Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5629
Gene name Gene Name - the full gene name approved by the HGNC.	Prospero homeobox 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PROX1
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q32.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene

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miRTarBase ID	miRNA	Experiments	Reference
MIRT003630	hsa-miR-181a-5p	Luciferase reporter assay, qRT-PCR, Western blot	20558617
MIRT003630	hsa-miR-181a-5p	Luciferase reporter assay, qRT-PCR, Western blot	20558617
MIRT018128	hsa-miR-335-5p	Microarray	18185580
MIRT019318	hsa-miR-148b-3p	Microarray	17612493
MIRT037355	hsa-miR-877-5p	CLASH	23622248
MIRT510934	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT510932	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT510931	hsa-miR-3924	HITS-CLIP	21572407
MIRT707916	hsa-miR-377-3p	HITS-CLIP	21572407
MIRT566288	hsa-miR-2681-5p	HITS-CLIP	21572407
MIRT510930	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT510930	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT510934	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT555208	hsa-miR-4666a-5p	PAR-CLIP	20371350
MIRT510932	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT510931	hsa-miR-3924	PAR-CLIP	20371350
MIRT566288	hsa-miR-2681-5p	PAR-CLIP	20371350
MIRT510930	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT510934	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT555212	hsa-miR-4501	PAR-CLIP	21572407
MIRT555211	hsa-miR-567	PAR-CLIP	21572407
MIRT555210	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT555209	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT555208	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT510932	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT510931	hsa-miR-3924	PAR-CLIP	21572407
MIRT555207	hsa-miR-297	PAR-CLIP	21572407
MIRT555206	hsa-miR-8070	PAR-CLIP	21572407
MIRT510934	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT510932	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT510931	hsa-miR-3924	PAR-CLIP	23446348
MIRT510930	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT003630	hsa-miR-181a-5p	Luciferase reporter assay, qRT-PCR, Western blot	25706394
MIRT003630	hsa-miR-181a-5p	Luciferase reporter assay, qRT-PCR, Western blot	25706394
MIRT555210	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT555210	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT555209	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT555209	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT733604	hsa-miR-140-5p	Immunofluorescence, qRT-PCR, Western blotting	33987369
MIRT510934	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT510932	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT510931	hsa-miR-3924	HITS-CLIP	21572407
MIRT707916	hsa-miR-377-3p	HITS-CLIP	21572407
MIRT566288	hsa-miR-2681-5p	HITS-CLIP	21572407
MIRT510930	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT510930	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT510934	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT555208	hsa-miR-4666a-5p	PAR-CLIP	20371350
MIRT510932	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT510931	hsa-miR-3924	PAR-CLIP	20371350
MIRT566288	hsa-miR-2681-5p	PAR-CLIP	20371350
MIRT510930	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT510934	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT555212	hsa-miR-4501	PAR-CLIP	21572407
MIRT555211	hsa-miR-567	PAR-CLIP	21572407
MIRT555210	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT555209	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT555208	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT510932	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT510931	hsa-miR-3924	PAR-CLIP	21572407
MIRT555207	hsa-miR-297	PAR-CLIP	21572407
MIRT555206	hsa-miR-8070	PAR-CLIP	21572407
MIRT510934	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT510932	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT510931	hsa-miR-3924	PAR-CLIP	23446348
MIRT510930	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT756420	hsa-miR-340-5p	Luciferase reporter assay, Western blotting, qRT-PCR	34495369
MIRT1265313	hsa-miR-203	CLIP-seq
MIRT1265314	hsa-miR-3150b-3p	CLIP-seq
MIRT1265315	hsa-miR-3613-3p	CLIP-seq
MIRT1265316	hsa-miR-3662	CLIP-seq
MIRT1265317	hsa-miR-4689	CLIP-seq
MIRT1265318	hsa-miR-4712-3p	CLIP-seq
MIRT1265319	hsa-miR-4784	CLIP-seq
MIRT1265320	hsa-miR-653	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
HEY1	Repression	22719258
NFKB1	Activation	19901262
PAX6	Activation	11554737
RELA	Activation	19901262

