PRKG2 (protein kinase cGMP-dependent 2)

Gene

• Entrez ID: 5593
• Gene name: Protein kinase cGMP-dependent 2
• Gene symbol: PRKG2
• Synonyms (NCBI Gene): AMD4, PKG2, PRKGR2, SMDP, cGK2, cGKII
• Disease Acronyms (UniProt): AMD4, SMDP
• Chromosome: 4
• Chromosome location: 4q21.21
• Summary: This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosine kinases. The membrane-bound protein is a regulator of intestinal secr

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018075	hsa-miR-335-5p	Microarray	18185580
MIRT023857	hsa-miR-1-3p	Microarray	18668037
MIRT618399	hsa-miR-548a-5p	HITS-CLIP	23824327
MIRT618398	hsa-miR-548ab	HITS-CLIP	23824327
MIRT618397	hsa-miR-548ad-5p	HITS-CLIP	23824327
MIRT618396	hsa-miR-548ae-5p	HITS-CLIP	23824327
MIRT618395	hsa-miR-548ak	HITS-CLIP	23824327
MIRT618394	hsa-miR-548am-5p	HITS-CLIP	23824327
MIRT618393	hsa-miR-548ap-5p	HITS-CLIP	23824327
MIRT618392	hsa-miR-548aq-5p	HITS-CLIP	23824327
MIRT618391	hsa-miR-548ar-5p	HITS-CLIP	23824327
MIRT618390	hsa-miR-548as-5p	HITS-CLIP	23824327
MIRT618389	hsa-miR-548au-5p	HITS-CLIP	23824327
MIRT618388	hsa-miR-548ay-5p	HITS-CLIP	23824327
MIRT618387	hsa-miR-548b-5p	HITS-CLIP	23824327
MIRT618386	hsa-miR-548bb-5p	HITS-CLIP	23824327
MIRT618385	hsa-miR-548c-5p	HITS-CLIP	23824327
MIRT618384	hsa-miR-548d-5p	HITS-CLIP	23824327
MIRT618383	hsa-miR-548h-5p	HITS-CLIP	23824327
MIRT618382	hsa-miR-548i	HITS-CLIP	23824327
MIRT618381	hsa-miR-548j-5p	HITS-CLIP	23824327
MIRT618380	hsa-miR-548o-5p	HITS-CLIP	23824327
MIRT618379	hsa-miR-548w	HITS-CLIP	23824327
MIRT618378	hsa-miR-548y	HITS-CLIP	23824327
MIRT618377	hsa-miR-559	HITS-CLIP	23824327
MIRT618376	hsa-miR-548av-5p	HITS-CLIP	23824327
MIRT618375	hsa-miR-548k	HITS-CLIP	23824327
MIRT618374	hsa-miR-8054	HITS-CLIP	23824327
MIRT618373	hsa-miR-548l	HITS-CLIP	23824327
MIRT618372	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT618371	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT618370	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT618369	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT618399	hsa-miR-548a-5p	HITS-CLIP	23824327
MIRT618398	hsa-miR-548ab	HITS-CLIP	23824327
MIRT618397	hsa-miR-548ad-5p	HITS-CLIP	23824327
MIRT618396	hsa-miR-548ae-5p	HITS-CLIP	23824327
MIRT618395	hsa-miR-548ak	HITS-CLIP	23824327
MIRT618394	hsa-miR-548am-5p	HITS-CLIP	23824327
MIRT618393	hsa-miR-548ap-5p	HITS-CLIP	23824327
MIRT618392	hsa-miR-548aq-5p	HITS-CLIP	23824327
MIRT618391	hsa-miR-548ar-5p	HITS-CLIP	23824327
MIRT618390	hsa-miR-548as-5p	HITS-CLIP	23824327
MIRT618389	hsa-miR-548au-5p	HITS-CLIP	23824327
MIRT618388	hsa-miR-548ay-5p	HITS-CLIP	23824327
MIRT618387	hsa-miR-548b-5p	HITS-CLIP	23824327
MIRT618386	hsa-miR-548bb-5p	HITS-CLIP	23824327
MIRT618385	hsa-miR-548c-5p	HITS-CLIP	23824327
MIRT618384	hsa-miR-548d-5p	HITS-CLIP	23824327
MIRT618383	hsa-miR-548h-5p	HITS-CLIP	23824327
MIRT618382	hsa-miR-548i	HITS-CLIP	23824327
MIRT618381	hsa-miR-548j-5p	HITS-CLIP	23824327
MIRT618380	hsa-miR-548o-5p	HITS-CLIP	23824327
MIRT618379	hsa-miR-548w	HITS-CLIP	23824327
MIRT618378	hsa-miR-548y	HITS-CLIP	23824327
MIRT618377	hsa-miR-559	HITS-CLIP	23824327
MIRT618376	hsa-miR-548av-5p	HITS-CLIP	23824327
MIRT618375	hsa-miR-548k	HITS-CLIP	23824327
MIRT618374	hsa-miR-8054	HITS-CLIP	23824327
MIRT618373	hsa-miR-548l	HITS-CLIP	23824327
MIRT618372	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT618371	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT618370	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT618369	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT1263666	hsa-miR-1267	CLIP-seq
MIRT1263667	hsa-miR-185	CLIP-seq
MIRT1263668	hsa-miR-298	CLIP-seq
MIRT1263669	hsa-miR-3678-3p	CLIP-seq
MIRT1263670	hsa-miR-4306	CLIP-seq
MIRT1263671	hsa-miR-4428	CLIP-seq
MIRT1263672	hsa-miR-4644	CLIP-seq
MIRT1263673	hsa-miR-4652-3p	CLIP-seq
MIRT1263674	hsa-miR-548a-3p	CLIP-seq
MIRT1263675	hsa-miR-548ae	CLIP-seq
MIRT1263676	hsa-miR-548aj	CLIP-seq
MIRT1263677	hsa-miR-548am	CLIP-seq
MIRT1263678	hsa-miR-548e	CLIP-seq
MIRT1263679	hsa-miR-548f	CLIP-seq
MIRT1263680	hsa-miR-548x	CLIP-seq
MIRT1263681	hsa-miR-578	CLIP-seq
MIRT2077600	hsa-miR-4496	CLIP-seq
MIRT2077601	hsa-miR-651	CLIP-seq
MIRT2304149	hsa-miR-3647-3p	CLIP-seq
MIRT2304150	hsa-miR-4729	CLIP-seq
MIRT2601115	hsa-miR-1251	CLIP-seq
MIRT2601116	hsa-miR-219-5p	CLIP-seq
MIRT2601117	hsa-miR-3190	CLIP-seq
MIRT2601118	hsa-miR-3920	CLIP-seq
MIRT2601119	hsa-miR-3978	CLIP-seq
MIRT2601120	hsa-miR-4252	CLIP-seq
MIRT2601121	hsa-miR-4274	CLIP-seq
MIRT2601122	hsa-miR-4445	CLIP-seq
MIRT2601123	hsa-miR-4519	CLIP-seq
MIRT2601124	hsa-miR-4752	CLIP-seq
MIRT2601125	hsa-miR-4782-3p	CLIP-seq
MIRT2601126	hsa-miR-495	CLIP-seq
MIRT2601127	hsa-miR-508-3p	CLIP-seq
MIRT2601128	hsa-miR-539	CLIP-seq
MIRT2601129	hsa-miR-580	CLIP-seq
MIRT2601130	hsa-miR-760	CLIP-seq
MIRT2601115	hsa-miR-1251	CLIP-seq
MIRT2688647	hsa-miR-2054	CLIP-seq
MIRT2601116	hsa-miR-219-5p	CLIP-seq
MIRT2601117	hsa-miR-3190	CLIP-seq
MIRT2688648	hsa-miR-374c	CLIP-seq
MIRT2688649	hsa-miR-380	CLIP-seq
MIRT2601118	hsa-miR-3920	CLIP-seq
MIRT2601119	hsa-miR-3978	CLIP-seq
MIRT2601120	hsa-miR-4252	CLIP-seq
MIRT2601121	hsa-miR-4274	CLIP-seq
MIRT2601122	hsa-miR-4445	CLIP-seq
MIRT2601123	hsa-miR-4519	CLIP-seq
MIRT2601124	hsa-miR-4752	CLIP-seq
MIRT2601125	hsa-miR-4782-3p	CLIP-seq
MIRT2601126	hsa-miR-495	CLIP-seq
MIRT2688650	hsa-miR-499-3p	CLIP-seq
MIRT2688651	hsa-miR-499a-3p	CLIP-seq
MIRT2601127	hsa-miR-508-3p	CLIP-seq
MIRT2601128	hsa-miR-539	CLIP-seq
MIRT2601129	hsa-miR-580	CLIP-seq
MIRT2688652	hsa-miR-655	CLIP-seq
MIRT2601130	hsa-miR-760	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004672	Function	Protein kinase activity	TAS	8607838
GO:0004692	Function	CGMP-dependent protein kinase activity	TAS
GO:0005524	Function	ATP binding	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006468	Process	Protein phosphorylation	IMP	15905169
GO:0007165	Process	Signal transduction	TAS	8607838
GO:0016324	Component	Apical plasma membrane	IEA
GO:0030553	Function	CGMP binding	IEA
GO:0031965	Component	Nuclear membrane	IEA
GO:0036289	Process	Peptidyl-serine autophosphorylation	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0072659	Process	Protein localization to plasma membrane	IEA
GO:2001226	Process	Negative regulation of chloride transport	IEA

