Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	56142
Gene name	Protocadherin alpha 6
Gene symbol	PCDHA6
Synonyms (NCBI Gene)	CNR2CNRN2CNRS2CRNR2PCDH-ALPHA6
Chromosome	5
Chromosome location	5q31.3
Summary	This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha ge

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Show/Hide all (149)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028979	hsa-miR-26b-5p	Microarray	19088304
MIRT053676	hsa-miR-181a-5p	Microarray	22942087
MIRT053711	hsa-miR-221-3p	Microarray	22942087
MIRT637159	hsa-miR-6890-3p	HITS-CLIP	19536157
MIRT637158	hsa-miR-6823-5p	HITS-CLIP	19536157
MIRT637157	hsa-miR-7113-5p	HITS-CLIP	19536157
MIRT637156	hsa-miR-4685-5p	HITS-CLIP	19536157
MIRT637155	hsa-miR-6837-5p	HITS-CLIP	19536157
MIRT717270	hsa-miR-6741-3p	HITS-CLIP	19536157
MIRT637151	hsa-miR-1304-3p	HITS-CLIP	19536157
MIRT717269	hsa-miR-1307-3p	HITS-CLIP	19536157
MIRT717268	hsa-miR-4638-5p	HITS-CLIP	19536157
MIRT637148	hsa-miR-4772-3p	HITS-CLIP	19536157
MIRT637147	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT637145	hsa-miR-6791-3p	HITS-CLIP	19536157
MIRT637146	hsa-miR-6829-3p	HITS-CLIP	19536157
MIRT717267	hsa-miR-4284	HITS-CLIP	19536157
MIRT637143	hsa-miR-5001-3p	HITS-CLIP	19536157
MIRT637142	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT662895	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT662894	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT662893	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT662892	hsa-miR-940	HITS-CLIP	23824327
MIRT662891	hsa-miR-3929	HITS-CLIP	23824327
MIRT662890	hsa-miR-4419b	HITS-CLIP	23824327
MIRT662889	hsa-miR-4478	HITS-CLIP	23824327
MIRT662887	hsa-miR-5002-5p	HITS-CLIP	23824327
MIRT662888	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT662886	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT662885	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT662884	hsa-miR-665	HITS-CLIP	23824327
MIRT662883	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT662882	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT662881	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT662880	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT662879	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT662878	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT662877	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT662876	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT662875	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT662874	hsa-miR-3122	HITS-CLIP	23824327
MIRT662873	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT662872	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT662871	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT637160	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT637159	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT637158	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT637157	hsa-miR-7113-5p	HITS-CLIP	23824327
MIRT637156	hsa-miR-4685-5p	HITS-CLIP	23824327
MIRT637155	hsa-miR-6837-5p	HITS-CLIP	23824327
MIRT637154	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT637153	hsa-miR-4421	HITS-CLIP	23824327
MIRT637152	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT637151	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT637149	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT637150	hsa-miR-1976	HITS-CLIP	23824327
MIRT637148	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT637147	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT637145	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT637146	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT637144	hsa-miR-4279	HITS-CLIP	23824327
MIRT637143	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT637142	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT637141	hsa-miR-498	HITS-CLIP	23824327
MIRT449598	hsa-miR-548l	PAR-CLIP	22100165
MIRT449596	hsa-miR-3681-5p	PAR-CLIP	22100165
MIRT449597	hsa-miR-6849-5p	PAR-CLIP	22100165
MIRT449595	hsa-miR-4635	PAR-CLIP	22100165
MIRT449594	hsa-miR-3145-3p	PAR-CLIP	22100165
MIRT449593	hsa-miR-3201	PAR-CLIP	22100165
MIRT449592	hsa-miR-4791	PAR-CLIP	22100165
MIRT449591	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT449590	hsa-miR-376b-5p	PAR-CLIP	22100165
MIRT449589	hsa-miR-376c-5p	PAR-CLIP	22100165
MIRT449588	hsa-miR-488-3p	PAR-CLIP	22100165
MIRT449587	hsa-miR-511-5p	PAR-CLIP	22100165
MIRT637159	hsa-miR-6890-3p	HITS-CLIP	19536157
MIRT637158	hsa-miR-6823-5p	HITS-CLIP	19536157
MIRT637157	hsa-miR-7113-5p	HITS-CLIP	19536157
MIRT637156	hsa-miR-4685-5p	HITS-CLIP	19536157
MIRT637155	hsa-miR-6837-5p	HITS-CLIP	19536157
MIRT717270	hsa-miR-6741-3p	HITS-CLIP	19536157
MIRT637151	hsa-miR-1304-3p	HITS-CLIP	19536157
MIRT717269	hsa-miR-1307-3p	HITS-CLIP	19536157
MIRT717268	hsa-miR-4638-5p	HITS-CLIP	19536157
MIRT637148	hsa-miR-4772-3p	HITS-CLIP	19536157
MIRT637147	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT637145	hsa-miR-6791-3p	HITS-CLIP	19536157
MIRT637146	hsa-miR-6829-3p	HITS-CLIP	19536157
MIRT717267	hsa-miR-4284	HITS-CLIP	19536157
MIRT637143	hsa-miR-5001-3p	HITS-CLIP	19536157
MIRT637142	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT662895	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT662894	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT662893	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT662892	hsa-miR-940	HITS-CLIP	23824327
MIRT662891	hsa-miR-3929	HITS-CLIP	23824327
MIRT662890	hsa-miR-4419b	HITS-CLIP	23824327
MIRT662889	hsa-miR-4478	HITS-CLIP	23824327
MIRT662887	hsa-miR-5002-5p	HITS-CLIP	23824327
MIRT662888	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT662886	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT662885	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT662884	hsa-miR-665	HITS-CLIP	23824327
MIRT662883	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT662882	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT662881	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT662880	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT662879	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT662878	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT662877	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT662876	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT662875	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT662874	hsa-miR-3122	HITS-CLIP	23824327
MIRT662873	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT662872	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT662871	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT637160	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT637159	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT637158	hsa-miR-6823-5p	HITS-CLIP	23824327
MIRT637157	hsa-miR-7113-5p	HITS-CLIP	23824327
MIRT637156	hsa-miR-4685-5p	HITS-CLIP	23824327
MIRT637155	hsa-miR-6837-5p	HITS-CLIP	23824327
MIRT637154	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT637153	hsa-miR-4421	HITS-CLIP	23824327
MIRT637152	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT637151	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT637149	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT637150	hsa-miR-1976	HITS-CLIP	23824327
MIRT637148	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT637147	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT637145	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT637146	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT637144	hsa-miR-4279	HITS-CLIP	23824327
MIRT637143	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT637142	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT637141	hsa-miR-498	HITS-CLIP	23824327
MIRT449598	hsa-miR-548l	PAR-CLIP	22100165
MIRT449596	hsa-miR-3681-5p	PAR-CLIP	22100165
MIRT449597	hsa-miR-6849-5p	PAR-CLIP	22100165
MIRT449595	hsa-miR-4635	PAR-CLIP	22100165
MIRT449594	hsa-miR-3145-3p	PAR-CLIP	22100165
MIRT449593	hsa-miR-3201	PAR-CLIP	22100165
MIRT449592	hsa-miR-4791	PAR-CLIP	22100165
MIRT449591	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT449590	hsa-miR-376b-5p	PAR-CLIP	22100165
MIRT449589	hsa-miR-376c-5p	PAR-CLIP	22100165
MIRT449588	hsa-miR-488-3p	PAR-CLIP	22100165
MIRT449587	hsa-miR-511-5p	PAR-CLIP	22100165