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	15205472
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	19210544
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISS
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	15143342, 15205472, 16488887, 19264593
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	19210544
GO:0001822	Process	Kidney development	IEP	8812486
GO:0001889	Process	Liver development	IEA
GO:0001889	Process	Liver development	IEP	11789987
GO:0001938	Process	Positive regulation of endothelial cell proliferation	IDA	19210544
GO:0001945	Process	Lymph vessel development	IEA
GO:0001946	Process	Lymphangiogenesis	IDA	12412020
GO:0002088	Process	Lens development in camera-type eye	IEP	8812486
GO:0002089	Process	Lens morphogenesis in camera-type eye	IEA
GO:0002194	Process	Hepatocyte cell migration	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	IMP	18815287
GO:0005515	Function	Protein binding	IPI	15205472, 16488887, 18815287, 19210544, 19264593, 21988832
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	11850194, 15143342, 15205472, 19210544
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	11850194
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006366	Process	Transcription by RNA polymerase II	IEA
GO:0007405	Process	Neuroblast proliferation	IEA
GO:0007406	Process	Negative regulation of neuroblast proliferation	IEA
GO:0007417	Process	Central nervous system development	IEA
GO:0007420	Process	Brain development	IEP	8812486
GO:0007623	Process	Circadian rhythm	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	12198161
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IMP	17062673
GO:0010468	Process	Regulation of gene expression	IDA	12198161
GO:0010468	Process	Regulation of gene expression	IEA
GO:0010595	Process	Positive regulation of endothelial cell migration	IDA	19210544
GO:0010631	Process	Epithelial cell migration	IEA
GO:0016922	Function	Nuclear receptor binding	IPI	15143342, 15205472, 16488887
GO:0021516	Process	Dorsal spinal cord development	ISS	11789987
GO:0021542	Process	Dentate gyrus development	IEA
GO:0021542	Process	Dentate gyrus development	ISS
GO:0021707	Process	Cerebellar granule cell differentiation	IEA
GO:0021707	Process	Cerebellar granule cell differentiation	ISS
GO:0021915	Process	Neural tube development	ISS	11789987
GO:0030240	Process	Skeletal muscle thin filament assembly	IEA
GO:0030240	Process	Skeletal muscle thin filament assembly	ISS
GO:0030324	Process	Lung development	IEP	8812486
GO:0030910	Process	Olfactory placode formation	ISS	11789987
GO:0031016	Process	Pancreas development	IEA
GO:0031016	Process	Pancreas development	IEP	11789987
GO:0031667	Process	Response to nutrient levels	IEA
GO:0035295	Process	Tube development	IEA
GO:0042752	Process	Regulation of circadian rhythm	IMP	23723244
GO:0043049	Process	Otic placode formation	ISS	11789987
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045071	Process	Negative regulation of viral genome replication	IDA	19264593
GO:0045165	Process	Cell fate commitment	IEA
GO:0045787	Process	Positive regulation of cell cycle	IEA
GO:0045787	Process	Positive regulation of cell cycle	ISS
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	15143342, 15205472
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	16488887, 23723244
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	18815287
