Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	55909
Gene name	Bridging integrator 3
Gene symbol	BIN3
Synonyms (NCBI Gene)	-
Chromosome	8
Chromosome location	8p21.3
Summary	The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and

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miRTarBase ID	miRNA	Experiments	Reference
MIRT026045	hsa-miR-196a-5p	Sequencing	20371350
MIRT027575	hsa-miR-98-5p	Microarray	19088304
MIRT032138	hsa-let-7d-5p	Sequencing	20371350
MIRT045640	hsa-miR-149-5p	CLASH	23622248
MIRT821509	hsa-let-7a	CLIP-seq
MIRT821510	hsa-let-7b	CLIP-seq
MIRT821511	hsa-let-7c	CLIP-seq
MIRT821512	hsa-let-7d	CLIP-seq
MIRT821513	hsa-let-7e	CLIP-seq
MIRT821514	hsa-let-7f	CLIP-seq
MIRT821515	hsa-let-7g	CLIP-seq
MIRT821516	hsa-let-7i	CLIP-seq
MIRT821517	hsa-miR-193a-5p	CLIP-seq
MIRT821518	hsa-miR-3618	CLIP-seq
MIRT821519	hsa-miR-3689d	CLIP-seq
MIRT821520	hsa-miR-370	CLIP-seq
MIRT821521	hsa-miR-3927	CLIP-seq
MIRT821522	hsa-miR-4317	CLIP-seq
MIRT821523	hsa-miR-4323	CLIP-seq
MIRT821524	hsa-miR-4443	CLIP-seq
MIRT821525	hsa-miR-4458	CLIP-seq
MIRT821526	hsa-miR-4500	CLIP-seq
MIRT821527	hsa-miR-4731-5p	CLIP-seq
MIRT821528	hsa-miR-515-5p	CLIP-seq
MIRT821529	hsa-miR-518a-5p	CLIP-seq
MIRT821530	hsa-miR-527	CLIP-seq
MIRT821531	hsa-miR-664	CLIP-seq
MIRT821532	hsa-miR-934	CLIP-seq
MIRT821533	hsa-miR-98	CLIP-seq
MIRT1942854	hsa-miR-1302	CLIP-seq
MIRT1942855	hsa-miR-2277-3p	CLIP-seq
MIRT1942856	hsa-miR-3657	CLIP-seq
MIRT1942857	hsa-miR-3660	CLIP-seq
MIRT821520	hsa-miR-370	CLIP-seq
MIRT1942858	hsa-miR-3909	CLIP-seq
MIRT1942859	hsa-miR-4298	CLIP-seq
MIRT1942860	hsa-miR-4436b-5p	CLIP-seq
MIRT1942861	hsa-miR-4526	CLIP-seq
MIRT1942862	hsa-miR-4648	CLIP-seq
MIRT1942863	hsa-miR-4669	CLIP-seq
MIRT1942864	hsa-miR-4691-5p	CLIP-seq
MIRT1942865	hsa-miR-4693-3p	CLIP-seq
MIRT1942866	hsa-miR-574-5p	CLIP-seq
MIRT821509	hsa-let-7a	CLIP-seq
MIRT821510	hsa-let-7b	CLIP-seq
MIRT821511	hsa-let-7c	CLIP-seq
MIRT821512	hsa-let-7d	CLIP-seq
MIRT821513	hsa-let-7e	CLIP-seq
MIRT821514	hsa-let-7f	CLIP-seq
MIRT821515	hsa-let-7g	CLIP-seq
MIRT821516	hsa-let-7i	CLIP-seq
MIRT2181610	hsa-miR-1587	CLIP-seq
MIRT2181611	hsa-miR-1910	CLIP-seq
MIRT821517	hsa-miR-193a-5p	CLIP-seq
MIRT1942855	hsa-miR-2277-3p	CLIP-seq
MIRT2181612	hsa-miR-331-3p	CLIP-seq
MIRT2181613	hsa-miR-3622b-5p	CLIP-seq
MIRT1942856	hsa-miR-3657	CLIP-seq
MIRT2181614	hsa-miR-3685	CLIP-seq
MIRT821519	hsa-miR-3689d	CLIP-seq
MIRT2181615	hsa-miR-378g	CLIP-seq
MIRT1942858	hsa-miR-3909	CLIP-seq
MIRT2181616	hsa-miR-3912	CLIP-seq
MIRT821521	hsa-miR-3927	CLIP-seq
MIRT821524	hsa-miR-4443	CLIP-seq
MIRT821525	hsa-miR-4458	CLIP-seq
MIRT2181617	hsa-miR-4492	CLIP-seq
MIRT2181618	hsa-miR-4498	CLIP-seq
MIRT821526	hsa-miR-4500	CLIP-seq
MIRT2181619	hsa-miR-4656	CLIP-seq
MIRT1942863	hsa-miR-4669	CLIP-seq
MIRT2181620	hsa-miR-4675	CLIP-seq
MIRT1942864	hsa-miR-4691-5p	CLIP-seq
MIRT1942865	hsa-miR-4693-3p	CLIP-seq
MIRT2181621	hsa-miR-4720-5p	CLIP-seq
MIRT821527	hsa-miR-4731-5p	CLIP-seq
MIRT2181622	hsa-miR-4740-3p	CLIP-seq
MIRT2181623	hsa-miR-4741	CLIP-seq
MIRT2181624	hsa-miR-4799-3p	CLIP-seq
MIRT1942866	hsa-miR-574-5p	CLIP-seq
MIRT2181625	hsa-miR-762	CLIP-seq
MIRT821533	hsa-miR-98	CLIP-seq
