PRM1 (protamine 1)

Gene

• Entrez ID: 5619
• Gene name: Protamine 1
• Gene symbol: PRM1
• Synonyms (NCBI Gene): CT94.1, P1
• Chromosome: 16
• Chromosome location: 16p13.13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1264485	hsa-miR-1266	CLIP-seq
MIRT1264486	hsa-miR-3143	CLIP-seq
MIRT1264487	hsa-miR-3664-3p	CLIP-seq
MIRT1264488	hsa-miR-4269	CLIP-seq
MIRT1264489	hsa-miR-4433	CLIP-seq
MIRT1264490	hsa-miR-4490	CLIP-seq
MIRT1264491	hsa-miR-4514	CLIP-seq
MIRT1264492	hsa-miR-4518	CLIP-seq
MIRT1264493	hsa-miR-4692	CLIP-seq
MIRT1264494	hsa-miR-4722-5p	CLIP-seq
MIRT1264495	hsa-miR-4742-5p	CLIP-seq
MIRT1264496	hsa-miR-4774-5p	CLIP-seq
MIRT1264497	hsa-miR-543	CLIP-seq
MIRT1264498	hsa-miR-940	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Activation	18721868

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000786	Component	Nucleosome	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	TAS	2081589
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS	2081589
GO:0005694	Component	Chromosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	TAS	2081589
GO:0030154	Process	Cell differentiation	IEA
GO:0030261	Process	Chromosome condensation	IEA
GO:0035092	Process	Sperm DNA condensation	IEA
GO:0051276	Process	Chromosome organization	TAS	2081589

Other IDs

• MIM: 182880
• HGNC: 9447
• e!Ensembl: ENSG00000175646

Protein

• UniProt ID: P04553
• Protein name: Sperm protamine P1 (Cysteine-rich protamine)
• Protein function: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00260	Protamine_P1	2 → 50	Protamine P1	Family

• Tissue specificity: TISSUE SPECIFICITY: Testis.
• Sequence:

  MARYRCCRSQSRSRYYRQRQRSRRRRRRSCQTRRRAMRCCRPRYRPRCRRH

• Sequence length: 51

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Arthritis Juvenile	Associate	30940621	★☆☆☆☆ Found in Text Mining only
Azoospermia	Associate	34158577	★☆☆☆☆ Found in Text Mining only
Cryptorchidism	Associate	18687424	★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Associate	16952514	★☆☆☆☆ Found in Text Mining only
Infertility	Associate	16952514, 18390561, 38065301	★☆☆☆☆ Found in Text Mining only
Infertility Male	Associate	16199539, 38065301	★☆☆☆☆ Found in Text Mining only
Leukemia Prolymphocytic T Cell	Associate	19036087	★☆☆☆☆ Found in Text Mining only
Smoke Inhalation Injury	Associate	28969455	★☆☆☆☆ Found in Text Mining only
Young Syndrome	Associate	27027467	★☆☆☆☆ Found in Text Mining only