STK31 (serine/threonine kinase 31)

Gene

• Entrez ID: 56164
• Gene name: Serine/threonine kinase 31
• Gene symbol: STK31
• Synonyms (NCBI Gene): SGK396, TDRD8
• Chromosome: 7
• Chromosome location: 7p15.3
• Summary: This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT734067	hsa-miR-543	Luciferase reporter assay, qRT-PCR	33128354

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

Other IDs

• MIM: 605790
• HGNC: 11407
• e!Ensembl: ENSG00000196335

Protein

• UniProt ID: Q9BXU1
• Protein name: Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine-protein kinase NYD-SPK) (Sugen kinase 396) (SgK396)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00567	TUDOR	28 → 147	Tudor domain	Domain
  PF00069	Pkinase	793 → 974	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Testis specific.
• Sequence:

  MWVQGHSSRASATESVSFSGIVQMDEDTHYDKVEDVVGSHIEDAVTFWAQSINRNKDIMK
  IGCSLSEVCPQASSVLGNLDPNKIYGGLFSEDQCWYRCKVLKIISVEKCLVRYIDYGNTE
  ILNRSDIVEIPLELQFSSVAKKYKLWGLHIPSDQEVTQFDQGTTFLGSLIFEKEIKMRIK
  ATSEDGTVIAQAEYGSVDIGEEVLKKGFAEKCRLASRTDICEEKKLDPGQLVLRNLKSPI
  PLWGHRSNQSTFSRPKGHLSEKMTLDLKDENDAGNLITFPKESLAVGDFNLGSNVSLEKI
  KQDQKLIEENEKLKTEKDALLESYKALELKVEQIAQELQQEKAAAVDLTNHLEYTLKTYI
  DTRMKNLAAKMEILKEMRHVDISVRFGKDLSDAIQVLDEGCFTTPASLNGLEIIWAEYSL
  AQENIKTCEYVSEGNILIAQRNEMQQKLYMSVEDFILEVDESSLNKRLKTLQDLSVSLEA
  VYGQAKEGANSDEILKKFYDWKCDKREEFTSVRSETDASLHRLVAWFQRTLKVFDLSVEG
  SLISEDAMDNIDEILEKTESSVCKELEIALVDQGDADKEIISNTYSQVLQKIHSEERLIA
  TVQAKYKDSIEFKKQLIEYLNKSPSVDHLLSIKKTLKSLKALLRWKLVEKSNLEESDDPD
  GSQIEKIKEEITQLRNNVFQEIYHEREEYEMLTSLAQKWFPELPLLHPEIGLLKYMNSGG
  LLTMSLERDLLDAEPMKELSSKRPLVRSEVNGQIILLKGYSVDVDTEAKVIERAATYHRA
  WREAEGDSGLLPLIFLFLCKSDPMAYLMVPYYPRANLNAVQANMPLNSEETLKVMKGVAQ
  GLHTLHKADIIHGSLHQNNVFALNREQGIVGDFDFTKSVSQRASVNMMVGDLSLMSPELK
  MGKPASPGSDLYAYGCLLLWLSVQNQEFEINKDGIPKVDQFHLDDKVKSLLCSLICYRSS
  MTAEQVLNAECFLMPKEQSVPNPEKDTEYTLYKKEEEIKTENLDKCMEKTRNGEANFDC

• Sequence length: 1019

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATYPICAL FEMORAL FRACTURE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEAD AND NECK MALIGNANT NEOPLASIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OROPHARYNX CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIPHERAL NEUROPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Carcinogenesis	Associate	27044426, 35389570	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	18281482, 28412729, 30753380, 31894338	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Stimulate	24667656, 35389570	★☆☆☆☆ Found in Text Mining only
Gastrointestinal Neoplasms	Associate	18281482, 28412729	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Associate	31894338	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Stimulate	28412729	★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	28412729	★☆☆☆☆ Found in Text Mining only
Neoplasms	Stimulate	18281482, 28422722	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	21097718, 24667656, 27044426, 27321817, 31894338, 35389570	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Associate	28422722	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Stimulate	36424885	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Associate	18281482, 21097718	★☆☆☆☆ Found in Text Mining only
Testicular Neoplasms	Associate	27044426, 28412729, 31894338	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Associate	27044426	★☆☆☆☆ Found in Text Mining only