Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55959
Gene name Gene Name - the full gene name approved by the HGNC.
Sulfatase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SULF2
Synonyms (NCBI Gene) Gene synonyms aliases
HSULF-2
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20q13.12
Summary Summary of gene provided in NCBI Entrez Gene.
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan su
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016500 hsa-miR-193b-3p Microarray 20304954
MIRT636206 hsa-miR-605-5p HITS-CLIP 23824327
MIRT636204 hsa-miR-339-5p HITS-CLIP 23824327
MIRT636202 hsa-miR-4425 HITS-CLIP 23824327
MIRT636203 hsa-miR-3147 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001822 Process Kidney development ISS
GO:0002063 Process Chondrocyte development ISS
GO:0003094 Process Glomerular filtration ISS
GO:0004065 Function Arylsulfatase activity IDA 12368295
GO:0004065 Function Arylsulfatase activity IMP 19520866
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610013 20392 ENSG00000196562
Protein
UniProt ID Q8IWU5
Protein name Extracellular sulfatase Sulf-2 (hSulf-2) (Arylsulfatase) (EC 3.1.6.1) (N-acetylglucosamine-6-sulfatase) (EC 3.1.6.14) [Cleaved into: Extracellular sulfatase Sulf-2 secreted form]
Protein function Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:30788513, PubMed:35294879). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00884 Sulfatase 44 375 Sulfatase Family
PF12548 DUF3740 528 664 Sulfatase protein Family
Tissue specificity TISSUE SPECIFICITY: Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney and placenta. {ECO:0000269|PubMed:12368295}.
Sequence
MGPPSLVLCLLSATVFSLLGGSSAFLSHHRLKGRFQRDRRNIRPNIILVLTDDQDVELGS
MQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVHNHNTYTNNENCSSPSWQA
QHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVK
EKHGSDYSKDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFP
NASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNM
LVETGELDNTYIVYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGCLNPHIV
LNIDLAPTILDIAGL
DIPADMDGKSILKLLDTERPVNRFHLKKKMRVWRDSFLVERGKLL
HKRDNDKVDAQEENFLPKYQRVKDLCQRAEYQTACEQLGQKWQCVEDATGKLKLHKCKGP
MRLGGSRALSNLVPKYYGQGSEACTCDSGDYKLSLAGRRKKLFKKKYKASYVRSRSIRSV
AIEVDGRVYHVGLGDAAQPRNLTKRHWPGAPEDQDDKDGGDFSGTGGLPDYSAANPIKVT
HRCYILENDTVQCDLDLYKSLQAWKDHKLHIDHEIETLQNKIKNLREVRGHLKKKRPEEC
DCHK
ISYHTQHKGRLKHRGSSLHPFRKGLQEKDKVWLLREQKRKKKLRKLLKRLQNNDTC
SMPGLTCFTHDNQHWQTAPFWTLGPFCACTSANNNTYWCMRTINETHNFLFCEFATGFLE
YFDLNTDPYQLMNAVNTLDRDVLNQLHVQLMELRSCKGYKQCNPRTRNMDLGLKDGGSYE
QYRQFQRRKWPEMKRPSSKSLGQLWEGWEG
Sequence length 870
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Unknown
Disease term Disease name Evidence References Source
Endometriosis Endometriosis 21063030, 20864642 ClinVar
Atrial Fibrillation Atrial Fibrillation GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Oligodendroglioma Oligodendroglioma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 26882224
Atherosclerosis Associate 24339435
Breast Neoplasms Associate 19056696, 21599997, 27506935
Carcinogenesis Stimulate 17460759
Carcinogenesis Associate 25887999
Carcinoma Hepatocellular Associate 21040406, 21104785, 21599997, 24612962, 33076548
Carcinoma Non Small Cell Lung Associate 26882224, 31499680
Carcinoma Pancreatic Ductal Associate 27560551
Carcinoma Renal Cell Associate 21739484, 27589337
Cell Transformation Neoplastic Associate 19056696, 25887999