MIRT2384785	hsa-miR-3672	CLIP-seq
MIRT821520	hsa-miR-370	CLIP-seq
MIRT2384786	hsa-miR-4786-5p	CLIP-seq
MIRT2384787	hsa-miR-769-5p	CLIP-seq
MIRT2181611	hsa-miR-1910	CLIP-seq
MIRT1942855	hsa-miR-2277-3p	CLIP-seq
MIRT2485154	hsa-miR-2861	CLIP-seq
MIRT2485155	hsa-miR-3064-5p	CLIP-seq
MIRT2485156	hsa-miR-3135b	CLIP-seq
MIRT2485157	hsa-miR-320e	CLIP-seq
MIRT2485158	hsa-miR-3616-3p	CLIP-seq
MIRT2485159	hsa-miR-3652	CLIP-seq
MIRT2485160	hsa-miR-4267	CLIP-seq
MIRT2485161	hsa-miR-4276	CLIP-seq
MIRT2485162	hsa-miR-431	CLIP-seq
MIRT2485163	hsa-miR-4430	CLIP-seq
MIRT2485164	hsa-miR-4446-3p	CLIP-seq
MIRT2485165	hsa-miR-4457	CLIP-seq
MIRT2181617	hsa-miR-4492	CLIP-seq
MIRT2181618	hsa-miR-4498	CLIP-seq
MIRT2485166	hsa-miR-4512	CLIP-seq
MIRT2485167	hsa-miR-4646-5p	CLIP-seq
MIRT2485168	hsa-miR-4685-5p	CLIP-seq
MIRT2485169	hsa-miR-4721	CLIP-seq
MIRT2485170	hsa-miR-4722-3p	CLIP-seq
MIRT821527	hsa-miR-4731-5p	CLIP-seq
MIRT2181622	hsa-miR-4740-3p	CLIP-seq
MIRT2485171	hsa-miR-4747-5p	CLIP-seq
MIRT2485172	hsa-miR-4751	CLIP-seq
MIRT2485173	hsa-miR-4755-3p	CLIP-seq
MIRT2485174	hsa-miR-4763-5p	CLIP-seq
MIRT2485175	hsa-miR-511	CLIP-seq
MIRT2181625	hsa-miR-762	CLIP-seq
MIRT2485176	hsa-miR-765	CLIP-seq
MIRT2485177	hsa-miR-938	CLIP-seq
MIRT2181611	hsa-miR-1910	CLIP-seq
MIRT1942855	hsa-miR-2277-3p	CLIP-seq
MIRT2485154	hsa-miR-2861	CLIP-seq
MIRT2485155	hsa-miR-3064-5p	CLIP-seq
MIRT2485157	hsa-miR-320e	CLIP-seq
MIRT2485158	hsa-miR-3616-3p	CLIP-seq
MIRT2485161	hsa-miR-4276	CLIP-seq
MIRT2485162	hsa-miR-431	CLIP-seq
MIRT2485164	hsa-miR-4446-3p	CLIP-seq
MIRT2485165	hsa-miR-4457	CLIP-seq
MIRT2485166	hsa-miR-4512	CLIP-seq
MIRT2485167	hsa-miR-4646-5p	CLIP-seq
MIRT2485168	hsa-miR-4685-5p	CLIP-seq
MIRT2485169	hsa-miR-4721	CLIP-seq
MIRT2485170	hsa-miR-4722-3p	CLIP-seq
MIRT821527	hsa-miR-4731-5p	CLIP-seq
MIRT2181622	hsa-miR-4740-3p	CLIP-seq
MIRT2485171	hsa-miR-4747-5p	CLIP-seq
MIRT2485173	hsa-miR-4755-3p	CLIP-seq
MIRT2485174	hsa-miR-4763-5p	CLIP-seq
MIRT2485175	hsa-miR-511	CLIP-seq
MIRT2485177	hsa-miR-938	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	18654987, 32296183, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0006897	Process	Endocytosis	IBA
GO:0006897	Process	Endocytosis	IEA
GO:0007015	Process	Actin filament organization	NAS	11274158
GO:0008093	Function	Cytoskeletal anchor activity	NAS	11274158
GO:0008104	Process	Intracellular protein localization	IMP	11274158
GO:0008289	Function	Lipid binding	IBA
GO:0009826	Process	Unidimensional cell growth	IMP	11274158
GO:0010591	Process	Regulation of lamellipodium assembly	IEA
GO:0014839	Process	Myoblast migration involved in skeletal muscle regeneration	IEA
GO:0015629	Component	Actin cytoskeleton	IBA
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0043403	Process	Skeletal muscle tissue regeneration	IEA
GO:0048589	Process	Developmental growth	IEA
GO:0048741	Process	Skeletal muscle fiber development	IEA
GO:0051301	Process	Cell division	IEA
GO:0051666	Process	Actin cortical patch localization	IBA
GO:0051666	Process	Actin cortical patch localization	IEA
GO:0061640	Process	Cytoskeleton-dependent cytokinesis	NAS	11274158
GO:0097320	Process	Plasma membrane tubulation	IBA

