Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55971
Gene name Gene Name - the full gene name approved by the HGNC.	BAR/IMD domain containing adaptor protein 2 like 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	BAIAP2L1
Synonyms (NCBI Gene) Gene synonyms aliases	IRTKS
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q21.3-q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by th

Show/Hide all(156)

miRTarBase ID	miRNA	Experiments
MIRT740076	hsa-miR-1184	CLIP-seq
MIRT815516	hsa-miR-1205	CLIP-seq
MIRT815517	hsa-miR-1250	CLIP-seq
MIRT815518	hsa-miR-1262	CLIP-seq
MIRT815519	hsa-miR-1297	CLIP-seq
MIRT815520	hsa-miR-151-3p	CLIP-seq
MIRT815521	hsa-miR-1827	CLIP-seq
MIRT815522	hsa-miR-188-5p	CLIP-seq
MIRT740074	hsa-miR-205	CLIP-seq
MIRT815523	hsa-miR-2054	CLIP-seq
MIRT815524	hsa-miR-216a	CLIP-seq
MIRT815525	hsa-miR-2278	CLIP-seq
MIRT815526	hsa-miR-26a	CLIP-seq
MIRT815527	hsa-miR-26b	CLIP-seq
MIRT740075	hsa-miR-3127-3p	CLIP-seq
MIRT815528	hsa-miR-3145-3p	CLIP-seq
MIRT815529	hsa-miR-3148	CLIP-seq
MIRT815530	hsa-miR-3158-5p	CLIP-seq
MIRT815531	hsa-miR-3160-3p	CLIP-seq
MIRT815532	hsa-miR-3170	CLIP-seq
MIRT815533	hsa-miR-3192	CLIP-seq
MIRT815534	hsa-miR-3612	CLIP-seq
MIRT815535	hsa-miR-3659	CLIP-seq
MIRT815536	hsa-miR-3663-5p	CLIP-seq
MIRT815537	hsa-miR-3665	CLIP-seq
MIRT815538	hsa-miR-3689a-3p	CLIP-seq
MIRT815539	hsa-miR-3689c	CLIP-seq
MIRT815540	hsa-miR-3714	CLIP-seq
MIRT815541	hsa-miR-382	CLIP-seq
MIRT815542	hsa-miR-4269	CLIP-seq
MIRT815543	hsa-miR-4314	CLIP-seq
MIRT740071	hsa-miR-4447	CLIP-seq
MIRT815544	hsa-miR-4457	CLIP-seq
MIRT815545	hsa-miR-4465	CLIP-seq
MIRT740070	hsa-miR-4472	CLIP-seq
MIRT815546	hsa-miR-4477a	CLIP-seq
MIRT815547	hsa-miR-4477b	CLIP-seq
MIRT815548	hsa-miR-4484	CLIP-seq
MIRT815549	hsa-miR-4487	CLIP-seq
MIRT815550	hsa-miR-4490	CLIP-seq
MIRT815551	hsa-miR-4527	CLIP-seq
MIRT815552	hsa-miR-4532	CLIP-seq
MIRT815553	hsa-miR-4646-5p	CLIP-seq
MIRT815554	hsa-miR-4658	CLIP-seq
MIRT815555	hsa-miR-4663	CLIP-seq
MIRT815556	hsa-miR-4690-5p	CLIP-seq
MIRT815557	hsa-miR-4699-3p	CLIP-seq
MIRT815558	hsa-miR-4701-3p	CLIP-seq
MIRT815559	hsa-miR-4728-5p	CLIP-seq
MIRT815560	hsa-miR-4729	CLIP-seq
MIRT815561	hsa-miR-4731-3p	CLIP-seq
MIRT815562	hsa-miR-4760-3p	CLIP-seq
MIRT740077	hsa-miR-4763-5p	CLIP-seq
MIRT815563	hsa-miR-4772-3p	CLIP-seq
MIRT815564	hsa-miR-4780	CLIP-seq
MIRT815565	hsa-miR-4792	CLIP-seq
MIRT815566	hsa-miR-4795-3p	CLIP-seq
MIRT815567	hsa-miR-4797-5p	CLIP-seq
MIRT815568	hsa-miR-4801	CLIP-seq
MIRT815569	hsa-miR-490-3p	CLIP-seq
MIRT740072	hsa-miR-541	CLIP-seq
MIRT815570	hsa-miR-548an	CLIP-seq
MIRT740078	hsa-miR-550a	CLIP-seq
MIRT815571	hsa-miR-558	CLIP-seq
MIRT815572	hsa-miR-561	CLIP-seq
MIRT815573	hsa-miR-574-5p	CLIP-seq
MIRT815574	hsa-miR-579	CLIP-seq
MIRT815575	hsa-miR-623	CLIP-seq
MIRT815576	hsa-miR-650	CLIP-seq
MIRT740073	hsa-miR-654-5p	CLIP-seq
MIRT815577	hsa-miR-657	CLIP-seq
MIRT815578	hsa-miR-664	CLIP-seq
MIRT1941249	hsa-miR-103a	CLIP-seq
MIRT1941250	hsa-miR-107	CLIP-seq
MIRT815519	hsa-miR-1297	CLIP-seq
MIRT1941251	hsa-miR-149	CLIP-seq
MIRT1941252	hsa-miR-15a	CLIP-seq
MIRT1941253	hsa-miR-15b	CLIP-seq
MIRT1941254	hsa-miR-16	CLIP-seq
MIRT1941255	hsa-miR-195	CLIP-seq
MIRT1941256	hsa-miR-24	CLIP-seq
MIRT815526	hsa-miR-26a	CLIP-seq
MIRT815527	hsa-miR-26b	CLIP-seq
MIRT1941257	hsa-miR-3064-5p	CLIP-seq
MIRT1941258	hsa-miR-3126-3p	CLIP-seq
MIRT815540	hsa-miR-3714	CLIP-seq
MIRT1941259	hsa-miR-3934	CLIP-seq
MIRT1941260	hsa-miR-3944-5p	CLIP-seq
MIRT1941261	hsa-miR-424	CLIP-seq
