Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	56241
Gene name Gene Name - the full gene name approved by the HGNC.	Sushi domain containing 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SUSD2
Synonyms (NCBI Gene) Gene synonyms aliases	BK65A6.2, W5C5
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q11.23

Show/Hide all(136)

miRTarBase ID	miRNA	Experiments	Reference
MIRT722813	hsa-miR-1266-5p	HITS-CLIP	19536157
MIRT722812	hsa-miR-4518	HITS-CLIP	19536157
MIRT722811	hsa-miR-3934-3p	HITS-CLIP	19536157
MIRT722810	hsa-miR-296-5p	HITS-CLIP	19536157
MIRT722809	hsa-miR-6798-5p	HITS-CLIP	19536157
MIRT722808	hsa-miR-4707-5p	HITS-CLIP	19536157
MIRT722807	hsa-miR-4772-5p	HITS-CLIP	19536157
MIRT732657	hsa-miR-141-3p	Immunoprecipitaion (IP), Luciferase reporter assay, qRT-PCR	33836533
MIRT722813	hsa-miR-1266-5p	HITS-CLIP	19536157
MIRT722812	hsa-miR-4518	HITS-CLIP	19536157
MIRT722811	hsa-miR-3934-3p	HITS-CLIP	19536157
MIRT722810	hsa-miR-296-5p	HITS-CLIP	19536157
MIRT722809	hsa-miR-6798-5p	HITS-CLIP	19536157
MIRT722808	hsa-miR-4707-5p	HITS-CLIP	19536157
MIRT722807	hsa-miR-4772-5p	HITS-CLIP	19536157
MIRT1403959	hsa-let-7a	CLIP-seq
MIRT1403960	hsa-let-7b	CLIP-seq
MIRT1403961	hsa-let-7c	CLIP-seq
MIRT1403962	hsa-let-7d	CLIP-seq
MIRT1403963	hsa-let-7e	CLIP-seq
MIRT1403964	hsa-let-7f	CLIP-seq
MIRT1403965	hsa-let-7g	CLIP-seq
MIRT1403966	hsa-let-7i	CLIP-seq
MIRT1403967	hsa-miR-1200	CLIP-seq
MIRT1403968	hsa-miR-1207-5p	CLIP-seq
MIRT1403969	hsa-miR-122	CLIP-seq
MIRT1403970	hsa-miR-1231	CLIP-seq
MIRT1403971	hsa-miR-125a-3p	CLIP-seq
MIRT1403972	hsa-miR-1294	CLIP-seq
MIRT1403973	hsa-miR-1297	CLIP-seq
MIRT1403974	hsa-miR-1321	CLIP-seq
MIRT1403975	hsa-miR-1343	CLIP-seq
MIRT1403976	hsa-miR-1915	CLIP-seq
MIRT1403977	hsa-miR-202	CLIP-seq
MIRT1403978	hsa-miR-24	CLIP-seq
MIRT1403979	hsa-miR-2467-5p	CLIP-seq
MIRT1403980	hsa-miR-26a	CLIP-seq
MIRT1403981	hsa-miR-26b	CLIP-seq
MIRT1403982	hsa-miR-3127-5p	CLIP-seq
MIRT1403983	hsa-miR-3150a-3p	CLIP-seq
MIRT1403984	hsa-miR-3155	CLIP-seq
MIRT1403985	hsa-miR-3155b	CLIP-seq
MIRT1403986	hsa-miR-3175	CLIP-seq
MIRT1403987	hsa-miR-3180-5p	CLIP-seq
MIRT1403988	hsa-miR-3188	CLIP-seq
MIRT1403989	hsa-miR-3200-5p	CLIP-seq
MIRT1403990	hsa-miR-326	CLIP-seq
MIRT1403991	hsa-miR-330-5p	CLIP-seq
MIRT1403992	hsa-miR-331-5p	CLIP-seq
MIRT1403993	hsa-miR-365	CLIP-seq
MIRT1403994	hsa-miR-3663-5p	CLIP-seq
MIRT1403995	hsa-miR-3664-3p	CLIP-seq
MIRT1403996	hsa-miR-3673	CLIP-seq
MIRT1403997	hsa-miR-3714	CLIP-seq
MIRT1403998	hsa-miR-3914	CLIP-seq
MIRT1403999	hsa-miR-3918	CLIP-seq
MIRT1404000	hsa-miR-3934	CLIP-seq
MIRT1404001	hsa-miR-3975	CLIP-seq
MIRT1404002	hsa-miR-4270	CLIP-seq
MIRT1404003	hsa-miR-4278	CLIP-seq
