SUSD2 (sushi domain containing 2)

Gene

• Entrez ID: 56241
• Gene name: Sushi domain containing 2
• Gene symbol: SUSD2
• Synonyms (NCBI Gene): BK65A6.2, W5C5
• Chromosome: 22
• Chromosome location: 22q11.23

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT722813	hsa-miR-1266-5p	HITS-CLIP	19536157
MIRT722812	hsa-miR-4518	HITS-CLIP	19536157
MIRT722811	hsa-miR-3934-3p	HITS-CLIP	19536157
MIRT722810	hsa-miR-296-5p	HITS-CLIP	19536157
MIRT722809	hsa-miR-6798-5p	HITS-CLIP	19536157
MIRT722808	hsa-miR-4707-5p	HITS-CLIP	19536157
MIRT722807	hsa-miR-4772-5p	HITS-CLIP	19536157
MIRT732657	hsa-miR-141-3p	Immunoprecipitaion (IP), Luciferase reporter assay, qRT-PCR	33836533
MIRT722813	hsa-miR-1266-5p	HITS-CLIP	19536157
MIRT722812	hsa-miR-4518	HITS-CLIP	19536157
MIRT722811	hsa-miR-3934-3p	HITS-CLIP	19536157
MIRT722810	hsa-miR-296-5p	HITS-CLIP	19536157
MIRT722809	hsa-miR-6798-5p	HITS-CLIP	19536157
MIRT722808	hsa-miR-4707-5p	HITS-CLIP	19536157
MIRT722807	hsa-miR-4772-5p	HITS-CLIP	19536157
MIRT1403959	hsa-let-7a	CLIP-seq
MIRT1403960	hsa-let-7b	CLIP-seq
MIRT1403961	hsa-let-7c	CLIP-seq
MIRT1403962	hsa-let-7d	CLIP-seq
MIRT1403963	hsa-let-7e	CLIP-seq
MIRT1403964	hsa-let-7f	CLIP-seq
MIRT1403965	hsa-let-7g	CLIP-seq
MIRT1403966	hsa-let-7i	CLIP-seq
MIRT1403967	hsa-miR-1200	CLIP-seq
MIRT1403968	hsa-miR-1207-5p	CLIP-seq
MIRT1403969	hsa-miR-122	CLIP-seq
MIRT1403970	hsa-miR-1231	CLIP-seq
MIRT1403971	hsa-miR-125a-3p	CLIP-seq
MIRT1403972	hsa-miR-1294	CLIP-seq
MIRT1403973	hsa-miR-1297	CLIP-seq
MIRT1403974	hsa-miR-1321	CLIP-seq
MIRT1403975	hsa-miR-1343	CLIP-seq
MIRT1403976	hsa-miR-1915	CLIP-seq
MIRT1403977	hsa-miR-202	CLIP-seq
MIRT1403978	hsa-miR-24	CLIP-seq
MIRT1403979	hsa-miR-2467-5p	CLIP-seq
MIRT1403980	hsa-miR-26a	CLIP-seq
MIRT1403981	hsa-miR-26b	CLIP-seq
MIRT1403982	hsa-miR-3127-5p	CLIP-seq
MIRT1403983	hsa-miR-3150a-3p	CLIP-seq
MIRT1403984	hsa-miR-3155	CLIP-seq
MIRT1403985	hsa-miR-3155b	CLIP-seq
MIRT1403986	hsa-miR-3175	CLIP-seq
MIRT1403987	hsa-miR-3180-5p	CLIP-seq
MIRT1403988	hsa-miR-3188	CLIP-seq
MIRT1403989	hsa-miR-3200-5p	CLIP-seq
MIRT1403990	hsa-miR-326	CLIP-seq
MIRT1403991	hsa-miR-330-5p	CLIP-seq
MIRT1403992	hsa-miR-331-5p	CLIP-seq
MIRT1403993	hsa-miR-365	CLIP-seq
MIRT1403994	hsa-miR-3663-5p	CLIP-seq
MIRT1403995	hsa-miR-3664-3p	CLIP-seq
MIRT1403996	hsa-miR-3673	CLIP-seq
MIRT1403997	hsa-miR-3714	CLIP-seq
MIRT1403998	hsa-miR-3914	CLIP-seq
MIRT1403999	hsa-miR-3918	CLIP-seq
MIRT1404000	hsa-miR-3934	CLIP-seq
MIRT1404001	hsa-miR-3975	CLIP-seq
MIRT1404002	hsa-miR-4270	CLIP-seq
MIRT1404003	hsa-miR-4278	CLIP-seq
MIRT1404004	hsa-miR-4324	CLIP-seq
MIRT1404005	hsa-miR-4326	CLIP-seq
MIRT1404006	hsa-miR-4436a	CLIP-seq
MIRT1404007	hsa-miR-4437	CLIP-seq
MIRT1404008	hsa-miR-4441	CLIP-seq
MIRT1404009	hsa-miR-4450	CLIP-seq
MIRT1404010	hsa-miR-4458	CLIP-seq
MIRT1404011	hsa-miR-4465	CLIP-seq