MIM	HGNC	e!Ensembl
606396	1054	ENSG00000147439

Q9NQY0

Protein name

Bridging integrator 3

Protein function

Involved in cytokinesis and septation where it has a role in the localization of F-actin.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03114	BAR	10 → 225	BAR domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed except in brain. {ECO:0000269|PubMed:11274158}.

Sequence

MSWIPFKIGQPKKQIVPKTVERDFEREYGKLQQLEEQTRRLQKDMKKSTDADLAMSKSAV
KISLDLLSNPLCEQDQDLLNMVTALDTAMKRMDAFNQEKVNQIQKTVIEPLKKFGSVFPS
LNMAVKRREQALQDYRRLQAKVEKYEEKEKTGPVLAKLHQAREELRPVREDFEAKNRQLL
EEMPRFYGSRLDYFQPSFESLIRAQVVYYSEMHKIFGDLSHQLDQPGHSDEQRERENEAK
LSELRALSIVADD

Sequence length

253

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Clear cell carcinoma of kidney	Uncertain significance	rs368195300	RCV005927192

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Carcinogenesis	Associate	36068491
Esophageal Neoplasms	Associate	36475339
Glioblastoma	Associate	35915159
Neoplasms	Associate	35915159, 36475339

BIN3 (bridging integrator 3)