Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	5607
Gene name	Mitogen-activated protein kinase kinase 5
Gene symbol	MAP2K5
Synonyms (NCBI Gene)	HsT17454MAPKK5MEK5PRKMK5
Chromosome	15
Chromosome location	15q23
Summary	The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, a

Show/Hide all (4)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018716	hsa-miR-335-5p	Microarray	18185580
MIRT024959	hsa-miR-214-3p	Microarray;Other	19859982
MIRT438086	hsa-miR-330-3p	Genotyping	24436253
MIRT438086	hsa-miR-330-3p	Genotyping	24436253

Show/Hide all (50)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0000165	Process	MAPK cascade	IBA
GO:0000165	Process	MAPK cascade	IEA
GO:0000165	Process	MAPK cascade	IEA
GO:0000165	Process	MAPK cascade	ISS	20551324
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004672	Function	Protein kinase activity	TAS	7759517
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004708	Function	MAP kinase kinase activity	IBA
GO:0004708	Function	MAP kinase kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	7759517, 14743216, 17474147, 18588859, 21516116, 21988832, 22939624, 25241761, 28514442, 29892012, 31515488, 31980649, 32296183, 32707033, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005819	Component	Spindle	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	7759517
GO:0007507	Process	Heart development	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030307	Process	Positive regulation of cell growth	IEA
GO:0032717	Process	Negative regulation of interleukin-8 production	IEA
GO:0032717	Process	Negative regulation of interleukin-8 production	ISS	20551324
GO:0034115	Process	Negative regulation of heterotypic cell-cell adhesion	IEA
GO:0034115	Process	Negative regulation of heterotypic cell-cell adhesion	ISS	20551324
GO:0034392	Process	Negative regulation of smooth muscle cell apoptotic process	IEA
GO:0034392	Process	Negative regulation of smooth muscle cell apoptotic process	ISS
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IEA
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	ISS	20551324
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048009	Process	Insulin-like growth factor receptor signaling pathway	IEA
GO:0050679	Process	Positive regulation of epithelial cell proliferation	IEA
GO:0051247	Process	Positive regulation of protein metabolic process	IEA
GO:0051247	Process	Positive regulation of protein metabolic process	ISS
GO:0060761	Process	Negative regulation of response to cytokine stimulus	IEA
GO:0060761	Process	Negative regulation of response to cytokine stimulus	ISS	20551324
GO:0070375	Process	ERK5 cascade	IEA
GO:0071363	Process	Cellular response to growth factor stimulus	IEA
GO:0071363	Process	Cellular response to growth factor stimulus	ISS	20551324
GO:0071499	Process	Cellular response to laminar fluid shear stress	TAS	20551324
GO:0090051	Process	Negative regulation of cell migration involved in sprouting angiogenesis	IEA
GO:0090051	Process	Negative regulation of cell migration involved in sprouting angiogenesis	ISS	20551324
GO:0106310	Function	Protein serine kinase activity	IEA
GO:2000342	Process	Negative regulation of chemokine (C-X-C motif) ligand 2 production	IEA
GO:2000342	Process	Negative regulation of chemokine (C-X-C motif) ligand 2 production	ISS	20551324
GO:2001240	Process	Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA
GO:2001240	Process	Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISS	20551324

MIM	HGNC	e!Ensembl
602520	6845	ENSG00000137764

Q13163

Protein name

Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)

Protein function

Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac developme

PDB

2NPT , 2O2V , 4IC7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00564	PB1	18 → 100	PB1 domain	Domain
PF00069	Pkinase	166 → 419	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in many adult tissues. Abundant in heart and skeletal muscle.

Sequence

MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF
EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL
KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC
TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC
DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ
KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV
QFNDGNAAVVSMWVCRALEERRSQQGPP

Sequence length

448

Interactions

View interactions

	KEGG
	MAPK signaling pathway Gap junction Neurotrophin signaling pathway Oxytocin signaling pathway Fluid shear stress and atherosclerosis

MAP2K5 (mitogen-activated protein kinase kinase 5)