GO:0046619	Process	Lens placode formation involved in camera-type eye formation	IEA
GO:0046619	Process	Lens placode formation involved in camera-type eye formation	ISS	11850194
GO:0048511	Process	Rhythmic process	IEA
GO:0048646	Process	Anatomical structure formation involved in morphogenesis	IEA
GO:0048664	Process	Neuron fate determination	IEA
GO:0048839	Process	Inner ear development	IEA
GO:0048845	Process	Venous blood vessel morphogenesis	IEA
GO:0048845	Process	Venous blood vessel morphogenesis	ISS
GO:0050692	Function	DNA binding domain binding	IPI	15205472
GO:0050693	Function	LBD domain binding	IPI	15143342, 15205472
GO:0055005	Process	Ventricular cardiac myofibril assembly	IEA
GO:0055005	Process	Ventricular cardiac myofibril assembly	ISS
GO:0055009	Process	Atrial cardiac muscle tissue morphogenesis	IEA
GO:0055009	Process	Atrial cardiac muscle tissue morphogenesis	ISS
GO:0055010	Process	Ventricular cardiac muscle tissue morphogenesis	IEA
GO:0055010	Process	Ventricular cardiac muscle tissue morphogenesis	ISS
GO:0060042	Process	Retina morphogenesis in camera-type eye	ISS	11789987
GO:0060059	Process	Embryonic retina morphogenesis in camera-type eye	IEA
GO:0060059	Process	Embryonic retina morphogenesis in camera-type eye	IEP	12692551
GO:0060214	Process	Endocardium formation	IEA
GO:0060214	Process	Endocardium formation	ISS
GO:0060298	Process	Positive regulation of sarcomere organization	IEA
GO:0060298	Process	Positive regulation of sarcomere organization	ISS
GO:0060412	Process	Ventricular septum morphogenesis	IEA
GO:0060412	Process	Ventricular septum morphogenesis	ISS
GO:0060414	Process	Aorta smooth muscle tissue morphogenesis	IEA
GO:0060414	Process	Aorta smooth muscle tissue morphogenesis	ISS
GO:0060421	Process	Positive regulation of heart growth	IEA
GO:0060421	Process	Positive regulation of heart growth	ISS
GO:0060836	Process	Lymphatic endothelial cell differentiation	IDA	12198161
GO:0060836	Process	Lymphatic endothelial cell differentiation	IEA
GO:0060836	Process	Lymphatic endothelial cell differentiation	IEA
GO:0060837	Process	Blood vessel endothelial cell differentiation	IEA
GO:0060838	Process	Lymphatic endothelial cell fate commitment	IMP	18815287
GO:0061114	Process	Branching involved in pancreas morphogenesis	IEA
GO:0070309	Process	Lens fiber cell morphogenesis	IEA
GO:0070309	Process	Lens fiber cell morphogenesis	IEP	11850194
GO:0070365	Process	Hepatocyte differentiation	IEA
GO:0070365	Process	Hepatocyte differentiation	IEP	15232737
GO:0070858	Process	Negative regulation of bile acid biosynthetic process	IMP	16488887
GO:0072574	Process	Hepatocyte proliferation	IEA
GO:0090425	Process	Acinar cell differentiation	IEA
GO:0097150	Process	Neuronal stem cell population maintenance	IEA
GO:0097150	Process	Neuronal stem cell population maintenance	ISS
GO:1900748	Process	Positive regulation of vascular endothelial growth factor signaling pathway	IMP	19210544
GO:1901978	Process	Positive regulation of cell cycle checkpoint	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:2000179	Process	Positive regulation of neural precursor cell proliferation	IEA
GO:2000179	Process	Positive regulation of neural precursor cell proliferation	ISS
GO:2000979	Process	Positive regulation of forebrain neuron differentiation	IEA
GO:2000979	Process	Positive regulation of forebrain neuron differentiation	ISS