MIRT1404012	hsa-miR-4500	CLIP-seq
MIRT1404013	hsa-miR-4514	CLIP-seq
MIRT1404014	hsa-miR-4648	CLIP-seq
MIRT1404015	hsa-miR-4649-3p	CLIP-seq
MIRT1404016	hsa-miR-4654	CLIP-seq
MIRT1404017	hsa-miR-4667-5p	CLIP-seq
MIRT1404018	hsa-miR-4678	CLIP-seq
MIRT1404019	hsa-miR-4692	CLIP-seq
MIRT1404020	hsa-miR-4700-5p	CLIP-seq
MIRT1404021	hsa-miR-4711-5p	CLIP-seq
MIRT1404022	hsa-miR-4716-3p	CLIP-seq
MIRT1404023	hsa-miR-4726-3p	CLIP-seq
MIRT1404024	hsa-miR-4728-5p	CLIP-seq
MIRT1404025	hsa-miR-4739	CLIP-seq
MIRT1404026	hsa-miR-4753-3p	CLIP-seq
MIRT1404027	hsa-miR-4756-5p	CLIP-seq
MIRT1404028	hsa-miR-4763-3p	CLIP-seq
MIRT1404029	hsa-miR-4765	CLIP-seq
MIRT1404030	hsa-miR-4768-5p	CLIP-seq
MIRT1404031	hsa-miR-4769-5p	CLIP-seq
MIRT1404032	hsa-miR-4793-3p	CLIP-seq
MIRT1404033	hsa-miR-484	CLIP-seq
MIRT1404034	hsa-miR-485-5p	CLIP-seq
MIRT1404035	hsa-miR-507	CLIP-seq
MIRT1404036	hsa-miR-520a-5p	CLIP-seq
MIRT1404037	hsa-miR-525-5p	CLIP-seq
MIRT1404038	hsa-miR-544b	CLIP-seq
MIRT1404039	hsa-miR-557	CLIP-seq
MIRT1404040	hsa-miR-609	CLIP-seq
MIRT1404041	hsa-miR-637	CLIP-seq
MIRT1404042	hsa-miR-760	CLIP-seq
MIRT1404043	hsa-miR-764	CLIP-seq
MIRT1404044	hsa-miR-939	CLIP-seq
MIRT1404045	hsa-miR-940	CLIP-seq
MIRT1404046	hsa-miR-98	CLIP-seq
MIRT1403969	hsa-miR-122	CLIP-seq
MIRT2121194	hsa-miR-1266	CLIP-seq
MIRT1403974	hsa-miR-1321	CLIP-seq
MIRT1403976	hsa-miR-1915	CLIP-seq
MIRT2121195	hsa-miR-2110	CLIP-seq
MIRT2121196	hsa-miR-2117	CLIP-seq
MIRT1403978	hsa-miR-24	CLIP-seq
MIRT1403983	hsa-miR-3150a-3p	CLIP-seq
MIRT1403984	hsa-miR-3155	CLIP-seq
MIRT1403985	hsa-miR-3155b	CLIP-seq
MIRT2121197	hsa-miR-3162-5p	CLIP-seq
MIRT1403995	hsa-miR-3664-3p	CLIP-seq
MIRT2121198	hsa-miR-4260	CLIP-seq
MIRT2121199	hsa-miR-4273	CLIP-seq
MIRT2121200	hsa-miR-4294	CLIP-seq
MIRT2121201	hsa-miR-4433	CLIP-seq
MIRT2121202	hsa-miR-4459	CLIP-seq
MIRT2121203	hsa-miR-4464	CLIP-seq
MIRT2121204	hsa-miR-4670-3p	CLIP-seq
MIRT1404023	hsa-miR-4726-3p	CLIP-seq
MIRT1404025	hsa-miR-4739	CLIP-seq
MIRT2121205	hsa-miR-4748	CLIP-seq
MIRT1404027	hsa-miR-4756-5p	CLIP-seq
MIRT2121206	hsa-miR-4768-3p	CLIP-seq
MIRT1404033	hsa-miR-484	CLIP-seq
MIRT2121207	hsa-miR-615-5p	CLIP-seq
MIRT2121208	hsa-miR-924	CLIP-seq
MIRT1403976	hsa-miR-1915	CLIP-seq
MIRT2395437	hsa-miR-2392	CLIP-seq
MIRT1404023	hsa-miR-4726-3p	CLIP-seq
MIRT2121207	hsa-miR-615-5p	CLIP-seq
MIRT2637008	hsa-miR-1178	CLIP-seq
MIRT2637009	hsa-miR-3907	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	23131994, 25351403, 32296183
GO:0005615	Component	Extracellular space	IBA
GO:0005886	Component	Plasma membrane	IDA	23131994
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0051782	Process	Negative regulation of cell division	IDA	25351403
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:1902807	Process	Negative regulation of cell cycle G1/S phase transition	IDA	25351403

