PBK (PDZ binding kinase)

Gene

• Entrez ID: 55872
• Gene name: PDZ binding kinase
• Gene symbol: PBK
• Synonyms (NCBI Gene): CT84, HEL164, Nori-3, SPK, TOPK
• Chromosome: 8
• Chromosome location: 8p21.1
• Summary: This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be invo

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004449	hsa-miR-373-3p	Microarray	15685193
MIRT004449	hsa-miR-373-3p	Microarray	15685193
MIRT695240	hsa-miR-449b-3p	HITS-CLIP	23313552
MIRT695239	hsa-miR-4699-3p	HITS-CLIP	23313552
MIRT695238	hsa-miR-216b-3p	HITS-CLIP	23313552
MIRT695240	hsa-miR-449b-3p	HITS-CLIP	23313552
MIRT695239	hsa-miR-4699-3p	HITS-CLIP	23313552
MIRT695238	hsa-miR-216b-3p	HITS-CLIP	23313552
MIRT1215592	hsa-miR-1183	CLIP-seq
MIRT1215593	hsa-miR-224	CLIP-seq
MIRT1215594	hsa-miR-3130-5p	CLIP-seq
MIRT1215595	hsa-miR-3653	CLIP-seq
MIRT1215596	hsa-miR-3658	CLIP-seq
MIRT1215597	hsa-miR-3668	CLIP-seq
MIRT1215598	hsa-miR-3924	CLIP-seq
MIRT1215599	hsa-miR-3973	CLIP-seq
MIRT1215600	hsa-miR-4255	CLIP-seq
MIRT1215601	hsa-miR-4263	CLIP-seq
MIRT1215602	hsa-miR-4310	CLIP-seq
MIRT1215603	hsa-miR-4468	CLIP-seq
MIRT1215604	hsa-miR-4482	CLIP-seq
MIRT1215605	hsa-miR-4799-5p	CLIP-seq
MIRT1215606	hsa-miR-520d-5p	CLIP-seq
MIRT1215607	hsa-miR-520g	CLIP-seq
MIRT1215608	hsa-miR-520h	CLIP-seq
MIRT1215609	hsa-miR-524-5p	CLIP-seq
MIRT1215610	hsa-miR-548a-3p	CLIP-seq
MIRT1215611	hsa-miR-548a-5p	CLIP-seq
MIRT1215612	hsa-miR-548ab	CLIP-seq
MIRT1215613	hsa-miR-548ak	CLIP-seq
MIRT1215614	hsa-miR-548b-5p	CLIP-seq
MIRT1215615	hsa-miR-548c-5p	CLIP-seq
MIRT1215616	hsa-miR-548d-5p	CLIP-seq
MIRT1215617	hsa-miR-548e	CLIP-seq
MIRT1215618	hsa-miR-548f	CLIP-seq
MIRT1215619	hsa-miR-548h	CLIP-seq
MIRT1215620	hsa-miR-548i	CLIP-seq
MIRT1215621	hsa-miR-548j	CLIP-seq
MIRT1215622	hsa-miR-548k	CLIP-seq
MIRT1215623	hsa-miR-548n	CLIP-seq
MIRT1215624	hsa-miR-548t	CLIP-seq
MIRT1215625	hsa-miR-548w	CLIP-seq
MIRT1215626	hsa-miR-548y	CLIP-seq
MIRT1215627	hsa-miR-559	CLIP-seq
MIRT1215628	hsa-miR-576-5p	CLIP-seq
MIRT2062037	hsa-miR-1207-3p	CLIP-seq
MIRT2062038	hsa-miR-590-3p	CLIP-seq
MIRT2062037	hsa-miR-1207-3p	CLIP-seq
MIRT2290561	hsa-miR-1273f	CLIP-seq
MIRT2290562	hsa-miR-143	CLIP-seq
MIRT2290563	hsa-miR-145	CLIP-seq
MIRT2290564	hsa-miR-3161	CLIP-seq
MIRT2290565	hsa-miR-409-3p	CLIP-seq
MIRT1215600	hsa-miR-4255	CLIP-seq
MIRT2290566	hsa-miR-4276	CLIP-seq
MIRT2290567	hsa-miR-4302	CLIP-seq
MIRT2290568	hsa-miR-4708-5p	CLIP-seq
MIRT2290569	hsa-miR-4770	CLIP-seq
MIRT2290570	hsa-miR-4793-5p	CLIP-seq
MIRT2290571	hsa-miR-545	CLIP-seq
MIRT1215611	hsa-miR-548a-5p	CLIP-seq
MIRT1215612	hsa-miR-548ab	CLIP-seq
MIRT1215613	hsa-miR-548ak	CLIP-seq
MIRT1215614	hsa-miR-548b-5p	CLIP-seq
MIRT1215615	hsa-miR-548c-5p	CLIP-seq
MIRT1215616	hsa-miR-548d-5p	CLIP-seq
MIRT1215619	hsa-miR-548h	CLIP-seq
MIRT1215620	hsa-miR-548i	CLIP-seq
MIRT1215621	hsa-miR-548j	CLIP-seq
MIRT1215623	hsa-miR-548n	CLIP-seq
MIRT2290572	hsa-miR-548p	CLIP-seq
MIRT1215624	hsa-miR-548t	CLIP-seq
MIRT1215625	hsa-miR-548w	CLIP-seq
MIRT1215626	hsa-miR-548y	CLIP-seq
MIRT1215627	hsa-miR-559	CLIP-seq
MIRT2290573	hsa-miR-579	CLIP-seq
MIRT2290574	hsa-miR-582-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ATM	Unknown	15220931

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000278	Process	Mitotic cell cycle	NAS	10779557
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS	10779557
GO:0004708	Function	MAP kinase kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	10779557, 12620389, 17482142, 20622899, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	25575812
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032435	Process	Negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA
GO:0032873	Process	Negative regulation of stress-activated MAPK cascade	IEA
GO:0034644	Process	Cellular response to UV	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IEA
GO:0050728	Process	Negative regulation of inflammatory response	IEA
GO:0051403	Process	Stress-activated MAPK cascade	IBA
GO:0051403	Process	Stress-activated MAPK cascade	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

Other IDs

• MIM: 611210
• HGNC: 18282
• e!Ensembl: ENSG00000168078

Protein

• UniProt ID: Q96KB5
• Protein name: Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase)
• Protein function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint durin
• PDB: 5J0A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	33 → 318	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:11378444}.
• Sequence:

  MEGISNFKTPSKLSEKKKSVLCSTPTINIPASPFMQKLGFGTGVNVYLMKRSPRGLSHSP
  WAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGE
  KSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFE
  TIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEM
  MTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVC
  TNEDPKDRPSAAHIVEALETDV

• Sequence length: 322