MIM	HGNC	e!Ensembl
601546	9459	ENSG00000117707

Protein

UniProt ID

Q92786

Protein name

Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1)

Protein function

Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key

PDB

2LMD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05044	HPD	579 → 732	Homeo-prospero domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:8812486

Sequence

MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSAMNPQGSEQDVEYSVVQ
HADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTG
SEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSP
SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK
QQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMC
ELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQELNTAM
SQVVDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPNP
LDTFGNVQMASSTDQTEALPLVVRKNSSDQSASGPAAGGHHQPLHQSPLSATTGFTTSTF
RHPFPLPLMAYPFQSPLGAPSGSFSGKDRASPESLDLTRDTTSLRTKMSSHHLSHHPCSP
AHPPSTAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSS
NMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCE
LYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSE
VPEIFKSPNCLQELLHE

Sequence length

737

Interactions

View interactions

Show/Hide Unknown Diseases (7)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Anxiety Disorder	Anxiety	N/A	N/A	GWAS
Breast Cancer	Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy	N/A	N/A	GWAS
Diabetes	Type 2 diabetes (adjusted for BMI) or polycystic ovary syndrome (pleiotropy), Type 2 diabetes with neurological manifestations (PheCode 250.24), Type 2 diabetes (PheCode 250.2), Type 2 diabetes, Type 2 diabetes (age of onset), Type 2 diabetes or polycystic ovary syndrome (pleiotropy)	N/A	N/A	GWAS
Glioblastoma	Glioblastoma	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Obesity	Obesity	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (80)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Acquired Immunodeficiency Syndrome	Associate	20064070
Adenocarcinoma	Associate	22067331, 22143938
Adenocarcinoma Follicular	Associate	31060342
Albuminuria	Associate	28060188
Astrocytoma	Associate	27626492
Brain Neoplasms	Associate	27626492
Breast Neoplasms	Associate	29059430, 38206773
Carcinogenesis	Associate	18455124, 25526434, 27411302, 31060342
Carcinoma Hepatocellular	Associate	18400094, 22023334
Carcinoma Non Small Cell Lung	Associate	37925421
Carcinoma Pancreatic Ductal	Associate	27411302, 36209277
Carcinoma Renal Cell	Associate	24797520
Carcinoma Small Cell	Associate	35400238
Cholangiocarcinoma	Associate	18400094, 22067331
Colonic Diseases	Associate	18455124
Colonic Neoplasms	Associate	22067331
Colorectal Neoplasms	Stimulate	18455124, 36594098
Colorectal Neoplasms	Associate	21970873, 28854215, 29162097, 31451731, 36730426, 37224811
Death	Inhibit	27411302
Diabetes Gestational	Stimulate	32390949
Diabetes Gestational	Associate	36313769
Diabetes Mellitus	Associate	28060188, 31010169
Diabetes Mellitus Type 2	Associate	20081858, 21103350, 28060188, 31010169, 34209638
Focal Cortical Dysplasia	Associate	20452788
Glioblastoma	Associate	27626492
Glioma	Associate	21559010
Glucose Intolerance	Associate	33353041
Heart Defects Congenital	Associate	19471316
Heart Diseases	Associate	19471316
Heart Failure Diastolic	Associate	33303070
Hemangioendothelioma Epithelioid	Associate	22067331
Hemangioma	Associate	22067331
Hemangiosarcoma	Associate	21909081, 22067331
Hereditary Breast and Ovarian Cancer Syndrome	Associate	16507917, 29059430
Hyperglycemia	Associate	24122840
Hyperinsulinism	Associate	20185807
Hypoplastic Left Heart Syndrome	Associate	19471316
Infections	Stimulate	18057235
Inflammation	Associate	31010169
Intestinal Diseases	Associate	18455124
Intestinal Neoplasms	Associate	28854215
Kaposiform Hemangioendothelioma	Associate	22067331
Liver Cirrhosis	Associate	18400094
Liver Neoplasms	Associate	18400094
Lung Neoplasms	Associate	35281529
Lymphangioma	Associate	22067331
Lymphangiosarcoma	Associate	20459536
Lymphatic Metastasis	Associate	24797520, 35838046
Lymphedema	Associate	30431105
Metabolic Diseases	Associate	34209638
Mouth Neoplasms	Associate	25526434
Neoplasm Metastasis	Associate	24647631, 31060342, 34791715
Neoplasms	Associate	18400094, 18455124, 21970873, 22023334, 22067331, 24647631, 27411302, 27626492, 31060342, 31451731, 31560170, 35030967, 35786664, 36730426
Neoplasms	Inhibit	18400094, 21559010, 24797520, 25526434, 38206773
Neoplasms	Stimulate	29162097
Obesity	Associate	23818313, 34890032
Osteonecrosis	Associate	26590194
Osteosarcoma	Associate	35030967
Pancreatic Neoplasms	Associate	35786664
Pancreatitis	Associate	38273351
Paraganglioma	Associate	22067331
Pre Eclampsia	Associate	32566660
Prediabetic State	Associate	34209638
Rectal Neoplasms	Inhibit	20680711
Retinal Dysplasia	Associate	18455124
Retinoblastoma	Associate	34583623
Rhabdomyosarcoma	Associate	36459642
Right ventricle hypoplasia	Associate	19471316
Sarcoma Kaposi	Associate	20064070, 22067331, 22719258, 32518203, 32518204
Sarcoma Synovial	Associate	22067331
Squamous Cell Carcinoma of Head and Neck	Associate	24647631, 34791715, 36811957
Squamous Cell Carcinoma of Head and Neck	Inhibit	25526434
Stomach Neoplasms	Associate	25706394, 28854215, 31560170
Thrombasthenia	Associate	37486381
Thyroid cancer follicular	Associate	31060342, 31717665
Thyroid Cancer Papillary	Associate	30061172
Thyroid Neoplasms	Associate	30061172, 31060342
Urinary Bladder Neoplasms	Associate	22529986
Uterine Cervical Neoplasms	Associate	28351298
Vascular Neoplasms	Associate	20064070

PROX1 (prospero homeobox 1)