APOM (apolipoprotein M)

Gene
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55937
Gene name Gene Name - the full gene name approved by the HGNC.
Apolipoprotein M
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
APOM
Synonyms (NCBI Gene) Gene synonyms aliases
G3a, HSPC336, NG20, apo-M
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.33
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded pr
Transcription factors
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(4)
Transcription factor Regulation Reference
HNF1A Unknown 21454713
JUN Unknown 21454713
JUNB Unknown 21454713
NR4A2 Unknown 17977826
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(40)
GO ID Ontology Definition Evidence Reference
GO:0005319 Function Lipid transporter activity IBA
GO:0005319 Function Lipid transporter activity IDA 16682745
GO:0005543 Function Phospholipid binding IBA
GO:0005543 Function Phospholipid binding IDA 22204862
GO:0005576 Component Extracellular region IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
606907 13916 ENSG00000204444
Protein
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O95445
Protein name Apolipoprotein M (Apo-M) (ApoM) (Protein G3a)
Protein function Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
PDB 2WEW , 2WEX , 2YG2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF11032 ApoM 1 → 187 ApoM domain Domain
Tissue specificity TISSUE SPECIFICITY: Plasma protein. Expressed in liver and kidney.
Sequence
Sequence length 188
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Retinoid metabolism and transport
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Lung adenocarcinoma Lung adenocarcinoma N/A N/A GWAS
Rheumatoid arthritis Rheumatoid arthritis N/A N/A GWAS
Show/Hide Text Mining Associations (47)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abnormalities Drug Induced Associate 37181037
Alzheimer Disease Associate 26950848
Arthritis Rheumatoid Associate 21844665, 24341666, 26686423
Atherosclerosis Inhibit 21454713
Atherosclerosis Associate 24642298, 31791242, 36980195
Blood Coagulation Disorders Associate 32237898
Carcinoma Hepatocellular Associate 22995142
Carcinoma Renal Cell Inhibit 37211224
Cardiovascular Diseases Associate 30869115
Colorectal Neoplasms Associate 20846402, 29067439