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	10380929
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	TAS	10380929
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0007399	Process	Nervous system development	TAS	10380929
GO:0016020	Component	Membrane	IEA
GO:0050839	Function	Cell adhesion molecule binding	IBA

MIM	HGNC	e!Ensembl
606312	8672	ENSG00000081842

Q9UN73

Protein name

Protocadherin alpha-6 (PCDH-alpha-6)

Protein function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08266	Cadherin_2	30 → 112	Cadherin-like	Domain
PF00028	Cadherin	138 → 233	Cadherin domain	Domain
PF00028	Cadherin	247 → 341	Cadherin domain	Domain
PF00028	Cadherin	355 → 446	Cadherin domain	Domain
PF00028	Cadherin	460 → 556	Cadherin domain	Domain
PF00028	Cadherin	577 → 670	Cadherin domain	Domain
PF15974	Cadherin_tail	800 → 933	Cadherin C-terminal cytoplasmic tail, catenin-binding region	Family

Sequence

MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV
PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD
VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL
DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP
TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG
EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR
EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA
YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQVSARDA
GVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSLGAGQVVAKVRAVDAD
SGYNAWLSYELQPPASSARFPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALT
ATATVLVSLVESGQAPKASSRASVGAAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTA
LRCSAPPTEGACTADKPTLVCSSAVGSWSYSQQRRQRVCSGEGPPKMDLMAFSPSLSPCP
IMMGKAENQDLNEDHDAKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWP
TVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIR
QEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ

Sequence length

950

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POST-TRAUMATIC STRESS DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Myopia	Associate	36036911	★★★★★ ★☆☆☆☆ Found in Text Mining only

PCDHA6 (protocadherin alpha 6)