MIRT1941262	hsa-miR-4284	CLIP-seq
MIRT815545	hsa-miR-4465	CLIP-seq
MIRT815552	hsa-miR-4532	CLIP-seq
MIRT815563	hsa-miR-4772-3p	CLIP-seq
MIRT1941263	hsa-miR-4794	CLIP-seq
MIRT1941264	hsa-miR-497	CLIP-seq
MIRT1941249	hsa-miR-103a	CLIP-seq
MIRT1941250	hsa-miR-107	CLIP-seq
MIRT2180029	hsa-miR-122	CLIP-seq
MIRT2180030	hsa-miR-125a-3p	CLIP-seq
MIRT815519	hsa-miR-1297	CLIP-seq
MIRT1941251	hsa-miR-149	CLIP-seq
MIRT1941252	hsa-miR-15a	CLIP-seq
MIRT1941253	hsa-miR-15b	CLIP-seq
MIRT1941254	hsa-miR-16	CLIP-seq
MIRT815522	hsa-miR-188-5p	CLIP-seq
MIRT2180031	hsa-miR-1910	CLIP-seq
MIRT1941255	hsa-miR-195	CLIP-seq
MIRT1941256	hsa-miR-24	CLIP-seq
MIRT815526	hsa-miR-26a	CLIP-seq
MIRT815527	hsa-miR-26b	CLIP-seq
MIRT2180032	hsa-miR-298	CLIP-seq
MIRT1941257	hsa-miR-3064-5p	CLIP-seq
MIRT2180033	hsa-miR-3074-3p	CLIP-seq
MIRT1941258	hsa-miR-3126-3p	CLIP-seq
MIRT2180034	hsa-miR-3140-5p	CLIP-seq
MIRT1941259	hsa-miR-3934	CLIP-seq
MIRT1941260	hsa-miR-3944-5p	CLIP-seq
MIRT1941261	hsa-miR-424	CLIP-seq
MIRT1941262	hsa-miR-4284	CLIP-seq
MIRT2180035	hsa-miR-4422	CLIP-seq
MIRT740071	hsa-miR-4447	CLIP-seq
MIRT815545	hsa-miR-4465	CLIP-seq
MIRT740070	hsa-miR-4472	CLIP-seq
MIRT2180036	hsa-miR-4492	CLIP-seq
MIRT2180037	hsa-miR-4498	CLIP-seq
MIRT815552	hsa-miR-4532	CLIP-seq
MIRT2180038	hsa-miR-4676-5p	CLIP-seq
MIRT815560	hsa-miR-4729	CLIP-seq
MIRT2180039	hsa-miR-4766-5p	CLIP-seq
MIRT815563	hsa-miR-4772-3p	CLIP-seq
MIRT1941263	hsa-miR-4794	CLIP-seq
MIRT1941264	hsa-miR-497	CLIP-seq
MIRT2180040	hsa-miR-575	CLIP-seq
MIRT2180041	hsa-miR-762	CLIP-seq
MIRT2180042	hsa-miR-764	CLIP-seq
MIRT2180043	hsa-miR-892b	CLIP-seq
MIRT815519	hsa-miR-1297	CLIP-seq
MIRT815526	hsa-miR-26a	CLIP-seq
MIRT815527	hsa-miR-26b	CLIP-seq
MIRT815545	hsa-miR-4465	CLIP-seq
MIRT815552	hsa-miR-4532	CLIP-seq
MIRT815519	hsa-miR-1297	CLIP-seq
MIRT815526	hsa-miR-26a	CLIP-seq
MIRT815527	hsa-miR-26b	CLIP-seq
MIRT815545	hsa-miR-4465	CLIP-seq
MIRT815552	hsa-miR-4532	CLIP-seq
MIRT815519	hsa-miR-1297	CLIP-seq
MIRT815526	hsa-miR-26a	CLIP-seq
MIRT815527	hsa-miR-26b	CLIP-seq
MIRT815545	hsa-miR-4465	CLIP-seq
MIRT815552	hsa-miR-4532	CLIP-seq
MIRT815519	hsa-miR-1297	CLIP-seq
MIRT815526	hsa-miR-26a	CLIP-seq
MIRT815527	hsa-miR-26b	CLIP-seq
MIRT815545	hsa-miR-4465	CLIP-seq
MIRT815552	hsa-miR-4532	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	21098279, 22921828, 25519916, 32296183
GO:0005654	Component	Nucleoplasm	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA	19366662
GO:0005886	Component	Plasma membrane	IDA
GO:0005912	Component	Adherens junction	HDA	25468996
GO:0007009	Process	Plasma membrane organization	IEA
GO:0009617	Process	Response to bacterium	IDA	19366662
GO:0015629	Component	Actin cytoskeleton	IDA	19366662
GO:0030838	Process	Positive regulation of actin filament polymerization	IBA	21873635
GO:0030838	Process	Positive regulation of actin filament polymerization	IDA	21098279
GO:0046626	Process	Regulation of insulin receptor signaling pathway	IEA
GO:0051017	Process	Actin filament bundle assembly	IBA	21873635
GO:0051764	Process	Actin crosslink formation	IBA	21873635
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0070064	Function	Proline-rich region binding	IDA	21098279
GO:0098609	Process	Cell-cell adhesion	IEA
GO:0098641	Function	Cadherin binding involved in cell-cell adhesion	HDA	25468996
GO:2000251	Process	Positive regulation of actin cytoskeleton reorganization	IBA	21873635
GO:2000251	Process	Positive regulation of actin cytoskeleton reorganization	IMP	19366662

