
Entrez ID 56341
Gene name Protein arginine methyltransferase 8
Gene symbol PRMT8
Synonyms (NCBI Gene)
HRMT1L3HRMT1L4
Chromosome 12
Chromosome location 12p13.32
Summary Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, p
miRNA miRNA information provided by mirtarbase database.
386
miRTarBase ID miRNA Experiments Reference
MIRT043830 hsa-miR-330-3p CLASH 23622248
MIRT610157 hsa-miR-8485 HITS-CLIP 19536157
MIRT610156 hsa-miR-329-3p HITS-CLIP 19536157
MIRT610155 hsa-miR-362-3p HITS-CLIP 19536157
MIRT618539 hsa-miR-3925-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 16051612, 17925405, 18320585, 19060904, 23455924, 25416956, 29892012, 32296183, 33961781
GO:0005634 Component Nucleus IDA 16051612
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IDA 16051612, 18320585
GO:0005886 Component Plasma membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610086 5188 ENSG00000111218
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NR22
Protein name Protein arginine N-methyltransferase 8 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4)
Protein function S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein
PDB 4X41 , 5DST
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06325 PrmA 102 201 Family
Tissue specificity TISSUE SPECIFICITY: Brain-specific. {ECO:0000269|PubMed:16051612}.
Sequence
MGMKHSSRCLLLRRKMAENAAESTEVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGK
MSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGS
GTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVD
IIISEWMGYCLFYESMLNTVI
FARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWE
NVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQR
NDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISM
KPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR
Sequence length 394
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
PELVIC ORGAN PROLAPSE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
RESTLESS LEGS SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Glioma Associate 22688887
★☆☆☆☆
Found in Text Mining only
Leukemia Myeloid Acute Associate 30289875
★☆☆☆☆
Found in Text Mining only
Neurocognitive Disorders Associate 35240980
★☆☆☆☆
Found in Text Mining only
Phenylketonurias Associate 39337507
★☆☆☆☆
Found in Text Mining only