GSDMB (gasdermin B)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55876
Gene name Gene Name - the full gene name approved by the HGNC.
Gasdermin B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GSDMB
Synonyms (NCBI Gene) Gene synonyms aliases
GSDMB-1, GSDML, PP4052, PRO2521
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Alternative splicing and the use of alternative promote
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(6)
miRTarBase ID miRNA Experiments Reference
MIRT017179 hsa-miR-335-5p Microarray 18185580
MIRT529037 hsa-miR-5692a PAR-CLIP 21572407
MIRT529037 hsa-miR-5692a PAR-CLIP 22012620
MIRT735131 hsa-miR-15a-5p Microarray, qRT-PCR 33291534
MIRT529037 hsa-miR-5692a PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(11)
GO ID Ontology Definition Evidence Reference
GO:0001786 Function Phosphatidylserine binding IBA 21873635
GO:0003674 Function Molecular_function ND
GO:0005546 Function Phosphatidylinositol-4,5-bisphosphate binding IBA 21873635
GO:0005575 Component Cellular_component ND
GO:0005737 Component Cytoplasm IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
611221 23690 ENSG00000073605
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q8TAX9
Protein name Gasdermin-B (Gasdermin-like protein) [Cleaved into: Gasdermin-B, N-terminal (GSDMB-NT) (p30); Gasdermin-B, C-terminal (GSDMB-CT) (p16)]
Protein function [Gasdermin-B]: Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death (PubMed:32299851). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moie
PDB 5TIB , 5TJ2 , 5TJ4 , 7WJQ , 8EFP , 8ET1 , 8ET2 , 8GTJ , 8GTK , 8GTN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04598 Gasdermin 4 → 237 Gasdermin pore forming domain Domain
PF17708 Gasdermin_C 243 → 382 Gasdermin PUB domain Domain
Tissue specificity TISSUE SPECIFICITY: In the gastrointestinal tract, expressed in proliferating cells, including in the basal cell layer of esophagus and in isthmus/neck of stomach. {ECO:0000269|PubMed:19051310}.
Sequence
Sequence length 411
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (5)
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Diabetes mellitus Diabetes Mellitus, Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)		 19430480
Lymphoblastic leukemia Precursor Cell Lymphoblastic Leukemia Lymphoma rs387906351, rs104894562, rs398122513, rs398122840, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699
View all (13 more)		 29348612
Multiple sclerosis Multiple Sclerosis rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039
View all (4 more)		 22190364
Show/Hide Unknown Diseases (8)
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma, Childhood asthma 21907864, 27439200, 24406073, 30929738, 22561531, 20860503, 17611496, 24241537, 29273806, 31036433, 28461288, 29785011, 31619474, 21804549 ClinVar, GWAS
Diabetes Diabetes GWAS
Cervical Cancer Cervical Cancer Our screens identified 10 miRNAs that enhance fitness of HeLa cells and have been reported to be up-regulated in cervical cancer (Table2). GWAS, CBGDA
Crohn Disease Crohn Disease GWAS
Show/Hide Text Mining Associations (38)
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Rheumatoid Associate 22694930, 29193869
Asthma Associate 18923164, 19732864, 20372189, 20503266, 22069270, 22271045, 22370936, 22694930, 23096927, 23154084, 24044605, 24066901, 24934276, 25256354, 25299150
View all (26 more)
Asthma Inhibit 29330013, 33909500
Autoimmune Diseases Associate 19732864, 24044605, 28272342
Ben Ari Shuper Mimouni syndrome Associate 36967681
Breast Neoplasms Associate 21247443, 28154144
Bronchiolitis Associate 26782568
Carcinoma Hepatocellular Stimulate 34731088
Carcinoma Non Small Cell Lung Associate 35422093
Carcinoma Renal Cell Associate 34957313, 35308143, 38179741