MIM	HGNC	e!Ensembl
611877	21649	ENSG00000006453

Protein

UniProt ID

Q9UHR4

Protein name

BAR/IMD domain-containing adapter protein 2-like 1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1) (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)

Protein function

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662,

PDB

2KXC , 2LNH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08397	IMD	16 → 236	IRSp53/MIM homology domain	Family
PF14604	SH3_9	347 → 398	Variant SH3 domain	Domain

Sequence

MSRGPEEVNRLTESTYRNVMEQFNPGLRNLINLGKNYEKAVNAMILAGKAYYDGVAKIGE
IATGSPVSTELGHVLIEISSTHKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATLK
RYQTEHKNKLESLEKSQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSRQSEIQKFIAD
GCKEALLEEKRRFCFLVDKHCGFANHIHYYHLQSAELLNSKLPRWQETCVDAIKVPEKIM
NMIEEIKTPASTPVSGTPQASPMIERSNVVRKDYDTLSKCSPKMPPAPSGRAYTSPLIDM
FNNPATAAPNSQRVNNSTGTSEDPSLQRSVSVATGLNMMKKQKVKTIFPHTAGSNKTLLS
FAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSYTKLLEENETEAVTVPTPSPTPVRS
ISTVNLSENSSVVIPPPDYLECLSMGAAADRRADSARTTSTFKAPASKPETAAPNDANGT
AKPPFLSGENPFATVKLRPTVTNDRSAPIIR

Sequence length

511

Interactions

View interactions

	KEGG
	Pathogenic Escherichia coli infection

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451 View all (71 more)	29059683
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	17568789

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Evidence	Source
Unknown
Breast cancer	Breast cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA
Gout	Gout		GWAS
Hypogonadism	Hypogonadism		GWAS

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Stimulate	36308067
Carcinoma Hepatocellular	Associate	26222696
Lymphatic Metastasis	Stimulate	36308067
Neoplasms	Associate	26222696, 26892443, 37248248
Ovarian Neoplasms	Stimulate	26222696
Pancreatic Neoplasms	Associate	34321959
Stomach Neoplasms	Associate	34374630
Thyroid Cancer Papillary	Associate	36217175
Thyroiditis	Associate	36217175
Triple Negative Breast Neoplasms	Associate	36308067

BAIAP2L1 (BAR/IMD domain containing adaptor protein 2 like 1)