Other IDs

• MIM: 615825
• HGNC: 30667
• e!Ensembl: ENSG00000099994

Protein

• UniProt ID: Q9UGT4
• Protein name: Sushi domain-containing protein 2
• Protein function: May be a cytokine receptor for GPR15LG. May be a tumor suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01033	Somatomedin_B	29 → 64	Somatomedin B domain	Family
  PF03782	AMOP	289 → 431	AMOP domain	Domain
  PF00094	VWD	447 → 613	von Willebrand factor type D domain	Family
  PF00084	Sushi	725 → 778	Sushi repeat (SCR repeat)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus (PubMed:23131994). Also expressed in col
• Sequence:

  MKPALLPWALLLLATALGPGPGPTADAQESCSMRCGALDGPCSCHPTCSGLGTCCLDFRD
  FCLEILPYSGSMMGGKDFVVRHFKMSSPTDASVICRFKDSIQTLGHVDSSGQVHCVSPLL
  YESGRIPFTVSLDNGHSFPRAGTWLAVHPNKVSMMEKSELVNETRWQYYGTANTSGNLSL
  TWHVKSLPTQTITIELWGYEETGMPYSQEWTAKWSYLYPLATHIPNSGSFTFTPKPAPPS
  YQRWRVGALRIIDSKNYAGQKDVQALWTNDHALAWHLSDDFREDPVAWARTQCQAWEELE
  DQLPNFLEELPDCPCTLTQARADSGRFFTDYGCDMEQGSVCTYHPGAVHCVRSVQASLRY
  GSGQQCCYTADGTQLLTADSSGGSTPDRGHDWGAPPFRTPPRVPSMSHWLYDVLSFYYCC
  LWAPDCPRYMQRRPSNDCRNYRPPRLASAFGDPHFVTFDGTNFTFNGRGEYVLLEAALTD
  LRVQARAQPGTMSNGTETRGTGLTAVAVQEGNSDVVEVRLANRTGGLEVLLNQEVLSFTE
  QSWMDLKGMFLSVAAGDRVSIMLASGAGLEVSVQGPFLSVSVLLPEKFLTHTHGLLGTLN
  NDPTDDFTLHSGRVLPPGTSPQELFLFGANWTVHNASSLLTYDSWFLVHNFLYQPKHDPT
  FEPLFPSETTLNPSLAQEAAKLCGDDHFCNFDVAATGSLSTGTATRVAHQLHQRRMQSLQ
  PVVSCGWLAPPPNGQKEGNRYLAGSTIYFHCDNGYSLAGAETSTCQADGTWSSPTPKCQP
  GRSYAVLLGIIFGGLAVVAAVALVYVLLRRRKGNTHVWGAQP

• Sequence length: 822