MIRT1404004	hsa-miR-4324	CLIP-seq
MIRT1404005	hsa-miR-4326	CLIP-seq
MIRT1404006	hsa-miR-4436a	CLIP-seq
MIRT1404007	hsa-miR-4437	CLIP-seq
MIRT1404008	hsa-miR-4441	CLIP-seq
MIRT1404009	hsa-miR-4450	CLIP-seq
MIRT1404010	hsa-miR-4458	CLIP-seq
MIRT1404011	hsa-miR-4465	CLIP-seq
MIRT1404012	hsa-miR-4500	CLIP-seq
MIRT1404013	hsa-miR-4514	CLIP-seq
MIRT1404014	hsa-miR-4648	CLIP-seq
MIRT1404015	hsa-miR-4649-3p	CLIP-seq
MIRT1404016	hsa-miR-4654	CLIP-seq
MIRT1404017	hsa-miR-4667-5p	CLIP-seq
MIRT1404018	hsa-miR-4678	CLIP-seq
MIRT1404019	hsa-miR-4692	CLIP-seq
MIRT1404020	hsa-miR-4700-5p	CLIP-seq
MIRT1404021	hsa-miR-4711-5p	CLIP-seq
MIRT1404022	hsa-miR-4716-3p	CLIP-seq
MIRT1404023	hsa-miR-4726-3p	CLIP-seq
MIRT1404024	hsa-miR-4728-5p	CLIP-seq
MIRT1404025	hsa-miR-4739	CLIP-seq
MIRT1404026	hsa-miR-4753-3p	CLIP-seq
MIRT1404027	hsa-miR-4756-5p	CLIP-seq
MIRT1404028	hsa-miR-4763-3p	CLIP-seq
MIRT1404029	hsa-miR-4765	CLIP-seq
MIRT1404030	hsa-miR-4768-5p	CLIP-seq
MIRT1404031	hsa-miR-4769-5p	CLIP-seq
MIRT1404032	hsa-miR-4793-3p	CLIP-seq
MIRT1404033	hsa-miR-484	CLIP-seq
MIRT1404034	hsa-miR-485-5p	CLIP-seq
MIRT1404035	hsa-miR-507	CLIP-seq
MIRT1404036	hsa-miR-520a-5p	CLIP-seq
MIRT1404037	hsa-miR-525-5p	CLIP-seq
MIRT1404038	hsa-miR-544b	CLIP-seq
MIRT1404039	hsa-miR-557	CLIP-seq
MIRT1404040	hsa-miR-609	CLIP-seq
MIRT1404041	hsa-miR-637	CLIP-seq
MIRT1404042	hsa-miR-760	CLIP-seq
MIRT1404043	hsa-miR-764	CLIP-seq
MIRT1404044	hsa-miR-939	CLIP-seq
MIRT1404045	hsa-miR-940	CLIP-seq
MIRT1404046	hsa-miR-98	CLIP-seq
MIRT1403969	hsa-miR-122	CLIP-seq
MIRT2121194	hsa-miR-1266	CLIP-seq
MIRT1403974	hsa-miR-1321	CLIP-seq
MIRT1403976	hsa-miR-1915	CLIP-seq
MIRT2121195	hsa-miR-2110	CLIP-seq
MIRT2121196	hsa-miR-2117	CLIP-seq
MIRT1403978	hsa-miR-24	CLIP-seq
MIRT1403983	hsa-miR-3150a-3p	CLIP-seq
MIRT1403984	hsa-miR-3155	CLIP-seq
MIRT1403985	hsa-miR-3155b	CLIP-seq
MIRT2121197	hsa-miR-3162-5p	CLIP-seq
MIRT1403995	hsa-miR-3664-3p	CLIP-seq
MIRT2121198	hsa-miR-4260	CLIP-seq
MIRT2121199	hsa-miR-4273	CLIP-seq
MIRT2121200	hsa-miR-4294	CLIP-seq
MIRT2121201	hsa-miR-4433	CLIP-seq
MIRT2121202	hsa-miR-4459	CLIP-seq
MIRT2121203	hsa-miR-4464	CLIP-seq
MIRT2121204	hsa-miR-4670-3p	CLIP-seq
MIRT1404023	hsa-miR-4726-3p	CLIP-seq
MIRT1404025	hsa-miR-4739	CLIP-seq
MIRT2121205	hsa-miR-4748	CLIP-seq
MIRT1404027	hsa-miR-4756-5p	CLIP-seq
MIRT2121206	hsa-miR-4768-3p	CLIP-seq
MIRT1404033	hsa-miR-484	CLIP-seq
MIRT2121207	hsa-miR-615-5p	CLIP-seq
MIRT2121208	hsa-miR-924	CLIP-seq
MIRT1403976	hsa-miR-1915	CLIP-seq
MIRT2395437	hsa-miR-2392	CLIP-seq
MIRT1404023	hsa-miR-4726-3p	CLIP-seq
MIRT2121207	hsa-miR-615-5p	CLIP-seq
MIRT2637008	hsa-miR-1178	CLIP-seq
MIRT2637009	hsa-miR-3907	CLIP-seq