Other IDs

• MIM: 601591
• HGNC: 9416
• e!Ensembl: ENSG00000138669

Protein

• UniProt ID: Q13237
• Protein name: cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII)
• Protein function: Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379). Acts d
• PDB: 5BV6, 5C6C, 5C8W, 5JIX, 5JIZ, 6BQ8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00027	cNMP_binding	186 → 269	Cyclic nucleotide-binding domain	Domain
  PF00027	cNMP_binding	304 → 393	Cyclic nucleotide-binding domain	Domain
  PF00069	Pkinase	453 → 711	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly concentrated in brain, lung and intestinal mucosa.
• Sequence:

  MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK
  QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG
  AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM
  VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC
  TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID
  CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL
  ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS
  MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA
  MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS
  ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK
  IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN
  LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK
  ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF

• Sequence length: 762

Pathways

KEGG:

cGMP-PKG signaling pathway
Hormone signaling
Gap junction
Platelet activation
Circadian entrainment
Thermogenesis
Long-term depression
Olfactory transduction
Regulation of lipolysis in adipocytes
Renin secretion
Salivary secretion

Reactome:

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
cGMP effects

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Colorectal cancer	Adenocarcinoma of large intestine	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208

Unknown
Disease term	Disease name	Evidence	References	Source
Acromesomelic dysplasia	acromesomelic dysplasia 4			GenCC
Schizophrenia	Schizophrenia			GWAS
Insomnia	Insomnia			GWAS
Alopecia Areata	Alopecia Areata			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Acromesomelic dysplasia	Associate	33887582
Brain Neoplasms	Associate	19543319
Coronary Artery Disease	Associate	23233742
Glioma	Associate	19543319
Gout	Associate	32124961
Mastocytosis Systemic	Associate	33663081
Neoplasms	Associate	19543319, 33663081, 37522128
Neuroendocrine Tumors	Associate	37522128
Osteosarcoma	Associate	29617357