PRL (prolactin)

Gene
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5617
Gene name Gene Name - the full gene name approved by the HGNC.
Prolactin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PRL
Synonyms (NCBI Gene) Gene synonyms aliases
GHA1
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p22.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lact
Transcription factors
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(20)
Transcription factor Regulation Reference
CEBPA Unknown 17187171
CEBPB Unknown 10455153
CEBPD Unknown 10455153
CREB1 Unknown 17187171
ERF Repression 9822660
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(21)
GO ID Ontology Definition Evidence Reference
GO:0001937 Process Negative regulation of endothelial cell proliferation IDA 23619365
GO:0005148 Function Prolactin receptor binding IBA 21873635
GO:0005179 Function Hormone activity IBA 21873635
GO:0005515 Function Protein binding IPI 22325776, 23048206, 32296183
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
176760 9445 ENSG00000172179
Protein
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P01236
Protein name Prolactin (PRL)
Protein function Prolactin acts primarily on the mammary gland by promoting lactation.
PDB 1RW5 , 2Q98 , 3D48 , 3EW3 , 3MZG , 3N06 , 3N0P , 3NCB , 3NCC , 3NCE , 3NCF , 3NPZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00103 Hormone_1 15 → 227 Somatotropin hormone family Domain
Sequence
Sequence length 227
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Neuroactive ligand-receptor interaction
Hormone signaling
PI3K-Akt signaling pathway
JAK-STAT signaling pathway
Prolactin signaling pathway 		  Prolactin receptor signaling
Amyloid fiber formation
Growth hormone receptor signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (10)
Causal
Disease term Disease name dbSNP ID References
Adenocarcinoma Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular rs121913530, rs886039394, rs121913474 6280079
Anemia Anemia rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966
View all (89 more)		 10340396
Autism Autistic Disorder rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699
View all (8 more)		 18207134
Carcinoma Carcinoma, Cribriform, Carcinoma, Granular Cell rs121912654, rs555607708, rs786202962, rs1564055259 6280079
Show/Hide Unknown Diseases (4)
Unknown
Disease term Disease name Evidence References Source
Congestive heart failure Congestive heart failure 18926768 ClinVar
Endometriosis Endometriosis 11925390 ClinVar
Heart failure Heart failure, Left-Sided Heart Failure, Heart Failure, Right-Sided 18926768 ClinVar
Myocardial infarction Myocardial Failure 18926768 ClinVar
Show/Hide Text Mining Associations (143)
Associations from Text Mining
Disease Name Relationship Type References
22q11 Deletion Syndrome Associate 17653112
6 pyruvoyl tetrahydropterin synthase deficiency Associate 33234470
Abdominal Injuries Associate 31167208
Abnormalities Drug Induced Inhibit 7670563
Abortion Habitual Stimulate 26370377
Abortion Habitual Associate 31861421
Abortion Spontaneous Associate 23541403
Acromegaly Associate 38003353
Adenoma Associate 12011941, 1358601, 14762579, 15141147, 2035258, 2273209, 26884293, 27779153, 32597492, 33010004, 34530798
Adenomyosis Associate 35773139