Show/Hide all(7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	23131994, 32296183
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	23131994
GO:0016021	Component	Integral component of membrane	IEA
GO:0051782	Process	Negative regulation of cell division	IDA	25351403
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:1902807	Process	Negative regulation of cell cycle G1/S phase transition	IDA	25351403

MIM	HGNC	e!Ensembl
615825	30667	ENSG00000099994

Protein

UniProt ID

Q9UGT4

Protein name

Sushi domain-containing protein 2

Protein function

May be a cytokine receptor for GPR15LG. May be a tumor suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01033	Somatomedin_B	29 → 64	Somatomedin B domain	Family
PF03782	AMOP	289 → 431	AMOP domain	Domain
PF00094	VWD	447 → 613	von Willebrand factor type D domain	Family
PF00084	Sushi	725 → 778	Sushi repeat (SCR repeat)	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus (PubMed:23131994). Also expressed in col

Sequence

MKPALLPWALLLLATALGPGPGPTADAQESCSMRCGALDGPCSCHPTCSGLGTCCLDFRD
FCLEILPYSGSMMGGKDFVVRHFKMSSPTDASVICRFKDSIQTLGHVDSSGQVHCVSPLL
YESGRIPFTVSLDNGHSFPRAGTWLAVHPNKVSMMEKSELVNETRWQYYGTANTSGNLSL
TWHVKSLPTQTITIELWGYEETGMPYSQEWTAKWSYLYPLATHIPNSGSFTFTPKPAPPS
YQRWRVGALRIIDSKNYAGQKDVQALWTNDHALAWHLSDDFREDPVAWARTQCQAWEELE
DQLPNFLEELPDCPCTLTQARADSGRFFTDYGCDMEQGSVCTYHPGAVHCVRSVQASLRY
GSGQQCCYTADGTQLLTADSSGGSTPDRGHDWGAPPFRTPPRVPSMSHWLYDVLSFYYCC
LWAPDCPRYMQRRPSNDCRNYRPPRLASAFGDPHFVTFDGTNFTFNGRGEYVLLEAALTD
LRVQARAQPGTMSNGTETRGTGLTAVAVQEGNSDVVEVRLANRTGGLEVLLNQEVLSFTE
QSWMDLKGMFLSVAAGDRVSIMLASGAGLEVSVQGPFLSVSVLLPEKFLTHTHGLLGTLN
NDPTDDFTLHSGRVLPPGTSPQELFLFGANWTVHNASSLLTYDSWFLVHNFLYQPKHDPT
FEPLFPSETTLNPSLAQEAAKLCGDDHFCNFDVAATGSLSTGTATRVAHQLHQRRMQSLQ
PVVSCGWLAPPPNGQKEGNRYLAGSTIYFHCDNGYSLAGAETSTCQADGTWSSPTPKCQP
GRSYAVLLGIIFGGLAVVAAVALVYVLLRRRKGNTHVWGAQP

Sequence length

822

Interactions

View interactions

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Amyotrophic lateral sclerosis	Amyotrophic Lateral Sclerosis	rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733 View all (171 more)	23624525
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537	29212778

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis			GWAS

Show/Hide Text Mining Associations (20)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	31387209
Carcinoma Renal Cell	Inhibit	26815503
Carcinoma Renal Cell	Associate	37328520
Chemical and Drug Induced Liver Injury	Associate	30259711
Colorectal Neoplasms	Inhibit	25351403
Congenital Microtia	Associate	37107637
Death	Inhibit	28841682
Endometrial Neoplasms	Associate	28841682
Glioma	Associate	33537815
Heart Defects Congenital	Associate	37107637
Lung Neoplasms	Inhibit	26815503
Neoplasm Metastasis	Stimulate	30259711
Neoplasm Metastasis	Associate	35894945
Neoplasms	Inhibit	26815503, 29759990
Neoplasms	Associate	30335544
Ovarian Neoplasms	Associate	29759990, 32977853, 35894945
Ovarian Neoplasms	Inhibit	30335544
Retinoblastoma	Inhibit	35259051
Stomach Neoplasms	Associate	30259711
Thrombosis	Associate	37328520

SUSD2 (sushi domain containing 2)